activins has been researched along with Cancer of the Uterus in 14 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells." | 7.80 | Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells. ( Castellucci, M; Catherino, WH; Ciarmela, P; Ciavattini, A; Giannubilo, SR; Islam, MS; Protic, O; Tranquilli, AL, 2014) |
| "Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation." | 7.78 | A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. ( Andrews, DM; Castro, L; Di, X; Dixon, D; Hermon, T; Moore, AB; Tucker, CJ; Xiao, H; Yu, L; Zheng, X, 2012) |
| "Uterine leiomyoma is the most common benign gynecological tumor in women of reproductive age and represents the single most common indication for hysterectomy." | 5.40 | Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. ( Carrarelli, P; Castellucci, M; Ciarmela, P; Islam, MS; Janjusevic, M; Petraglia, F; Tosti, C; Zupi, E, 2014) |
| "To determine the effect of tranilast (an antiallergic drug known to suppress fibrosis or to stabilize mast cells) on extracellular matrix production in human leiomyoma and myometrial cells." | 3.80 | Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells. ( Castellucci, M; Catherino, WH; Ciarmela, P; Ciavattini, A; Giannubilo, SR; Islam, MS; Protic, O; Tranquilli, AL, 2014) |
| "Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation." | 3.78 | A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells. ( Andrews, DM; Castro, L; Di, X; Dixon, D; Hermon, T; Moore, AB; Tucker, CJ; Xiao, H; Yu, L; Zheng, X, 2012) |
| "The link between a wide range of pregnancy complications and unexplained elevated mid-trimester levels of maternal serum alpha-fetoprotein (MSAFP) and maternal serum human chorionic gonadotrophin (MShCG), with its subunits, is becoming established." | 2.40 | Maternal serum biochemical screening for pregnancy complications other than aneuploidy. ( Jauniaux, E; Pahal, GS, 1997) |
| "Uterine leiomyomas (fibroids or myomas) are the most common benign tumors of premenopausal women and new medical treatments are needed." | 1.48 | Omega-3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells. ( Castellucci, C; Ciarmela, P; Ciavattini, A; Fiorini, R; Frega, NG; Gagliardi, R; Giannubilo, SR; Greco, S; Islam, MS; Pacetti, D; Zannotti, A, 2018) |
| "After strawberry treatment, leiomyoma cells showed a significant decreased rate of ECAR, while OCR was unchanged in both myometrial and leiomyoma cells." | 1.46 | An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells. ( Battino, M; Capocasa, F; Castellucci, M; Ciarmela, P; Ciavattini, A; Forbes-Hernandez, TY; Gasparrini, M; Giampieri, F; Giannubilo, SR; Greco, S; Islam, MS; Janjusevic, M; Mazzoni, L; Mezzetti, B, 2017) |
| "Uterine leiomyomas are highly prevalent benign tumors of premenopausal women and the most common indication for hysterectomy." | 1.40 | Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function. ( Castellucci, M; Catherino, WH; Ciarmela, P; Ciavattini, A; Giannubilo, SR; Gray, PC; Islam, MS; Janjusevic, M; Lamanna, P; Petraglia, F; Protic, O; Tranquilli, AL, 2014) |
| "Uterine leiomyoma is the most common benign gynecological tumor in women of reproductive age and represents the single most common indication for hysterectomy." | 1.40 | Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. ( Carrarelli, P; Castellucci, M; Ciarmela, P; Islam, MS; Janjusevic, M; Petraglia, F; Tosti, C; Zupi, E, 2014) |
| "Women with partial hydatidiform moles had significantly higher serum levels of inhibin A (P < 0." | 1.31 | Serum activin A and inhibin A. New clinical markers for hydatidiform mole. ( Bomè, A; Cobellis, L; Danero, S; Florio, P; Luisi, S; Petraglia, F; Severi, FM, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 1 (7.14) | 29.6817 |
| 2010's | 10 (71.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Bao, H | 2 |
| Sin, TK | 2 |
| Zhang, G | 2 |
| Protic, O | 4 |
| Islam, MS | 8 |
| Greco, S | 4 |
| Giannubilo, SR | 7 |
| Lamanna, P | 2 |
| Petraglia, F | 6 |
| Ciavattini, A | 7 |
| Castellucci, M | 7 |
| Hinz, B | 2 |
| Ciarmela, P | 8 |
| Castellucci, C | 1 |
| Fiorini, R | 1 |
| Gagliardi, R | 1 |
| Zannotti, A | 1 |
| Frega, NG | 1 |
| Pacetti, D | 1 |
| Giampieri, F | 2 |
| Gasparrini, M | 2 |
| Forbes Hernandez, TY | 1 |
