activins has been researched along with Cancer of Testis in 27 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human testis and testis cancer specimens from orchidectomies were cultured in 'hanging drops' and effects of activin A and follistatin treatment were investigated in seminoma cultures." | 1.40 | Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche. ( Joensen, UN; Jørgensen, A; Loveland, KL; Nielsen, JE; Rajpert-De Meyts, E; Toft, BG; Young, J, 2014) |
| "Germ cell testicular cancer is understood to arise during embryogenesis, based on the persistence of embryonic germ cell markers in carcinoma in situ and seminoma." | 1.37 | TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF-beta ligands and retinoic acid. ( Itman, C; Jaiprakash, A; Kitazawa, R; Looijenga, LH; Loveland, KL; Mithraprabhu, S; Young, JC, 2011) |
| "Additional samples examined were from testicular cancer patients and from normal men subjected to gonadotropin suppression with androgen-based contraceptives." | 1.35 | Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas. ( Dias, VL; Loveland, KL; McLachlan, R; Rajpert-De Meyts, E, 2009) |
| "Testicular tumors were either absent or unilaterally slow growing and less hemorrhagic in the majority of double-knockout males." | 1.34 | SMAD3 regulates gonadal tumorigenesis. ( Graff, JM; Li, Q; Loveland, KL; Matzuk, MM; O'Connor, AE, 2007) |
| "Inhibin-deficient mice die of a severe wasting syndrome due to increased activin signaling through activin receptor type II." | 1.34 | Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein. ( Kumar, R; Li, Q; Loveland, KL; Matzuk, MM; O'Connor, AE; Seehra, JS; Underwood, K, 2007) |
| "Neither normal Leydig cells nor Leydig cell tumors produce activin." | 1.28 | Testicular Leydig cells in vitro secrete only inhibin alpha-subunits, whereas Leydig cell tumors can secrete bioactive inhibin. ( de Jong, FH; de Winter, JP; Grootenhuis, AJ; Klaij, IA; Rommerts, FF; Timmerman, MA; Vanderstichele, HM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (37.04) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Radhakrishnan, K | 1 |
| Luu, M | 1 |
| Iaria, J | 1 |
| Sutherland, JM | 1 |
| McLaughlin, EA | 1 |
| Zhu, HJ | 1 |
| Loveland, KL | 10 |
| Moody, SC | 1 |
| Wakitani, S | 1 |
| Young, JC | 2 |
| Western, PS | 1 |
| Wijayarathna, R | 1 |
| de Kretser, DM | 2 |
| Meinhardt, A | 1 |
| Middendorff, R | 1 |
| Ludlow, H | 1 |
| Groome, NP | 1 |
| Loveland, KA | 1 |
| Hedger, MP | 2 |
| Szarek, M | 1 |
| Bergmann, M | 1 |
| Konrad, L | 1 |
| Schuppe, HC | 1 |
| Kliesch, S | 1 |
| Jørgensen, A | 1 |
| Young, J | 1 |
| Nielsen, JE | 1 |
| Joensen, UN | 1 |
| Toft, BG | 1 |
| Rajpert-De Meyts, E | 2 |
| Marino, FE | 2 |
| Risbridger, G | 2 |
| Gold, E | 2 |
| Haverfield, JT | 1 |
| Stanton, PG | 1 |
| Zahid, H | 1 |
| Nicholls, PK | 1 |
| Olcorn, JS | 1 |
| Makanji, Y | 2 |
| Itman, CM | 1 |
| Simpson, ER | 1 |
| Meachem, SJ | 1 |
| Dias, VL | 1 |
| McLachlan, R | 1 |
| Rajanahally, S | 1 |
| Agno, JE | 1 |
| Nalam, RL | 1 |
| Weinstein, MB | 1 |
