activins has been researched along with Cancer of Ovary in 77 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Epithelial ovarian cancer comprises ∼85% of all ovarian cancer cases." | 2.52 | The role of reproductive hormones in epithelial ovarian carcinogenesis. ( Annunziata, CM; Bunch, KP; Gharwan, H, 2015) |
| "Ovarian juvenile granulosa cell tumors are a rare cause of sexual precocity." | 2.39 | Immunoreactive inhibin, müllerian inhibitory substance, and activin as biochemical markers for juvenile granulosa cell tumors. ( Gitelman, SE; Silverman, LA, 1996) |
| "Patients with advanced solid tumors were enrolled in 8 dose cohorts ranging from 0." | 1.51 | First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors. ( Cadoo, KA; Cangemi, NA; Haqq, CM; Hyman, DM; Liu, JF; Makker, V; Navarro, WH; Rasco, DW; Tao, JJ, 2019) |
| "The role of activin A in promoting ovarian cancer cell migration and invasion has been previously reported, however, the underlying molecular mechanisms remain largely unknown." | 1.51 | Activin A promotes ovarian cancer cell migration by suppressing E-cadherin expression. ( Cheng, JC; Klausen, C; Leung, PCK; Yi, Y, 2019) |
| "Herein we show that primary human ovarian cancer cells possess intact autocrine BMP, TGFβ and activin signalling." | 1.37 | Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling. ( Nachtigal, MW; Thériault, BL, 2011) |
| "Testicular tumors were either absent or unilaterally slow growing and less hemorrhagic in the majority of double-knockout males." | 1.34 | SMAD3 regulates gonadal tumorigenesis. ( Graff, JM; Li, Q; Loveland, KL; Matzuk, MM; O'Connor, AE, 2007) |
| "However, its effects on OSE and ovarian cancer cells are unknown." | 1.33 | Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells. ( Ethier, JF; Shaw, TJ; Steller, MD; Vanderhyden, BC, 2005) |
| "In patient PP, a residual tumor was found 6 years after primary surgery; at the time A levels were elevated, while inhibin levels remained low." | 1.32 | Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin. ( Bläuer, M; Puistola, U; Tuohimaa, P; Vihko, KK, 2003) |
| "Previous studies of activin in human ovarian cancer suggest that activin may promote the growth of the tumor." | 1.31 | Tumor stroma as the main source of inhibin production in ovarian epithelial tumors. ( Chang, L; Cho, MM; Hsieh, J; Lu, JJ; Luo, F; Stanczyk, FZ; Wang, CY; Zhang, C; Zheng, W, 2000) |
| "Women with epithelial ovarian cancer had significantly higher serum levels of pro-alphaC immunoreactivity (P = 0." | 1.31 | Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma. ( Bose, C; Dawnay, A; Evans, LW; Groome, NP; Jacobs, IJ; Menon, U; Riley, SC; Thomas, J, 2000) |
| "Activin A was measured in the serum of ovarian cancer patients, and activin A, total inhibin, and FS protein secretion was measured from primary epithelial tumors in vitro." | 1.30 | Presence of activin, inhibin, and follistatin in epithelial ovarian carcinoma. ( Crowley, WF; Lambert-Messerlian, G; Schneyer, AL; Welt, CK; Zheng, W, 1997) |
