acyclovir and Adrenoleukodystrophy

EBV-associated post-transplant lymphoproliferative disorder (PTLD) is a well-recognized complication following solid organ transplantation and hematopoietic stem cell transplantation (HSCT) using bone marrow or peripheral blood as stem cell sources, but rarely reported in umbilical cord blood transplantation (UCBT). We report two cases in unrelated UCBT setting and added the following new information to the literature: (i) EBV-related PTLD can be presented late in recipients of unrelated UCBT; (ii) in contrast to reported literatures that PTLD is a serious complication with unfavorable outcome, especially in monomorphic form, our cases showed that the clinical course may be relatively benign if treatment is initiated promptly.

Topics: Acyclovir; Adrenoleukodystrophy; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antiviral Agents; Child; Child, Preschool; Combined Modality Therapy; Cord Blood Stem Cell Transplantation; Cyclosporine; Epstein-Barr Virus Infections; Graft vs Host Disease; Herpesvirus 4, Human; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosuppressive Agents; Lymphoproliferative Disorders; Male; Postoperative Complications; Prednisolone; Remission Induction; Rituximab; Tumor Virus Infections; Virus Activation