activins has been researched along with Cancer of Pituitary in 28 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Prolactin-secreting pituitary adenomas (prolactinomas) are the most common form of pituitary tumors in humans." | 2.45 | Activin, TGF-beta and menin in pituitary tumorigenesis. ( Lebrun, JJ, 2009) |
| "Among pituitary adenomas, prolactinomas are the most frequently diagnosed (about 50%)." | 1.72 | Oophorectomy improves pituitary activin inhibitory function preventing lactotroph hyperplasia development. ( Abeledo-Machado, A; Camilletti, MA; Diaz-Torga, G; Faraoni, EY; Gutierrez, S; Marcial López, CA; Peña-Zanoni, M; Perez, PA; Rulli, SB, 2022) |
| "As activins inhibit prolactin gene expression through the inhibition of Pit-1 involving the p38MAPK pathway, in the present work, we studied the local activin system as an alternative inhibitory system for lactotroph hyperplasia treatment." | 1.56 | Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia. ( Abeledo Machado, AI; Camilletti, MA; Díaz-Torga, G; Faraoni, EY; Gutiérrez, S; Marcial López, CA; Peña-Zanoni, M; Pérez, PA; Rulli, SB, 2020) |
| "Discovering markers to identify prolactinoma proliferative and invading character is therefore crucial to develop new diagnostic/prognostic strategies." | 1.48 | ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation. ( Auger, C; Bertolino, P; Chanal, M; Gadet, R; Hennino, A; Jouanneau, E; Karam, V; Mikaélian, I; Principe, M; Raverot, G; Raverot, V; Vasiljevic, A; Wierinckx, A, 2018) |
| "Human pituitary tumors specifically express alternatively spliced activin type I receptor Alk4 mRNAs, producing C-terminus truncated isoforms designated Alk4-2, 4-3, and 4-4." | 1.31 | Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells. ( Danila, DC; Haidar, JN; Klibanski, A; Zhang, X; Zhou, Y, 2002) |
| "We selected 19 pituitary adenomas that had been excised by transsphenoidal surgery and determined by immunocytochemical criteria to be gonadotroph adenomas." | 1.29 | Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas. ( Asa, SL; Bashey, HM; Cirullo, R; Gennarelli, TA; Haddad, G; Penabad, JL; Snyder, PJ, 1994) |
| "In 33% of the human pituitary tumors studied, significant (P less than 0." | 1.28 | The effects of activin on follicle-stimulating hormone secretion and biosynthesis in human glycoprotein hormone-producing pituitary adenomas. ( Alexander, JM; Bikkal, HA; Jameson, JL; Klibanski, A; Schwall, RH, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 12 (42.86) | 18.2507 |
| 2000's | 11 (39.29) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Peña-Zanoni, M | 2 |
| Faraoni, EY | 2 |
| Abeledo-Machado, A | 1 |
| Perez, PA | 2 |
| Marcial López, CA | 2 |
| Camilletti, MA | 2 |
| Gutierrez, S | 2 |
| Rulli, SB | 2 |
| Diaz-Torga, G | 2 |
| Ziverec, A | 1 |
| Chanal, M | 2 |
| Raymond, P | 1 |
| Ilie, MD | 1 |
| De Alcubierre, D | 1 |
| Pasternack, A | 1 |
| Ritvos, O | 1 |
| Raverot, G | 2 |
| Bertolino, P | 2 |
| Abeledo Machado, AI | 1 |
| Principe, M | 1 |
| Karam, V | 1 |
| Wierinckx, A | 1 |
| Mikaélian, I | 1 |
| Gadet, R | 1 |
| Auger, C | 1 |
| Raverot, V | 1 |
| Jouanneau, E | 1 |
| Vasiljevic, A | 1 |
| Hennino, A | 1 |
| Lebrun, JJ | 1 |
| Danila, DC | 4 |
| Zhang, X | 4 |
| Zhou, Y | 3 |
| Haidar, JN | 1 |
| Klibanski, A | 6 |
| Takeda, M | 2 |
| Otsuka, F | 2 |
| Suzuki, J | 2 |
| Kishida, M | 1 |
| Ogura, T | 2 |
| Tamiya, T | 1 |
| Makino, H | 2 |
| Otani, H | 1 |
| Inagaki, K | 1 |
| Miyoshi, T | 1 |
| Mimura, Y | 1 |
| Gaddy-Kurten, D | 1 |
| Vale, WW | 1 |
| Yamashita, H | 1 |
| Okadome, T | 1 |
| Franzén, P | 1 |
| ten Dijke, P | 1 |
| Heldin, CH | 1 |
| Miyazono, K | 1 |
| Haddad, G | 1 |
