Compounds > activins

activins and Disease Models, Animal

activins has been researched along with Disease Models, Animal in 84 studies

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (5.95)18.2507
2000's15 (17.86)29.6817
2010's50 (59.52)24.3611
2020's14 (16.67)2.80

Authors

AuthorsStudies
Bostantzoglou, C; Fari, O; Gaga, M; Morianos, I; Photiades, A; Potaris, K; Semitekolou, M; Tsitsopoulou, A; Valakos, D; Vatsellas, G; Xanthou, G1
Gremminger, VL; Jeong, Y; Joseph, D; Kleiner, S; Krueger, P; Omosule, CL; Phillips, CL; Rafique, A; Silvey, S; Weiler, B1
Aartsma-Rus, A; Alqallaf, A; Cutrupi, F; Engelbeen, S; Palo, A; Patel, K; Plomp, J; Tanganyika-de Winter, C; Vaiyapuri, S; van Putten, M1
Andersen, S; Bjørkøy, G; Grønberg, BH; Hatakeyama, S; Jacobi, C; Kim, J; Lach-Trifilieff, E; Lambert, C; Moestue, S; Nonstad, U; Pettersen, K; Schilb, A; van der Veen, A1
Chen, DX; Cheng, YW; Liu, RM; Luo, Y; Xiao, JH; Yu, CY; Zhao, YJ; Zhong, JJ1
Cui, X; Ge, J; Li, J; Liao, F; Liu, Z; Shan, Y; Sun, H; Yang, Y; Zhao, Y1
Bauer, J; Castellanos, K; Fantuzzi, G; Hwang, RF; Jung, B; Krett, NL; Mancinelli, G; Papachristou, GI; Thomas, AL; Whitcomb, DC; Xia, Y; Yazici, C1
Shen, K; Yuen, TJ1
Ballarò, R; Baumann, M; Euro, L; Hentilä, J; Hulmi, JJ; Lalowski, M; Lautaoja, JH; Nissinen, TA; Penna, F; Pirinen, E; Pöllänen, N; Ritvos, O; Soliymani, R1
Ahmed, R; Burton, DR; Carnathan, DG; Crotty, S; Dhadvai, P; Ellebedy, AH; Enemuo, CA; Gebru, EH; Kaushik, K; Locci, M; Ozorowski, G; Pauthner, MG; Rasheed, MAU; Silvestri, G; Ward, AB1
Chen, A; Huang, F; Lu, C; Wu, X; Wu, Y; Xian, S; Zeng, Z1
Becher, JC; Boardman, JP; Gressens, P; Holloway, RK; Ireland, G; Miron, VE; Smith, C; Sullivan, G1
Emoto, N; Fujiyama, T; Guignabert, C; Hirata, KI; Humbert, M; Ikeda, K; Miyagawa, K; Ryanto, GRT; Tu, L; Yanagisawa, M1
Ask, K; Gao, B; Krepinsky, JC; Li, R; Naiel, S; O'Neil, K; Soomro, A; Trink, J1
Bauer, J; Castellanos, K; Dawson, D; Grimaldo, S; Grippo, P; Guzman, G; Hwang, R; Jung, B; Krett, N; Mancinelli, G; McKinney, R; Torres, C1
Boor, P; Cohen, CD; Eichinger, F; Hoxha, E; Huber, TB; Kilic, T; Klinkhammer, BM; Kretz, O; Kretzler, M; Kylies, D; Lindenmeyer, MT; Liu, S; Lu, S; Martin, IV; Matsakas, A; Menon, R; Meyer, C; Mitchell, R; Nair, V; Omairi, S; Ostendorf, T; Paolini, A; Pasternack, A; Patel, K; Puelles, VG; Ritvos, O; Sandri, M; Solagna, F; Tezze, C; Tharaux, PL; Turner, JE; Wanner, N; Wiesch, JSZ; Wu, G; Zhao, Y1
Banos, A; Brodie, TM; Gaga, M; Hawrylowicz, CM; Kapasa, M; Konstantopoulos, D; Morianos, I; Paraskevopoulos, G; Poulos, N; Sallusto, F; Samitas, K; Semitekolou, M; Tousa, S; Trochoutsou, AI; Xanthou, G1
Bhushan, S; Chen, JL; de Kretser, DM; Fijak, M; Gregorevic, P; Hayward, S; Hedger, MP; Loveland, KL; Meinhardt, A; Muir, JA; Nicolas, N; Stanton, PG1
El-Kerdasy, HI; Hussien, NI; Ibrahim, ME1
Bauer, J; Carroll, T; Dirmeier, A; Fantuzzi, G; Jung, B; Krett, N; Kunst, C; Pang, J; Papachristou, G; Staudacher, JJ; Whitcomb, DC; Wilson, A; Xia, Y; Yazici, C1
Hu, J; Huang, CX; Shan, YG; Tang, YH; Wang, X; Wang, ZQ; Zou, Q1
Biswas, AA; Cogswell, CA; Cummins, SM; Devarakonda, PM; Goldhamer, DJ; Hunter, JW; Kaartinen, V; Lees-Shepard, JB; Legendre, NP; Nicholas, SE; Schneider, MJ; Stoessel, SJ; Yamamoto, M; Yamamoto, S1
Bibikova, E; Danilova, N; Lin, S; Sakamoto, KM; Wilkes, M; Youn, MY1
Bading, H; Buchthal, B; Weiss, U1
Sugatani, T1
Biondi, A; Bresolin, S; Cricrì, G; D'Amico, G; Dander, E; Gaspari, S; Kronnie, GT; Locatelli, F; Lupi, M; Marino, N; Pagni, F; Portale, F; Rizzari, C; Russo, B; Silvestri, D; Ubezio, P; Valsecchi, MG; Vergani, P1
Barisione, C; Garibotto, G; Koppe, L; Picciotto, D; Verzola, D1
Benson, M; Bezzerides, V; Biersmith, M; Chaudhari, V; Damilano, F; Elmariah, S; Gerszten, RE; Glass, DJ; Hobson, R; Houstis, N; Lach-Trifilieff, E; Lee, SJ; Lindman, BR; Platt, C; Quintero, P; Roh, JD; Rosenzweig, A; Seidman, CE; Seidman, JG; Xiao, C; Yeri, A; Zlotoff, D1
Erdenebayar, O; Irahara, M; Kadota, Y; Kasai, K; Kato, T; Kawakita, T; Keyama, K; Kuwahara, A; Matsuzaki, T; Yoshida, K1
Dankbar, B; Diller, M; Frommer, K; Hasseli, R; Hülser, ML; Müller-Ladner, U; Neumann, E; Pap, T; Rehart, S; Sauerbier, M; Tarner, I; Tsiklauri, L1
Ceppa, EP; Couch, ME; House, MG; Jiang, G; Jiang, Y; Koniaris, LG; Liu, J; Liu, Y; Nakeeb, A; Poirier, C; Pons, M; Sandusky, GE; Schmidt, CM; Shahda, S; Zhong, X; Zimmers, TA; Zyromski, NJ1