| "None of the patients with an epithelial ovarian cancer presented an increase of serum inhibin B." | 1.30 | Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors. ( Bidart, JM; Lhomme, C; Luisi, S; Pautier, P; Petraglia, F; Rey, R; Sabourin, JC, 1998) |
| "The previous study of activin in ovarian cancer cell lines suggests that activin may promote growth of ovarian cancer." | 1.30 | Imbalanced expression of inhibin and activin subunits in primary epithelial ovarian cancer. ( Felix, JC; Lambert-Messerlian, G; Lauchlan, SC; Luo, MP; Schneyer, AL; Sung, CJ; Welt, C; Ying, SY; Zhang, Z; Zheng, W, 1998) |
| " We hypothesized that cell surface FS would differentially regulate the bioavailability of endogenous and exogenous activin in these cells." | 1.30 | Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin. ( Delbaere, A; Schneyer, AL; Sidis, Y, 1999) |
| "Although ovarian cancer is the most common gynecological malignancy with a relatively poor 5-yr survival record, the mechanism(s) by which these tumors arise is not well understood." | 1.29 | Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation. ( Crowley, WF; Di Simone, N; Schneyer, AL; Sluss, PM; Wang, QF, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 22 (28.57) | 18.2507 |
| 2000's | 34 (44.16) | 29.6817 |
| 2010's | 18 (23.38) | 24.3611 |
| 2020's | 3 (3.90) | 2.80 |
| Authors | Studies |
|---|---|
| Horst, B | 2 |
| Pradhan, S | 1 |
| Chaudhary, R | 1 |
| Listik, E | 1 |
| Quintero-Macias, L | 1 |
| Choi, AS | 1 |
| Southard, M | 1 |
| Liu, Y | 1 |
| Whitaker, R | 1 |
| Hempel, N | 1 |
| Berchuck, A | 1 |
| Nixon, AB | 1 |
| Lee, NY | 1 |
| Henis, YI | 1 |
| Mythreye, K | 2 |
| Evans, ET | 1 |
| Arend, RC | 1 |
| Pettersen, K | 1 |
| Andersen, S | 1 |
| van der Veen, A | 1 |
| Nonstad, U | 1 |
| Hatakeyama, S | 1 |
| Lambert, C | 1 |
| Lach-Trifilieff, E | 1 |
| Moestue, S | 1 |
| Kim, J | 1 |
| Grønberg, BH | 1 |
| Schilb, A | 1 |
| Jacobi, C | 1 |
| Bjørkøy, G | 1 |
| Reader, KL | 2 |
| Marino, FE | 3 |
| Nicholson, HD | 1 |
| Risbridger, GP | 1 |
| Gold, EJ | 1 |
| Tao, JJ | 1 |
| Cangemi, NA | 1 |
| Makker, V | 1 |
| Cadoo, KA | 1 |
| Liu, JF | 1 |
| Rasco, DW | 1 |
| Navarro, WH | 1 |
| Haqq, CM | 1 |
| Hyman, DM | 1 |
| Yi, Y | 1 |
| Cheng, JC | 1 |
| Klausen, C | 1 |
| Leung, PCK | 1 |
| Tournier, I | 1 |
| Marlin, R | 1 |
| Walton, K | 1 |
| Charbonnier, F | 1 |
| Coutant, S | 1 |
| Théry, JC | 1 |
| Charbonnier, C | 1 |
| Spurrell, C | 1 |
| Vezain, M | 1 |
| Ippolito, L | 1 |
| Bougeard, G | 1 |
| Roman, H | 1 |
| Tinat, J | 1 |
| Sabourin, JC | 2 |
| Stoppa-Lyonnet, D | 1 |
| Caron, O | 1 |
| Bressac-de Paillerets, B | 1 |
| Vaur, D | 1 |
| King, MC | 1 |
| Harrison, C | 3 |
| Frebourg, T | 1 |
