activins has been researched along with Cirrhosis in 38 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells." | 7.80 | Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells. ( Castellucci, M; Catherino, WH; Ciarmela, P; Ciavattini, A; Giannubilo, SR; Islam, MS; Protic, O; Tranquilli, AL, 2014) |
| "Ramipril is a recently developed angiotensin converting enzyme (ACE) inhibitor." | 5.43 | Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure. ( Liu, H; Liu, M; Liu, Z; Wei, Q; Yang, C; Yang, J; Yang, P, 2016) |
| "To determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells." | 3.80 | Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells. ( Castellucci, M; Catherino, WH; Ciarmela, P; Ciavattini, A; Giannubilo, SR; Islam, MS; Protic, O; Tranquilli, AL, 2014) |
| "Activins were inhibited generally with follistatin, or specifically with neutralizing antibodies or type I receptor downregulation." | 1.91 | A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling. ( Gao, B; Kakoki, M; Khajehei, M; Krepinsky, JC; Li, R; MacDonald, M; O'Neil, K; Soomro, A; Zhang, D, 2023) |
| "Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs." | 1.56 | Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts. ( Faust, I; Fischer, B; Hendig, D; Knabbe, C; Kuhn, J; Ly, TD; Plümers, R; Schmidt, V, 2020) |
| "Fibrosis is a feature of EAO." | 1.51 | Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis. ( Bergmann, M; Bhushan, S; Fietz, D; Fijak, M; Groome, NP; Hedger, MP; Kauerhof, AC; Kliesch, S; Loveland, KA; Meinhardt, A; Nicolas, N; Pilatz, A; Schuppe, HC; Wahle, E, 2019) |
| "Lupus nephritis is a life-threatening complication of systemic lupus erythematosus (SLE)." | 1.46 | Involvement of infiltrating macrophage-derived activin A in the progression of renal damage in MRL-lpr mice. ( Hiromura, K; Ikeuchi, H; Kadiombo, AT; Kaneko, Y; Kayakabe, K; Maeshima, A; Nojima, Y; Sakairi, T, 2017) |
| "After strawberry treatment, leiomyoma cells showed a significant decreased rate of ECAR, while OCR was unchanged in both myometrial and leiomyoma cells." | 1.46 | An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells. ( Battino, M; Capocasa, F; Castellucci, M; Ciarmela, P; Ciavattini, A; Forbes-Hernandez, TY; Gasparrini, M; Giampieri, F; Giannubilo, SR; Greco, S; Islam, MS; Janjusevic, M; Mazzoni, L; Mezzetti, B, 2017) |
| "Ramipril is a recently developed angiotensin converting enzyme (ACE) inhibitor." | 1.43 | Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure. ( Liu, H; Liu, M; Liu, Z; Wei, Q; Yang, C; Yang, J; Yang, P, 2016) |
| "The hallmark of fibrosis is the excessive accumulation of collagen." | 1.33 | Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels. ( Bank, RA; De Groot, J; de Wit, EC; Huizinga, TW; van der Slot, AJ; van Dura, EA; Zuurmond, AM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.63) | 18.2507 |
| 2000's | 9 (23.68) | 29.6817 |
| 2010's | 18 (47.37) | 24.3611 |
| 2020's | 10 (26.32) | 2.80 |
| Authors | Studies |
|---|---|
| Krepinsky, JC | 3 |
| Xu, PC | 1 |
| You, M | 1 |
| Yu, SY | 1 |
| Luan, Y | 1 |
| Eldani, M | 1 |
| Caffrey, TC | 1 |
| Grandgenett, PM | 1 |
| O'Connell, KA | 1 |
| Shukla, SK | 1 |
| Kattamuri, C | 1 |
| Hollingsworth, MA | 1 |
| Singh, PK | 1 |
| Thompson, TB | 1 |
| Chung, S | 1 |
| Kim, SY | 1 |
| Soomro, A | 1 |
| Khajehei, M | 1 |
| Li, R | 1 |
| O'Neil, K | 1 |
| Zhang, D | 2 |
| Gao, B | 2 |
| MacDonald, M | 1 |
| Kakoki, M | 1 |
| Valenzuela-Vallejo, L | 1 |
| Chrysafi, P | 1 |
| Kouvari, M | 1 |
| Guatibonza-Garcia, V | 1 |
