Compounds > activins

activins and Ovarian Neoplasms

activins has been researched along with Ovarian Neoplasms in 77 studies

Research

Studies (77)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's22 (28.57)18.2507
2000's34 (44.16)29.6817
2010's18 (23.38)24.3611
2020's3 (3.90)2.80

Authors

AuthorsStudies
Berchuck, A; Chaudhary, R; Choi, AS; Hempel, N; Henis, YI; Horst, B; Lee, NY; Listik, E; Liu, Y; Mythreye, K; Nixon, AB; Pradhan, S; Quintero-Macias, L; Southard, M; Whitaker, R1
Arend, RC; Evans, ET; Horst, B; Mythreye, K1
Andersen, S; Bjørkøy, G; Grønberg, BH; Hatakeyama, S; Jacobi, C; Kim, J; Lach-Trifilieff, E; Lambert, C; Moestue, S; Nonstad, U; Pettersen, K; Schilb, A; van der Veen, A1
Gold, EJ; Marino, FE; Nicholson, HD; Reader, KL; Risbridger, GP1
Cadoo, KA; Cangemi, NA; Haqq, CM; Hyman, DM; Liu, JF; Makker, V; Navarro, WH; Rasco, DW; Tao, JJ1
Cheng, JC; Klausen, C; Leung, PCK; Yi, Y1
Bougeard, G; Bressac-de Paillerets, B; Caron, O; Charbonnier, C; Charbonnier, F; Coutant, S; Frebourg, T; Harrison, C; Ippolito, L; King, MC; Marlin, R; Roman, H; Sabourin, JC; Spurrell, C; Stoppa-Lyonnet, D; Théry, JC; Tinat, J; Tournier, I; Vaur, D; Vezain, M; Walton, K1
Gold, E; Marino, FE; Risbridger, G1
Gold, E; Reader, KL1
Annunziata, CM; Bunch, KP; Gharwan, H1
de Kretser, DM; Wijayarathna, R1
Burdette, JE; Davis, DA; Dean, M1
Bilandzic, M; Chu, S; Escalona, RM; Farnworth, PG; Findlay, JK; Fuller, PJ; Harrison, C; Nicholls, P; Stenvers, KL; Wang, Y1
Baguley, BC; Love, DR; Marshall, ES; Ramachandran, A; Shelling, AN1
Mabuchi, Y; Minami, S; Umesaki, N; Yamoto, M3
Agno, JE; Li, Q; Loveland, KL; Matzuk, MM; Nalam, RL; Rajanahally, S; Weinstein, MB1
Huang, F; Li, H1
Robertson, DM1
McNeilly, AS1
Drummond, AE; Fuller, PJ1
Nachtigal, MW; Thériault, BL1
Karve, TM; Kumar, D; Li, X; Preet, A; Rosen, EM; Saha, T; Salamanca, C; Sneed, R; Xu, J1
Gold, E; Harrison, C; Makanji, Y; Marino, FE; Risbridger, G1
Burger, HG; Tong, S; Wallace, EM1
Bavers, DL; Beuschlein, F; Bleasdale, SE; Hammer, GD; Looyenga, BD; Mutch, C; Nilson, JH; Parlow, AF1
Bläuer, M; Puistola, U; Tuohimaa, P; Vihko, KK1
Fu, Y; Nachtigal, MW; O'Connor, LM; Shepherd, TG1
Bützow, R; Hydén-Granskog, C; Kosma, VM; Kuulasmaa, T; Liu, J; Vänttinen, T; Voutilainen, R1
Tanaka, T; Toujima, S; Umesaki, N1
Brown, CA; Chen, L; Matzuk, MM; Wu, X; Yan, C1
Burger, HG; Fuller, PJ; Robertson, DM1
Cobellis, L; Danero, S; Luisi, S; Petraglia, F; Pirtoli, L; Reis, FM; Scambia, G1
Ethier, JF; Shaw, TJ; Steller, MD; Vanderhyden, BC1
Chudecka-Głaz, A; Rzepka-Górska, I1
Agarwal, A; Kumanov, P; Nandipati, KC; Robeva, R; Tomova, A1
Nakano, R1
Burdette, JE; Kilen, SM; Mayo, KE; Oliver, RM; Ulyanov, V; Woodruff, TK1
Graff, JM; Li, Q; Loveland, KL; Matzuk, MM; O'Connor, AE1
Hammer, GD; Looyenga, BD1
Antenos, M; Do, TV; Kubba, LA; Rademaker, AW; Sturgis, CD; Woodruff, TK1
Hsueh, AJ; Huhtaniemi, IT; Kananen, K; Markkula, M; Rainio, E; Su, JG1
Kaipia, A; Toppari, J1
Burger, HG; Gurusinghe, CJ; Healy, DL; Jobling, T; Mamers, P1
Bradley, A; Finegold, MJ; Hsueh, AJ; Lewis, KA; Matzuk, MM; Perlas, E; Shikone, T; Vale, W1
Burger, HG1
Crowley, WF; Di Simone, N; Schneyer, AL; Sluss, PM; Wang, QF1
Crowley, WF; Khoury, RH; McConnell, DS; Midgley, AR; Padmanahban, V; Schneyer, AL; Sluss, PM; Smith, PC; Wang, QF1
Bradley, A; Coerver, KA; Finegold, MJ; Mather, J; Matzuk, MM; Woodruff, TK1
Healy, DL; Wallace, EM1
Gitelman, SE; Silverman, LA1
Arora, DS; Charnock, FM; Cooke, IE; Ganesan, TS; Groome, NP; Manek, S; Ramsdale, J; Wells, M1
Crowley, WF; Lambert-Messerlian, G; Schneyer, AL; Welt, CK; Zheng, W1
DePetris, G; Hanna, I; Lambert-Messerlian, G; Lauchlan, SC; Steinhoff, M; Sung, CJ; Zheng, W1
Bidart, JM; Lhomme, C; Luisi, S; Pautier, P; Petraglia, F; Rey, R; Sabourin, JC1
Felix, JC; Lambert-Messerlian, G; Lauchlan, SC; Luo, MP; Schneyer, AL; Sung, CJ; Welt, C; Ying, SY; Zhang, Z; Zheng, W1
Fukuda, J; Ito, I; Leung, PC; Tanaka, T1
Minami, S; Nakano, R; Shikone, T; Yamashita, K; Yamoto, M1
Delbaere, A; Schneyer, AL; Sidis, Y1
Huhtaniemi, I; Rahman, NA1
Boime, I; Byrne, MC; Kumar, TR; Matzuk, MM; Palapattu, G; Wang, P; Woodruff, TK1
DePasquale, SE; Gajewski, WH; Lambert-Messerlian, GM; Maybruck, WM; Steinhoff, MM1
Bläuer, M; Vihko, KK1
Auersperg, N; Fukuda, J; Ito, I; Leung, PC; Minegishi, T; Shinozaki, H1
Hudson, NL; Juengel, JL; McNatty, KP; Quirke, LD; Smith, P; Tisdall, DJ1
Chen, L; Cipriano, SC; Kumar, TR; Matzuk, MM1
Abe, K; Hirakawa, T; Ibuki, Y; Kameda, T; Minegishi, T; Tano, M1
Chang, L; Cho, MM; Hsieh, J; Lu, JJ; Luo, F; Stanczyk, FZ; Wang, CY; Zhang, C; Zheng, W1
Bose, C; Dawnay, A; Evans, LW; Groome, NP; Jacobs, IJ; Menon, U; Riley, SC; Thomas, J1
Auersperg, N; Cheng, KW; Choi, KC; Kang, SK; Leung, PC; Nathwani, PS1
Auersperg, N; Choi, KC; Kang, SK; Leung, PC; Tai, CJ1
Burns, KH; Chen, L; Cipriano, SC; Koff, A; Matzuk, MM1
Arcuri, F; Cataldi, P; Cobellis, L; De Palo, G; Petraglia, F; Pilotti, S; Raspagliesi, F; Reis, FM1
Woodruff, TK1
Burger, HG; Chu, S; Fikret, S; Fuller, PJ1
Burger, HG; Groome, N; Healy, D; Jobling, T; Mamers, P; McCloud, P; McNeilage, J; Pruysers, E; Robertson, DM; Stephenson, T; Tsigos, A1