| Risbridger, G | 2 |
| Gold, E | 3 |
| Gharwan, H | 1 |
| Bunch, KP | 1 |
| Annunziata, CM | 1 |
| Wijayarathna, R | 1 |
| de Kretser, DM | 1 |
| Dean, M | 1 |
| Davis, DA | 1 |
| Burdette, JE | 2 |
| Bilandzic, M | 1 |
| Chu, S | 2 |
| Farnworth, PG | 1 |
| Nicholls, P | 1 |
| Wang, Y | 1 |
| Escalona, RM | 1 |
| Fuller, PJ | 4 |
| Findlay, JK | 1 |
| Stenvers, KL | 1 |
| Ramachandran, A | 1 |
| Marshall, ES | 1 |
| Love, DR | 1 |
| Baguley, BC | 1 |
| Shelling, AN | 1 |
| Mabuchi, Y | 3 |
| Yamoto, M | 4 |
| Minami, S | 4 |
| Umesaki, N | 4 |
| Rajanahally, S | 1 |
| Agno, JE | 1 |
| Nalam, RL | 1 |
| Weinstein, MB | 1 |
| Loveland, KL | 2 |
| Matzuk, MM | 8 |
| Li, Q | 2 |
| Li, H | 1 |
| Huang, F | 1 |
| Robertson, DM | 3 |
| McNeilly, AS | 1 |
| Drummond, AE | 1 |
| Thériault, BL | 1 |
| Nachtigal, MW | 2 |
| Karve, TM | 1 |
| Preet, A | 1 |
| Sneed, R | 1 |
| Salamanca, C | 1 |
| Li, X | 1 |
| Xu, J | 1 |
| Kumar, D | 1 |
| Rosen, EM | 1 |
| Saha, T | 1 |
| Makanji, Y | 1 |
| Tong, S | 1 |
| Wallace, EM | 2 |
| Burger, HG | 6 |
| Beuschlein, F | 1 |
| Looyenga, BD | 2 |
| Bleasdale, SE | 1 |
| Mutch, C | 1 |
| Bavers, DL | 1 |
| Parlow, AF | 1 |
| Nilson, JH | 1 |
| Hammer, GD | 2 |
| Vihko, KK | 2 |
| Bläuer, M | 2 |
| Puistola, U | 1 |
| Tuohimaa, P | 1 |
| Fu, Y | 1 |
| O'Connor, LM | 1 |
| Shepherd, TG | 1 |
| Liu, J | 1 |
| Kuulasmaa, T | 1 |
| Kosma, VM | 1 |
| Bützow, R | 1 |
| Vänttinen, T | 1 |
| Hydén-Granskog, C | 1 |
| Voutilainen, R | 1 |
| Tanaka, T | 2 |
| Toujima, S | 1 |
| Wu, X | 1 |
| Chen, L | 3 |
| Brown, CA | 1 |
| Yan, C | 1 |
| Cobellis, L | 2 |
| Reis, FM | 2 |
| Luisi, S | 2 |
| Danero, S | 1 |
| Pirtoli, L | 1 |
| Scambia, G | 1 |
| Petraglia, F | 3 |
| Steller, MD | 1 |
| Shaw, TJ | 1 |
| Vanderhyden, BC | 1 |
| Ethier, JF | 1 |
| Chudecka-Głaz, A | 1 |
| Rzepka-Górska, I | 1 |
| Kumanov, P | 1 |
| Nandipati, KC | 1 |
| Tomova, A | 1 |
| Robeva, R | 1 |
| Agarwal, A | 1 |
| Nakano, R | 2 |
| Oliver, RM | 1 |
| Ulyanov, V | 1 |
| Kilen, SM | 1 |
| Mayo, KE | 1 |
| Woodruff, TK | 5 |
| Graff, JM | 1 |
| O'Connor, AE | 1 |
| Do, TV | 1 |
| Kubba, LA | 1 |
| Antenos, M | 1 |
| Rademaker, AW | 1 |
| Sturgis, CD | 1 |
| Kananen, K | 1 |
| Markkula, M | 1 |
| Rainio, E | 1 |
| Su, JG | 1 |
| Hsueh, AJ | 2 |
| Huhtaniemi, IT | 1 |
| Toppari, J | 1 |
| Kaipia, A | 1 |
| Gurusinghe, CJ | 1 |
| Healy, DL | 2 |
| Jobling, T | 2 |
| Mamers, P | 2 |
| Shikone, T | 2 |
| Perlas, E | 1 |
| Finegold, MJ | 2 |
| Lewis, KA | 1 |
| Vale, W | 1 |
| Bradley, A | 2 |
| Di Simone, N | 1 |
| Crowley, WF | 3 |
| Wang, QF | 2 |
| Sluss, PM | 2 |
| Schneyer, AL | 5 |
| Khoury, RH | 1 |
| Smith, PC | 1 |
| McConnell, DS | 1 |
| Padmanahban, V | 1 |
| Midgley, AR | 1 |
| Coerver, KA | 1 |
| Mather, J | 1 |
| Silverman, LA | 1 |
| Gitelman, SE | 1 |
| Arora, DS | 1 |
| Cooke, IE | 1 |
| Ganesan, TS | 1 |
| Ramsdale, J | 1 |
