activins has been researched along with Cancer of Pancreas in 25 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal adenocarcinoma (PDAC)." | 1.72 | Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin. ( Koniaris, LG; Liu, S; Liu, Y; Narasimhan, A; Shahda, S; Silverman, LM; Wan, J; Young, AR; Zhong, X; Zimmers, TA, 2022) |
| "During tumorigenesis, cancer cells use two different approaches to evade this barrier, either downregulating activin B and/or downregulating ALK7." | 1.51 | ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis. ( Hanahan, D; Marinoni, I; Michael, IP; Perren, A; Saghafinia, S; Tichet, M; Zangger, N, 2019) |
| "However, engrafted primary human pancreatic cancer tissue with a substantial stroma showed no response due to limited drug delivery." | 1.37 | Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy. ( Aicher, A; Alcala, S; Balic, A; Bartenstein, P; Berger, F; Cebrián, DÁ; Garcia, E; Heeschen, C; Hermann, PC; Heuchel, R; Hidalgo, M; Huber, S; Löhr, M; Lonardo, E; Miranda-Lorenzo, I; Mueller, MT; Ramirez, JC; Rodriguez-Arabaolaza, I; Torres-Ruíz, R; Zagorac, S, 2011) |
| "In 74 pancreatic cancers analysed, 36% lacked Sel1L expression, although there was no significant correlation between the expression of Sel1L and any clinicopathologic parameter, including survival." | 1.32 | SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo. ( Bassi, C; Beghelli, S; Bernardi, LR; Biunno, I; Bonora, A; Cattaneo, M; Ménard, S; Moore, PS; Orlandi, R; Orlandini, S; Scarpa, A; Sorio, C; Talamini, G; Zamboni, G, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 4 (16.00) | 29.6817 |
| 2010's | 9 (36.00) | 24.3611 |
| 2020's | 8 (32.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yi, Z | 2 |
| Wei, S | 1 |
| Jin, L | 1 |
| Jeyarajan, S | 2 |
| Yang, J | 2 |
| Gu, Y | 2 |
| Kim, HS | 2 |
| Schechter, S | 1 |
| Lu, S | 2 |
| Paulsen, MT | 2 |
| Bedi, K | 2 |
| Narayanan, IV | 2 |
| Ljungman, M | 2 |
| Crawford, HC | 1 |
| Pasca di Magliano, M | 1 |
| Ge, K | 2 |
| Dou, Y | 2 |
| Shi, J | 2 |
| Xu, PC | 1 |
| You, M | 1 |
| Yu, SY | 1 |
| Luan, Y | 1 |
| Eldani, M | 1 |
| Caffrey, TC | 1 |
| Grandgenett, PM | 1 |
| O'Connell, KA | 1 |
| Shukla, SK | 1 |
| Kattamuri, C | 1 |
| Hollingsworth, MA | 1 |
| Singh, PK | 1 |
| Thompson, TB | 1 |
| Chung, S | 1 |
| Kim, SY | 1 |
| Zhong, X | 2 |
| Narasimhan, A | 1 |
| Silverman, LM | 1 |
| Young, AR | 1 |
| Shahda, S | 2 |
| Liu, S | 1 |
| Wan, J | 1 |
| Liu, Y | 2 |
| Koniaris, LG | 2 |
| Zimmers, TA | 2 |
| Chen, YI | 1 |
| Chang, CC | 1 |
| Hsu, MF | 1 |
| Jeng, YM | 1 |
| Tien, YW | 1 |
| Chang, MC | 1 |
| Chang, YT | 1 |
| Hu, CM | 1 |
| Lee, WH | 1 |
| Cao, Y | 1 |
| Zhao, L | 1 |
| Magnuson, B | 1 |
| Babaniamansour, S | 1 |
| Shameon, S | 1 |
| Xu, C | 1 |
| Qiu, P | 1 |
| Thomas, D | 1 |
| Crawford, H | 1 |
| di Magliano, MP | 1 |
| Yang, B | 1 |
| Michael, IP | 2 |
| Saghafinia, S | 2 |
| Hanahan, D | 2 |
| Zhao, Y | 1 |
| Wu, Z | 1 |
| Chanal, M | 1 |
| Guillaumond, F | 1 |
