activins has been researched along with Colorectal Cancer in 14 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling." | 2.55 | Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer. ( Beauchamp, D; Jung, B; Staudacher, JJ, 2017) |
| "In conclusion, in colon cancer cell migration, activin utilizes NFkB to induce MDM2 activity leading to the degradation of p21 in a PI3K dependent mechanism." | 1.46 | NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway. ( Baik, SH; Bauer, J; Carroll, T; Guzman, G; Jana, A; Jung, B; Khalid, A; Krett, NL; Ozden, O; Staudacher, JJ; Yazici, C, 2017) |
| "Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide." | 1.46 | Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer. ( Bauer, J; Carroll, T; Grippo, P; Guzman, G; Jana, A; Jung, B; Kerr, D; Krett, N; Mancinelli, G; Özden, Ö; Staudacher, JJ; Tian, J, 2017) |
| "A population of colorectal cancer cells was selected by the treatment of activin A." | 1.43 | Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression. ( Kang, SO; Liu, R; Sun, B; Wang, JH; Xu, C, 2016) |
| "Cachexia is a multifactorial syndrome, characterized by the loss of skeletal muscle mass and not fully reversible by nutritional support." | 1.42 | Role of Activin A and myostatin in human cancer cachexia. ( de Barsy, M; Frateur, L; Gruson, D; Lause, P; Loumaye, A; Nachit, M; Thissen, JP; Trefois, P; van Maanen, A, 2015) |
| "Early diagnostics of colorectal cancer is complicated by the lack of reliable serum biomarkers." | 1.42 | Activin A as a novel biomarker for colorectal adenocarcinoma in humans. ( Cui, XL; Liu, ZH; Niu, LM; Qi, Y; Wu, S; Xie, DX, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Daitoku, N | 1 |
| Miyamoto, Y | 1 |
| Hiyoshi, Y | 1 |
| Tokunaga, R | 1 |
| Sakamoto, Y | 1 |
| Sawayama, H | 1 |
| Ishimoto, T | 1 |
| Baba, Y | 1 |
| Yoshida, N | 1 |
| Baba, H | 1 |
| Peng, H | 1 |
| Ye, T | 1 |
| Deng, L | 1 |
| Yang, X | 1 |
| Jiang, Z | 1 |
| Guo, J | 1 |
| Bauer, J | 3 |
| Emon, MAB | 1 |
| Staudacher, JJ | 4 |
| Thomas, AL | 1 |
| Zessner-Spitzenberg, J | 1 |
| Mancinelli, G | 2 |
| Krett, N | 2 |
| Saif, MT | 1 |
| Jung, B | 4 |
| Jana, A | 2 |
| Krett, NL | 1 |
| Guzman, G | 2 |
| Khalid, A | 1 |
| Ozden, O | 2 |
| Baik, SH | 1 |
| Carroll, T | 2 |
| Yazici, C | 1 |
| Tian, J | 1 |
| Kerr, D | 1 |
| Grippo, P | 1 |
| Hagman, H | 1 |
| Bendahl, PO | 1 |
| Lidfeldt, J | 1 |
| Belting, M | 1 |
| Johnsson, A | 1 |
| Loumaye, A | 1 |
| de Barsy, M | 1 |
| Nachit, M | 1 |
| Lause, P | 1 |
| Frateur, L | 1 |
| van Maanen, A | 1 |
| Trefois, P | 1 |
| Gruson, D | 1 |
| Thissen, JP | 1 |
| Bi, X | 1 |
| Xia, X | 1 |
| Fan, D | 1 |
| Mu, T | 1 |
| Zhang, Q | 1 |
| Iozzo, RV | 1 |
| Yang, W | 1 |
| Wu, S | 1 |
| Qi, Y | 1 |
| Niu, LM | 1 |
| Xie, DX | 1 |
| Cui, XL | 1 |
| Liu, ZH | 1 |
| Liu, R | 1 |
| Wang, JH | 1 |
| Xu, C | 1 |
| Sun, B | 1 |
| Kang, SO | 1 |
| Beauchamp, D | 1 |
| Lin, YL | 1 |
| Tsai, NM | 1 |
| Hsieh, CH | 1 |
| Ho, SY | 1 |
| Chang, J | 1 |
| Wu, HY | 1 |
| Hsu, MH | 1 |
| Chang, CC | 1 |
| Liao, KW | 1 |
| Jackson, TL | 1 |
| Mold, DE | 1 |
| Huang, RC | 1 |
| Zhou, S | 1 |
| Buckhaults, P | 1 |
| Zawel, L | 1 |
| Bunz, F | 1 |
| Riggins, G | 1 |
| Dai, JL | 1 |
| Kern, SE | 1 |
| Kinzler, KW | 1 |
| Vogelstein, B | 1 |
