Compounds > activins

activins and Myositis Ossificans

activins has been researched along with Myositis Ossificans in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's17 (65.38)24.3611
2020's9 (34.62)2.80

Authors

AuthorsStudies
Hao, J; Meng, X; Wang, H1
Goldhamer, DJ; Stoessel, SJ; Yamamoto, M; Yamamoto, S1
Jin, Y; Kamakura, T; Kawai, S; Maekawa, H; Matsuda, S; Nagata, S; Nishio, M; Niwa, A; Saito, MK; Toguchida, J; Yoshitomi, H1
de Vries, TJ; Eekhoff, EMW; Koster, J; Loos, BG; Schoenmaker, T; Volckmann, R; Zwaak, J1
Aykul, S; Corpina, RA; Cunanan, CJ; Dimitriou, A; Economides, AN; Goebel, EJ; Idone, V; Jimenez, J; Kim, HJ; Lees-Shepard, JB; Leidich, R; Martinez-Hackert, E; McClain, J; Murphy, AJ; Nannuru, KC; Rafique, A; Rothman, NJ; Thompson, TB; Wang, X; Zhang, Q1
Brydges, S; Das, N; Economides, AN; Hatsell, SJ; Huber, AK; Hwang, C; Jimenez, J; Levi, B; Lim, WK; Marini, S; Murphy, AJ; Nannuru, KC; Pagani, CA; Xie, L1
Botman, E; Bravenboer, N; De Vries, TJ; Eekhoff, EMW; Kelder, A; Micha, D; Netelenbos, C; Sariyildiz, M; Schoenmaker, T1
Catheline, SE; Chung, J; Koyama, E; Mundy, C; Pacifici, M; Qin, L; Rux, D; Sinha, S; Yao, L1
Perrien, DS; Pierce, JL1
Alessi Wolken, DM; Economides, AN; Hatsell, SJ; Idone, V; Yu, PB1
Hino, K; Horigome, K; Ikeya, M; Jin, Y; Kawakami, K; Komura, S; Nagata, S; Nishio, M; Ohta, A; Toguchida, J; Yamada, Y; Zhao, C1
Das, N; Economides, AN; Graul, C; Hatsell, SJ; Hesterman, J; Huang, L; Idone, V; Lobo, M; Lyon, MC; Murphy, AJ; Nannuru, K; Palmer, K; Qian, X; Rajamani, S; Silva, MD; Soares, EJ; Stewart, RC; Upadhyay, J; Wang, L; Wellman, TJ; Wen, X; Xie, L1
Kaplan, FS; Pignolo, RJ; Shore, EM; Wang, H1
Biswas, AA; Cogswell, CA; Cummins, SM; Devarakonda, PM; Goldhamer, DJ; Hunter, JW; Kaartinen, V; Lees-Shepard, JB; Legendre, NP; Nicholas, SE; Schneider, MJ; Stoessel, SJ; Yamamoto, M; Yamamoto, S1
Bocciardi, R; Cappato, S; Giacopelli, F; Ravazzolo, R1
Devarakonda, PM; Goldhamer, DJ; Lees-Shepard, JB; Nicholas, SE; Schneider, MJ; Stoessel, SJ; Yamamoto, M1
Bravenboer, N; de Vries, TJ; Eekhoff, EMW; Forouzanfar, T; Micha, D; Netelenbos, C; Schoenmaker, T; Wouters, F1
Gao, J; Hua, P; Lin, H; Shi, F1
Chernomorsky, R; Corpina, RA; D'Ambrosio, D; Das, N; Economides, AN; Feeley, K; Hatsell, SJ; Huang, L; Idone, V; Jimenez, J; Kim, HJ; Makhoul, G; Murphy, AJ; Nannuru, KC; Schoenherr, CJ; Wang, L; Wen, X; Wolken, DM; Xie, L; Yancopoulos, GD; Yu, PB1
Ebise, H; Hino, K; Horigome, K; Ikeya, M; Matsuda, S; Matsumoto, Y; Nagata, S; Nishio, M; Sekiguchi, K; Shibata, M; Toguchida, J1
Fotsis, T; Sanchez-Duffhues, G; ten Dijke, P1
Kaplan, FS; Pignolo, RJ; Shore, EM1
Katagiri, T1
Barruet, E; Hsiao, EC; Kim, H; Lwin, W; Morales, BM; Srivastava, D; Theodoris, CV; Urrutia, A; White, MP; Wong, SA1
Deichsel, A; Gossen, M; Hildebrand, L; Seemann, P; Stange, K1
de Gorter, DJ; Jankipersadsing, V; Ten Dijke, P1

Reviews

7 review(s) available for activins and Myositis Ossificans

ArticleYear
Recent progress in drug development for fibrodysplasia ossificans progressiva.
    Molecular and cellular biochemistry, 2022, Volume: 477, Issue:10

    Topics: Activins; Bone Morphogenetic Proteins; Drug Development; Humans; Ligands; Mutation; Myositis Ossificans; Ossification, Heterotopic; Transforming Growth Factor beta

