activins has been researched along with Kahler Disease in 15 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lenalidomide is a known and approved treatment strategy for relapsed MM." | 1.39 | Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy. ( Cirstea, D; Eda, H; Fulciniti, M; Mahindra, A; Nemani, N; Patel, K; Raje, N; Santo, L; Scullen, T; Vallet, S; Yee, A, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ge, J | 1 |
| Sun, H | 1 |
| Li, J | 1 |
| Shan, Y | 1 |
| Zhao, Y | 1 |
| Liao, F | 1 |
| Yang, Y | 1 |
| Cui, X | 1 |
| Liu, Z | 1 |
| Li, L | 1 |
| Tong, M | 1 |
| Zhao, YT | 1 |
| He, Y | 1 |
| Zhou, HY | 1 |
| Zhang, GF | 1 |
| Zhang, YJ | 1 |
| Scullen, T | 1 |
| Santo, L | 2 |
| Vallet, S | 2 |
| Fulciniti, M | 2 |
| Eda, H | 1 |
| Cirstea, D | 2 |
| Patel, K | 2 |
| Nemani, N | 1 |
| Yee, A | 1 |
| Mahindra, A | 1 |
| Raje, N | 2 |
| Silbermann, R | 1 |
| Bolzoni, M | 1 |
| Storti, P | 1 |
| Guasco, D | 1 |
| Bonomini, S | 1 |
| Zhou, D | 1 |
| Wu, J | 1 |
| Anderson, JL | 1 |
| Windle, JJ | 1 |
| Aversa, F | 1 |
| Roodman, GD | 1 |
| Giuliani, N | 1 |
| Purushothaman, A | 1 |
| Toole, BP | 1 |
| Olsen, OE | 1 |
| Wader, KF | 1 |
| Hella, H | 1 |
| Mylin, AK | 1 |
| Turesson, I | 1 |
| Nesthus, I | 1 |
| Waage, A | 1 |
| Sundan, A | 1 |
| Holien, T | 1 |
| Mukherjee, S | 1 |
| Vaghela, N | 1 |
| Hideshima, T | 1 |
| Pozzi, S | 1 |
| Sohani, AR | 1 |
| Guimaraes, A | 1 |
| Xie, W | 1 |
| Chauhan, D | 1 |
| Schoonmaker, JA | 1 |
| Attar, E | 1 |
| Churchill, M | 1 |
| Weller, E | 1 |
| Munshi, N | 1 |
| Seehra, JS | 1 |
| Weissleder, R | 1 |
| Anderson, KC | 1 |
| Scadden, DT | 1 |
| Chantry, AD | 1 |
| Heath, D | 1 |
| Mulivor, AW | 1 |
| Pearsall, S | 1 |
| Baud'huin, M | 1 |
| Coulton, L | 1 |
| Evans, H | 1 |
| Abdul, N | 1 |
| Werner, ED | 1 |
| Bouxsein, ML | 1 |
| Key, ML | 1 |
| Seehra, J | 1 |
| Arnett, TR | 1 |
| Vanderkerken, K | 1 |
| Croucher, P | 1 |
| Terpos, E | 2 |
| Kastritis, E | 2 |
| Christoulas, D | 1 |
| Gkotzamanidou, M | 1 |
| Eleutherakis-Papaiakovou, E | 1 |
| Kanellias, N | 1 |
| Papatheodorou, A | 1 |
| Dimopoulos, MA | 2 |
| Petrov, RV | 1 |
| Stepanenko, RN | 1 |
| Mikhaĭlova, AA | 1 |
| Nishihara, T | 2 |
| Okahashi, N | 1 |
| Ueda, N | 1 |
| Yamato, K | 1 |
| Koseki, T | 1 |
| Kisaki, M | 1 |
| Ikeda, Y | 1 |
| Zipori, D | 1 |
| Barda-Saad, M | 1 |
| Borisova, AM | 1 |
| Glazko, AV | 1 |
| Golenkov, AK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 1, Multicenter, Open-label, Dose-escalation Study of Sotatercept (ACE-011) in Combination With Lenalidomide or Pomalidomide and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma[NCT01562405] | Phase 1 | 33 participants (Actual) | Interventional | 2012-05-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for activins and Kahler Disease
| Article | Year |
|---|---|
Prevention and treatment of myeloma bone disease.
Topics: Activins; Bone Density Conservation Agents; Bone Morphogenetic Proteins; Bone Neoplasms; Diphosphona | 2012 |
[Activin A induces apoptotic cell death of myeloma cells].
Topics: Activins; Animals; Apoptosis; Humans; Inhibins; Multiple Myeloma; Tretinoin | 1996 |
Role of activin A in negative regulation of normal and tumor B lymphocytes.
Topics: Activins; Apoptosis; B-Lymphocytes; Bone Marrow Cells; Cell Cycle; Cell Differentiation; Follistatin | 2001 |
12 other studies available for activins and Kahler Disease
| Article | Year |
|---|---|
Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis.
Topics: Activins; Animals; Caspase 12; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, | 2019 |
Membrane translocation of Bruton kinase in multiple myeloma cells is associated with osteoclastogenic phenotype in bone metastatic lesions.
Topics: Activins; Agammaglobulinaemia Tyrosine Kinase; Aged; Bone Neoplasms; Cell Membrane; Chemokine CCL5; | 2018 |
Lenalidomide in combination with an activin A-neutralizing antibody: preclinical rationale for a novel anti-myeloma strategy.
Topics: Activins; Angiogenesis Inhibitors; Antibodies, Neutralizing; Antineoplastic Agents; Cell Differentia | 2013 |
Bone marrow monocyte-/macrophage-derived activin A mediates the osteoclastogenic effect of IL-3 in multiple myeloma.
Topics: Activins; Animals; Bone Diseases; Humans; Interleukin-3; Macrophages; Mice; Mice, Inbred C57BL; Mono | 2014 |
Serglycin proteoglycan is required for multiple myeloma cell adhesion, in vivo growth, and vascularization.
Topics: Activins; Animals; Bone Marrow Cells; Cell Adhesion; Cell Line, Tumor; Gene Expression Regulation, N | 2014 |
Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Bone Morphogenetic Proteins; Cell L | 2015 |
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Topics: Activins; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line, Tumor; Down-Regulation; Enzym | 2010 |
Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivo.
Topics: Activins; Animals; Bone Neoplasms; Bone Resorption; Calcification, Physiologic; Cell Line, Tumor; HE | 2010 |
Circulating activin-A is elevated in patients with advanced multiple myeloma and correlates with extensive bone involvement and inferior survival; no alterations post-lenalidomide and dexamethasone therapy.
Topics: Activins; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bone and Bones; Case-Control Studie | 2012 |
[B-activin and immunocorrection].
Topics: Activins; Adjuvants, Immunologic; Animals; Bone Marrow; Humans; Leukemia; Lymphoma, Non-Hodgkin; Mul | 1984 |
Activin A induces apoptotic cell death.
Topics: Activins; Animals; Apoptosis; Cell Line; Cell Survival; DNA Damage; Dose-Response Relationship, Drug | 1993 |
[Effect of human regulatory myelopeptides on the elaboration of a factor inhibiting leukocyte migration].
Topics: Activins; Agammaglobulinemia; B-Lymphocytes; Bone Marrow; Humans; Leukocyte Migration-Inhibitory Fac | 1988 |