| Manek, S | 1 |
| Charnock, FM | 1 |
| Groome, NP | 2 |
| Wells, M | 1 |
| Welt, CK | 1 |
| Lambert-Messerlian, G | 3 |
| Zheng, W | 4 |
| Sung, CJ | 2 |
| Hanna, I | 1 |
| DePetris, G | 1 |
| Steinhoff, M | 1 |
| Lauchlan, SC | 2 |
| Pautier, P | 1 |
| Rey, R | 1 |
| Lhomme, C | 1 |
| Bidart, JM | 1 |
| Luo, MP | 1 |
| Welt, C | 1 |
| Zhang, Z | 1 |
| Ying, SY | 1 |
| Felix, JC | 1 |
| Fukuda, J | 2 |
| Ito, I | 2 |
| Leung, PC | 4 |
| Yamashita, K | 1 |
| Delbaere, A | 1 |
| Sidis, Y | 1 |
| Rahman, NA | 1 |
| Huhtaniemi, I | 1 |
| Kumar, TR | 2 |
| Palapattu, G | 1 |
| Wang, P | 1 |
| Boime, I | 1 |
| Byrne, MC | 1 |
| Lambert-Messerlian, GM | 1 |
| DePasquale, SE | 1 |
| Maybruck, WM | 1 |
| Steinhoff, MM | 1 |
| Gajewski, WH | 1 |
| Minegishi, T | 2 |
| Shinozaki, H | 1 |
| Auersperg, N | 3 |
| Juengel, JL | 1 |
| Quirke, LD | 1 |
| Tisdall, DJ | 1 |
| Smith, P | 1 |
| Hudson, NL | 1 |
| McNatty, KP | 1 |
| Cipriano, SC | 2 |
| Kameda, T | 1 |
| Hirakawa, T | 1 |
| Abe, K | 1 |
| Tano, M | 1 |
| Ibuki, Y | 1 |
| Lu, JJ | 1 |
| Luo, F | 1 |
| Hsieh, J | 1 |
| Wang, CY | 1 |
| Zhang, C | 1 |
| Chang, L | 1 |
| Cho, MM | 1 |
| Stanczyk, FZ | 1 |
| Menon, U | 1 |
| Riley, SC | 1 |
| Thomas, J | 1 |
| Bose, C | 1 |
| Dawnay, A | 1 |
| Evans, LW | 1 |
| Jacobs, IJ | 1 |
| Choi, KC | 2 |
| Kang, SK | 2 |
| Nathwani, PS | 1 |
| Cheng, KW | 1 |
| Tai, CJ | 1 |
| Burns, KH | 1 |
| Koff, A | 1 |
| Cataldi, P | 1 |
| De Palo, G | 1 |
| Raspagliesi, F | 1 |
| Pilotti, S | 1 |
| Arcuri, F | 1 |
| Fikret, S | 1 |
| Stephenson, T | 1 |
| Pruysers, E | 1 |
| McCloud, P | 1 |
| Tsigos, A | 1 |
| Groome, N | 1 |
| McNeilage, J | 1 |
| Healy, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-Label Multiple Ascending Dose Phase 1/1B Pharmacokinetic and Pharmacodynamic Study of STM 434, an Activin Type 2B Receptor Fc Fusion, Alone and in Combination With Liposomal Doxorubicin in Patients With Ovarian Cancer or Other Advanced Solid Tumor[NCT02262455] | Phase 1 | 32 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Diagnostic Value of Calponin 2 in Identifying Tubal Pregnancies[NCT05591599] | 407 participants (Anticipated) | Observational | 2022-12-05 | Recruiting | |||
| Aromatase Activity and Ovarian Growth Factors in Preovulatory Follicles[NCT00334971] | 116 participants (Anticipated) | Interventional | 2004-09-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
20 reviews available for activins and Cancer of Ovary
| Article | Year |
|---|---|
Evolving roles of activins and inhibins in ovarian cancer pathophysiology.
Topics: Activins; Endocrine System; Female; Humans; Inhibins; Ovarian Neoplasms; Signal Transduction | 2023 |
Activins and activin antagonists in the human ovary and ovarian cancer.
Topics: Activins; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Huma | 2015 |
The role of reproductive hormones in epithelial ovarian carcinogenesis.