| Goehrig, D | 2 |
| Bachy, S | 1 |
| Principe, M | 1 |
| Ziverec, A | 1 |
| Flaman, JM | 1 |
| Collin, G | 1 |
| Tomasini, R | 1 |
| Pasternack, A | 1 |
| Ritvos, O | 2 |
| Vasseur, S | 1 |
| Bernard, D | 1 |
| Hennino, A | 2 |
| Bertolino, P | 2 |
| Talar-Wojnarowska, R | 1 |
| Wozniak, M | 1 |
| Borkowska, A | 1 |
| Olakowski, M | 1 |
| Malecka-Panas, E | 1 |
| Mancinelli, G | 1 |
| Torres, C | 1 |
| Krett, N | 1 |
| Bauer, J | 1 |
| Castellanos, K | 1 |
| McKinney, R | 1 |
| Dawson, D | 1 |
| Guzman, G | 1 |
| Hwang, R | 1 |
| Grimaldo, S | 1 |
| Grippo, P | 1 |
| Jung, B | 1 |
| Tichet, M | 1 |
| Zangger, N | 1 |
| Marinoni, I | 1 |
| Perren, A | 1 |
| Pons, M | 1 |
| Poirier, C | 1 |
| Jiang, Y | 1 |
| Liu, J | 1 |
| Sandusky, GE | 1 |
| Nakeeb, A | 1 |
| Schmidt, CM | 1 |
| House, MG | 1 |
| Ceppa, EP | 1 |
| Zyromski, NJ | 1 |
| Jiang, G | 1 |
| Couch, ME | 1 |
| Togashi, Y | 1 |
| Kogita, A | 1 |
| Sakamoto, H | 1 |
| Hayashi, H | 1 |
| Terashima, M | 1 |
| de Velasco, MA | 1 |
| Sakai, K | 1 |
| Fujita, Y | 1 |
| Tomida, S | 1 |
| Kitano, M | 1 |
| Okuno, K | 1 |
| Kudo, M | 1 |
| Nishio, K | 1 |
| Sainz, B | 2 |
| Alcala, S | 2 |
| Garcia, E | 2 |
| Sanchez-Ripoll, Y | 2 |
| Azevedo, MM | 1 |
| Cioffi, M | 2 |
| Tatari, M | 1 |
| Miranda-Lorenzo, I | 3 |
| Hidalgo, M | 3 |
| Gomez-Lopez, G | 1 |
| Cañamero, M | 1 |
| Erkan, M | 1 |
| Kleeff, J | 2 |
| García-Silva, S | 1 |
| Sancho, P | 1 |
| Hermann, PC | 3 |
| Heeschen, C | 3 |
| Trabulo, SM | 1 |
| Lonardo, E | 2 |
| Dorado, J | 1 |
| Reis Vieira, C | 1 |
| Ramirez, JC | 2 |
| Aicher, A | 2 |
| Hahn, S | 1 |
| Ripoche, D | 1 |
| Charbord, J | 1 |
| Teinturier, R | 1 |
| Bonnavion, R | 1 |
| Jaafar, R | 1 |
| Cordier-Bussat, M | 1 |
| Zhang, CX | 1 |
| Andersson, O | 1 |
| Perkhofer, L | 1 |
| Walter, K | 1 |
| Costa, IG | 1 |
| Carrasco, MC | 1 |
| Eiseler, T | 1 |
| Hafner, S | 1 |
| Genze, F | 1 |
| Zenke, M | 1 |
| Bergmann, W | 1 |
| Illing, A | 1 |
| Hohwieler, M | 1 |
| Köhntop, R | 1 |
| Lin, Q | 1 |
| Holzmann, KH | 1 |
| Seufferlein, T | 1 |
| Wagner, M | 1 |
| Liebau, S | 1 |
| Kleger, A | 1 |
| Müller, M | 1 |
| Mueller, MT | 1 |
| Huber, S | 1 |
| Balic, A | 1 |
| Zagorac, S | 1 |
| Rodriguez-Arabaolaza, I | 1 |
| Torres-Ruíz, R | 1 |
| Cebrián, DÁ | 1 |
| Heuchel, R | 1 |
| Löhr, M | 1 |
| Berger, F | 1 |
| Bartenstein, P | 1 |
| Cattaneo, M | 1 |
| Orlandini, S | 1 |
| Beghelli, S | 1 |
| Moore, PS | 1 |
| Sorio, C | 1 |
| Bonora, A | 1 |
| Bassi, C | 1 |
| Talamini, G | 1 |
| Zamboni, G | 1 |
| Orlandi, R | 1 |
| Ménard, S | 1 |
| Bernardi, LR | 1 |
| Biunno, I | 1 |
| Scarpa, A | 1 |
| La Rosa, S | 1 |
| Uccella, S | 1 |
| Marchet, S | 1 |
| Capella, C | 1 |
| Lloyd, RV | 1 |
| Mogami, H | 1 |
| Kanzaki, M | 2 |
| Nobusawa, R | 1 |
| Zhang, YQ | 2 |
| Furukawa, M | 1 |
| Kojima, I | 3 |
| Shibata, H | 1 |
| Takeuchi, T | 1 |
| Miyazaki, J | 1 |
| de Winter, JP | 1 |
| Roelen, BA | 1 |
| ten Dijke, P | 1 |
| van der Burg, B | 1 |
| van den Eijnden-van Raaij, AJ | 1 |