Cannell, M; Castonguay, R; Davies, MV; Grinberg, AV; Keates, S; Kumar, R; Li, J; Liharska, K; Mulivor, AW; Pearsall, RS; Sako, D; Spaits, M; Suragani, RNVS; Troy, ME; Wallner, S; Widrick, J1
de Kretser, DM; Hedger, MP1
Cui, XL; Ge, JY; Liu, HY; Liu, ZH; Qi, Y; Wang, DH; Wang, YN; Zhang, HJ1
Nakajima, T; Nishii, H; Yanagihara, M1
Calvo, F; Conway, EM; Lei, V; O'Byrne, AM; Suresh Babu, S; Valdez, Y; Xu, A1
Avó, LR; Bueno, PG; Leal, AM; Nonaka, KO; Selistre-Araújo, HS; Silva, RN1
Hulmi, JJ; Koli, K; Leppäranta, O; Ma, H; Myllärniemi, M; Pasternack, A; Ritvos, O; Rönty, M; Sutinen, E; Tikkanen, J1
de Kretser, DM; Hardy, CL; Hedger, MP; King, SJ; Mackay, F; Mifsud, NA; O'Hehir, RE; Phillips, DJ; Rolland, JM; Wilson, JW1
Arber, C; Cambray, S; Dunnett, SB; Fjodorova, M; Heuer, A; Kelly, C; Li, M; Noakes, Z; Precious, SV; Risner-Janiczek, JR; Rodríguez, TA; Rosser, AE; Ungless, MA1
Li, KM; Rentsch, P; Stayte, S; Vissel, B1
Adachi, S; Handa, O; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Kimura, R; Kokura, S; Matsuyama, T; Mizushima, K; Naito, Y; Oka, K; Okajima, M; Okayama, T; Sakai, H; Sakamoto, N; Takagi, T; Uchiyama, K1
Acharya, R; Adhikari, S; Ciayadi, R; Gurusinghe, S; Hearn, MT; Kelso, GF; Leaw, B; Lim, R; Potdar, M; Rahman, R; Wallace, EM1
Chen, JL; Colgan, TD; Gregorevic, P; Hagg, A; Harrison, CA; Qian, H; Walton, KL; Watt, MJ1
Castillo, JC; Eleftherianos, I; Patrnogic, J1
Liu, H; Liu, M; Liu, Z; Wei, Q; Yang, C; Yang, J; Yang, P1
Agapova, OA; Berman, AG; Fang, Y; Faugere, MC; Hruska, KA; Malluche, HH; Smith, W; Sugatani, T; Sung, V; Wallace, JM1
Bamberger, M; Li, KM; Rentsch, P; Stayte, S; Tröscher, AR; Vissel, B1
Abizanda, G; Andreu, EJ; García-Guzmán, M; López, T; Moreno-Montañés, J; Perez, VL; Prósper, F; Sabater, AL1
Abdalmula, A; Bailey, SR; Blacklaws, BA; Dooley, LM; Ghosh, P; House, JV; Itescu, S; Kaufman, C; Kimpton, WG; Washington, EA1
Cheng, D; Hong, S; Hu, Y; O'Connor, MB; Perrimon, N; Pissios, P; Sappe, B; Song, W; Wei, N; Zhu, C1
Han, F; Li, J; Liu, M; Mao, C; Yang, P1
de Kretser, DM; Hammes, HP; Hedger, MP; Linn, T; Ludlow, H; Maresch, CC; Stute, DC1
Kaitu'u-Lino, TJ; Morison, NB; Phillips, DJ; Salamonsen, LA1
de Kretser, DM; Hedger, MP; Phillips, DJ1
Dang, T; Hardy, CL; Lemasurier, JS; Mollard, R; O'Hehir, RE; Olsson, F; Phillips, DJ; Plebanski, M; Rolland, JM; Yang, M; Yao, J1
Barrett, KE; Jung, B; Resta, S; Sarvetnick, N; Zhang, YQ1
Hall, AK; Mukerji, SS; Rainey, RN; Rhodes, JL1
Buscher, D; Díaz, A; Hurlé, JM; Hurlé, MA; Izpisúa-Belmonte, JC; Lantero, A; Merino, D; Merino, R; Morchón, N; Tramullas, M; Villar, A1
Gregory, LG; Jones, CP; Lloyd, CM; Mathie, SA; Pegorier, S; Walker, SA1
Brown, CW; Zamani, N1
Bertucci, MC; Jenkin, G; Loose, JM; Miller, SL; Wallace, EM1
Mathew, SJ1
Andreakos, E; Apostolou, E; Foster, M; Giaglis, S; Mentzelopoulos, S; Pasternack, A; Protopapadakis, E; Ritis, K; Ritvos, O; Sideras, P; Sountoulidis, A; Stavropoulos, A; Tzelepis, GE; Xirakia, C1
Akazawa, H; Fukushima, N; Hagiwara, N; Honda, A; Komuro, I; Matsuura, K; Murasaki, KM; Nagai, T; Okano, T; Seki, A; Shimizu, T; Takahashi, T1
Fujino, M; Hinohara, A; Ishizaki, M; Murakami, T; Nishimatsu, S; Noji, S; Ohsawa, Y; Okada, T; Shimizu, K; Shimizu, T; Suga, T; Sunada, Y; Tsuchida, K; Uchino, M1
Clay, CM; Graham, JK; Johnson, E; Keri, RA; Magee, C; Seachrist, DD; Veeramachaneni, DN1
Hardy, CL; Harrison, CA; Loveland, KL; Mohamud, R; Nguyen, HA; O'Hehir, RE; Oh, DY; Plebanski, M; Rolland, JM; Yao, J1
Becker, JC; Domschke, W; Hertel, M; Markmann, A; Pohle, T; Shahin, M; Werner, S1
Brück, W; Bunkowski, S; E O'Connor, A; Gerber, J; Michel, U; Nau, R; Phillips, DJ1
Arkenbout, EK; de Vries, CJ; Engelse, MA; Pannekoek, H1
Foster, JA; Herkenham, M; McIntyre, DC; Puchowicz, MJ1
Alexander, S; Begum, S; Bolton, M; Hermansson, M; Saklatvala, J; Sawaji, Y; Wait, R; Wallace, A1
Boehler, T; Budde, K; Gaedeke, J; Neumayer, HH; Peters, H1
Dow, AL; Duman, RS; Russell, DS1
An, L; Cao, YL; Wang, P; Zhu, WW1
Bristol-Gould, SK; Hutten, CG; Kilen, SM; Mayo, KE; Sturgis, C; Woodruff, TK1
Anderson, GP; de Kretser, DM; Hardy, CL; O'Connor, AE; O'Hehir, RE; Phillips, DJ; Rolland, JM; Sebire, K; Yao, J1
Hsueh, AJ; Huhtaniemi, IT; Kananen, K; Markkula, M; Rainio, E; Su, JG1
Huhtaniemi, I; Kananen, K; Markkula, M; McNeilly, A; Mikola, M; Rainio, EM1
Dudarev, VP; Lanovenko, II; Nevhad, AP1
Gebauer, S; Haustein, UF; Petri, JB; Schurk, S1
Eto, Y; Miwa, K; Sakai, R1
Canny, B; de Kretser, D; Jenkin, G; Loose, J; O'Connor, A; Schneider-Kolsky, M; Wallace, E; Ward, J; Young, R1