2022
Do Interactions of Vitamin D
    Current osteoporosis reports, 2021, Volume: 19, Issue:3

    Topics: Activins; Animals; Bone Morphogenetic Proteins; Cholecalciferol; Chondrogenesis; Humans; Myositis Ossificans; Signal Transduction

2021
The obligatory role of Activin A in the formation of heterotopic bone in Fibrodysplasia Ossificans Progressiva.
    Bone, 2018, Volume: 109

    Topics: Activin Receptors, Type I; Activins; Humans; Mutation; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction; Stem Cells

2018
The Horizon of a Therapy for Rare Genetic Diseases: A "Druggable" Future for Fibrodysplasia Ossificans Progressiva.
    International journal of molecular sciences, 2018, Mar-26, Volume: 19, Issue:4

    Topics: Activin Receptors, Type I; Activins; Amino Acid Substitution; Bone Morphogenetic Proteins; Clinical Trials as Topic; Drug Repositioning; Humans; Myositis Ossificans; Signal Transduction

2018
The role of Activin A in fibrodysplasia ossificans progressiva: a prominent mediator.
    Bioscience reports, 2019, 08-30, Volume: 39, Issue:8

    Topics: Activins; Animals; Humans; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction

2019
Granting immunity to FOP and catching heterotopic ossification in the Act.
    Seminars in cell & developmental biology, 2016, Volume: 49

    Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Proteins; Humans; Immunity, Innate; Mutation, Missense; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction

2016
[Fibrodysplasia ossificans progressiva and osteoimmunology].
    Clinical calcium, 2016, Volume: 26, Issue:5

    Topics: Activins; Animals; Bone Morphogenetic Proteins; Genetic Predisposition to Disease; Humans; Mutation; Myositis Ossificans; Ossification, Heterotopic

2016

Other Studies

19 other study(ies) available for activins and Myositis Ossificans

ArticleYear
Overexpression of Wild-Type ACVR1 in Fibrodysplasia Ossificans Progressiva Mice Rescues Perinatal Lethality and Inhibits Heterotopic Ossification.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022, Volume: 37, Issue:11

    Topics: Activin Receptors, Type I; Activins; Animals; Humans; Mice; Mice, Transgenic; Mutation; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction

2022
Recapitulation of pro-inflammatory signature of monocytes with ACVR1A mutation using FOP patient-derived iPSCs.
    Orphanet journal of rare diseases, 2022, 09-21, Volume: 17, Issue:1

    Topics: Activin Receptors, Type I; Activins; Animals; Doxycycline; Humans; Inflammation; Lipopolysaccharides; Mice; Monocytes; Mutation; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction; Transforming Growth Factor beta

2022
Transcriptomic Differences Underlying the Activin-A Induced Large Osteoclast Formation in Both Healthy Control and Fibrodysplasia Ossificans Progressiva Osteoclasts.
    International journal of molecular sciences, 2023, Apr-06, Volume: 24, Issue:7

    Topics: Activin Receptors, Type I; Activins; Humans; Mutation; Myositis Ossificans; Ossification, Heterotopic; Osteoclasts; Transcriptome

2023
Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop.
    eLife, 2020, 06-09, Volume: 9

    Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein Receptors, Type II; Bone Morphogenetic Proteins; Gene Knock-In Techniques; Mice; Mice, Transgenic; Mutation; Myositis Ossificans; Signal Transduction

2020
Activin A does not drive post-traumatic heterotopic ossification.
    Bone, 2020, Volume: 138

    Topics: Activin Receptors, Type I; Activins; Animals; Humans; Mice; Myositis Ossificans; Ossification, Heterotopic

2020
Activin-A Induces Fewer, but Larger Osteoclasts From Monocytes in Both Healthy Controls and Fibrodysplasia Ossificans Progressiva Patients.
    Frontiers in endocrinology, 2020, Volume: 11

    Topics: Activins; Adult; Aged; Bone Resorption; Case-Control Studies; Cell Differentiation; Female; Humans; Male; Middle Aged; Monocytes; Myositis Ossificans; Osteoclasts; Osteogenesis; Signal Transduction; Young Adult

2020
Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice.
    Science signaling, 2021, 02-09, Volume: 14, Issue:669

    Topics: Activins; Animals; Chondrogenesis; Mice; Myositis Ossificans; Ossification, Heterotopic; Osteogenesis

2021
Activin-A enhances mTOR signaling to promote aberrant chondrogenesis in fibrodysplasia ossificans progressiva.
    The Journal of clinical investigation, 2017, Sep-01, Volume: 127, Issue:9

    Topics: Activins; Animals; Cell Differentiation; Chondrocytes; Chondrogenesis; Embryonic Stem Cells; Female; Humans; Induced Pluripotent Stem Cells; Inhibitory Concentration 50; Lysophospholipids; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Myositis Ossificans; Oligonucleotide Array Sequence Analysis; Phosphoric Diester Hydrolases; Point Mutation; Recombinant Proteins; Signal Transduction; TOR Serine-Threonine Kinases; Transforming Growth Factor beta