| Ishiwata, T | 1 |
| Friess, H | 1 |
| Büchler, MW | 1 |
| Korc, M | 1 |
| Tikhomirov, V | 1 |
| Tikhomirova, S | 1 |
| Sieber, S | 1 |
| Schiffman, MK | 1 |
| Mashima, H | 1 |
25 other studies available for activins and Cancer of Pancreas
| Article | Year |
|---|---|
KDM6A Regulates Cell Plasticity and Pancreatic Cancer Progression by Noncanonical Activin Pathway.
Topics: Activins; Animals; Cell Plasticity; Histone Demethylases; Humans; Mice; Pancreas; Pancreatic Neoplas | 2022 |
Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling.
Topics: Activins; Adipocytes, White; Adiposity; Animals; Atrophy; Carcinoma, Pancreatic Ductal; Case-Control | 2022 |
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Topics: Activins; Adenocarcinoma; Animals; Cachexia; Carcinoma, Pancreatic Ductal; Estradiol; Female; Follis | 2022 |
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Topics: Activins; Adenocarcinoma; Animals; Cachexia; Carcinoma, Pancreatic Ductal; Estradiol; Female; Follis | 2022 |
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Topics: Activins; Adenocarcinoma; Animals; Cachexia; Carcinoma, Pancreatic Ductal; Estradiol; Female; Follis | 2022 |
Sex specificity of pancreatic cancer cachexia phenotypes, mechanisms, and treatment in mice and humans: role of Activin.
Topics: Activins; Adenocarcinoma; Animals; Cachexia; Carcinoma, Pancreatic Ductal; Estradiol; Female; Follis | 2022 |
Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.
Topics: Activins; Carcinoma, Pancreatic Ductal; Cell Communication; Epithelial-Mesenchymal Transition; Human | 2022 |
Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.
Topics: Activins; Carcinoma, Pancreatic Ductal; Cell Communication; Epithelial-Mesenchymal Transition; Human | 2022 |
Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.
Topics: Activins; Carcinoma, Pancreatic Ductal; Cell Communication; Epithelial-Mesenchymal Transition; Human | 2022 |
Homophilic ATP1A1 binding induces activin A secretion to promote EMT of tumor cells and myofibroblast activation.
Topics: Activins; Carcinoma, Pancreatic Ductal; Cell Communication; Epithelial-Mesenchymal Transition; Human | 2022 |
KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
Topics: Activins; Animals; Cell Line, Tumor; Cell Plasticity; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; | 2023 |
KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
Topics: Activins; Animals; Cell Line, Tumor; Cell Plasticity; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; | 2023 |
KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
Topics: Activins; Animals; Cell Line, Tumor; Cell Plasticity; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; | 2023 |
KMT2D links TGF-β signaling to noncanonical activin pathway and regulates pancreatic cancer cell plasticity.
Topics: Activins; Animals; Cell Line, Tumor; Cell Plasticity; Humans; Mice; MicroRNAs; Pancreatic Neoplasms; | 2023 |
A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis.