| Mylonakis, SC | 1 |
| Katsarou, A | 1 |
| Verrastro, O | 1 |
| Markakis, G | 1 |
| Eslam, M | 1 |
| Papatheodoridis, G | 1 |
| Mingrone, G | 1 |
| George, J | 1 |
| Mantzoros, CS | 1 |
| Paddock, SJ | 1 |
| O'Meara, CC | 1 |
| Ly, TD | 1 |
| Plümers, R | 1 |
| Fischer, B | 1 |
| Schmidt, V | 1 |
| Hendig, D | 1 |
| Kuhn, J | 1 |
| Knabbe, C | 1 |
| Faust, I | 1 |
| Hreha, TN | 1 |
| Collins, CA | 1 |
| Daugherty, AL | 1 |
| Griffith, JM | 1 |
| Hruska, KA | 1 |
| Hunstad, DA | 1 |
| Xian, S | 1 |
| Chen, A | 1 |
| Wu, X | 2 |
| Lu, C | 1 |
| Wu, Y | 2 |
| Huang, F | 1 |
| Zeng, Z | 1 |
| Jiang, L | 1 |
| Liu, B | 1 |
| Qi, Y | 1 |
| Zhu, L | 1 |
| Cui, X | 1 |
| Liu, Z | 2 |
| Yuan, C | 1 |
| Ni, L | 1 |
| Wang, Q | 1 |
| Yu, Y | 1 |
| Zhang, P | 1 |
| Chen, Y | 1 |
| Li, C | 1 |
| Chen, J | 1 |
| Wang, Y | 1 |
| Li, Y | 1 |
| Nicolas, N | 3 |
| Muir, JA | 1 |
| Hayward, S | 2 |
| Chen, JL | 1 |
| Stanton, PG | 1 |
| Gregorevic, P | 1 |
| de Kretser, DM | 5 |
| Loveland, KL | 2 |
| Bhushan, S | 3 |
| Meinhardt, A | 3 |
| Fijak, M | 3 |
| Hedger, MP | 5 |
| Kiagiadaki, F | 1 |
| Kampa, M | 1 |
| Voumvouraki, A | 1 |
| Castanas, E | 1 |
| Kouroumalis, E | 1 |
| Notas, G | 1 |
| Giampieri, F | 2 |
| Islam, MS | 3 |
| Greco, S | 2 |
| Gasparrini, M | 2 |
| Forbes Hernandez, TY | 1 |
| Delli Carpini, G | 1 |
| Giannubilo, SR | 3 |
| Ciavattini, A | 3 |
| Mezzetti, B | 2 |
| Mazzoni, L | 2 |
| Capocasa, F | 2 |
| Castellucci, M | 3 |
| Battino, M | 2 |
| Ciarmela, P | 3 |
| Lee, MJ | 1 |
| Pickering, RT | 1 |
| Shibad, V | 1 |
| Karastergiou, K | 1 |
| Jager, M | 1 |
| Layne, MD | 1 |
| Fried, SK | 1 |
| Mehta, N | 1 |
| Gava, AL | 1 |
| Kauerhof, AC | 1 |
| Wahle, E | 2 |
| Loveland, KA | 1 |
| Fietz, D | 1 |
| Bergmann, M | 1 |
| Groome, NP | 1 |
| Kliesch, S | 1 |
| Schuppe, HC | 2 |
| Pilatz, A | 1 |
| Venteclef, N | 1 |
| Guglielmi, V | 1 |
| Balse, E | 1 |
| Gaborit, B | 1 |
| Cotillard, A | 1 |
| Atassi, F | 1 |
| Amour, J | 1 |
| Leprince, P | 1 |
| Dutour, A | 1 |
| Clément, K | 1 |
| Hatem, SN | 1 |
| Forrester, HB | 1 |
| Ivashkevich, A | 1 |
| McKay, MJ | 1 |
| Leong, T | 1 |
| Sprung, CN | 1 |
| Protic, O | 1 |
| Tranquilli, AL | 1 |
| Catherino, WH | 1 |
| Wei, Q | 1 |
| Liu, H | 1 |
| Liu, M | 1 |
| Yang, C | 1 |
| Yang, J | 1 |
| Yang, P | 1 |
| Kadiombo, AT | 1 |
| Maeshima, A | 3 |
| Kayakabe, K | 1 |
| Ikeuchi, H | 1 |
| Sakairi, T | 1 |
| Kaneko, Y | 1 |
| Hiromura, K | 1 |
| Nojima, Y | 3 |
| Michel, V | 1 |
| Ludlow, H | 1 |
| Janjusevic, M | 1 |
| Forbes-Hernandez, TY | 1 |
| Bjørnstad, JL | 1 |
| Neverdal, NO | 1 |
| Vengen, OA | 1 |
| Knudsen, CW | 1 |
| Husebye, T | 1 |
| Pepper, J | 1 |
| Lie, M | 1 |
| Christensen, G | 1 |
| Tønnessen, T | 1 |
| O'Hehir, RE | 1 |
| Hardy, CL | 1 |
| Dani, C | 1 |
| Antsiferova, M | 1 |
| Werner, S | 3 |
| Ohnishi, N | 1 |
| Miyata, T | 1 |
| Ohnishi, H | 1 |
| Yasuda, H | 1 |
| Tamada, K | 1 |
| Ueda, N | 1 |
| Mashima, H | 1 |
| Sugano, K | 1 |
| Yamashita, S | 1 |
| Kojima, I | 2 |
| Sulyok, S | 1 |
| Wankell, M | 1 |
| Alzheimer, C | 2 |
| Koinuma, D | 1 |
| Imamura, T | 1 |
| Miyazono, K | 1 |
| van der Slot, AJ | 1 |
| van Dura, EA | 1 |
| de Wit, EC | 1 |
| De Groot, J | 1 |
| Huizinga, TW | 1 |
| Bank, RA | 1 |
| Zuurmond, AM | 1 |
| Aoki, F | 1 |
| Matsuse, T | 1 |
| Fukuchi, Y | 1 |
| Eto, Y | 1 |
| Matsui, H | 1 |
| Hosoi, T | 1 |
| Oka, T | 1 |
| Ohga, E | 1 |
| Nagase, T | 1 |