Reviews

20 review(s) available for activins and Ovarian Neoplasms

ArticleYear
Evolving roles of activins and inhibins in ovarian cancer pathophysiology.
    American journal of physiology. Cell physiology, 2023, 02-01, Volume: 324, Issue:2

    Topics: Activins; Endocrine System; Female; Humans; Inhibins; Ovarian Neoplasms; Signal Transduction

2023
Activins and activin antagonists in the human ovary and ovarian cancer.
    Molecular and cellular endocrinology, 2015, Nov-05, Volume: 415

    Topics: Activins; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibins; Ovarian Neoplasms; Ovary; Signal Transduction

2015
The role of reproductive hormones in epithelial ovarian carcinogenesis.
    Endocrine-related cancer, 2015, Volume: 22, Issue:6

    Topics: Activins; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Differentiation; Cell Transformation, Neoplastic; Chickens; Drug Screening Assays, Antitumor; Epithelial Cells; Fallopian Tubes; Female; Genes, Neoplasm; Genitalia, Female; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hypothalamo-Hypophyseal System; Immune System; Immunotherapy; Inhibins; Mice; Models, Animal; Models, Biological; Mutation; Neovascularization, Pathologic; NF-kappa B; Ovarian Neoplasms; Primates; Stromal Cells; Tumor Microenvironment

2015
Activins in reproductive biology and beyond.
    Human reproduction update, 2016, Volume: 22, Issue:3

    Topics: Activins; Animals; Female; Follistatin; Glycoproteins; Humans; Inhibin-beta Subunits; Inhibins; Male; Ovarian Neoplasms; Ovary; Pre-Eclampsia; Pregnancy; Reproduction; Testis