Topics: Activin Receptors, Type I; Activins; Algorithms; Animals; Cell Line, Tumor; Cell Transformation, Neo | 2019 |
Oncogene-Induced Senescence Limits the Progression of Pancreatic Neoplasia through Production of Activin A.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Animals; Carcinoma, Pancreatic Duct | 2020 |
Clinical significance of activin A and myostatin in patients with pancreatic adenocarcinoma and progressive weight loss.
Topics: Activins; Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers, Tumor; Disease Progression; Female; H | 2020 |
Role of stromal activin A in human pancreatic cancer and metastasis in mice.
Topics: Activins; Adenocarcinoma; Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Di | 2021 |
ALK7 Signaling Manifests a Homeostatic Tissue Barrier That Is Abrogated during Tumorigenesis and Metastasis.
Topics: Activin Receptors, Type I; Activins; Animals; Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Line | 2019 |
The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy.
Topics: Activin Receptors, Type II; Activins; Animals; Biomarkers; Body Weights and Measures; Cachexia; Carc | 2019 |
Activin signal promotes cancer progression and is involved in cachexia in a subset of pancreatic cancer.
Topics: Activins; Aged; Aged, 80 and over; Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cachexi | 2015 |
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.
Topics: Activins; Animals; Antimicrobial Cationic Peptides; Carcinogenesis; Carcinoma, Pancreatic Ductal; Ca | 2015 |
The miR-17-92 cluster counteracts quiescence and chemoresistance in a distinct subpopulation of pancreatic cancer stem cells.
Topics: Activins; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Cycle Checkpo | 2015 |
ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation.
Topics: Activins; Animals; Cell Dedifferentiation; Gene Expression Regulation, Neoplastic; Insulin; Insulin- | 2015 |
Tbx3 fosters pancreatic cancer growth by increased angiogenesis and activin/nodal-dependent induction of stemness.
Topics: AC133 Antigen; Activins; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Movement; Cell Proliferatio | 2016 |
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Topics: AC133 Antigen; Activins; Animals; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Biom | 2011 |
SEL1L expression in pancreatic adenocarcinoma parallels SMAD4 expression and delays tumor growth in vitro and in vivo.
Topics: Activins; Adenosarcoma; Animals; DNA-Binding Proteins; Humans; Immunohistochemistry; Intracellular S | 2003 |
Localization of inhibins and activins in normal endocrine cells and endocrine tumors of the gut and pancreas: an immunohistochemical and in situ hybridization study.
Topics: Activins; Endocrine Gland Neoplasms; Endocrine Glands; Enteroendocrine Cells; Follistatin; Gastroint | 2004 |
Modulation of adenosine triphosphate-sensitive potassium channel and voltage-dependent calcium channel by activin A in HIT-T15 cells.
Topics: Action Potentials; Activins; Adenosine Triphosphate; Animals; Calcium Channels; Cricetinae; Electric | 1995 |
Two distinct signaling pathways activated by activin A in glucose-responsive pancreatic beta-cell lines.
Topics: Activin Receptors; Activins; Animals; Calcium; Cell Division; Cell Line; Gene Expression; Glucose; G | 1996 |
DPC4 (SMAD4) mediates transforming growth factor-beta1 (TGF-beta1) induced growth inhibition and transcriptional response in breast tumour cells.
Topics: Activins; Alternative Splicing; Amino Acid Sequence; Base Sequence; Basic Helix-Loop-Helix Leucine Z | 1997 |
Concomitant over-expression of activin/inhibin beta subunits and their receptors in human pancreatic cancer.
Topics: Activin Receptors; Activins; Adolescent; Adult; Aged; Aged, 80 and over; Blotting, Northern; Carcino | 1998 |
A pancreatic intraductal papillary mucinous tumor causing recurrent acute pancreatitis at the onset of menstrual periods.
Topics: Activins; Acute Disease; Adult; Cholangiopancreatography, Endoscopic Retrograde; Cystadenoma, Mucino | 2000 |
Changes in the expression of transcription factors in pancreatic AR42J cells during differentiation into insulin-producing cells.
Topics: Activins; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; DNA, Antisens | 2001 |