activins has been researched along with Granulocytic Leukemia, Chronic in 8 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Induction of differentiation sensitizes chronic myeloid leukemia (CML) cells to the BCR-ABL inhibitor imatinib by mechanisms that remain unknown." | 1.72 | Activin A downregulates the CD69-MT2A axis via p38MAPK to induce erythroid differentiation that sensitizes BCR-ABL-positive cells to imatinib. ( Chen, CW; Chen, YC; Fan, CK; Huang, HM; Huang, NK; Lee, YL; Liu, CW, 2022) |
| "We have previously reported that human chronic myeloid leukemia (CML) KU812 and K562 cells show inhibited cellular proliferation in response to treatment with activin A, a member of TGF-beta superfamily." | 1.33 | p27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells. ( Fukuchi, Y; Ikeda, Y; Kawamura, C; Kizaki, M; Yamato, K, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CW | 1 |
| Huang, NK | 1 |
| Lee, YL | 1 |
| Fan, CK | 1 |
| Chen, YC | 1 |
| Liu, CW | 1 |
| Huang, HM | 3 |
| Huang, YW | 1 |
| Lee, WH | 1 |
| Tsai, YH | 1 |
| Fukuchi, Y | 2 |
| Yamato, K | 2 |
| Kawamura, C | 2 |
| Ikeda, Y | 2 |
| Kizaki, M | 2 |
| Chen, CH | 1 |
| Lin, JY | 1 |
| Liu, FH | 1 |
| Chang, JL | 1 |
| Umezawa, A | 1 |
| Nishihara, T | 1 |
| Donaldson, CJ | 1 |
| Mathews, LS | 1 |
| Vale, WW | 1 |
| Schwall, RH | 1 |
| Lai, C | 1 |
| Yu, J | 1 |
| Maderazo, L | 1 |
| Shao, LE | 1 |
| Frigon, NL | 1 |
| Vaughan, J | 1 |
| Vale, W | 1 |
| Yu, A | 1 |
8 other studies available for activins and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Activin A downregulates the CD69-MT2A axis via p38MAPK to induce erythroid differentiation that sensitizes BCR-ABL-positive cells to imatinib.
Topics: Activins; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Apoptosis; Cell Differentiation; Dr | 2022 |
Activin A induction of erythroid differentiation sensitizes K562 chronic myeloid leukemia cells to a subtoxic concentration of imatinib.
Topics: Activins; Antineoplastic Agents; Benzamides; Cell Differentiation; Dose-Response Relationship, Drug; | 2014 |
p27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells.
Topics: Activins; Apoptosis; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; GATA1 Transcription | 2006 |
Basic fibroblast growth factor inhibits p38-mediated cell differentiation and growth inhibition by activin A but not by histone deacetylase inhibitors in CML cells.
Topics: Activins; Cell Differentiation; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; Fibroblast | 2008 |
Mcl-1, an early-induction molecule, modulates activin A-induced apoptosis and differentiation of CML cells.
Topics: Activins; Apoptosis; Caspase Inhibitors; Cell Differentiation; Cell Division; Drug Interactions; Ery | 2001 |
Molecular cloning and binding properties of the human type II activin receptor.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; Gene L | 1992 |
Erythroid differentiation bioassays for activin.
Topics: Activins; Biological Assay; Cell Differentiation; Cell Line; Erythropoiesis; Hemin; Hemoglobins; Hum | 1991 |
Specific roles of activin/inhibin in human erythropoiesis in vitro.
Topics: Activins; Cell Differentiation; Cell Line; Cells, Cultured; Colony-Forming Units Assay; Erythropoies | 1991 |