Reviews

6 review(s) available for activins and Disease Models, Animal

ArticleYear
Systemic Activation of Activin A Signaling Causes Chronic Kidney Disease-Mineral Bone Disorder.
    International journal of molecular sciences, 2018, Aug-23, Volume: 19, Issue:9

    Topics: Activin Receptors; Activins; Animals; Bone and Bones; Bone Remodeling; Bone Resorption; Chronic Kidney Disease-Mineral and Bone Disorder; Disease Models, Animal; Gene Expression Regulation; Humans; Kidney; Mice; Osteogenesis; Osteoporosis; Parathyroid Hormone; RANK Ligand; Signal Transduction; Smad Proteins

2018
Emerging role of myostatin and its inhibition in the setting of chronic kidney disease.
    Kidney international, 2019, Volume: 95, Issue:3

    Topics: Activin Receptors, Type II; Activins; Anabolic Agents; Animals; Clinical Trials as Topic; Disease Models, Animal; Exercise Therapy; Feeding Behavior; Humans; Muscle, Skeletal; Myostatin; Proteolysis; Renal Insufficiency, Chronic; Sarcopenia; Signal Transduction; Treatment Outcome

2019
The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis.
    Cytokine & growth factor reviews, 2013, Volume: 24, Issue:3

    Topics: Activins; Animals; Asthma; Disease Models, Animal; Female; Fibrosis; Follistatin; Humans; Inflammation; Inhibins; Male; Wound Healing

2013
Activin and related proteins in inflammation: not just interested bystanders.
    Cytokine & growth factor reviews, 2009, Volume: 20, Issue:2

    Topics: Activins; Animals; Disease Models, Animal; Endometrium; Female; Follistatin; Humans; Inflammation; Lymphocytes; Male; Pregnancy; Testis; Toll-Like Receptors

2009
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure.
    Endocrine reviews, 2011, Volume: 32, Issue:3

    Topics: Activins; Adipogenesis; Animals; Disease Models, Animal; Energy Metabolism; Humans; Mice; Signal Transduction; Transforming Growth Factor beta

2011
Activin and TR3 orphan receptor: two 'atheroprotective' genes as evidenced in dedicated mouse models.
    Clinical and experimental pharmacology & physiology, 2003, Volume: 30, Issue:11

    Topics: Activins; Animals; Arteriosclerosis; Disease Models, Animal; Humans; Inhibin-beta Subunits; Mice; Mice, Transgenic; Nuclear Receptor Subfamily 4, Group A, Member 1; Receptors, Steroid; Receptors, Thyroid Hormone

2003

Other Studies

78 other study(ies) available for activins and Disease Models, Animal

ArticleYear
Activin-A impedes the establishment of CD4
    Journal of experimental & clinical cancer research : CR, 2021, Sep-21, Volume: 40, Issue:1

    Topics: Activins; Adoptive Transfer; Animals; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Disease Progression; Disease Susceptibility; Gene Expression Regulation, Neoplastic; HMGB Proteins; Humans; Immunity, Cellular; Immunophenotyping; Lung Neoplasms; Lymphocyte Count; Lymphocytes, Tumor-Infiltrating; Mice; Mice, Transgenic; Signal Transduction

2021
Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2022, Volume: 37, Issue:5

    Topics: Activins; Animals; Body Weight; Disease Models, Animal; Female; Femur; Male; Mice; Myostatin; Osteogenesis Imperfecta; X-Ray Microtomography

2022
The therapeutic potential of soluble activin type IIB receptor treatment in a limb girdle muscular dystrophy type 2D mouse model.
    Neuromuscular disorders : NMD, 2022, Volume: 32, Issue:5

    Topics: Activin Receptors; Activins; Animals; Disease Models, Animal; Mice; Muscle, Skeletal; Myostatin; Sarcoglycanopathies; Sarcoglycans

2022
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.
    Journal of cachexia, sarcopenia and muscle, 2020, Volume: 11, Issue:1

    Topics: Activins; Animals; Autocrine Communication; Autophagy; Cachexia; Disease Models, Animal; Female; Humans; Interleukin-6; Mice; Ovarian Neoplasms; Signal Transduction

2020
Effects of hyaluronic acid on differentiation of human amniotic epithelial cells and cell-replacement therapy in type 1 diabetic mice.
    Experimental cell research, 2019, 11-15, Volume: 384, Issue:2

    Topics: Activins; Amnion; Animals; Cell Culture Techniques; Cell Differentiation; Cell- and Tissue-Based Therapy; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Embryonic Stem Cells; Endoderm; Epithelial Cells; Humans; Hyaluronic Acid; Inflammation; Insulin; Insulin-Secreting Cells; Male; Mice; Pancreas

2019
Involvement of CHOP in activin A‑induced myeloma NS‑1 cell apoptosis.
    Oncology reports, 2019, Volume: 42, Issue:6

    Topics: Activins; Animals; Caspase 12; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Endoplasmic Reticulum Stress; Gene Expression Regulation, Neoplastic; Humans; Injections, Intralesional; Male; Mice; Multiple Myeloma; Protein Phosphatase 1; Transcription Factor CHOP; Up-Regulation

2019
Activin A Modulates Inflammation in Acute Pancreatitis and Strongly Predicts Severe Disease Independent of Body Mass Index.
    Clinical and translational gastroenterology, 2020, Volume: 11, Issue:5

    Topics: Activins; Animals; Anti-Inflammatory Agents; Biomarkers; Body Mass Index; Cell Line; Ceruletide; Cohort Studies; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Macrophage Activation; Macrophages; Mice; Pancreas; Pancreatitis; Patient Admission; Predictive Value of Tests; Severity of Illness Index