| Delli Carpini, G | 1 |
| Mezzetti, B | 2 |
| Mazzoni, L | 2 |
| Capocasa, F | 2 |
| Battino, M | 2 |
| Catherino, WH | 3 |
| Janjusevic, M | 3 |
| Gray, PC | 1 |
| Tranquilli, AL | 2 |
| Carrarelli, P | 1 |
| Zupi, E | 1 |
| Tosti, C | 1 |
| Toti, P | 1 |
| Occhini, R | 1 |
| Cinti, S | 1 |
| Forbes-Hernandez, TY | 1 |
| Di, X | 1 |
| Andrews, DM | 1 |
| Tucker, CJ | 1 |
| Yu, L | 1 |
| Moore, AB | 1 |
| Zheng, X | 1 |
| Castro, L | 1 |
| Hermon, T | 1 |
| Xiao, H | 1 |
| Dixon, D | 1 |
| Florio, P | 2 |
| Severi, FM | 1 |
| Cobellis, L | 1 |
| Danero, S | 1 |
| Bomè, A | 1 |
| Luisi, S | 2 |
| Pahal, GS | 1 |
| Jauniaux, E | 1 |
| Casarosa, E | 1 |
| Genazzani, AR | 1 |
| Pautier, P | 1 |
| Lhommé, C | 1 |
| Bidart, JM | 1 |
| Driul, PG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Vitamin D Deficit in Women With Uterine Fibroids[NCT04030182] | 127 participants (Actual) | Observational | 2019-12-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for activins and Cancer of the Uterus
| Article | Year |
|---|---|
Activin A in Inflammation, Tissue Repair, and Fibrosis: Possible Role as Inflammatory and Fibrotic Mediator of Uterine Fibroid Development and Growth.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Cell Transformation, Neoplastic; Fe | 2017 |
Maternal serum biochemical screening for pregnancy complications other than aneuploidy.
Topics: Activins; alpha-Fetoproteins; Aneuploidy; Chorionic Gonadotropin; Female; Humans; Hydatidiform Mole; | 1997 |
1 trial available for activins and Cancer of the Uterus
| Article | Year |
|---|---|
Serum levels of dimeric activin A are not a marker of placental tumors in the course of chemotherapy.
Topics: Activins; Adolescent; Adult; Biomarkers; Choriocarcinoma; Chorionic Gonadotropin; Female; Growth Sub | 1998 |
11 other studies available for activins and Cancer of the Uterus
| Article | Year |
|---|---|
Activin A induces tumorigenesis of leiomyoma via regulation of p38β MAPK-mediated signal cascade.
Topics: Activins; Animals; Carcinogenesis; Cell Line, Tumor; Female; Humans; Leiomyoma; MAP Kinase Signaling | 2020 |
Omega-3 fatty acids modulate the lipid profile, membrane architecture, and gene expression of leiomyoma cells.
Topics: Activins; Adult; Cell Membrane; Cholesterol Side-Chain Cleavage Enzyme; Docosahexaenoic Acids; Eicos | 2018 |
Activin A induces leiomyoma cell proliferation, extracellular matrix (ECM) accumulation and myofibroblastic transformation of myometrial cells via p38 MAPK.
Topics: Activins; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Extracellul | 2018 |
Romina: A powerful strawberry with in vitro efficacy against uterine leiomyoma cells.
Topics: Activins; Antioxidants; Apoptosis; Cell Survival; Collagen Type I; Female; Fibronectins; Fibrosis; F | 2019 |
Role of activin-A and myostatin and their signaling pathway in human myometrial and leiomyoma cell function.
Topics: Activins; Adult; Cell Line, Tumor; Cell Proliferation; Collagen Type I; Female; Fibronectins; Humans | 2014 |
Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells.
Topics: Activins; Administration, Oral; Adult; Anti-Allergic Agents; Cell Line, Tumor; Collagen Type I; Coll | 2014 |
Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells.
Topics: Activins; Adult; Female; Gene Expression Regulation, Neoplastic; Humans; Leiomyoma; Middle Aged; Nor | 2014 |
Possible involvement of inflammatory/reparative processes in the development of uterine fibroids.
Topics: Actins; Activins; Antigens, CD34; Collagen; Desmin; Female; Fibroblasts; Humans; Immunohistochemistr | 2016 |
An anthocyanin rich strawberry extract induces apoptosis and ROS while decreases glycolysis and fibrosis in human uterine leiomyoma cells.
Topics: Activins; Anthocyanins; Apoptosis; Blotting, Western; Cell Survival; Collagen Type I; Collagen Type | 2017 |
A high concentration of genistein down-regulates activin A, Smad3 and other TGF-β pathway genes in human uterine leiomyoma cells.
Topics: Activins; Anticarcinogenic Agents; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inh | 2012 |
Serum activin A and inhibin A. New clinical markers for hydatidiform mole.
Topics: Activins; Adult; Biomarkers, Tumor; Female; Humans; Hydatidiform Mole; Inhibins; Pregnancy; Uterine | 2002 |