2016
[Activin and activin receptors in related gynecologic and obstetric diseases].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2010, Volume: 35, Issue:8

    Topics: Activin Receptors; Activins; Animals; Endometrial Neoplasms; Endometriosis; Female; Humans; Ovarian Neoplasms; Pre-Eclampsia; Pregnancy

2010
Inhibins and activins in blood: predictors of female reproductive health?
    Molecular and cellular endocrinology, 2012, Aug-15, Volume: 359, Issue:1-2

    Topics: Activins; Animals; Biomarkers; Female; Health; Humans; Infertility, Female; Inhibins; Menopause; Ovarian Follicle; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Reproduction

2012
Diagnostic applications for inhibin and activins.
    Molecular and cellular endocrinology, 2012, Aug-15, Volume: 359, Issue:1-2

    Topics: Activins; Animals; Biomarkers; Biomarkers, Tumor; Female; Humans; Infertility, Female; Inhibins; Male; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnancy; Spermatogenesis

2012
Activin and inhibin, estrogens and NFκB, play roles in ovarian tumourigenesis is there crosstalk?
    Molecular and cellular endocrinology, 2012, Aug-15, Volume: 359, Issue:1-2

    Topics: Activin Receptors; Activins; Animals; Cell Transformation, Neoplastic; Female; Humans; Inhibins; NF-kappa B; Ovarian Neoplasms; Receptor Cross-Talk; Receptors, Estrogen; Signal Transduction

2012
Inhibins and activins: clinical advances in reproductive medicine.
    Clinical endocrinology, 2003, Volume: 58, Issue:2

    Topics: Activins; Animals; Biomarkers; Female; Fetus; Follicle Stimulating Hormone; Follicular Fluid; Humans; Inhibins; Male; Menstrual Cycle; Ovarian Neoplasms; Ovary; Placenta; Pregnancy; Pregnancy Complications; Reproduction; Testis

2003
Inhibin/activin and ovarian cancer.
    Endocrine-related cancer, 2004, Volume: 11, Issue:1

    Topics: Activins; Animals; Female; Gene Expression Regulation; Humans; Inhibins; Mice; Ovarian Neoplasms; Ovary; Signal Transduction

2004
Significance of inhibin in reproductive pathophysiology and current clinical applications.
    Reproductive biomedicine online, 2005, Volume: 10, Issue:6

    Topics: Activins; Adult; Age Factors; alpha-Macroglobulins; Chromosomes, Human, Y; Exocrine Glands; Female; Fertilization in Vitro; Follistatin; Humans; Infant, Newborn; Infertility, Male; Inhibins; Male; Menstrual Cycle; Ovarian Neoplasms; Polycystic Ovary Syndrome; Pregnancy; Reproduction; Sequence Deletion

2005
[Ovarian tumors].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 4

    Topics: Activins; Animals; Biomarkers, Tumor; Female; Humans; Inhibins; Ovarian Neoplasms; Prognosis; Transforming Growth Factor beta

2006
[Inhibin and activin].
    Duodecim; laaketieteellinen aikakauskirja, 1994, Volume: 110, Issue:10

    Topics: Activins; Biomarkers, Tumor; Female; Growth Substances; Humans; Inhibins; Male; Ovarian Neoplasms; Ovary; Testicular Neoplasms; Testis

1994
Clinical review 46: Clinical utility of inhibin measurements.
    The Journal of clinical endocrinology and metabolism, 1993, Volume: 76, Issue:6

    Topics: Activins; Adult; Biological Assay; Biomarkers, Tumor; Female; Follistatin; Glycoproteins; Humans; Inhibins; Male; Ovarian Neoplasms; Radioimmunoassay; Reference Standards; Sensitivity and Specificity; Sex Characteristics

1993
Inhibins and activins: roles in clinical practice.
    British journal of obstetrics and gynaecology, 1996, Volume: 103, Issue:10

    Topics: Activins; Down Syndrome; Female; Follicle Stimulating Hormone; Forecasting; Growth Substances; Humans; Hydatidiform Mole; Inhibins; Male; Ovarian Neoplasms; Pregnancy

1996
Immunoreactive inhibin, müllerian inhibitory substance, and activin as biochemical markers for juvenile granulosa cell tumors.
    The Journal of pediatrics, 1996, Volume: 129, Issue:6

    Topics: Activins; Anti-Mullerian Hormone; Biomarkers, Tumor; Child; Child, Preschool; Female; Glycoproteins; Granulosa Cell Tumor; Growth Inhibitors; Growth Substances; Humans; Inhibins; Mullerian Ducts; Ovarian Neoplasms; Testicular Hormones

1996
[Activins and inhibins--from laboratory to clinics].
    Duodecim; laaketieteellinen aikakauskirja, 1997, Volume: 113, Issue:17