| Wildi, S | 1 |
| Kleeff, J | 1 |
| Maruyama, H | 1 |
| Maurer, CA | 1 |
| Büchler, MW | 1 |
| Korc, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Activin A (ActA) in the Human Cancer Cachexia[NCT01604642] | 150 participants (Actual) | Interventional | 2012-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for activins and Colorectal Cancer
| Article | Year |
|---|---|
Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Colorectal Neoplasms; Germ-Line Mutation; Homeostasi | 2017 |
13 other studies available for activins and Colorectal Cancer
| Article | Year |
|---|---|
Activin A promotes cell proliferation, invasion and migration and predicts poor prognosis in patients with colorectal cancer.
Topics: Activins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Gene Expression | 2022 |
Sequential Treatment with Activin and Hepatocyte Growth Factor Induces FOXM1 to Promote Colorectal Cancer Liver Metastasis.
Topics: Activins; alpha-Fetoproteins; Colorectal Neoplasms; Forkhead Box Protein M1; Hepatocyte Growth Facto | 2022 |
Increased stiffness of the tumor microenvironment in colon cancer stimulates cancer associated fibroblast-mediated prometastatic activin A signaling.
Topics: Activins; Aged; Aged, 80 and over; Cadherins; Cancer-Associated Fibroblasts; Case-Control Studies; C | 2020 |
NFkB is essential for activin-induced colorectal cancer migration via upregulation of PI3K-MDM2 pathway.
Topics: Activins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Colonic Neoplasms; Colorectal Neoplasms; | 2017 |
Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer.
Topics: Activins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Gene Ex | 2017 |
Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic colorectal cancer.
Topics: Activins; Adult; Aged; Angiogenesis Inducing Agents; Antibodies, Monoclonal, Humanized; Bevacizumab; | 2018 |
Role of Activin A and myostatin in human cancer cachexia.
Topics: Activins; Adult; Aged; Aged, 80 and over; Body Composition; Cachexia; Colorectal Neoplasms; Cross-Se | 2015 |
Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro.
Topics: Activins; Animals; Caco-2 Cells; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Decorin; H | 2016 |
Activin A as a novel biomarker for colorectal adenocarcinoma in humans.
Topics: Activins; Adenocarcinoma; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Colorectal Neoplasms; F | 2015 |
Activin pathway enhances colorectal cancer stem cell self-renew and tumor progression.
Topics: Activin Receptors; Activins; Benzamides; Cell Self Renewal; Colorectal Neoplasms; Dioxoles; Disease | 2016 |
In vivo amelioration of endogenous antitumor autoantibodies via low-dose P4N through the LTA4H/activin A/BAFF pathway.
Topics: Activins; Animals; Antibodies, Neoplasm; Antineoplastic Agents; Autoantibodies; B-Cell Activating Fa | 2016 |
Targeted deletion of Smad4 shows it is required for transforming growth factor beta and activin signaling in colorectal cancer cells.
Topics: Activins; Cell Division; Colorectal Neoplasms; DNA Primers; DNA-Binding Proteins; Forkhead Transcrip | 1998 |
Overexpression of activin A in stage IV colorectal cancer.
Topics: Activins; Aged; Blotting, Northern; Case-Control Studies; Cell Division; Colon; Colonic Neoplasms; C | 2001 |