2020
Ex Vivo Myelination and Remyelination in Cerebellar Slice Cultures as a Quantitative Model for Developmental and Disease-Relevant Manipulations.
    Journal of visualized experiments : JoVE, 2020, 06-12, Issue:160

    Topics: Activins; Animals; Cell Differentiation; Cerebellum; Culture Media; Disease Models, Animal; Heterocyclic Compounds, 3-Ring; Mice, Transgenic; Myelin Sheath; Oligodendroglia; Remyelination

2020
Muscle NAD
    Molecular metabolism, 2020, Volume: 41

    Topics: Activin Receptors; Activins; Acute-Phase Proteins; Animals; Cachexia; Cell Line, Tumor; Disease Models, Animal; Male; Mice; Mitochondria; Muscle, Skeletal; Muscular Atrophy; Myostatin; NAD; Oxidative Phosphorylation; Serpins

2020
Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Activins; Adjuvants, Immunologic; AIDS Vaccines; Animals; Antibody Formation; Disease Models, Animal; env Gene Products, Human Immunodeficiency Virus; HIV Antibodies; HIV Infections; HIV-1; Humans; Immunization; Immunization Schedule; Immunophenotyping; Macaca mulatta; Male; Protein Multimerization; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory

2020
Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease.
    Molecular medicine reports, 2021, Volume: 23, Issue:1

    Topics: Activins; Animals; Disease Models, Animal; Female; Fibrosis; Freund's Adjuvant; Mitral Valve; Rats; Rheumatic Heart Disease; Signal Transduction; Smad2 Protein; Smad3 Protein; Streptococcus pyogenes

2021
Microglial inflammasome activation drives developmental white matter injury.
    Glia, 2021, Volume: 69, Issue:5

    Topics: Activins; Animals; Brain Injuries; Disease Models, Animal; Follistatin; Inflammasomes; Mice; Microglia; NLR Family, Pyrin Domain-Containing 3 Protein; White Matter

2021
An endothelial activin A-bone morphogenetic protein receptor type 2 link is overdriven in pulmonary hypertension.
    Nature communications, 2021, 03-19, Volume: 12, Issue:1

    Topics: Activins; Animals; Apoptosis; Bone Morphogenetic Protein Receptors, Type II; Disease Models, Animal; Endocytosis; Endothelial Cells; Gene Knockout Techniques; Humans; Hypertension, Pulmonary; Hypoxia; Inhibin-beta Subunits; Inhibins; Lung; Mice; Mice, Inbred C57BL; Pulmonary Arterial Hypertension; Vascular Remodeling

2021
Activin A and Cell-Surface GRP78 Are Novel Targetable RhoA Activators for Diabetic Kidney Disease.
    International journal of molecular sciences, 2021, Mar-11, Volume: 22, Issue:6

    Topics: Activins; Animals; Antibodies, Neutralizing; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Follistatin; Gene Expression Regulation; Heat-Shock Proteins; Humans; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; Nephrectomy; Primary Cell Culture; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Streptozocin

2021
Role of stromal activin A in human pancreatic cancer and metastasis in mice.
    Scientific reports, 2021, 04-12, Volume: 11, Issue:1

    Topics: Activins; Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Epithelial Cells; Epithelium; Gene Expression Regulation, Neoplastic; Humans; Mice; Neoplasm Metastasis; Pancreatic Neoplasms; Pancreatic Stellate Cells; Prognosis; Stromal Cells; Survival Analysis; Tumor Burden; Up-Regulation

2021
Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.
    The Journal of clinical investigation, 2021, 06-01, Volume: 131, Issue:11

    Topics: Activin Receptors, Type II; Activins; Animals; Cachexia; Disease Models, Animal; HEK293 Cells; Humans; Mice; Mice, Knockout; Muscle, Skeletal; Muscular Atrophy; Renal Insufficiency, Chronic; Wasting Syndrome

2021
Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 04-04, Volume: 114, Issue:14

    Topics: Activins; Animals; Asthma; Basic Helix-Loop-Helix Transcription Factors; CD4-Positive T-Lymphocytes; Cell Differentiation; Disease Models, Animal; Gene Expression Regulation; Humans; Hypersensitivity; Inducible T-Cell Co-Stimulator Protein; Interferon Regulatory Factors; Interleukin-10; Mice, SCID; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Signal Transduction; T-Lymphocytes, Regulatory

2017
Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin.
    Reproduction (Cambridge, England), 2017, Volume: 154, Issue:3

    Topics: Activins; Animals; Apoptosis; Autoimmune Diseases; Biomarkers; Blood-Testis Barrier; Disease Models, Animal; Disease Progression; Fibrosis; Follistatin; Gene Expression Regulation; Gene Transfer Techniques; Inflammation Mediators; Male; Mice, Inbred C57BL; Orchitis; Recombinant Proteins; Testis; Up-Regulation

2017
Protective effect of rimonabant, a canabinoid receptor 1 antagonist, on nonalcoholic fatty liver disease in a rat model through modulation of the hepatic expression of activin A and follistatin.
    Canadian journal of physiology and pharmacology, 2017, Volume: 95, Issue:12

    Topics: Activins; Animals; Biomarkers; Cannabinoid Receptor Antagonists; Cytoprotection; Disease Models, Animal; Follistatin; Gene Expression Regulation; Liver; Male; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger; Transforming Growth Factor beta

2017
Activin in acute pancreatitis: Potential risk-stratifying marker and novel therapeutic target.
    Scientific reports, 2017, 10-06, Volume: 7, Issue:1

    Topics: Activins; Animals; Antibodies, Neutralizing; Biomarkers; Disease Models, Animal; Female; Genotype; Humans; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Targeted Therapy; Pancreatitis; Prognosis; Risk Assessment; Severity of Illness Index

2017
Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats.
    Molecular medicine reports, 2018, Volume: 17, Issue:4

    Topics: Activins; Animals; Biomarkers; Cytokines; Disease Models, Animal; Follistatin; Heart Function Tests; Immunohistochemistry; Inflammation Mediators; Male; Myocardial Infarction; Myocardium; NF-kappa B; Rats; Sympathetic Nervous System; Ventricular Remodeling

2018
Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.
    Nature communications, 2018, 02-02, Volume: 9, Issue:1

    Topics: Activin Receptors, Type I; Activins; Animals; Disease Models, Animal; Female; Gene Knock-In Techniques; Male; Mice, Transgenic; Muscle, Skeletal; Myositis Ossificans; Osteogenesis; Stem Cells; Wound Healing