| Matzuk, MM | 9 |
| Li, Q | 3 |
| Jaiprakash, A | 1 |
| Mithraprabhu, S | 1 |
| Itman, C | 1 |
| Kitazawa, R | 1 |
| Looijenga, LH | 2 |
| Harrison, C | 1 |
| Graff, JM | 1 |
| O'Connor, AE | 2 |
| Looyenga, BD | 1 |
| Hammer, GD | 1 |
| Kumar, R | 1 |
| Underwood, K | 1 |
| Seehra, JS | 1 |
| Toppari, J | 2 |
| Kaipia, A | 2 |
| Shikone, T | 1 |
| Perlas, E | 1 |
| Finegold, MJ | 2 |
| Lewis, KA | 1 |
| Vale, W | 1 |
| Bradley, A | 2 |
| Hsueh, AJ | 1 |
| Coerver, KA | 1 |
| Woodruff, TK | 3 |
| Mather, J | 1 |
| Shou, W | 1 |
| Caricasole, AA | 1 |
| van Schaik, RH | 1 |
| Zeinstra, LM | 1 |
| Wierikx, CD | 1 |
| van Gurp, RJ | 1 |
| van den Pol, M | 1 |
| Oosterhuis, JW | 1 |
| Pera, MF | 1 |
| Ward, A | 1 |
| de Bruijn, D | 1 |
| Kramer, P | 1 |
| de Jong, FH | 2 |
| van den Eijnden-van Raaij, AJ | 1 |
| Di Simone, N | 1 |
| Hall, HA | 1 |
| Welt, C | 1 |
| Schneyer, AL | 1 |
| Kaleva, M | 1 |
| Laato, M | 1 |
| Krummen, LA | 1 |
| Mather, JP | 1 |
| Salmi, TT | 1 |
| Rahman, NA | 1 |
| Huhtaniemi, I | 1 |
| Kumar, TR | 2 |
| Palapattu, G | 1 |
| Wang, P | 1 |
| Boime, I | 1 |
| Byrne, MC | 1 |
| Cipriano, SC | 2 |
| Chen, L | 2 |
| Burns, KH | 1 |
| Koff, A | 1 |
| Cobellis, L | 1 |
| Cataldi, P | 1 |
| Reis, FM | 1 |
| De Palo, G | 1 |
| Raspagliesi, F | 1 |
| Pilotti, S | 1 |
| Arcuri, F | 1 |
| Petraglia, F | 1 |
| de Winter, JP | 1 |
| Timmerman, MA | 1 |
| Vanderstichele, HM | 1 |
| Klaij, IA | 1 |
| Grootenhuis, AJ | 1 |
| Rommerts, FF | 1 |
1 review available for activins and Cancer of Testis
| Article | Year |
|---|---|
[Inhibin and activin].
Topics: Activins; Biomarkers, Tumor; Female; Growth Substances; Humans; Inhibins; Male; Ovarian Neoplasms; O | 1994 |
26 other studies available for activins and Cancer of Testis
| Article | Year |
|---|---|
Activin and BMP Signalling in Human Testicular Cancer Cell Lines, and a Role for the Nucleocytoplasmic Transport Protein Importin-5 in Their Crosstalk.
Topics: Active Transport, Cell Nucleus; Activins; Animals; beta Karyopherins; Cell Line; Humans; Karyopherin | 2023 |
Evidence that activin A directly modulates early human male germline differentiation status.
Topics: Activins; Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation; Germ Cells; H | 2020 |
Activin over-expression in the testis of mice lacking the inhibin α-subunit gene is associated with androgen deficiency and regression of the male reproductive tract.
Topics: Activins; Aging; Androgens; Animals; Epididymis; Follistatin; Gene Expression Regulation; Inhibins; | 2018 |
Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice.
Topics: Activins; Adult; Chemokine CCL17; Chemokine CXCL12; Gene Expression Regulation, Neoplastic; Humans; | 2019 |
Hanging drop cultures of human testis and testis cancer samples: a model used to investigate activin treatment effects in a preserved niche.
Topics: Activins; Adult; Antigens, Neoplasm; Apoptosis; Carcinoma in Situ; Cell Culture Techniques; Cells, C | 2014 |
The inhibin/activin signalling pathway in human gonadal and adrenal cancers.