| Orimo, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "Contribution of Left Atrial Epicardial Fat Quantification by Computed Tomography and Left Atrial Strain by MRI in Atrial-Fibrilation Ablation: The CTStrain-AF Study"[NCT04281329] | 130 participants (Anticipated) | Observational | 2022-04-01 | Recruiting | |||
| Randomised Controlled Trial Into the Role of Ramipril in Fibrosis Reduction in Rheumatic Heart Disease: The RamiRHeD Trial Protocol[NCT03991910] | Phase 3 | 66 participants (Anticipated) | Interventional | 2019-06-27 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for activins and Cirrhosis
| Article | Year |
|---|---|
The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis.
Topics: Activins; Animals; Asthma; Disease Models, Animal; Female; Fibrosis; Follistatin; Humans; Inflammati | 2013 |
The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair.
Topics: Activins; Animals; Fibrosis; Follistatin; Humans; Immunomodulation; Inflammation; Lymphocytes; TGF-b | 2012 |
Activins in adipogenesis and obesity.
Topics: Activins; Adipogenesis; Adipose Tissue; Animals; Biomarkers; Cell Differentiation; Cell Proliferatio | 2013 |
The bright and the dark sides of activin in wound healing and cancer.
Topics: Activins; Animals; Cicatrix; Fibrosis; Humans; Neoplasms; Signal Transduction; Wound Healing | 2012 |
[Activin].
Topics: Activins; Animals; Cell Division; Collagen; Fibroblasts; Fibrosis; Follistatin; Humans; Kidney; Kidn | 2004 |
Activin: an important regulator of wound repair, fibrosis, and neuroprotection.
Topics: Activins; Animals; Fibrosis; Follistatin; Humans; Neuroprotective Agents; Transfection; Wound Healin | 2004 |
[TGF-beta family (TGF-beta, activin, BMP)].
Topics: Activins; Apoptosis; Bone Morphogenetic Proteins; Cell Differentiation; DNA-Binding Proteins; Fibros | 2005 |
Roles of activin in tissue repair, fibrosis, and inflammatory disease.
Topics: Activins; Animals; Cicatrix; Cytokines; Fibrosis; Humans; Inflammation; Wound Healing | 2006 |
Therapeutic potential of follistatin to promote tissue regeneration and prevent tissue fibrosis.
Topics: Activins; Animals; Fibrosis; Follistatin; Humans; Organogenesis; Regeneration | 2007 |
29 other studies available for activins and Cirrhosis
| Article | Year |
|---|---|
Activin B, a new player in kidney fibrosis?
Topics: Activins; Female; Fibrosis; Humans; Kidney; Kidney Diseases; Male | 2022 |
Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Topics: Activins; Adipocytes, White; Adiposity; Animals; Atrophy; Carcinoma, Pancreatic Ductal; Case-Control | 2022 |
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling.
Topics: Activins; Animals; Fibrosis; Mice; Renal Insufficiency, Chronic; Transforming Growth Factor beta | 2023 |
Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study.
Topics: Activins; Adiponectin; Biopsy; Fibrosis; Follistatin; Growth Differentiation Factor 15; Humans; Insu | 2023 |
Steps toward therapeutically targeting the activin type II receptor for treating heart failure.
Topics: Activin Receptors; Activins; Fibrosis; Heart Failure; Humans; Ventricular Remodeling | 2020 |
Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts.
Topics: Activin Receptors, Type I; Activins; Adult; Female; Fibroblasts; Fibrosis; Humans; Isoenzymes; Male; | 2020 |
Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring.
Topics: Activins; Androgens; Animals; Bacterial Load; Cytokines; Escherichia coli Infections; Female; Fibros | 2020 |
Activation of activin/Smad2 and 3 signaling pathway and the potential involvement of endothelial‑mesenchymal transition in the valvular damage due to rheumatic heart disease.
