activins has been researched along with Cancer of Prostate in 33 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Successful prostate cancer diagnosis and management continue to provide challenges for the clinician." | 2.41 | The role of inhibins and activins in prostate cancer pathogenesis. ( Dowling, CR; Risbridger, GP, 2000) |
| "A hallmark of prostate cancer progression is activin insensitivity; however, mechanisms underlying this are unclear." | 1.43 | Uric acid: a modulator of prostate cells and activin sensitivity. ( Bahn, A; Gold, E; Rodrigues, E; Sangkop, F; Singh, G, 2016) |
| "Mortality from prostate cancer (PCa) is due to the formation of metastatic disease." | 1.39 | Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors. ( Bergan, RC; Breen, MJ; Huang, X; Liu, W; Moran, DM; Vary, CP, 2013) |
| "Local androgen synthesis in prostate cancer (PC) may contribute to the development of castration-resistant PC (CRPC), but pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown." | 1.38 | Activin A stimulates AKR1C3 expression and growth in human prostate cancer. ( de Jong, FH; Dits, NF; Hofland, J; Jenster, G; Steenbergen, J; van Weerden, WM, 2012) |
| "The study of cancer cell dormancy is severely hampered by the lack of biological samples so that the mechanisms that regulate cell dormancy have not been extensively explored." | 1.37 | A dormant state modulated by osmotic pressure controls clonogenicity of prostate cancer cells. ( Dautry, F; Havard, M; Tchénio, T, 2011) |
| "Bone metastasis is the major cause of mortality associated with prostate cancer." | 1.35 | Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer. ( Chang, C; Chuang, YC; Hsieh, CY; Huang, HY; Huang, KE; Kang, HY; Li, CF; Shyr, CR; Tsai, MY, 2009) |
| "Using prostatic cancer cell (PCC) lines as a model of cancer cell proliferation, we have identified the fetal serum component activin A and its signaling through the activin receptor type II (ActRII), as necessary, although not sufficient, for PCC proliferation." | 1.35 | Activin receptor signaling regulates prostatic epithelial cell adhesion and viability. ( Atwood, CS; Bowen, RL; Bruce, E; Gallego, MJ; Haasl, RJ; Lyons, PF; Simon, DP; Vadakkadath Meethal, S; Weinecke, SL; Wilson, AC, 2009) |
| "Cultures from high grade prostatic intraepithelial neoplasia (HGPIN) have been established and immortalized by HPV-18 infection." | 1.30 | Growth of HPV-18 immortalized human prostatic intraepithelial neoplasia cell lines. Influence of IL-10, follistatin, activin-A, and DHT. ( Garcia, FU; Liu, A; Rhim, JS; Stearns, ME; Wang, M, 1999) |
| "Human prostate cancer cell lines have been used to investigate similar agents in malignancy." | 1.29 | Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells. ( Bradshaw, D; Dalkin, AC; Gilrain, JT; Myers, CE, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (27.27) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 10 (30.30) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| De Menna, M | 1 |
| Groenewoud, A | 1 |
| Thalmann, GN | 1 |
| Kruithof-de Julio, M | 1 |
| Snaar-Jagalska, BE | 1 |
| Handforth, C | 1 |
| D'Oronzo, S | 1 |
| Coleman, R | 1 |
| Brown, J | 1 |
| Jin, W | 1 |
| Chen, F | 1 |
| Wang, K | 1 |
| Song, Y | 1 |
| Fei, X | 1 |
| Wu, B | 1 |
| Breen, MJ | 1 |
| Moran, DM | 1 |
| Liu, W | 1 |
| Huang, X | 1 |
| Vary, CP | 1 |
| Bergan, RC | 1 |
| Sangkop, F | 1 |
| Singh, G | 1 |
| Rodrigues, E | 1 |
| Gold, E | 3 |
| Bahn, A | 1 |
| Ottley, EC | 1 |
| Nicholson, HD | 1 |
| Gold, EJ | 1 |
| Kang, HY | 1 |
| Huang, HY | 1 |
| Hsieh, CY | 1 |
| Li, CF | 1 |
| Shyr, CR | 1 |
| Tsai, MY | 1 |
| Chang, C | 1 |
| Chuang, YC | 1 |
| Huang, KE | 1 |
| Simon, DP | 1 |
| Vadakkadath Meethal, S | 1 |
| Wilson, AC | 1 |
| Gallego, MJ | 1 |
| Weinecke, SL | 1 |
| Bruce, E | 1 |
| Lyons, PF | 1 |
| Haasl, RJ | 1 |
| Bowen, RL | 1 |