2018
Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.
    Scientific reports, 2018, 03-26, Volume: 8, Issue:1

    Topics: Activin Receptors; Activins; Anemia, Diamond-Blackfan; Animals; Arginine; Benzamides; Benzhydryl Compounds; Complement C3a; Dioxoles; Disease Models, Animal; Humans; Immunity, Innate; Interferons; K562 Cells; Receptor, Transforming Growth Factor-beta Type I; Ribosomal Proteins; RNA, Small Interfering; Toll-Like Receptor 3; Transforming Growth Factor beta; Tumor Suppressor Protein p53; Up-Regulation; Zebrafish; Zebrafish Proteins

2018
Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model.
    Molecular therapy : the journal of the American Society of Gene Therapy, 2018, 10-03, Volume: 26, Issue:10

    Topics: Activins; Animals; Basic Helix-Loop-Helix Transcription Factors; Brain Ischemia; Calcium; Dependovirus; Disease Models, Animal; Genetic Therapy; Humans; Infarction, Middle Cerebral Artery; Infusions, Intraventricular; Mice; Neurons; Neuroprotection; Neuroprotective Agents; Plasminogen Activator Inhibitor 2; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Signal Transduction; Stroke

2018
ActivinA: a new leukemia-promoting factor conferring migratory advantage to B-cell precursor-acute lymphoblastic leukemic cells.
    Haematologica, 2019, Volume: 104, Issue:3

    Topics: Activins; Animals; Biomarkers, Tumor; Bone Marrow; Bone Marrow Cells; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytokines; Disease Models, Animal; Gene Expression Regulation, Leukemic; Humans; Inflammation Mediators; Mesenchymal Stem Cells; Mice; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Stromal Cells

2019
Activin type II receptor signaling in cardiac aging and heart failure.
    Science translational medicine, 2019, 03-06, Volume: 11, Issue:482

    Topics: Activin Receptors, Type II; Activins; Adult; Aged; Aged, 80 and over; Aging; Animals; Constriction, Pathologic; Disease Models, Animal; Follistatin-Related Proteins; Frailty; Heart Failure; Heart Ventricles; Humans; Ligands; Male; Mice, Inbred C57BL; Middle Aged; Myocardium; Myocytes, Cardiac; Pressure; Proteasome Endopeptidase Complex; Proteolysis; Rats; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Severity of Illness Index; Signal Transduction; Systole

2019
Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis.
    The journal of medical investigation : JMI, 2019, Volume: 66, Issue:1.2

    Topics: Activins; Animals; Disease Models, Animal; Endometriosis; Female; Injections, Intraperitoneal; Interleukin-6; Mice; Mice, Inbred C57BL; Tumor Necrosis Factor-alpha

2019
The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts.
    Arthritis research & therapy, 2019, 06-10, Volume: 21, Issue:1

    Topics: Activins; Animals; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Follistatin; Gene Expression Regulation; Humans; Immunohistochemistry; Mice; Mice, SCID; RNA; Synovial Membrane

2019
The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.
    Journal of cachexia, sarcopenia and muscle, 2019, Volume: 10, Issue:5

    Topics: Activin Receptors, Type II; Activins; Animals; Biomarkers; Body Weights and Measures; Cachexia; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Disease Management; Disease Models, Animal; Gene Expression; Humans; Immunohistochemistry; Mice; Muscle Fibers, Skeletal; Muscular Atrophy; Pancreatic Neoplasms; Prognosis; Proportional Hazards Models

2019
Follistatin-based ligand trap ACE-083 induces localized hypertrophy of skeletal muscle with functional improvement in models of neuromuscular disease.
    Scientific reports, 2019, 08-06, Volume: 9, Issue:1

    Topics: Activins; Animals; Bone Morphogenetic Proteins; Charcot-Marie-Tooth Disease; Disease Models, Animal; Follistatin; Growth Differentiation Factors; Humans; Hypertrophy; Ligands; Male; Mice; Mice, Inbred mdx; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Myostatin; Receptors, IgG; Recombinant Fusion Proteins

2019
Role of activin A in carbon tetrachloride-induced acute liver injury.
    World journal of gastroenterology, 2013, Jun-28, Volume: 19, Issue:24

    Topics: Activins; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Liver; Male; Mice; Mice, Inbred C57BL; Signal Transduction; Smad Proteins

2013
Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia.
    Journal of the neurological sciences, 2014, Feb-15, Volume: 337, Issue:1-2

    Topics: Activins; Analysis of Variance; Animals; Calcium-Binding Proteins; Cell Death; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Injections, Intraventricular; Ischemia; Male; Microfilament Proteins; Rats; Rats, Sprague-Dawley; Reperfusion; Smad Proteins; Subcellular Fractions; Time Factors; Tubulin

2014
TGFβ-mediated suppression of CD248 in non-cancer cells via canonical Smad-dependent signaling pathways is uncoupled in cancer cells.
    BMC cancer, 2014, Feb-20, Volume: 14

    Topics: Activins; Animals; Antigens, CD; Antigens, Neoplasm; Bone Morphogenetic Protein 2; Cell Line, Tumor; Cytokines; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; RNA Stability; RNA, Messenger; Signal Transduction; Smad Proteins; Transforming Growth Factor beta

2014
Effect of physical training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease model in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2014, Volume: 47, Issue:9

    Topics: Activins; Animals; Blood Glucose; Body Weight; Diet, High-Fat; Disease Models, Animal; Exercise Therapy; Fatty Liver; Follistatin; Gene Expression; Male; Non-alcoholic Fatty Liver Disease; Obesity; Physical Exertion; Random Allocation; Rats, Wistar; RNA, Messenger; Swimming

2014
Upregulation of activin-B and follistatin in pulmonary fibrosis - a translational study using human biopsies and a specific inhibitor in mouse fibrosis models.
    BMC pulmonary medicine, 2014, Nov-01, Volume: 14

    Topics: Activins; Animals; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Follistatin; Humans; Immunity, Cellular; Inhibin-beta Subunits; Male; Mice; Mice, Inbred C57BL; Protein Biosynthesis; Pulmonary Alveoli; Pulmonary Fibrosis; Quadriceps Muscle; Recombinant Fusion Proteins; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Up-Regulation

2014
The activin A antagonist follistatin inhibits cystic fibrosis-like lung inflammation and pathology.
    Immunology and cell biology, 2015, Volume: 93, Issue:6

    Topics: Activins; Adult; Animals; Body Weight; Cystic Fibrosis; Disease Models, Animal; Female; Follistatin; Humans; Inflammation Mediators; Lung; Macrophages; Male; Mice; Mice, Transgenic; Middle Aged; Mucus; Neutrophil Infiltration; Neutrophils; Pneumonia; Respiratory Function Tests; Respiratory Mucosa; Young Adult

