acyclovir and Diabetes-Mellitus--Type-1

Topics: Acyclovir; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Ganciclovir; Graft Rejection; Hospitalization; Humans; Incidence; Pancreas Transplantation

Topics: Actuarial Analysis; Acyclovir; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Graft Survival; Humans; Kidney Transplantation; Pancreas Transplantation; Retrospective Studies; Survival Rate

Topics: Acyclovir; Antiviral Agents; Diabetes Mellitus, Type 1; Female; Hand Dermatoses; Herpes Simplex; Humans; Immunohistochemistry; Middle Aged; Pseudolymphoma; Valacyclovir; Valine

Topics: Acyclovir; Antiviral Agents; Confusion; Diabetes Mellitus, Type 1; Female; Herpes Labialis; Humans; Hypertension; Kidney Failure, Chronic; Middle Aged; Nausea

Topics: Acyclovir; Antiviral Agents; Diabetes Mellitus, Type 1; Extravasation of Diagnostic and Therapeutic Materials; Hand Injuries; Herpes Zoster; Humans; Male; Middle Aged

Severity of varicella infection in 54 patients with diabetes mellitus seen in Arar Central Hospital, Saudi Arabia, between January 1992 and December 1994 was compared with that in 55 apparently healthy controls, seen during the same period. Persistent fever, defined as fever lasting more than five days; extensive skin eruption, defined as affecting more than 50% of the body surface; and secondary bacterial skin infection evidenced by a positive skin culture of Staphylococcus aureus or Streptococcus pyogenes occurred significantly more in diabetics than in healthy controls. The mean duration of the illness in diabetics was 16.8 +/- 3.24 days as compared to 13.6 +/- 3.32 days in healthy controls. These findings suggest that varicella runs a more aggressive course in diabetic patients compared to otherwise healthy individuals. Treatment with the anti-viral agent, acyclovir may be indicated in diabetics with varicella infection.

Topics: Acyclovir; Adolescent; Adult; Antiviral Agents; Case-Control Studies; Chickenpox; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Male; Saudi Arabia; Severity of Illness Index; Skin Diseases, Bacterial

Oral infection with Herpes Simplex Virus (HSV) is a frequent and well documented complication in immunosuppressed individuals including patients on immunosuppressive medication. We report the development of severe oral infection with HSV type 1 in a 34 year old woman with type 1 diabetes mellitus and end stage renal disease (ESRD) following cadaveric renal transplantation at the Western General Hospital, Edinburgh. The role of acyclovir in therapy and chemoprophylaxis is discussed.

Topics: Acyclovir; Adult; Diabetes Mellitus, Type 1; Female; Herpes Labialis; Humans; Kidney Failure, Chronic; Kidney Transplantation; Postoperative Complications