    Topics: Activins; Animals; Female; Fertilization in Vitro; Forecasting; Granulosa Cell Tumor; Humans; Infertility; Inhibins; Male; Menopause; Ovarian Neoplasms; Pregnancy; Pregnancy Complications; Recombinant Proteins; Reproductive Medicine

1997
Role of inhibins and activins in ovarian cancer.
    Cancer treatment and research, 2002, Volume: 107

    Topics: Activins; Cell Transformation, Neoplastic; Female; Granulosa Cell Tumor; Humans; Inhibins; Ovarian Follicle; Ovarian Neoplasms; Ovary; Signal Transduction

2002
Molecular pathogenesis of granulosa cell tumours.
    Molecular and cellular endocrinology, 2002, May-31, Volume: 191, Issue:1

    Topics: Activin Receptors; Activins; Animals; Female; Gene Expression Regulation, Neoplastic; Granulosa Cell Tumor; Inhibins; Ovarian Neoplasms; Receptors, Estrogen; Receptors, FSH; Receptors, Peptide; Signal Transduction

2002
Inhibins/activins as diagnostic markers for ovarian cancer.
    Molecular and cellular endocrinology, 2002, May-31, Volume: 191, Issue:1

    Topics: Activins; Antibodies, Monoclonal; Biomarkers, Tumor; Female; Follicle Stimulating Hormone; Granulosa Cell Tumor; Humans; Inhibins; Ovarian Neoplasms; Protein Subunits

2002

Other Studies

57 other study(ies) available for activins and Ovarian Neoplasms

ArticleYear
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.
    Communications biology, 2022, 06-02, Volume: 5, Issue:1

    Topics: Activin Receptors, Type II; Activins; Capillary Permeability; Female; Humans; Hypoxia; Inhibins; Ovarian Neoplasms

2022
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.
    Journal of cachexia, sarcopenia and muscle, 2020, Volume: 11, Issue:1

    Topics: Activins; Animals; Autocrine Communication; Autophagy; Cachexia; Disease Models, Animal; Female; Humans; Interleukin-6; Mice; Ovarian Neoplasms; Signal Transduction

2020
Role of activin C in normal ovaries and granulosa cell tumours of mice and humans.
    Reproduction, fertility, and development, 2018, Volume: 30, Issue:7

    Topics: Activins; Animals; Female; Granulosa Cell Tumor; Granulosa Cells; Humans; Inhibins; Mice; Ovarian Follicle; Ovarian Neoplasms; Ovary

2018
First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2019, Sep-15, Volume: 25, Issue:18

    Topics: Activins; Antineoplastic Agents; Granulosa Cells; Humans; Maximum Tolerated Dose; Neoplasms; Ovarian Neoplasms; Treatment Outcome

2019
Activin A promotes ovarian cancer cell migration by suppressing E-cadherin expression.
    Experimental cell research, 2019, 09-15, Volume: 382, Issue:2

    Topics: Activin Receptors, Type I; Activins; Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Phosphorylation; Signal Transduction; Smad Proteins; Snail Family Transcription Factors; Up-Regulation

2019
Germline mutations of inhibins in early-onset ovarian epithelial tumors.
    Human mutation, 2014, Volume: 35, Issue:3

    Topics: Activins; Carcinoma, Ovarian Epithelial; Cell Differentiation; Cohort Studies; Epithelial Cells; Exome; Female; Germ-Line Mutation; Granulosa Cells; Humans; Inhibin-beta Subunits; Inhibins; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Sequence Analysis, DNA; Young Adult

2014
The inhibin/activin signalling pathway in human gonadal and adrenal cancers.
    Molecular human reproduction, 2014, Volume: 20, Issue:12

    Topics: Activin Receptors, Type II; Activins; Adrenal Gland Neoplasms; Cell Line, Tumor; Databases, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Inhibin-beta Subunits; Inhibins; Male; Ovarian Neoplasms; Protein Structure, Tertiary; RNA, Messenger; Signal Transduction; Smad Proteins, Receptor-Regulated; Testicular Neoplasms

2014
Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling.
    Cancer letters, 2017, 04-10, Volume: 391

    Topics: Activins; Animals; Cell Movement; Cystadenocarcinoma, Serous; Fallopian Tube Neoplasms; Female; Humans; Mice; Ovarian Neoplasms; Signal Transduction; Transfection

2017
Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells.
    Molecular endocrinology (Baltimore, Md.), 2009, Volume: 23, Issue:4

    Topics: Activins; Cell Adhesion; Cell Line, Tumor; Female; Gene Silencing; Granulosa Cell Tumor; Humans; Inhibins; Ligands; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Receptors, Transforming Growth Factor beta; Transforming Growth Factor beta

2009
Activin is a potent growth suppressor of epithelial ovarian cancer cells.
    Cancer letters, 2009, Nov-28, Volume: 285, Issue:2

    Topics: Activins; Cell Line, Tumor; Cell Proliferation; Female; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction

2009
Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis.
    International journal of molecular medicine, 2010, Volume: 25, Issue:1