Topics: Activins; Animals; Disease Models, Animal; Female; Fibrosis; Freund's Adjuvant; Mitral Valve; Rats; | 2021 |
Antagonistic effects of activin A and TNF-α on the activation of L929 fibroblast cells via Smad3-independent signaling.
Topics: Activins; Animals; Cell Line; Cell Movement; Fibroblasts; Fibronectins; Fibrosis; MAP Kinase Signali | 2020 |
Activin A activation drives renal fibrosis through the STAT3 signaling pathway.
Topics: Activins; Cell Line; Databases, Genetic; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Kidney | 2021 |
The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation.
Topics: Activin Receptors, Type I; Activins; Adult; Aged; Angiotensin II; Animals; Atrial Fibrillation; Fema | 2017 |
Induction of experimental autoimmune orchitis in mice: responses to elevated circulating levels of the activin-binding protein, follistatin.
Topics: Activins; Animals; Apoptosis; Autoimmune Diseases; Biomarkers; Blood-Testis Barrier; Disease Models, | 2017 |
Activin-A causes Hepatic stellate cell activation via the induction of TNFα and TGFβ in Kupffer cells.
Topics: Activins; Aged; Animals; Case-Control Studies; Fibrosis; Hepatic Stellate Cells; Humans; Kupffer Cel | 2018 |
Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells.
Topics: Activins; Antioxidants; Apoptosis; Cell Survival; Collagen Type I; Female; Fibronectins; Fibrosis; F | 2019 |
Impaired Glucocorticoid Suppression of TGFβ Signaling in Human Omental Adipose Tissues Limits Adipogenesis and May Promote Fibrosis.
Topics: Activins; Adipogenesis; Adipose Tissue; Adult; Dexamethasone; Diabetes Mellitus, Type 2; Female; Fib | 2019 |
Follistatin Protects Against Glomerular Mesangial Cell Apoptosis and Oxidative Stress to Ameliorate Chronic Kidney Disease.
Topics: Activins; Animals; Antioxidants; Apoptosis; Calcium; Endoplasmic Reticulum Stress; Fibrosis; Follist | 2019 |
Investigation of activin A in inflammatory responses of the testis and its role in the development of testicular fibrosis.
Topics: Activins; Animals; Collagen; Fibronectins; Fibrosis; Follistatin; Humans; Infertility, Male; Male; M | 2019 |
Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines.
Topics: Activins; Adipokines; Adipose Tissue; Animals; Atrial Fibrillation; Atrial Remodeling; Cells, Cultur | 2015 |
Follistatin is induced by ionizing radiation and potentially predictive of radiosensitivity in radiation-induced fibrosis patient derived fibroblasts.
Topics: Activins; Alternative Splicing; Breast Neoplasms; Exons; Female; Fibroblasts; Fibrosis; Follistatin; | 2013 |
Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells.
Topics: Activins; Administration, Oral; Adult; Anti-Allergic Agents; Cell Line, Tumor; Collagen Type I; Coll | 2014 |
Ramipril attenuates left ventricular remodeling by regulating the expression of activin A-follistatin in a rat model of heart failure.
Topics: Activins; Animals; Biomarkers; Biopsy; Disease Models, Animal; Female; Fibrosis; Follistatin; Gene E | 2016 |
Involvement of infiltrating macrophage-derived activin A in the progression of renal damage in MRL-lpr mice.
Topics: Activins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Disease Prog | 2017 |
Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice.
Topics: Actins; Activins; Animals; Antigens, CD; Autoimmune Diseases; Cell Count; Cytokines; Epididymitis; F | 2017 |
An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells.
Topics: Activins; Anthocyanins; Apoptosis; Blotting, Western; Cell Survival; Collagen Type I; Collagen Type | 2017 |
Alterations in circulating activin A, GDF-15, TGF-beta3 and MMP-2, -3, and -9 during one year of left ventricular reverse remodelling in patients operated for severe aortic stenosis.
Topics: Activins; Aged; Aortic Valve Stenosis; Biomarkers; Female; Fibrosis; Growth Differentiation Factor 1 | 2008 |
Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis.
Topics: Actins; Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Autocrine Communic | 2003 |
Activin A is a potent activator of renal interstitial fibroblasts.
Topics: Activins; Animals; Cell Division; Fibroblasts; Fibrosis; Inhibin-beta Subunits; Kidney; Male; Rats; | 2004 |
Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.
Topics: Activins; Amino Acids; Cells, Cultured; Collagen Type I; Cross-Linking Reagents; Cytokines; Fibrobla | 2005 |
Expression of immunoreactive and bioactive activin A protein in adult murine lung after bleomycin treatment.
Topics: Activins; Animals; Biological Assay; Bleomycin; Bronchi; Cells, Cultured; Epithelium; Fibrosis; Grow | 1995 |