| Penabad, JL | 1 |
| Bashey, HM | 1 |
| Asa, SL | 1 |
| Gennarelli, TA | 1 |
| Cirullo, R | 1 |
| Snyder, PJ | 1 |
| Daniels, M | 1 |
| Harris, PE | 1 |
| James, RA | 1 |
| Turner, SJ | 1 |
| Dewar, JH | 1 |
| Kendall-Taylor, P | 1 |
| Alexander, JM | 3 |
| Bikkal, HA | 2 |
| Zervas, NT | 1 |
| Laws, ER | 1 |
| Ying, C | 1 |
| Zhang, Z | 1 |
| Huang, G | 1 |
| Li, SQ | 1 |
| Ying, SY | 1 |
| Demura, R | 1 |
| Kubo, O | 1 |
| Suzuki, T | 1 |
| Yajima, R | 1 |
| Tajima, S | 1 |
| Takakura, K | 1 |
| Demura, H | 1 |
| Aiba, M | 1 |
| Eto, Y | 1 |
| Sanno, N | 1 |
| Teramoto, A | 3 |
| Sugiyama, M | 1 |
| Matsuno, A | 1 |
| Takumi, I | 1 |
| Tahara, S | 1 |
| Osamura, RY | 1 |
| Inder, WJ | 1 |
| Swearingen, B | 1 |
| Hedley-Whyte, ET | 2 |
| Dickersin, GR | 1 |
| Fletcher, JA | 1 |
| Selig, MK | 1 |
| Johnson, SR | 2 |
| Tamura, N | 1 |
| Irahara, M | 1 |
| Kuwahara, A | 1 |
| Ushigoe, K | 1 |
| Sugino, H | 1 |
| Aono, T | 1 |
| Sun, H | 1 |
| Sigai, DP | 1 |
| Wessels, HT | 1 |
| Hofland, LJ | 1 |
| van der Wal, R | 1 |
| van Gastel, L | 1 |
| van Koetsveld, PM | 1 |
| de Herder, WW | 1 |
| de Jong, FH | 1 |
| Uccella, S | 1 |
| La Rosa, S | 1 |
| Genasetti, A | 1 |
| Capella, C | 1 |
| Sidis, Y | 1 |
| Tortoriello, DV | 1 |
| Holmes, WE | 1 |
| Pan, Y | 1 |
| Keutmann, HT | 1 |
| Schneyer, AL | 1 |
| Takano, K | 2 |
| Yamashita, N | 1 |
| Kojima, I | 2 |
| Kitaoka, M | 2 |
| Ogata, E | 2 |
| Jameson, JL | 1 |
| Schwall, RH | 1 |
| Tanaka, Y | 1 |
| Ramsdell, JS | 1 |
| Cheifetz, S | 1 |
| Ling, N | 1 |
| Guillemin, R | 1 |
| Massagué, J | 1 |
1 review available for activins and Cancer of Pituitary
| Article | Year |
|---|---|
Activin, TGF-beta and menin in pituitary tumorigenesis.
Topics: Activins; Adenoma; Gene Expression Regulation, Neoplastic; Humans; Pituitary Neoplasms; Prolactin; P | 2009 |
27 other studies available for activins and Cancer of Pituitary
| Article | Year |
|---|---|
Oophorectomy improves pituitary activin inhibitory function preventing lactotroph hyperplasia development.
Topics: Activins; Adult; Animals; Female; Humans; Hyperplasia; Inhibins; Lactotrophs; Mice; Ovariectomy; Pit | 2022 |
Inhibition of activin signalling reduces the growth of LβT2 gonadotroph pituitary tumours in mouse.
Topics: Activins; Animals; Endothelial Cells; Follicle Stimulating Hormone; Follicle Stimulating Hormone, be | 2023 |
Activin-inhibitory action on lactotrophs is decreased in lactotroph hyperplasia.
Topics: Activins; Animals; Dopamine Agonists; Drug Resistance, Neoplasm; Female; Genotype; Lactotrophs; Male | 2020 |
ALK7 expression in prolactinoma is associated with reduced prolactin and increased proliferation.
Topics: Activin Receptors, Type I; Activins; Animals; Humans; Pituitary Neoplasms; Prolactin; Prolactinoma; | 2018 |
Overexpression of wild-type activin receptor alk4-1 restores activin antiproliferative effects in human pituitary tumor cells.
Topics: Activin Receptors, Type I; Activins; Alternative Splicing; Animals; Cell Division; Cell Line; DNA; E | 2002 |
Involvement of activin/BMP system in development of human pituitary gonadotropinomas and nonfunctioning adenomas.
Topics: Activins; Adenoma; Adult; Aged; Bone Morphogenetic Proteins; Cell Division; Female; Follicle Stimula | 2003 |
Effects of peroxisome proliferator-activated receptor activation on gonadotropin transcription and cell mitosis induced by bone morphogenetic proteins in mouse gonadotrope LbetaT2 cells.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line, Tumor; Follistatin; Gene Expression Profi | 2007 |
Activin increases phosphorylation and decreases stability of the transcription factor Pit-1 in MtTW15 somatotrope cells.