2015
Activin A directs striatal projection neuron differentiation of human pluripotent stem cells.
    Development (Cambridge, England), 2015, Apr-01, Volume: 142, Issue:7

    Topics: Activins; Animals; Cell Differentiation; Cell Line; Cell Survival; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Embryonic Stem Cells; GABAergic Neurons; Ganglia; Hedgehog Proteins; Humans; Huntington Disease; Neostriatum; Neurons; Pluripotent Stem Cells; Rats; Repressor Proteins; Signal Transduction; Tumor Suppressor Proteins

2015
Activin A protects midbrain neurons in the 6-hydroxydopamine mouse model of Parkinson's disease.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Activins; Animals; Cell Survival; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopaminergic Neurons; Gene Expression Regulation; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Oxidopamine; Parkinson Disease, Secondary; Pars Compacta; Signal Transduction; Stereotaxic Techniques

2015
Tumor inoculation site affects the development of cancer cachexia and muscle wasting.
    International journal of cancer, 2015, Dec-01, Volume: 137, Issue:11

    Topics: Activins; Animals; Cachexia; Cell Line, Tumor; Disease Models, Animal; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Myocardium; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Transforming Growth Factor beta; Tripartite Motif Proteins; Tumor Microenvironment; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases

2015
Inhibition of activin A signalling in a mouse model of pre-eclampsia.
    Placenta, 2015, Volume: 36, Issue:8

    Topics: Activin Receptors; Activins; Animals; Disease Models, Animal; Female; Mice; Pre-Eclampsia; Pregnancy; Signal Transduction

2015
Differential Effects of IL6 and Activin A in the Development of Cancer-Associated Cachexia.
    Cancer research, 2016, 09-15, Volume: 76, Issue:18

    Topics: Activins; Animals; Blotting, Western; Cachexia; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neoplasms; Polymerase Chain Reaction

2016
TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster.
    Immunobiology, 2016, Volume: 221, Issue:12

    Topics: Activins; Animals; Animals, Genetically Modified; Bone Morphogenetic Proteins; Carrier Proteins; Cells, Cultured; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Host-Parasite Interactions; Immunity, Innate; Nematoda; Nematode Infections; Photorhabdus; Signal Transduction; Transcriptional Activation; Transforming Growth Factor beta

2016
Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure.
    Scientific reports, 2016, 09-19, Volume: 6

    Topics: Activins; Animals; Biomarkers; Biopsy; Disease Models, Animal; Female; Fibrosis; Follistatin; Gene Expression Regulation; Heart Failure; Heart Function Tests; Heart Ventricles; Hemodynamics; Immunohistochemistry; Myocardial Infarction; Ramipril; Rats; Ventricular Remodeling

2016
Ligand trap of the activin receptor type IIA inhibits osteoclast stimulation of bone remodeling in diabetic mice with chronic kidney disease.
    Kidney international, 2017, Volume: 91, Issue:1

    Topics: Activins; Animals; Bone Remodeling; Cells, Cultured; Chronic Kidney Disease-Mineral and Bone Disorder; Diabetes Mellitus, Experimental; Disease Models, Animal; Glomerular Filtration Rate; Hyperphosphatemia; Male; Mice; Mice, Knockout; Osteoblasts; Osteoclasts; Receptors, LDL; Recombinant Fusion Proteins; Renal Insufficiency, Chronic; Vascular Calcification; X-Ray Microtomography

2017
Activin A Inhibits MPTP and LPS-Induced Increases in Inflammatory Cell Populations and Loss of Dopamine Neurons in the Mouse Midbrain In Vivo.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Activins; Animals; Cell Survival; Disease Models, Animal; Dopaminergic Neurons; Inflammation; Lipopolysaccharides; Male; Mesencephalon; Mice; Mice, Inbred C57BL; MPTP Poisoning

2017
Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation.
    Investigative ophthalmology & visual science, 2017, 02-01, Volume: 58, Issue:2

    Topics: Activins; Analysis of Variance; Animals; Cell Culture Techniques; Cell Movement; Cell Proliferation; Cell Transplantation; Cells, Cultured; Connexin 43; Corneal Injuries; Disease Models, Animal; Electric Impedance; Endothelial Cells; Endothelium, Corneal; Insulin-Like Growth Factor I; Neuregulin-1; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rabbits; Signal Transduction; Smad2 Protein; Sodium-Potassium-Exchanging ATPase; Up-Regulation; Wound Healing; Zonula Occludens-1 Protein

2017
Immunoselected STRO-3
    Stem cell research & therapy, 2017, 02-07, Volume: 8, Issue:1

    Topics: Activins; Animals; Antigens, Surface; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Movement; Collagen Type II; Disease Models, Animal; Female; Gene Expression; Interferon-gamma; Interleukin-10; Interleukin-17; Joints; Macrophages; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Monocytes; Neutrophils; Sheep, Domestic; Synovial Fluid; Treatment Outcome

2017
Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
    Cell metabolism, 2017, 02-07, Volume: 25, Issue:2

    Topics: Activin Receptors; Activins; Animals; Carbohydrate Metabolism; Carrier Proteins; Dietary Carbohydrates; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enteroendocrine Cells; Fat Body; Gastrointestinal Tract; Glucagon; Hepatocytes; Hyperglycemia; Insect Hormones; Larva; Mice; Oligopeptides; Pyrrolidonecarboxylic Acid; Receptors, Glucagon; RNA Interference; RNA, Messenger; Signal Transduction

2017
Effects of the Activin A-Follistatin System on Myocardial Cell Apoptosis through the Endoplasmic Reticulum Stress Pathway in Heart Failure.
    International journal of molecular sciences, 2017, Feb-10, Volume: 18, Issue:2

    Topics: Activins; Angiotensin II; Animals; Apoptosis; Biomarkers; Caspase 3; Cell Line; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Follistatin; Heart Failure; Heart Ventricles; Hemodynamics; Immunohistochemistry; Myocytes, Cardiac; Natriuretic Peptide, Brain; Rats; Signal Transduction; Transcription Factor CHOP

2017
Hyperglycemia is associated with reduced testicular function and activin dysregulation in the Ins2
    Molecular and cellular endocrinology, 2017, 05-05, Volume: 446

    Topics: Activins; Animals; Blood Glucose; Body Weight; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Follistatin; Hyperglycemia; Inflammation Mediators; Insulin; Male; Mice, Inbred C57BL; Organ Size; Real-Time Polymerase Chain Reaction; Testis