    Topics: Activin Receptors; Activins; Adult; Endometriosis; Endometrium; Female; Humans; Immunohistochemistry; Inhibins; Middle Aged; Ovarian Neoplasms; Smad Proteins; Young Adult

2010
Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice.
    Reproductive biology and endocrinology : RB&E, 2010, Jun-21, Volume: 8

    Topics: Activins; Animals; Carcinoma; Female; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Ovarian Neoplasms; Smad2 Protein; Testicular Neoplasms

2010
Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.
    Cancer letters, 2011, Dec-26, Volume: 313, Issue:1

    Topics: Activins; Autocrine Communication; Blotting, Western; Bone Morphogenetic Proteins; Cell Line; Cell Movement; Cell Proliferation; Cell Shape; Female; Gene Expression; Humans; Inhibitor of Differentiation Protein 1; Molecular Sequence Data; Ovarian Neoplasms; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Smad Proteins; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured

2011
BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Activins; Blotting, Western; BRCA1 Protein; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cells, Cultured; Cluster Analysis; Female; Follistatin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasms, Glandular and Epithelial; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transfection

2012
Activin-β(c) reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice.
    The Journal of pathology, 2013, Volume: 229, Issue:4

    Topics: Activins; Animals; Apoptosis; Cachexia; Cell Line; Cell Proliferation; Dimerization; Disease Progression; Female; Follistatin; Gene Expression; Humans; Inhibin-beta Subunits; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Ovarian Neoplasms; Phosphorylation; Sequence Deletion; Smad2 Protein; Testicular Neoplasms

2013
Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.
    Molecular and cellular biology, 2003, Volume: 23, Issue:11

    Topics: Activins; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Animals; Apoptosis; Body Weight; Cachexia; DNA-Binding Proteins; Estradiol; Female; Humans; In Situ Hybridization; Inhibins; Luteinizing Hormone; Male; Mice; Mice, Knockout; Mice, Transgenic; Ovarian Neoplasms; Ovariectomy; Phenotype; Receptors, LH; Smad2 Protein; Testosterone; Trans-Activators

2003
Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin.
    Acta obstetricia et gynecologica Scandinavica, 2003, Volume: 82, Issue:6

    Topics: Activins; Adolescent; Biological Assay; Disease Progression; Female; Granulosa Cell Tumor; Humans; Inhibins; Middle Aged; Neoplasm, Residual; Ovarian Neoplasms

2003
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
    Biochemical and biophysical research communications, 2003, Oct-17, Volume: 310, Issue:2

    Topics: Activins; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Imidazoles; Inhibin-beta Subunits; Mitogen-Activated Protein Kinases; Mutation; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Smad Proteins; Trans-Activators; Transforming Growth Factor beta; Transforming Growth Factor beta1

2003
Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells.
    The Journal of clinical endocrinology and metabolism, 2003, Volume: 88, Issue:10

    Topics: Activins; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Neoplastic; Humans; Inhibins; Luteal Cells; Luteinizing Hormone; Ovarian Neoplasms; Oxytocics; Protein Kinase C; Proteoglycans; Receptors, Transforming Growth Factor beta; Sex Cord-Gonadal Stromal Tumors

2003
Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells.
    Oncology reports, 2004, Volume: 11, Issue:3

    Topics: Activins; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Inhibin-beta Subunits; Ovarian Neoplasms; Sensitivity and Specificity

2004
Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice.
    Molecular endocrinology (Baltimore, Md.), 2004, Volume: 18, Issue:6

    Topics: Activins; Animals; Bone Morphogenetic Protein 15; Cachexia; Cell Differentiation; Cell Proliferation; DNA-Binding Proteins; Female; Granulosa Cells; Growth Differentiation Factor 9; Homeodomain Proteins; In Situ Hybridization; Inhibins; Intercellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Mice, Transgenic; Oncogene Proteins; Ovarian Follicle; Ovarian Neoplasms; Protein Structure, Tertiary; Proto-Oncogene Proteins c-kit; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Stem Cell Factor; Steroidogenic Factor 1; Theca Cells; Time Factors; Transcription Factors; Up-Regulation; Wasting Syndrome

2004
High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer.
    Journal of the Society for Gynecologic Investigation, 2004, Volume: 11, Issue:4

    Topics: Activins; Adult; Aged; Aged, 80 and over; Ascitic Fluid; Cystadenocarcinoma; Cystadenoma, Serous; Endometriosis; Female; Humans; Inhibin-beta Subunits; Middle Aged; Ovarian Neoplasms; Survival Rate

2004
Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells.
    Molecular cancer research : MCR, 2005, Volume: 3, Issue:1

    Topics: Activins; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Collagen; DNA Primers; Drug Combinations; Drug Resistance, Neoplasm; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Inhibin-beta Subunits; Inhibins; Laminin; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Ovarian Neoplasms; Ovary; Polysaccharides; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation

2005
Activin A levels in serum and cyst fluid in epithelial tumors of the ovary.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2005, Volume: 89, Issue:2

    Topics: Activins; Adult; Biomarkers, Tumor; Female; Humans; Inhibin-beta Subunits; Middle Aged; Neoplasms, Glandular and Epithelial; Ovarian Cysts; Ovarian Neoplasms

2005
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma.
    Oncology reports, 2006, Volume: 15, Issue:2

    Topics: Activin Receptors; Activins; Adenocarcinoma, Clear Cell; Adult; Aged; Female; Humans; Immunohistochemistry; Inhibins; Middle Aged; Ovarian Neoplasms; Smad Proteins

2006
The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells.
    Oncology reports, 2006, Volume: 16, Issue:2

    Topics: Activin Receptors; Activins; Adenocarcinoma, Clear Cell; Autocrine Communication; Cell Proliferation; Female; Humans; Inhibin-beta Subunits; Ovarian Neoplasms; Phosphorylation; Smad Proteins; Smad2 Protein; Tumor Cells, Cultured

2006
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
    Endocrinology, 2007, Volume: 148, Issue:8

    Topics: Activins; Animals; Cell Division; Chronic Disease; Epithelial Cells; Female; Gonadotropins, Equine; Mice; Mice, Inbred Strains; Mice, Transgenic; Ovarian Cysts; Ovarian Neoplasms; Ovulation; Phosphorylation; Signal Transduction; Smad2 Protein; Superovulation; Transforming Growth Factor beta

2007
SMAD3 regulates gonadal tumorigenesis.
    Molecular endocrinology (Baltimore, Md.), 2007, Volume: 21, Issue:10

    Topics: Activins; Animals; Cell Transformation, Neoplastic; Female; Follicle Stimulating Hormone; Inhibins; Male; Mice; Mice, Knockout; Ovarian Neoplasms; RNA, Messenger; Smad3 Protein; Testicular Neoplasms; Wasting Syndrome; Weight Loss

2007
Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery.
    Molecular endocrinology (Baltimore, Md.), 2007, Volume: 21, Issue:10

    Topics: Activins; Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Cell Cycle; Cell Transformation, Neoplastic; Cyclin D2; Cyclins; Down-Regulation; Female; Follicle Stimulating Hormone; Gene Expression Profiling; Gonadotropins; Inhibins; Insulin-Like Growth Factor I; Male; Mice; Mice, Knockout; Neoplastic Stem Cells; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Repressor Proteins; Smad3 Protein; Testicular Neoplasms

2007
The role of activin A and Akt/GSK signaling in ovarian tumor biology.
    Endocrinology, 2008, Volume: 149, Issue:8

    Topics: Activins; Adult; Aged; Aged, 80 and over; Carcinoma; Cell Proliferation; Cystadenocarcinoma, Serous; Cystadenoma, Serous; Female; Glycogen Synthase Kinase 3; Humans; Middle Aged; Ovarian Neoplasms; Phosphorylation; Precancerous Conditions; Proto-Oncogene Proteins c-akt; Signal Transduction; Survival Analysis; Tumor Cells, Cultured

2008
Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines.
    Molecular endocrinology (Baltimore, Md.), 1995, Volume: 9, Issue:5

    Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Division; Cell Line; Cyclic AMP; Disease Models, Animal; Female; Gene Expression; Gonadotropins; Granulosa Cells; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Molecular Sequence Data; Neoplasms, Experimental; Ovarian Neoplasms; Promoter Regions, Genetic; Receptors, LH; RNA, Messenger; Simian virus 40; Steroids; Viral Fusion Proteins

1995
Inhibin and activin are demonstrable by immunohistochemistry in ovarian tumor tissue.
    Gynecologic oncology, 1995, Volume: 57, Issue:1

    Topics: Activins; Adenocarcinoma; Aged; Female; Granulosa Cell Tumor; Growth Substances; Humans; Immune Sera; Immunohistochemistry; Inhibins; Middle Aged; Ovarian Neoplasms

1995
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor.
    Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:8

    Topics: Activins; Adrenal Glands; Animals; Cell Division; Colforsin; Female; Follistatin; Glycoproteins; Gonadal Steroid Hormones; Inhibins; Male; Mice; Mice, Mutant Strains; Neoplasm Proteins; Ovarian Neoplasms; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Testicular Neoplasms; Tumor Cells, Cultured; Tumor Suppressor Protein p53

1994
Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation.
    Endocrinology, 1996, Volume: 137, Issue:2

    Topics: Activin Receptors; Activins; Base Sequence; Cell Division; Female; Follistatin; Glycoproteins; Homeostasis; Humans; Inhibins; Molecular Sequence Data; Oligonucleotide Probes; Ovarian Neoplasms; Receptors, Growth Factor; RNA, Messenger; Tumor Cells, Cultured

1996
A two-site monoclonal antibody immunoradiometric assay for human follistatin: secretion by a human ovarian teratocarcinoma-derived cell line (PA-1).
    The Journal of clinical endocrinology and metabolism, 1996, Volume: 81, Issue:4