Topics: Activins; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma; Cell Differ | 2015 |
Activins in reproductive biology and beyond.
Topics: Activins; Animals; Female; Follistatin; Glycoproteins; Humans; Inhibin-beta Subunits; Inhibins; Male | 2016 |
[Activin and activin receptors in related gynecologic and obstetric diseases].
Topics: Activin Receptors; Activins; Animals; Endometrial Neoplasms; Endometriosis; Female; Humans; Ovarian | 2010 |
Inhibins and activins in blood: predictors of female reproductive health?
Topics: Activins; Animals; Biomarkers; Female; Health; Humans; Infertility, Female; Inhibins; Menopause; Ova | 2012 |
Diagnostic applications for inhibin and activins.
Topics: Activins; Animals; Biomarkers; Biomarkers, Tumor; Female; Humans; Infertility, Female; Inhibins; Mal | 2012 |
Activin and inhibin, estrogens and NFκB, play roles in ovarian tumourigenesis is there crosstalk?
Topics: Activin Receptors; Activins; Animals; Cell Transformation, Neoplastic; Female; Humans; Inhibins; NF- | 2012 |
Inhibins and activins: clinical advances in reproductive medicine.
Topics: Activins; Animals; Biomarkers; Female; Fetus; Follicle Stimulating Hormone; Follicular Fluid; Humans | 2003 |
Inhibin/activin and ovarian cancer.
Topics: Activins; Animals; Female; Gene Expression Regulation; Humans; Inhibins; Mice; Ovarian Neoplasms; Ov | 2004 |
Significance of inhibin in reproductive pathophysiology and current clinical applications.
Topics: Activins; Adult; Age Factors; alpha-Macroglobulins; Chromosomes, Human, Y; Exocrine Glands; Female; | 2005 |
[Ovarian tumors].
Topics: Activins; Animals; Biomarkers, Tumor; Female; Humans; Inhibins; Ovarian Neoplasms; Prognosis; Transf | 2006 |
[Inhibin and activin].
Topics: Activins; Biomarkers, Tumor; Female; Growth Substances; Humans; Inhibins; Male; Ovarian Neoplasms; O | 1994 |
Clinical review 46: Clinical utility of inhibin measurements.
Topics: Activins; Adult; Biological Assay; Biomarkers, Tumor; Female; Follistatin; Glycoproteins; Humans; In | 1993 |
Inhibins and activins: roles in clinical practice.
Topics: Activins; Down Syndrome; Female; Follicle Stimulating Hormone; Forecasting; Growth Substances; Human | 1996 |
Immunoreactive inhibin, müllerian inhibitory substance, and activin as biochemical markers for juvenile granulosa cell tumors.
Topics: Activins; Anti-Mullerian Hormone; Biomarkers, Tumor; Child; Child, Preschool; Female; Glycoproteins; | 1996 |
[Activins and inhibins--from laboratory to clinics].
Topics: Activins; Animals; Female; Fertilization in Vitro; Forecasting; Granulosa Cell Tumor; Humans; Infert | 1997 |
Role of inhibins and activins in ovarian cancer.
Topics: Activins; Cell Transformation, Neoplastic; Female; Granulosa Cell Tumor; Humans; Inhibins; Ovarian F | 2002 |
Molecular pathogenesis of granulosa cell tumours.
Topics: Activin Receptors; Activins; Animals; Female; Gene Expression Regulation, Neoplastic; Granulosa Cell | 2002 |
Inhibins/activins as diagnostic markers for ovarian cancer.
Topics: Activins; Antibodies, Monoclonal; Biomarkers, Tumor; Female; Follicle Stimulating Hormone; Granulosa | 2002 |
57 other studies available for activins and Cancer of Ovary
| Article | Year |
|---|---|
Hypoxia-induced inhibin promotes tumor growth and vascular permeability in ovarian cancers.
Topics: Activin Receptors, Type II; Activins; Capillary Permeability; Female; Humans; Hypoxia; Inhibins; Ova | 2022 |
Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.
Topics: Activins; Animals; Autocrine Communication; Autophagy; Cachexia; Disease Models, Animal; Female; Hum | 2020 |
Role of activin C in normal ovaries and granulosa cell tumours of mice and humans.
