acyclovir and Adenoviridae-Infections

Topics: Acyclovir; Adenoviridae Infections; Antiviral Agents; Cytomegalovirus Infections; Diagnosis, Differential; Herpes Simplex; Humans; Pleurisy; Prognosis

Topics: Acyclovir; Adenoviridae Infections; Adult; Aged; Female; Humans; Keratitis; Keratitis, Dendritic; Male; Middle Aged; Ophthalmic Solutions

When adenovirus causes haemorrhagic cystitis in immunocompromised patients, vidarabine is used for its treatment because therapeutic choice is limited. Although vidarabine has been reported to be effective for these patients, its therapeutic basis has not yet been established. Vidarabine dose-dependently inhibited viral replication as assessed by a yield reduction assay. Viral protein synthesis was dose-dependently inhibited by vidarabine but not at all by acyclovir, and the degree of inhibition by vidarabine was different for each of the viral proteins, ranging from 0-40% of the untreated control. These results indicated the specificity and mechanism of action of vidarabine against adenovirus. The concentration of vidarabine and its metabolite in the bladder is suggested to exhibit effective anti-adenoviral activity in suppressing the replication of adenovirus. Thus, our results support vidarabine therapy as a possible candidate for adenovirus-induced haemorrhagic cystitis in immunocompromised patients.

Topics: Acyclovir; Adenoviridae; Adenoviridae Infections; Antiviral Agents; Cystitis; Dose-Response Relationship, Drug; Hemorrhage; Humans; Immunocompromised Host; Urinary Bladder; Vidarabine; Viral Proteins

Topics: Acyclovir; Adenoviridae Infections; Adenovirus Infections, Human; Antiviral Agents; Child, Preschool; Female; Ganciclovir; Humans; Immunosuppression Therapy; Liver Transplantation