    Topics: Activins; Animals; Antibodies, Monoclonal; Antibody Specificity; Biological Assay; Blotting, Western; Cell Division; Cell Line; Cells, Cultured; Corpus Luteum; Cross Reactions; Culture Media, Conditioned; Female; Follicular Fluid; Follistatin; Glycoproteins; Granulosa Cells; Humans; Immunoradiometric Assay; Inhibins; Male; Molecular Weight; Ovarian Neoplasms; Pituitary Gland; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Teratocarcinoma; Tumor Cells, Cultured

1996
Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.
    Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:5

    Topics: Activin Receptors; Activins; Animals; Cachexia; Female; Inhibins; Liver; Male; Mice; Mice, Mutant Strains; Oligopeptides; Ovarian Neoplasms; Peptides; Receptors, Growth Factor; Sex Cord-Gonadal Stromal Tumors; Signal Transduction; Stomach; Testicular Neoplasms; Weight Loss

1996
Immunohistochemical expression of inhibin/activin subunits in epithelial and granulosa cell tumours of the ovary.
    The Journal of pathology, 1997, Volume: 181, Issue:4

    Topics: Activins; Adult; Aged; Biomarkers, Tumor; Female; Granulosa Cell Tumor; Growth Substances; Humans; Immunoenzyme Techniques; Inhibins; Middle Aged; Neoplasm Proteins; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Ovary

1997
Presence of activin, inhibin, and follistatin in epithelial ovarian carcinoma.
    The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:11

    Topics: Activins; Adenocarcinoma, Clear Cell; Adenocarcinoma, Mucinous; Adult; Aged; Carcinoma; Cell Division; Cystadenocarcinoma, Serous; Epithelium; Female; Follistatin; Gene Expression; Glycoproteins; Humans; Inhibins; Middle Aged; Ovarian Neoplasms; RNA, Messenger

1997
Alpha and beta subunits of inhibin/activin as sex cord-stromal differentiation markers.
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 1997, Volume: 16, Issue:3

    Topics: Activins; Cell Differentiation; Female; Humans; Immunohistochemistry; Inhibins; Leydig Cells; Male; Ovarian Neoplasms; Peptides; Prostatic Secretory Proteins; Sertoli Cells; Sex Cord-Gonadal Stromal Tumors

1997
Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors.
    The Journal of clinical endocrinology and metabolism, 1998, Volume: 83, Issue:3

    Topics: Activins; Adult; Anti-Mullerian Hormone; Female; Glycoproteins; Granulosa Cell Tumor; Growth Inhibitors; Humans; Inhibins; Ovarian Neoplasms; Reference Values; Testicular Hormones

1998
Imbalanced expression of inhibin and activin subunits in primary epithelial ovarian cancer.
    Gynecologic oncology, 1998, Volume: 69, Issue:1

    Topics: Activin Receptors; Activins; Adult; Biomarkers, Tumor; Carcinoma; Epithelium; Female; Gene Expression; Humans; Immunohistochemistry; Inhibins; Ovarian Neoplasms; Polymerase Chain Reaction; Receptors, Growth Factor; RNA, Messenger

1998
Cell survival effect of activin against heat shock stress on OVCAR3.
    Life sciences, 1998, Volume: 63, Issue:25

    Topics: Activin Receptors; Activins; Adenocarcinoma; Blotting, Western; Cell Division; Cell Survival; Female; Follistatin; Glycoproteins; Growth Substances; Heat-Shock Response; Humans; Inhibins; Ovarian Neoplasms; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stress, Physiological; Tumor Cells, Cultured

1998
Immunohistochemical localization of inhibin and activin subunits in human epithelial ovarian tumors.
    American journal of obstetrics and gynecology, 1999, Volume: 180, Issue:2 Pt 1

    Topics: Activins; Cystadenocarcinoma, Mucinous; Cystadenoma, Mucinous; Cystadenoma, Serous; Female; Humans; Immunohistochemistry; Inhibins; Ovarian Neoplasms; Peptides; Prostatic Secretory Proteins

1999
Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin.
    Endocrinology, 1999, Volume: 140, Issue:6

    Topics: Activins; Cell Division; Female; Follistatin; Glycoproteins; Humans; Inhibins; Ovarian Neoplasms; Teratocarcinoma; Transcriptional Activation; Transfection; Tumor Cells, Cultured

1999
Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene.
    Molecular and cellular endocrinology, 1999, Mar-25, Volume: 149, Issue:1-2

    Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Artificial Gene Fusion; DNA, Neoplasm; Female; Granulosa Cell Tumor; Inhibins; Leydig Cell Tumor; Male; Mice; Mice, Transgenic; Neoplasms, Hormone-Dependent; Ovarian Neoplasms; Peptides; Promoter Regions, Genetic; RNA, Messenger; Testicular Neoplasms; Thymidine; Transforming Growth Factor beta; Tumor Cells, Cultured