2017
The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A-Dependent.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017, Volume: 32, Issue:12

    Topics: Activins; Animals; Magnetic Resonance Imaging; Mice; Myositis Ossificans; Ossification, Heterotopic; X-Ray Microtomography

2017
Activin A amplifies dysregulated BMP signaling and induces chondro-osseous differentiation of primary connective tissue progenitor cells in patients with fibrodysplasia ossificans progressiva (FOP).
    Bone, 2018, Volume: 109

    Topics: Activins; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Humans; Myositis Ossificans; Ossification, Heterotopic; Signal Transduction; Smad1 Protein; Smad5 Protein; Smad8 Protein

2018
Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.
    Nature communications, 2018, 02-02, Volume: 9, Issue:1

    Topics: Activin Receptors, Type I; Activins; Animals; Disease Models, Animal; Female; Gene Knock-In Techniques; Male; Mice, Transgenic; Muscle, Skeletal; Myositis Ossificans; Osteogenesis; Stem Cells; Wound Healing

2018
Palovarotene reduces heterotopic ossification in juvenile FOP mice but exhibits pronounced skeletal toxicity.
    eLife, 2018, 09-18, Volume: 7

    Topics: Activin Receptors, Type I; Activins; Animals; Bone and Bones; Cell Differentiation; Chondrogenesis; Joints; Luminescent Measurements; Mice; Myositis Ossificans; Ossification, Heterotopic; Osteochondroma; Osteogenesis; Pyrazoles; Receptor, Platelet-Derived Growth Factor alpha; Stilbenes; Survival Analysis

2018
The effect of Activin-A on periodontal ligament fibroblasts-mediated osteoclast formation in healthy donors and in patients with fibrodysplasia ossificans progressiva.
    Journal of cellular physiology, 2019, Volume: 234, Issue:7

    Topics: Activin Receptors, Type I; Activins; Adolescent; Adult; Case-Control Studies; Cell Communication; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coculture Techniques; Female; Fibroblasts; Humans; Inhibitor of Differentiation Protein 1; Lipopolysaccharide Receptors; Male; Myositis Ossificans; Osteoclasts; Osteogenesis; Periodontal Ligament; Phosphorylation; Signal Transduction; Smad3 Protein; Tacrolimus Binding Protein 1A; Young Adult

2019
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.
    Science translational medicine, 2015, Sep-02, Volume: 7, Issue:303

    Topics: Activin Receptors, Type I; Activins; Animals; Mice; Mice, Transgenic; Mutation; Myositis Ossificans; Protein Binding; Tacrolimus Binding Protein 1A

2015
Neofunction of ACVR1 in fibrodysplasia ossificans progressiva.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Dec-15, Volume: 112, Issue:50

    Topics: Activin Receptors, Type I; Activins; Bone Morphogenetic Proteins; Calcification, Physiologic; Chondrogenesis; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Myositis Ossificans; Signal Transduction; Transforming Growth Factor beta

2015
Signal Transduction: Gain of Activin Turns Muscle into Bone.
    Current biology : CB, 2015, Dec-07, Volume: 25, Issue:23

    Topics: Activin Receptors, Type I; Activins; Animals; Mutation; Myositis Ossificans

2015
The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling.
    Stem cell research & therapy, 2016, 08-17, Volume: 7, Issue:1

    Topics: Activin Receptors, Type I; Activins; Bone Morphogenetic Protein 4; Cell Differentiation; Cell Line; Chondrogenesis; Collagen; Endothelial Cells; Extracellular Matrix; Humans; Induced Pluripotent Stem Cells; Ligands; Mutation; Myositis Ossificans; Ossification, Heterotopic; Osteoblasts; Osteogenesis; Phosphorylation; Signal Transduction; Smad Proteins

2016
The Fibrodysplasia Ossificans Progressiva (FOP) mutation p.R206H in ACVR1 confers an altered ligand response.
    Cellular signalling, 2017, Volume: 29

    Topics: Activin Receptors, Type I; Activins; Alkaline Phosphatase; Animals; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Proteins; Cell Differentiation; Humans; Ligands; Mice; Mutation; Myositis Ossificans; NIH 3T3 Cells; Osteogenesis; Signal Transduction; Smad Proteins

2017
Deregulated bone morphogenetic protein receptor signaling underlies fibrodysplasia ossificans progressiva.
    Current pharmaceutical design, 2012, Volume: 18, Issue:27

    Topics: Activin Receptors, Type I; Activins; Animals; Bone Morphogenetic Protein Receptors; Bone Morphogenetic Proteins; Humans; Mutation; Myositis Ossificans; Ossification, Heterotopic; Receptors, Transforming Growth Factor beta; Signal Transduction; Transforming Growth Factor beta

2012