| Atwood, CS | 1 |
| Tumminello, FM | 2 |
| Badalamenti, G | 2 |
| Fulfaro, F | 1 |
| Incorvaia, L | 2 |
| Crescimanno, M | 2 |
| Flandina, C | 2 |
| Sepporta, MV | 1 |
| Leto, G | 2 |
| Risbridger, G | 1 |
| Havard, M | 1 |
| Dautry, F | 1 |
| Tchénio, T | 1 |
| Ottley, E | 1 |
| Hofland, J | 1 |
| van Weerden, WM | 1 |
| Steenbergen, J | 1 |
| Dits, NF | 1 |
| Jenster, G | 1 |
| de Jong, FH | 1 |
| Lin, SL | 2 |
| Ying, SY | 3 |
| Carey, JL | 1 |
| Sasur, LM | 1 |
| Kawakubo, H | 1 |
| Gupta, V | 1 |
| Christian, B | 1 |
| Bailey, PM | 1 |
| Maheswaran, S | 1 |
| Fujii, Y | 1 |
| Kawakami, S | 1 |
| Okada, Y | 1 |
| Kageyama, Y | 1 |
| Kihara, K | 1 |
| Planz, B | 1 |
| Oltean, H | 1 |
| Deix, T | 1 |
| Kirley, SD | 1 |
| Wang, QF | 2 |
| McDougal, WS | 1 |
| Marberger, M | 1 |
| Chen, G | 1 |
| Nomura, M | 1 |
| Morinaga, H | 1 |
| Matsubara, E | 1 |
| Okabe, T | 1 |
| Goto, K | 1 |
| Yanase, T | 1 |
| Zheng, H | 1 |
| Lu, J | 1 |
| Nawata, H | 1 |
| Rossi, MR | 1 |
| Ionov, Y | 1 |
| Bakin, AV | 1 |
| Cowell, JK | 1 |
| Gebbia, N | 1 |
| Rini, G | 1 |
| Dalkin, AC | 1 |
| Gilrain, JT | 1 |
| Bradshaw, D | 1 |
| Myers, CE | 1 |
| Tilly, KI | 1 |
| Tilly, JL | 1 |
| Preffer, F | 1 |
| Schneyer, AL | 1 |
| Crowley, WF | 1 |
| Sluss, PM | 1 |
| Zhang, Z | 1 |
| Zhao, Y | 1 |
| Batres, Y | 1 |
| Lin, MF | 1 |
| Thomas, TZ | 2 |
| Wang, H | 3 |
| Niclasen, P | 1 |
| O'Bryan, MK | 1 |
| Evans, LW | 2 |
| Groome, NP | 2 |
| Pedersen, J | 1 |
| Risbridger, GP | 7 |
| McPherson, SJ | 3 |
| Gurusinghe, CJ | 1 |
| Wang, M | 1 |
| Liu, A | 1 |
| Garcia, FU | 1 |
| Rhim, JS | 1 |
| Stearns, ME | 1 |
| Mellor, SL | 2 |
| Chuong, CM | 1 |
| Lin, S | 1 |
| Cancilla, B | 1 |
| Dowling, CR | 1 |
| Schmitt, JF | 1 |
6 reviews available for activins and Cancer of Prostate
| Article | Year |
|---|---|
Cancer Treatment and Bone Health.
Topics: Activins; Androgens; Antineoplastic Agents; Bone and Bones; Breast Neoplasms; Estrogens; Female; Gon | 2018 |
Activins and activin antagonists in the prostate and prostate cancer.
Topics: Activins; Animals; Cell Transformation, Neoplastic; Follistatin; Follistatin-Related Proteins; GPI-L | 2012 |
Insensitivity to the growth inhibitory effects of activin A: an acquired capability in prostate cancer progression.
Topics: Activins; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Growth Inhibitor | 2012 |
Role of activins in the male reproductive tract.
Topics: Activins; Animals; Cell Communication; Cell Division; Epididymis; Follistatin; Gene Expression Regul | 2000 |
The role of inhibins and activins in prostate cancer pathogenesis.
Topics: Activins; Animals; Humans; Inhibins; Male; Prostate; Prostatic Neoplasms; Signal Transduction; Testi | 2000 |
The contribution of inhibins and activins to malignant prostate disease.
Topics: Activins; Animals; Cell Division; Female; Humans; Inhibins; Male; Prostatic Neoplasms; Protein Subun | 2001 |
27 other studies available for activins and Cancer of Prostate
| Article | Year |
|---|---|
A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis.
Topics: Activins; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Gene Expression Regulation, | 2020 |
miR-15a/miR-16 cluster inhibits invasion of prostate cancer cells by suppressing TGF-β signaling pathway.
Topics: Activins; Animals; Cadherins; Cell Line; Cell Line, Tumor; Down-Regulation; Epithelial-Mesenchymal T | 2018 |
Endoglin-mediated suppression of prostate cancer invasion is regulated by activin and bone morphogenetic protein type II receptors.
Topics: Activin Receptors, Type II; Activins; Antigens, CD; Bone Morphogenetic Protein Receptors, Type II; C | 2013 |
Uric acid: a modulator of prostate cells and activin sensitivity.
Topics: Activins; Cell Line, Tumor; Glucose Transport Proteins, Facilitative; Humans; Male; Probenecid; Pros | 2016 |
Activin A regulates microRNAs and gene expression in LNCaP cells.
