activins has been researched along with Metastase in 11 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In older patients with cancer, high serum concentrations of activin A and myostatin were predictive of poor OS." | 1.51 | Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors. ( Baek, JY; Hong, DS; Hong, S; Hong, YS; Hwang, IG; Jang, JS; Kim, HJ; Kim, JH; Kim, JW; Kim, SH; Kim, TY; Lee, JH; Shin, SH; Sun, S; Woo, IS, 2019) |
| "During tumorigenesis, cancer cells use two different approaches to evade this barrier, either downregulating activin B and/or downregulating ALK7." | 1.51 | ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis. ( Hanahan, D; Marinoni, I; Michael, IP; Perren, A; Saghafinia, S; Tichet, M; Zangger, N, 2019) |
| "High-risk type II endometrial cancers account for ~30% of cases but ~75% of deaths due, in part, to their tendency to metastasize." | 1.43 | Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling. ( Cheng, JC; Klausen, C; Leung, PC; Xiong, S, 2016) |
| "Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown." | 1.38 | Activin A stimulates AKR1C3 expression and growth in human prostate cancer. ( de Jong, FH; Dits, NF; Hofland, J; Jenster, G; Steenbergen, J; van Weerden, WM, 2012) |
| "The study of cancer cell dormancy is severely hampered by the lack of biological samples so that the mechanisms that regulate cell dormancy have not been extensively explored." | 1.37 | A dormant state modulated by osmotic pressure controls clonogenicity of prostate cancer cells. ( Dautry, F; Havard, M; Tchénio, T, 2011) |
| "Bone metastasis is the major cause of mortality associated with prostate cancer." | 1.35 | Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. ( Chang, C; Chuang, YC; Hsieh, CY; Huang, HY; Huang, KE; Kang, HY; Li, CF; Shyr, CR; Tsai, MY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| De Menna, M | 1 |
| Groenewoud, A | 1 |
| Thalmann, GN | 1 |
| Kruithof-de Julio, M | 1 |
| Snaar-Jagalska, BE | 1 |
| Bauer, J | 2 |
| Emon, MAB | 1 |
| Staudacher, JJ | 1 |
| Thomas, AL | 1 |
| Zessner-Spitzenberg, J | 1 |
| Mancinelli, G | 2 |
| Krett, N | 2 |
| Saif, MT | 1 |
| Jung, B | 2 |
| Torres, C | 1 |
| Castellanos, K | 1 |
| McKinney, R | 1 |
| Dawson, D | 1 |
| Guzman, G | 1 |
| Hwang, R | 1 |
| Grimaldo, S | 1 |
| Grippo, P | 1 |
| Kim, SH | 1 |
| Kim, JW | 1 |
| Hwang, IG | 1 |
| Jang, JS | 1 |
| Hong, S | 1 |
| Kim, TY | 1 |
| Baek, JY | 1 |
| Shin, SH | 1 |
| Sun, S | 1 |
| Hong, DS | 1 |
| Kim, HJ | 1 |
| Hong, YS | 1 |
| Woo, IS | 1 |
| Lee, JH | 1 |
| Kim, JH | 1 |
| Michael, IP | 1 |
| Saghafinia, S | 1 |
| Tichet, M | 1 |
| Zangger, N | 1 |
| Marinoni, I | 1 |
| Perren, A | 1 |
| Hanahan, D | 1 |
| Xiong, S | 1 |
| Klausen, C | 1 |
| Cheng, JC | 1 |
| Leung, PC | 1 |
| Couto, HL | 1 |
| Dela Cruz, C | 1 |
| Buzelin, MA | 1 |
| Toppa, NH | 1 |
| Wainstein, AJ | 1 |
| Reis, FM | 1 |
| Leto, G | 1 |
| Incorvaia, L | 1 |
| Flandina, C | 1 |
| Ancona, C | 1 |
| Fulfaro, F | 1 |
| Crescimanno, M | 1 |
| Sepporta, MV | 1 |
| Badalamenti, G | 1 |
| Kang, HY | 1 |
| Huang, HY | 1 |
| Hsieh, CY | 1 |
| Li, CF | 1 |
| Shyr, CR | 1 |
| Tsai, MY | 1 |
| Chang, C | 1 |
| Chuang, YC | 1 |
| Huang, KE | 1 |
| Havard, M | 1 |
| Dautry, F | 1 |
| Tchénio, T | 1 |
| Hofland, J | 1 |
| van Weerden, WM | 1 |
| Steenbergen, J | 1 |
| Dits, NF | 1 |
| Jenster, G | 1 |
| de Jong, FH | 1 |
11 other studies available for activins and Metastase
| Article | Year |
|---|---|
A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis.
Topics: Activins; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, | 2020 |
Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling.
Topics: Activins; Aged; Aged, 80 and over; Cadherins; Cancer-Associated Fibroblasts; Case-Control Studies; C | 2020 |
Role of stromal activin A in human pancreatic cancer and metastasis in mice.
Topics: Activins; Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Di | 2021 |
Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors.
Topics: Activins; Aged; Aged, 80 and over; Antineoplastic Agents; Biliary Tract Neoplasms; Biomarkers; C-Rea | 2019 |
ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.
Topics: Activin Receptors, Type I; Activins; Animals; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Line | 2019 |
Activin B promotes endometrial cancer cell migration by down-regulating E-cadherin via SMAD-independent MEK-ERK1/2-SNAIL signaling.
Topics: Activins; Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Extracell | 2016 |
Follistatin Expression in Human Invasive Breast Tumors: Pathologic and Clinical Associations.
Topics: Activins; Breast Neoplasms; Carcinogenesis; Cell Cycle; Cell Proliferation; Disease Progression; Est | 2018 |
Clinical Impact of Cystatin C/Cathepsin L and Follistatin/Activin A Systems in Breast Cancer Progression: A Preliminary Report.
Topics: Activins; Aged; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Cathepsin L; Cystatin C; Diseas | 2016 |
Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer.
Topics: Active Transport, Cell Nucleus; Activins; Apoptosis; Bone Neoplasms; Cell Movement; Cell Nucleus; Ge | 2009 |
A dormant state modulated by osmotic pressure controls clonogenicity of prostate cancer cells.
Topics: Activins; Animals; Cell Cycle; Cell Line, Tumor; Culture Media, Conditioned; Humans; Male; Mice; Neo | 2011 |
Activin A stimulates AKR1C3 expression and growth in human prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Activins; Aldo-Keto Reductase Family 1 Member C3; Androgens; Animal | 2012 |