2017
A new role for activin in endometrial repair after menses.
    Endocrinology, 2009, Volume: 150, Issue:4

    Topics: Activins; Animals; Cell Line; Cells, Cultured; Disease Models, Animal; Endometrium; Female; Follistatin; Humans; Immunohistochemistry; Inhibin-beta Subunits; Male; Menstruation; Mice; Mice, Transgenic; Wound Healing

2009
Interleukin-13 regulates secretion of the tumor growth factor-{beta} superfamily cytokine activin A in allergic airway inflammation.
    American journal of respiratory cell and molecular biology, 2010, Volume: 42, Issue:6

    Topics: Activin Receptors; Activins; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Disease Models, Animal; Eosinophils; Epithelial Cells; Female; Humans; Inhibin-beta Subunits; Interleukin-13; Interleukin-5; Metaplasia; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin; Pneumonia; Recombinant Proteins; Respiratory Mucosa; Signal Transduction; Time Factors; Transforming Growth Factor beta

2010
Upregulation of activin signaling in experimental colitis.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:4

    Topics: Activin Receptors; Activins; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Cell Line; Cell Proliferation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Follistatin; Humans; Immunohistochemistry; Injections, Intraperitoneal; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors; Up-Regulation

2009
Delayed activin A administration attenuates tissue death after transient focal cerebral ischemia and is associated with decreased stress-responsive kinase activation.
    Journal of neurochemistry, 2009, Volume: 111, Issue:5

    Topics: Activins; Analysis of Variance; Animals; Blood Gas Analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Activation; Humans; Infarction, Middle Cerebral Artery; Injections, Intraventricular; JNK Mitogen-Activated Protein Kinases; Male; Mice; Microglia; Neurons; p38 Mitogen-Activated Protein Kinases; Rats; Reperfusion Injury; Time Factors

2009
BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Jan-27, Volume: 30, Issue:4

    Topics: Activins; Afferent Pathways; Animals; Bone Morphogenetic Protein 7; Cells, Cultured; Disease Models, Animal; Enkephalins; Hyperalgesia; Male; Membrane Proteins; Mice; Mice, Knockout; Narcotic Antagonists; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nerves; Peripheral Nervous System Diseases; Pro-Opiomelanocortin; Protein Precursors; Receptors, Opioid, delta; Sciatic Neuropathy; Signal Transduction; Spinal Cord; Transforming Growth Factor beta; Up-Regulation

2010
Overexpression of Smad2 drives house dust mite-mediated airway remodeling and airway hyperresponsiveness via activin and IL-25.
    American journal of respiratory and critical care medicine, 2010, Jul-15, Volume: 182, Issue:2

    Topics: Activins; Adenoviridae; Airway Remodeling; Allergens; Animals; Antibodies; Bronchial Hyperreactivity; Collagen; Dermatophagoides pteronyssinus; Disease Models, Animal; Female; Gene Expression; Goblet Cells; Hyperplasia; Immunohistochemistry; Interleukin-17; Lung; Mice; Mice, Inbred BALB C; Muscle, Smooth; Pyroglyphidae; Respiratory Mucosa; Smad2 Protein

2010
Anti-inflammatory therapy in an ovine model of fetal hypoxia induced by single umbilical artery ligation.
    Reproduction, fertility, and development, 2011, Volume: 23, Issue:2

    Topics: Activins; Amniotic Fluid; Animals; Anti-Inflammatory Agents; Dinoprostone; Disease Models, Animal; Female; Fetal Blood; Fetal Hypoxia; Hydrogen-Ion Concentration; Inflammation; Interleukin-6; Ligation; Oxygen; Pregnancy; Sheep; Sulfasalazine; Tumor Necrosis Factor-alpha; Umbilical Arteries

2011
InACTIVatINg cancer cachexia.
    Disease models & mechanisms, 2011, Volume: 4, Issue:3

    Topics: Activin Receptors, Type II; Activins; Animals; Cachexia; Disease Models, Animal; Humans; Mice; Muscle, Skeletal; Neoplasms; Signal Transduction; Transforming Growth Factor beta

2011
Activin-A overexpression in the murine lung causes pathology that simulates acute respiratory distress syndrome.
    American journal of respiratory and critical care medicine, 2012, Feb-15, Volume: 185, Issue:4

    Topics: Activin Receptors, Type II; Activins; Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; HMGB1 Protein; Humans; Lung; Mice; Mice, Inbred C57BL; Pulmonary Alveoli; Recombinant Fusion Proteins; Respiratory Distress Syndrome; Respiratory Mucosa; Up-Regulation

2012
A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure.
    PloS one, 2011, Volume: 6, Issue:12

    Topics: Activins; Animals; Bone Marrow Cells; Culture Media, Conditioned; Disease Models, Animal; Growth Hormone; Heart Failure; Humans; Mice

2011
An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy.
    Laboratory investigation; a journal of technical methods and pathology, 2012, Volume: 92, Issue:8

    Topics: Activin Receptors, Type I; Activins; Animals; Caveolin 3; Cell Differentiation; Cell Line; Disease Models, Animal; Female; Gene Expression Regulation; HEK293 Cells; Humans; Male; Mice; Mice, Transgenic; Muscle Development; Muscle Fibers, Skeletal; Muscular Dystrophies, Limb-Girdle; Myoblasts; Myostatin; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Satellite Cells, Skeletal Muscle; Signal Transduction; Transforming Growth Factor beta1

2012
Overexpression of follistatin in the mouse epididymis disrupts fluid resorption and sperm transit in testicular excurrent ducts.
    Biology of reproduction, 2012, Volume: 87, Issue:2

    Topics: Activins; Animals; Disease Models, Animal; Epididymis; Estrogen Receptor alpha; Female; Follistatin; Gonadotropins, Pituitary; Infertility, Male; Male; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Organ Size; Phenotype; Pituitary Gland; Promoter Regions, Genetic; Testis; Testosterone

2012
The activin A antagonist follistatin inhibits asthmatic airway remodelling.
    Thorax, 2013, Volume: 68, Issue:1

    Topics: Activins; Administration, Intranasal; Airway Remodeling; Analysis of Variance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Follistatin; Immunohistochemistry; Interleukin-13; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; Ovalbumin; Random Allocation; Reference Values; Sensitivity and Specificity; Transforming Growth Factor beta

2013
Dynamics and localization of activin A expression in rat gastric ulcers.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:3

    Topics: Activins; Animals; Biomarkers; Cell Count; Cell Division; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Matrix; Fibroblasts; Gastric Mucosa; Gene Expression; Immunohistochemistry; In Situ Hybridization; Inhibin-beta Subunits; Male; Mucous Membrane; Rats; Rats, Wistar; RNA, Messenger; Stomach Ulcer; Time Factors