Topics: Activins; Cell Cycle; Cell Line, Tumor; Gene Expression; Gene Expression Profiling; Gene Expression | 2016 |
Activin A enhances prostate cancer cell migration through activation of androgen receptor and is overexpressed in metastatic prostate cancer.
Topics: Active Transport, Cell Nucleus; Activins; Apoptosis; Bone Neoplasms; Cell Movement; Cell Nucleus; Ge | 2009 |
Activin receptor signaling regulates prostatic epithelial cell adhesion and viability.
Topics: Activin Receptors, Type II; Activins; ADAM Proteins; Cell Adhesion; Cell Line, Tumor; Cell Survival; | 2009 |
Serum follistatin in patients with prostate cancer metastatic to the bone.
Topics: Activins; Aged; Bone Neoplasms; Follistatin; Humans; Male; Middle Aged; Prostate-Specific Antigen; P | 2010 |
A dormant state modulated by osmotic pressure controls clonogenicity of prostate cancer cells.
Topics: Activins; Animals; Cell Cycle; Cell Line, Tumor; Culture Media, Conditioned; Humans; Male; Mice; Neo | 2011 |
Activin A stimulates AKR1C3 expression and growth in human prostate cancer.
Topics: 3-Hydroxysteroid Dehydrogenases; Activins; Aldo-Keto Reductase Family 1 Member C3; Androgens; Animal | 2012 |
Single-cell mRNA library analysis by Northern blot hybridization.
Topics: Activins; Biomarkers, Tumor; Blotting, Northern; Gene Expression; Gene Library; Humans; Male; Nuclei | 2003 |
Gene expression in precursor cells of prostate cancer associated with activin by combination of subtractive hybridization and microarray technologies.
Topics: Activins; Blotting, Northern; Cell Line, Tumor; Disease Progression; Gene Expression Profiling; Gene | 2004 |
Mutually antagonistic effects of androgen and activin in the regulation of prostate cancer cell growth.
Topics: Activins; Androgens; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibit | 2004 |
Regulation of prostate-specific antigen by activin A in prostate cancer LNCaP cells.
Topics: Activins; Androgens; Cell Division; Cell Line, Tumor; Dihydrotestosterone; Drug Interactions; Gene E | 2004 |
Effect of keratinocyte growth factor and activin on cell growth in the human prostatic cancer cell line LNCaP.
Topics: Activins; Cell Division; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Humans; Male; Prosta | 2004 |
Modulation of androgen receptor transactivation by FoxH1. A newly identified androgen receptor corepressor.
Topics: Activins; Animals; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Chlorocebus aethiops; COS Cell | 2005 |
Truncating mutations in the ACVR2 gene attenuates activin signaling in prostate cancer cells.
Topics: Activin Receptors; Activins; Base Sequence; Cell Line, Tumor; DNA Primers; Gene Expression; Humans; | 2005 |
Activin A circulating levels in patients with bone metastasis from breast or prostate cancer.
Topics: Activins; Aged; Aged, 80 and over; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Female; Huma | 2006 |
Activin inhibition of prostate cancer cell growth: selective actions on androgen-responsive LNCaP cells.
Topics: Activin Receptors; Activins; Androgens; Cell Division; Drug Resistance; Follistatin; Glycoproteins; | 1996 |
Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP.
Topics: Activin Receptors; Activins; Androgens; Apoptosis; Cell Division; Cell Separation; DNA Fragmentation | 1996 |
Regulation of growth and prostatic marker expression by activin A in an androgen-sensitive prostate cancer cell line LNCAP.
Topics: Acid Phosphatase; Activins; Androgens; Biomarkers, Tumor; Cell Differentiation; Cell Division; Human | 1997 |
Expression and localization of activin subunits and follistatins in tissues from men with high grade prostate cancer.
Topics: Activins; Animals; Biopsy, Needle; Epithelium; Follistatin; Gene Expression; Glycoproteins; Humans; | 1997 |
Growth inhibitory response to activin A and B by human prostate tumour cell lines, LNCaP and DU145.
Topics: Activins; Adjuvants, Immunologic; Blotting, Southern; DNA; Dose-Response Relationship, Drug; Follist | 1997 |
Recent progress in our understanding of inhibin in the prostate gland.
Topics: Activins; Animals; Follicle Stimulating Hormone; Follistatin; Glycoproteins; Growth Substances; Huma | 1998 |
Growth of HPV-18 immortalized human prostatic intraepithelial neoplasia cell lines. Influence of IL-10, follistatin, activin-A, and DHT.
Topics: Activins; Adjuvants, Immunologic; Androgens; Animals; Blotting, Western; Cell Adhesion; Cell Divisio | 1999 |
Expression of activin A and follistatin core proteins by human prostate tumor cell lines.
Topics: Activins; Alternative Splicing; Blotting, Western; Culture Media, Conditioned; Enzyme-Linked Immunos | 1999 |
Suppression of activin-induced apoptosis by novel antisense strategy in human prostate cancer cells.
Topics: Activins; Antisense Elements (Genetics); Apoptosis; Gene Expression; Gene Targeting; Humans; Inhibin | 1999 |