Topics: Activins; Animals; Female; Granulosa Cell Tumor; Granulosa Cells; Humans; Inhibins; Mice; Ovarian Fo | 2018 |
First-in-Human Phase I Study of the Activin A Inhibitor, STM 434, in Patients with Granulosa Cell Ovarian Cancer and Other Advanced Solid Tumors.
Topics: Activins; Antineoplastic Agents; Granulosa Cells; Humans; Maximum Tolerated Dose; Neoplasms; Ovarian | 2019 |
Activin A promotes ovarian cancer cell migration by suppressing E-cadherin expression.
Topics: Activin Receptors, Type I; Activins; Antigens, CD; Cadherins; Cell Line, Tumor; Cell Movement; Down- | 2019 |
Germline mutations of inhibins in early-onset ovarian epithelial tumors.
Topics: Activins; Carcinoma, Ovarian Epithelial; Cell Differentiation; Cohort Studies; Epithelial Cells; Exo | 2014 |
The inhibin/activin signalling pathway in human gonadal and adrenal cancers.
Topics: Activin Receptors, Type II; Activins; Adrenal Gland Neoplasms; Cell Line, Tumor; Databases, Genetic; | 2014 |
Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling.
Topics: Activins; Animals; Cell Movement; Cystadenocarcinoma, Serous; Fallopian Tube Neoplasms; Female; Huma | 2017 |
Loss of betaglycan contributes to the malignant properties of human granulosa tumor cells.
Topics: Activins; Cell Adhesion; Cell Line, Tumor; Female; Gene Silencing; Granulosa Cell Tumor; Humans; Inh | 2009 |
Activin is a potent growth suppressor of epithelial ovarian cancer cells.
Topics: Activins; Cell Line, Tumor; Cell Proliferation; Female; Flow Cytometry; Gene Expression; Gene Expres | 2009 |
Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis.
Topics: Activin Receptors; Activins; Adult; Endometriosis; Endometrium; Female; Humans; Immunohistochemistry | 2010 |
Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice.
Topics: Activins; Animals; Carcinoma; Female; Inhibins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mode | 2010 |
Human ovarian cancer cell morphology, motility, and proliferation are differentially influenced by autocrine TGFβ superfamily signalling.
Topics: Activins; Autocrine Communication; Blotting, Western; Bone Morphogenetic Proteins; Cell Line; Cell M | 2011 |
BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells.
Topics: Activins; Blotting, Western; BRCA1 Protein; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Mo | 2012 |
Activin-β(c) reduces reproductive tumour progression and abolishes cancer-associated cachexia in inhibin-deficient mice.
Topics: Activins; Animals; Apoptosis; Cachexia; Cell Line; Cell Proliferation; Dimerization; Disease Progres | 2013 |
Activin induces x-zone apoptosis that inhibits luteinizing hormone-dependent adrenocortical tumor formation in inhibin-deficient mice.
Topics: Activins; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenocortical Carcinoma; Animals; Apoptosis; Bo | 2003 |
Activin B in patients with granulosa cell tumors: serum levels in comparison to inhibin.
Topics: Activins; Adolescent; Biological Assay; Disease Progression; Female; Granulosa Cell Tumor; Humans; I | 2003 |
The p38 MAPK inhibitor, PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
Topics: Activins; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitor | 2003 |
Expression of betaglycan, an inhibin coreceptor, in normal human ovaries and ovarian sex cord-stromal tumors and its regulation in cultured human granulosa-luteal cells.
Topics: Activins; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein | 2003 |
Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells.
Topics: Activins; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; | 2004 |
Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice.
Topics: Activins; Animals; Bone Morphogenetic Protein 15; Cachexia; Cell Differentiation; Cell Proliferation | 2004 |
High concentrations of activin A in the peritoneal fluid of women with epithelial ovarian cancer.
Topics: Activins; Adult; Aged; Aged, 80 and over; Ascitic Fluid; Cystadenocarcinoma; Cystadenoma, Serous; En | 2004 |
Inhibin resistance is associated with aggressive tumorigenicity of ovarian cancer cells.