Topics: Activins; DNA; DNA-Binding Proteins; Growth Hormone; Growth Substances; Humans; Inhibins; Phosphoryl | 1995 |
A rat pituitary tumor cell line (GH3) expresses type I and type II receptors and other cell surface binding protein(s) for transforming growth factor-beta.
Topics: Activins; Animals; Base Sequence; Cells, Cultured; DNA Primers; Inhibins; Membrane Proteins; Molecul | 1995 |
Expression of activin/inhibin subunit messenger ribonucleic acids by gonadotroph adenomas.
Topics: Activins; Adenoma; Adult; Aged; Base Sequence; Female; Gene Expression Regulation, Neoplastic; Human | 1994 |
Effects of recombinant human activin A on growth hormone secretion by human somatotrophinomas in vitro.
Topics: Activins; Aged; Bromocriptine; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Growth Subs | 1993 |
Tumor-specific expression and alternate splicing of messenger ribonucleic acid encoding activin/transforming growth factor-beta receptors in human pituitary adenomas.
Topics: Activin Receptors; Activins; Adenoma; Adolescent; Adult; Alternative Splicing; Amino Acid Sequence; | 1996 |
Expression and localization of inhibin/activin and activin receptors in GH3 cells, a rat pituitary adenocarcinoma cell line.
Topics: Activin Receptors; Activins; Adenocarcinoma; Animals; Base Sequence; DNA, Complementary; Electrophor | 1996 |
Demonstration of activin in normal pituitary and in various human pituitary adenomas by immunohistochemistry.
Topics: Activins; Adenoma; Cushing Syndrome; Human Growth Hormone; Humans; Immunohistochemistry; Inhibins; P | 1996 |
Expression of Pit-1 mRNA and activin/inhibin subunits in clinically nonfunctioning pituitary adenomas. In situ hybridization and immunohistochemical analysis.
Topics: Activins; Adenoma; Adult; Aged; DNA-Binding Proteins; Female; Follicle Stimulating Hormone; Follicle | 1998 |
Activin effects on neoplastic proliferation of human pituitary tumors.
Topics: Activin Receptors; Activins; Adenoma; Adult; Aged; Aged, 80 and over; Blotting, Western; Cell Divisi | 2000 |
A human pituitary tumor-derived folliculostellate cell line.
Topics: Activin Receptors; Activins; Adenoma; Aged; Blotting, Western; Cell Transformation, Neoplastic; Chro | 2000 |
Effect of activin on production and secretion of prolactin and growth hormone in cultured rat GH3 cells.
Topics: Activins; Animals; Blotting, Northern; Gene Expression; Growth Hormone; Inhibins; Pituitary Neoplasm | 2000 |
Truncated activin type I receptor Alk4 isoforms are dominant negative receptors inhibiting activin signaling.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Adenoma; Animals; Bacterial Protein | 2000 |
In vitro secretion of FSH by cultured clinically nonfunctioning and gonadotroph pituitary adenomas is directly correlated with locally produced levels of activin A.
Topics: Activins; Adenoma; Adult; Aged; Analysis of Variance; Culture Media; Female; Follicle Stimulating Ho | 2001 |
Localization of inhibin/activin subunits in normal pituitary and in pituitary adenomas.
Topics: Activins; Adenoma; Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Immunohistoche | 2000 |
Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin.
Topics: Activin Receptors; Activins; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; COS Cell | 2002 |
Effects of activin A and somatostatin on intact FSH secretion and intracellular Ca2+ concentration in human FSH-secreting pituitary adenoma cells.
Topics: Activins; Adenoma; Calcium; Dose-Response Relationship, Drug; Follicle Stimulating Hormone; Humans; | 1992 |
The effects of activin on follicle-stimulating hormone secretion and biosynthesis in human glycoprotein hormone-producing pituitary adenomas.
Topics: Activins; Adenoma; Adult; Aged; Animals; Female; Follicle Stimulating Hormone; Glycoproteins; Homeos | 1991 |
Inhibition of growth hormone secretion by activin A in human growth hormone-secreting tumour cells.
Topics: Activins; Adult; Calcimycin; Calcium; Cytoplasm; Dose-Response Relationship, Drug; Female; Growth Ho | 1991 |
Transforming growth factor-alpha and -beta are potent and effective inhibitors of GH4 pituitary tumor cell proliferation.
Topics: Activins; Animals; Cell Adhesion; Cell Count; Cell Division; DNA; Inhibins; Interphase; Mitosis; Pho | 1991 |
A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin.
Topics: Activin Receptors; Activins; Animals; Binding, Competitive; Cell Line; Cell Membrane; Inhibins; Kine | 1988 |