Topics: Activin Receptors, Type II; Activins; Adrenal Gland Neoplasms; Cell Line, Tumor; Databases, Genetic; | 2014 |
Suppression of Sertoli cell tumour development during the first wave of spermatogenesis in inhibin α-deficient mice.
Topics: Activins; Animals; Follicle Stimulating Hormone; Inhibins; Male; Mice; Mice, Knockout; Sertoli Cell | 2017 |
Analysis of activin/TGFB-signaling modulators within the normal and dysfunctional adult human testis reveals evidence of altered signaling capacity in a subset of seminomas.
Topics: Activins; Adult; Health; Humans; Male; Models, Biological; Seminoma; Signal Transduction; Testicular | 2009 |
Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice.
Topics: Activins; Animals; Carcinoma; Female; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mode | 2010 |
TCam-2 seminoma cell line exhibits characteristic foetal germ cell responses to TGF-beta ligands and retinoic acid.
Topics: Activin Receptors, Type II; Activins; Adaptor Protein Complex 2; Biomarkers; Bone Morphogenetic Prot | 2011 |
Activin-β(c) reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice.
Topics: Activins; Animals; Apoptosis; Cachexia; Cell Line; Cell Proliferation; Dimerization; Disease Progres | 2013 |
SMAD3 regulates gonadal tumorigenesis.
Topics: Activins; Animals; Cell Transformation, Neoplastic; Female; Follicle Stimulating Hormone; Inhibins; | 2007 |
Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery.
Topics: Activins; Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Cell Cycle; Cell Transformation, Neopla | 2007 |
Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein.
Topics: Activin Receptors, Type II; Activins; Animals; Cachexia; Disease Progression; Female; Follicle Stimu | 2007 |
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor.
Topics: Activins; Adrenal Glands; Animals; Cell Division; Colforsin; Female; Follistatin; Glycoproteins; Gon | 1994 |
Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.
Topics: Activin Receptors; Activins; Animals; Cachexia; Female; Inhibins; Liver; Male; Mice; Mice, Mutant St | 1996 |
Role of androgens in testicular tumor development in inhibin-deficient mice.
Topics: Activins; Androgen-Insensitivity Syndrome; Androgens; Animals; Cachexia; Female; Hybridization, Gene | 1997 |
Human growth-differentiation factor 3 (hGDF3): developmental regulation in human teratocarcinoma cell lines and expression in primary testicular germ cell tumours.
Topics: Activins; Amino Acid Sequence; Base Sequence; DNA Fragmentation; DNA, Complementary; Gene Expression | 1998 |
Activin regulates betaA-subunit and activin receptor messenger ribonucleic acid and cellular proliferation in activin-responsive testicular tumor cells.
Topics: Activin Receptors; Activins; Animals; Cell Division; Follistatin; Glycoproteins; Inhibins; Male; Mic | 1998 |
Inhibin gene expression in a large cell calcifying Sertoli cell tumour and serum inhibin and activin levels.
Topics: Activins; Child; Gene Expression Regulation, Neoplastic; Humans; Inhibins; Male; Sertoli Cell Tumor; | 1998 |
Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene.
Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Artificial Gene Fusion; DNA, Neoplasm; Femal | 1999 |
Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis.
Topics: Activins; Animals; Crosses, Genetic; Female; Follicle Stimulating Hormone; Gene Expression Regulatio | 1999 |
Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice.
Topics: Activins; Animals; Disease Progression; Female; Follistatin; Glycoproteins; Inhibins; Liver Diseases | 2000 |
Inhibin and p27 interact to regulate gonadal tumorigenesis.
Topics: Activins; Animals; Blotting, Northern; Body Weight; Cell Cycle Proteins; Cell Division; Cyclin D2; C | 2001 |
Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits.
Topics: Activins; Adolescent; Adult; Aged; Biomarkers, Tumor; Carcinoma, Embryonal; Child; Choriocarcinoma; | 2001 |
Testicular Leydig cells in vitro secrete only inhibin alpha-subunits, whereas Leydig cell tumors can secrete bioactive inhibin.
Topics: Activins; Animals; Antibodies; Biological Assay; Blotting, Northern; Blotting, Western; Cells, Cultu | 1992 |