Topics: Activins; Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Collagen; DNA Primers; D | 2005 |
Activin A levels in serum and cyst fluid in epithelial tumors of the ovary.
Topics: Activins; Adult; Biomarkers, Tumor; Female; Humans; Inhibin-beta Subunits; Middle Aged; Neoplasms, G | 2005 |
Immunohistochemical localization of inhibin and activin subunits, activin receptors, and Smads in ovarian clear cell adenocarcinoma.
Topics: Activin Receptors; Activins; Adenocarcinoma, Clear Cell; Adult; Aged; Female; Humans; Immunohistoche | 2006 |
The autocrine effect of activin A on human ovarian clear cell adenocarcinoma cells.
Topics: Activin Receptors; Activins; Adenocarcinoma, Clear Cell; Autocrine Communication; Cell Proliferation | 2006 |
Ovarian epithelial inclusion cysts in chronically superovulated CD1 and Smad2 dominant-negative mice.
Topics: Activins; Animals; Cell Division; Chronic Disease; Epithelial Cells; Female; Gonadotropins, Equine; | 2007 |
SMAD3 regulates gonadal tumorigenesis.
Topics: Activins; Animals; Cell Transformation, Neoplastic; Female; Follicle Stimulating Hormone; Inhibins; | 2007 |
Genetic removal of Smad3 from inhibin-null mice attenuates tumor progression by uncoupling extracellular mitogenic signals from the cell cycle machinery.
Topics: Activins; Adrenal Cortex; Adrenal Cortex Neoplasms; Animals; Cell Cycle; Cell Transformation, Neopla | 2007 |
The role of activin A and Akt/GSK signaling in ovarian tumor biology.
Topics: Activins; Adult; Aged; Aged, 80 and over; Carcinoma; Cell Proliferation; Cystadenocarcinoma, Serous; | 2008 |
Gonadal tumorigenesis in transgenic mice bearing the mouse inhibin alpha-subunit promoter/simian virus T-antigen fusion gene: characterization of ovarian tumors and establishment of gonadotropin-responsive granulosa cell lines.
Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Base Sequence; Cell Division; Cell Line; Cyc | 1995 |
Inhibin and activin are demonstrable by immunohistochemistry in ovarian tumor tissue.
Topics: Activins; Adenocarcinoma; Aged; Female; Granulosa Cell Tumor; Growth Substances; Humans; Immune Sera | 1995 |
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor.
Topics: Activins; Adrenal Glands; Animals; Cell Division; Colforsin; Female; Follistatin; Glycoproteins; Gon | 1994 |
Characterization of inhibin/activin subunit, follistatin, and activin type II receptors in human ovarian cancer cell lines: a potential role in autocrine growth regulation.
Topics: Activin Receptors; Activins; Base Sequence; Cell Division; Female; Follistatin; Glycoproteins; Homeo | 1996 |
A two-site monoclonal antibody immunoradiometric assay for human follistatin: secretion by a human ovarian teratocarcinoma-derived cell line (PA-1).
Topics: Activins; Animals; Antibodies, Monoclonal; Antibody Specificity; Biological Assay; Blotting, Western | 1996 |
Activin signaling through activin receptor type II causes the cachexia-like symptoms in inhibin-deficient mice.
Topics: Activin Receptors; Activins; Animals; Cachexia; Female; Inhibins; Liver; Male; Mice; Mice, Mutant St | 1996 |
Immunohistochemical expression of inhibin/activin subunits in epithelial and granulosa cell tumours of the ovary.
Topics: Activins; Adult; Aged; Biomarkers, Tumor; Female; Granulosa Cell Tumor; Growth Substances; Humans; I | 1997 |
Presence of activin, inhibin, and follistatin in epithelial ovarian carcinoma.
Topics: Activins; Adenocarcinoma, Clear Cell; Adenocarcinoma, Mucinous; Adult; Aged; Carcinoma; Cell Divisio | 1997 |
Alpha and beta subunits of inhibin/activin as sex cord-stromal differentiation markers.
Topics: Activins; Cell Differentiation; Female; Humans; Immunohistochemistry; Inhibins; Leydig Cells; Male; | 1997 |
Inhibin B is the major form of inhibin/activin family secreted by granulosa cell tumors.