1999
Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:6

    Topics: Activins; Animals; Crosses, Genetic; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Hemorrhage; Homozygote; Humans; Infertility, Female; Infertility, Male; Inhibins; Male; Metallothionein; Mice; Mice, Mutant Strains; Mice, Transgenic; Oligopeptides; Ovarian Neoplasms; Ovary; Peptides; Polycystic Ovary Syndrome; Seminal Vesicles; Steroids; Testicular Neoplasms; Urinary Tract; Wasting Syndrome

1999
Secretion of activin A in recurrent epithelial ovarian carcinoma.
    Gynecologic oncology, 1999, Volume: 74, Issue:1

    Topics: Activins; Female; Growth Substances; Humans; Inhibins; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Ovarian Neoplasms

1999
Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma.
    British journal of cancer, 2000, Volume: 82, Issue:8

    Topics: Activin Receptors; Activins; Adenocarcinoma; DNA-Binding Proteins; Epithelial Cells; Female; Granulosa Cells; Growth Substances; Humans; Inhibins; Ovarian Neoplasms; Ovary; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Smad2 Protein; Smad4 Protein; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured

2000
Gene expression in abnormal ovarian structures of ewes homozygous for the inverdale prolificacy gene.
    Biology of reproduction, 2000, Volume: 62, Issue:6

    Topics: Activins; Animals; Female; Follistatin; Gene Expression; Glycoproteins; Granulosa Cells; Heterozygote; Homozygote; Infertility, Female; Inhibins; Ovarian Neoplasms; Ovary; Ovulation; Peptides; Proto-Oncogene Proteins c-kit; Receptors, FSH; RNA, Messenger; Sheep; Sheep Diseases; Stem Cell Factor; X Chromosome

2000
Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice.
    Endocrinology, 2000, Volume: 141, Issue:7

    Topics: Activins; Animals; Disease Progression; Female; Follistatin; Glycoproteins; Inhibins; Liver Diseases; Male; Metallothionein; Mice; Mice, Transgenic; Ovarian Neoplasms; Peptides; Stomach Diseases; Survival Analysis; Testicular Neoplasms; Wasting Syndrome

2000
Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:7

    Topics: Activin Receptors; Activins; Adult; Aged; Blotting, Northern; Carcinoma; Female; Humans; Inhibins; Middle Aged; Ovarian Neoplasms; Receptors, Gonadotropin; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic

2000
Tumor stroma as the main source of inhibin production in ovarian epithelial tumors.
    American journal of reproductive immunology (New York, N.Y. : 1989), 2000, Volume: 44, Issue:2

    Topics: Activins; Female; Follicle Stimulating Hormone; Humans; Immunohistochemistry; Inhibins; Luteinizing Hormone; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Protein Subunits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2000
Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma.
    BJOG : an international journal of obstetrics and gynaecology, 2000, Volume: 107, Issue:9

    Topics: Activins; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma in Situ; Case-Control Studies; Female; Follistatin; Glycoproteins; Humans; Immunoassay; Inhibins; Middle Aged; Ovarian Neoplasms; Postmenopause

2000
Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE).
    Molecular and cellular endocrinology, 2001, Mar-28, Volume: 174, Issue:1-2

    Topics: Activin Receptors; Activins; Autocrine Communication; Cell Division; Epithelial Cells; Female; Growth Substances; Humans; Inhibins; Neoplasm Proteins; Ovarian Neoplasms; Protein Subunits; Receptors, Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured

2001
The regulation of apoptosis by activin and transforming growth factor-beta in early neoplastic and tumorigenic ovarian surface epithelium.
    The Journal of clinical endocrinology and metabolism, 2001, Volume: 86, Issue:5

    Topics: Activin Receptors; Activins; Apoptosis; bcl-2-Associated X Protein; Cell Line; Female; Humans; Inhibins; Ovarian Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Receptors, Growth Factor; RNA, Messenger; Transforming Growth Factor beta

2001
Inhibin and p27 interact to regulate gonadal tumorigenesis.
    Molecular endocrinology (Baltimore, Md.), 2001, Volume: 15, Issue:6

    Topics: Activins; Animals; Blotting, Northern; Body Weight; Cell Cycle Proteins; Cell Division; Cyclin D2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Immunohistochemistry; Inhibins; Male; Mice; Mice, Knockout; Models, Biological; Ovarian Neoplasms; Ovary; Proto-Oncogene Proteins; Survival Rate; Testicular Neoplasms; Testis; Tumor Suppressor Proteins

2001
Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits.
    European journal of endocrinology, 2001, Volume: 145, Issue:6

    Topics: Activins; Adolescent; Adult; Aged; Biomarkers, Tumor; Carcinoma, Embryonal; Child; Choriocarcinoma; Dysgerminoma; Endodermal Sinus Tumor; Female; Humans; Inhibin-beta Subunits; Inhibins; Male; Middle Aged; Ovarian Neoplasms; Seminoma; Testicular Neoplasms

2001