acyclovir and Anemia--Hemolytic--Autoimmune

We have described a case of herpes genitalis in a patient with Evans's syndrome who had violaceous macules leading to deep ulcerations. This case serves as a reminder that HSV infection may be atypical and have an unusual course in immunocompromised patients. With the availability of specific therapy for this infection, it is important to consider HSV in the differential diagnosis of all ulcerative skin lesions.

Topics: Acyclovir; Anemia, Hemolytic, Autoimmune; Herpes Genitalis; Humans; Immunosuppression Therapy; Male; Middle Aged; Penile Diseases; Recurrence; Skin Ulcer; Syndrome; Thrombocytopenia

The authors report a peculiar form of Hodgkin's disease that is associated with Epstein-Barr virus infection. A 16-year-old patient was admitted for an autoimmune haemolytic anaemia associated with IgG auto-immune antibodies, linked to general clinical complications, cervical adenopathies and splenomegalia. The patient underwent hemicavectomy that was not histologically investigated. The ganglionar exeresis helped to establish the histological diagnosis of Hodgkin's disease, classic form with nodular sclerosis. Tumour cells were CD30 CD15 positive and neighbouring lymphoid cells were CD3 and CD20 positive. In situ hybridation allowed the detection of Epstein-Barr virus in tumour cells. Under ABVD chemotherapy supplemented with acyclovir and initial corticotherapy, mid-treatment evolution appears to be favourable. This observation is consistent with the hypothesis that tumour cells are of B cell origin during Hodgkin's disease, together with the involvement of Epstein-Barr virus in lymphomagenesis.

Topics: Acyclovir; Adolescent; Anemia, Hemolytic, Autoimmune; Antibiotics, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Autoantibodies; Bleomycin; Dacarbazine; Doxorubicin; Epstein-Barr Virus Infections; Hodgkin Disease; Humans; Immunoglobulin G; Male; Tumor Virus Infections; Vinblastine

Topics: Acyclovir; Anemia, Hemolytic, Autoimmune; Anti-Inflammatory Agents; Antiviral Agents; Chickenpox; Heart Failure; Hepatitis, Viral, Human; Hepatomegaly; Herpesvirus 3, Human; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Male; Methylprednisolone; Prednisolone; Splenomegaly

Topics: Acyclovir; Agglutinins; Anemia, Hemolytic, Autoimmune; Cryoglobulins; Cryopreservation; Herpes Zoster; Humans; Intraoperative Complications; Liver Cirrhosis; Liver Transplantation; Male; Middle Aged; Prednisone; Preoperative Care