2003
Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia.
    Journal of neurochemistry, 2003, Volume: 86, Issue:1

    Topics: Activins; Animals; Anti-Bacterial Agents; Apoptosis; Brain; Cerebrospinal Fluid; Disease Models, Animal; Disease Progression; Hippocampus; Immunohistochemistry; Meningitis, Pneumococcal; Microglia; Neurons; Rabbits; Up-Regulation

2003
Activin mRNA induced during amygdala kindling shows a spatiotemporal progression that tracks the spread of seizures.
    The Journal of comparative neurology, 2004, Aug-09, Volume: 476, Issue:1

    Topics: Activins; Amygdala; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Disease Models, Animal; Disease Progression; Epilepsy, Temporal Lobe; Functional Laterality; Glutamate Decarboxylase; Isoenzymes; Kindling, Neurologic; Neurons; Rats; Rats, Long-Evans; Reaction Time; RNA, Messenger; Seizures; Time Factors; Transcriptional Activation; Up-Regulation

2004
Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.
    The Journal of biological chemistry, 2004, Oct-15, Volume: 279, Issue:42

    Topics: Activins; Animals; Cartilage, Articular; Chondrocytes; Collagen Type II; Disease Models, Animal; Glycosaminoglycans; Humans; Inhibin-beta Subunits; Organ Culture Techniques; Osteoarthritis; Proteome; Reference Values; Swine; Tissue Inhibitor of Metalloproteinase-1

2004
Glomerular activin A overexpression is linked to fibrosis in anti-Thy1 glomerulonephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2005, Volume: 20, Issue:2

    Topics: Activins; Animals; Cells, Cultured; Disease Models, Animal; Enalapril; Fibroblast Growth Factor 2; Gene Expression Regulation; Glomerular Mesangium; Inflammation; Inhibin-beta Subunits; Interleukin-1; Male; Rats; Rats, Sprague-Dawley; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1

2005
Regulation of activin mRNA and Smad2 phosphorylation by antidepressant treatment in the rat brain: effects in behavioral models.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-18, Volume: 25, Issue:20

    Topics: Activins; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Blotting, Western; Brain; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electroshock; Fluoxetine; Gene Expression Regulation; Immunohistochemistry; In Situ Hybridization; Inhibin-beta Subunits; Inhibins; Male; Motor Activity; Phosphorylation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smad2 Protein; Time Factors

2005
[Protective effects and mechanism of activin in neonatal rats with hypoxic ischemic brain damage].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2005, Volume: 43, Issue:6

    Topics: Activins; Animals; Animals, Newborn; Apoptosis; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hippocampus; Hypoxia-Ischemia, Brain; Injections, Intraperitoneal; Male; Microscopy, Electron; Neuroprotective Agents; Rats; Rats, Wistar; Treatment Outcome

2005
The development of a mouse model of ovarian endosalpingiosis.
    Endocrinology, 2005, Volume: 146, Issue:12

    Topics: Activins; Animals; Anti-Mullerian Hormone; Choristoma; Cysts; Disease Models, Animal; Fallopian Tubes; Female; Fertility; Follicle Stimulating Hormone; Gene Expression; Gene Targeting; Genes, Dominant; Glycoproteins; Inhibins; Mice; Mice, Transgenic; Ovarian Diseases; Ovary; Phenotype; Promoter Regions, Genetic; Smad2 Protein; Testicular Hormones; Transgenes

2005
Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2006, Volume: 36, Issue:7

    Topics: Activins; Animals; Asthma; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Follistatin; Immunization; Interleukins; Lung; Lymph Nodes; Mice; Mice, Inbred BALB C; Mucus; Ovalbumin; Recombinant Proteins; Th2 Cells

2006
Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines.
    Molecular endocrinology (Baltimore, Md.), 1995, Volume: 9, Issue:5

    Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Division; Cell Line; Cyclic AMP; Disease Models, Animal; Female; Gene Expression; Gonadotropins; Granulosa Cells; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Molecular Sequence Data; Neoplasms, Experimental; Ovarian Neoplasms; Promoter Regions, Genetic; Receptors, LH; RNA, Messenger; Simian virus 40; Steroids; Viral Fusion Proteins

1995
Gonadectomy permits adrenocortical tumorigenesis in mice transgenic for the mouse inhibin alpha-subunit promoter/simian virus 40 T-antigen fusion gene: evidence for negative autoregulation of the inhibin alpha-subunit gene.
    Molecular endocrinology (Baltimore, Md.), 1996, Volume: 10, Issue:12

    Topics: Activins; Adrenal Cortex Neoplasms; Animals; Antigens, Polyomavirus Transforming; Castration; Cell Division; Disease Models, Animal; Estradiol; Female; Homeostasis; Immunohistochemistry; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Peptides; Progesterone; Promoter Regions, Genetic; Recombinant Fusion Proteins; Tumor Cells, Cultured

1996
[The regulatory mechanisms of the blood respiratory function in iron-deficiency anemias].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 1997, Volume: 43, Issue:3-4

    Topics: Activins; Adjuvants, Immunologic; Adolescent; Adult; Aged; Anemia, Iron-Deficiency; Animals; Disease Models, Animal; Drug Evaluation; Drug Evaluation, Preclinical; Female; Humans; Male; Middle Aged; Oligopeptides; Oxygen; Peptides; Rats; Rats, Wistar

1997
Cyclosporine A delays wound healing and apoptosis and suppresses activin beta-A expression in rats.
    European journal of dermatology : EJD, 1998, Volume: 8, Issue:2

    Topics: Activins; Animals; Apoptosis; Cyclosporine; Disease Models, Animal; Drug Evaluation, Preclinical; Fibroblasts; Granulation Tissue; Immunosuppressive Agents; Male; Oligopeptides; Peptides; Rats; Rats, Wistar; Time Factors; Wound Healing

1998
Local administration of activin promotes fracture healing in the rat fibula fracture model.
    Bone, 1999, Volume: 25, Issue:2

    Topics: Activins; Administration, Topical; Animals; Bone Development; Bony Callus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fibula; Fracture Healing; Fractures, Bone; Growth Substances; Immunoenzyme Techniques; Inhibins; Ovariectomy; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Stress, Mechanical; Tibia; Tibial Fractures; Weight-Bearing

1999
Physiological and regulatory roles of activin A in late pregnancy.
    Molecular and cellular endocrinology, 2001, Jun-30, Volume: 180, Issue:1-2

    Topics: Activins; Amniotic Fluid; Animals; Dinoprostone; Disease Models, Animal; Female; Fetal Diseases; Follistatin; Gestational Age; Humans; Hypoglycemia; Hypoxia; Kinetics; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Sheep; Uterus

2001