Topics: Activins; Adult; Anti-Mullerian Hormone; Female; Glycoproteins; Granulosa Cell Tumor; Growth Inhibit | 1998 |
Imbalanced expression of inhibin and activin subunits in primary epithelial ovarian cancer.
Topics: Activin Receptors; Activins; Adult; Biomarkers, Tumor; Carcinoma; Epithelium; Female; Gene Expressio | 1998 |
Cell survival effect of activin against heat shock stress on OVCAR3.
Topics: Activin Receptors; Activins; Adenocarcinoma; Blotting, Western; Cell Division; Cell Survival; Female | 1998 |
Immunohistochemical localization of inhibin and activin subunits in human epithelial ovarian tumors.
Topics: Activins; Cystadenocarcinoma, Mucinous; Cystadenoma, Mucinous; Cystadenoma, Serous; Female; Humans; | 1999 |
Differential response to exogenous and endogenous activin in a human ovarian teratocarcinoma-derived cell line (PA-1): regulation by cell surface follistatin.
Topics: Activins; Cell Division; Female; Follistatin; Glycoproteins; Humans; Inhibins; Ovarian Neoplasms; Te | 1999 |
Hormonal regulation of proliferation of granulosa and Leydig cell lines derived from gonadal tumors of transgenic mice expressing the inhibin-alpha subunit promoter/simian virus 40 T-antigen fusion gene.
Topics: Activins; Animals; Antigens, Polyomavirus Transforming; Artificial Gene Fusion; DNA, Neoplasm; Femal | 1999 |
Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesis.
Topics: Activins; Animals; Crosses, Genetic; Female; Follicle Stimulating Hormone; Gene Expression Regulatio | 1999 |
Secretion of activin A in recurrent epithelial ovarian carcinoma.
Topics: Activins; Female; Growth Substances; Humans; Inhibins; Middle Aged; Neoplasm Recurrence, Local; Neop | 1999 |
Presence of activin signal transduction in normal ovarian cells and epithelial ovarian carcinoma.
Topics: Activin Receptors; Activins; Adenocarcinoma; DNA-Binding Proteins; Epithelial Cells; Female; Granulo | 2000 |
Gene expression in abnormal ovarian structures of ewes homozygous for the inverdale prolificacy gene.
Topics: Activins; Animals; Female; Follistatin; Gene Expression; Glycoproteins; Granulosa Cells; Heterozygot | 2000 |
Follistatin is a modulator of gonadal tumor progression and the activin-induced wasting syndrome in inhibin-deficient mice.
Topics: Activins; Animals; Disease Progression; Female; Follistatin; Glycoproteins; Inhibins; Liver Diseases | 2000 |
Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms.
Topics: Activin Receptors; Activins; Adult; Aged; Blotting, Northern; Carcinoma; Female; Humans; Inhibins; M | 2000 |
Tumor stroma as the main source of inhibin production in ovarian epithelial tumors.
Topics: Activins; Female; Follicle Stimulating Hormone; Humans; Immunohistochemistry; Inhibins; Luteinizing | 2000 |
Serum inhibin, activin and follistatin in postmenopausal women with epithelial ovarian carcinoma.
Topics: Activins; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma in Situ; Case-Control Studies; Femal | 2000 |
Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE).
Topics: Activin Receptors; Activins; Autocrine Communication; Cell Division; Epithelial Cells; Female; Growt | 2001 |
The regulation of apoptosis by activin and transforming growth factor-beta in early neoplastic and tumorigenic ovarian surface epithelium.
Topics: Activin Receptors; Activins; Apoptosis; bcl-2-Associated X Protein; Cell Line; Female; Humans; Inhib | 2001 |
Inhibin and p27 interact to regulate gonadal tumorigenesis.
Topics: Activins; Animals; Blotting, Northern; Body Weight; Cell Cycle Proteins; Cell Division; Cyclin D2; C | 2001 |
Gonadal malignant germ cell tumors express immunoreactive inhibin/activin subunits.
Topics: Activins; Adolescent; Adult; Aged; Biomarkers, Tumor; Carcinoma, Embryonal; Child; Choriocarcinoma; | 2001 |