activins has been researched along with Cancer of Lung in 15 studies
Activins: Activins are produced in the pituitary, gonads, and other tissues. By acting locally, they stimulate pituitary FSH secretion and have diverse effects on cell differentiation and embryonic development. Activins are glycoproteins that are hetero- or homodimers of INHIBIN-BETA SUBUNITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous preclinical studies have shown that activin A is overexpressed in malignant pleural mesothelioma (MPM), associates with cancer cachexia, and is observed in in vitro resistance to platinum-based chemotherapy." | 7.96 | Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy. ( Ilonen, I; Järvinen, T; Koli, K; Lauri, H; Lemström, K; Myllärniemi, M; Ollila, H; Paajanen, J; Räsänen, J; Ritvos, O; Rouvinen, E; Sutinen, E, 2020) |
| "Resistance to platinum chemotherapy is a long-standing problem in the management of lung adenocarcinoma." | 7.88 | Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. ( Alamgeer, M; Barrow, R; Boolell, V; Burgess, A; Cain, JE; Chin, V; Croucher, DR; de Kretser, DM; Ganju, V; Gonzalez-Rajal, A; Han, JZR; Harrison, CA; Hastings, JF; Hedger, MP; Jayasekara, WSN; Kita, B; Kostyrko, K; Kumar, B; Lee, HC; Lorensuhewa, N; Marini, KD; Marquez, C; Martelotto, LG; McCloy, RA; Oakes, SR; Robinson, BW; Rossello, FJ; Sweet-Cordero, EA; Szczepny, A; Vaghjiani, V; Watkins, DN; Waugh, T; Wu, J, 2018) |
| "Previous preclinical studies have shown that activin A is overexpressed in malignant pleural mesothelioma (MPM), associates with cancer cachexia, and is observed in in vitro resistance to platinum-based chemotherapy." | 3.96 | Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy. ( Ilonen, I; Järvinen, T; Koli, K; Lauri, H; Lemström, K; Myllärniemi, M; Ollila, H; Paajanen, J; Räsänen, J; Ritvos, O; Rouvinen, E; Sutinen, E, 2020) |
| "Resistance to platinum chemotherapy is a long-standing problem in the management of lung adenocarcinoma." | 3.88 | Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy. ( Alamgeer, M; Barrow, R; Boolell, V; Burgess, A; Cain, JE; Chin, V; Croucher, DR; de Kretser, DM; Ganju, V; Gonzalez-Rajal, A; Han, JZR; Harrison, CA; Hastings, JF; Hedger, MP; Jayasekara, WSN; Kita, B; Kostyrko, K; Kumar, B; Lee, HC; Lorensuhewa, N; Marini, KD; Marquez, C; Martelotto, LG; McCloy, RA; Oakes, SR; Robinson, BW; Rossello, FJ; Sweet-Cordero, EA; Szczepny, A; Vaghjiani, V; Watkins, DN; Waugh, T; Wu, J, 2018) |
| "In older patients with cancer, high serum concentrations of activin A and myostatin were predictive of poor OS." | 1.51 | Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors. ( Baek, JY; Hong, DS; Hong, S; Hong, YS; Hwang, IG; Jang, JS; Kim, HJ; Kim, JH; Kim, JW; Kim, SH; Kim, TY; Lee, JH; Shin, SH; Sun, S; Woo, IS, 2019) |
| "Malignant mesothelioma is an asbestos exposure related tumor affecting mainly pleura and it usually has a dismal prognosis." | 1.42 | Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth. ( Koli, K; Myllärniemi, M; Pasternack, A; Ritvos, O; Rönty, M; Sutinen, E; Tamminen, JA; Yin, M, 2015) |
| "Cachexia is a multifactorial syndrome, characterized by the loss of skeletal muscle mass and not fully reversible by nutritional support." | 1.42 | Role of Activin A and myostatin in human cancer cachexia. ( de Barsy, M; Frateur, L; Gruson, D; Lause, P; Loumaye, A; Nachit, M; Thissen, JP; Trefois, P; van Maanen, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 5 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Morianos, I | 1 |
| Tsitsopoulou, A | 1 |
| Potaris, K | 1 |
| Valakos, D | 1 |
| Fari, O | 1 |
| Vatsellas, G | 1 |
| Bostantzoglou, C | 1 |
| Photiades, A | 1 |
| Gaga, M | 1 |
| Xanthou, G | 1 |
| Semitekolou, M | 1 |
| Barany, N | 1 |
| Rozsas, A | 3 |
| Megyesfalvi, Z | 1 |
| Grusch, M | 3 |
| Hegedus, B | 3 |
| Lang, C | 1 |
| Boettiger, K | 1 |
| Schwendenwein, A | 1 |
| Tisza, A | 1 |
| Renyi-Vamos, F | 2 |
| Schelch, K | 1 |
| Hoetzenecker, K | 1 |
| Hoda, MA | 3 |
| Paku, S | 1 |
| Laszlo, V | 3 |
| Dome, B | 3 |
| Lim, J | 1 |
| Murphy, A | 1 |
| Wong, S | 1 |
| Nagrial, A | 1 |
| Karikios, D | 1 |
| Daneshvar, D | 1 |
| McCloy, R | 1 |
| Steinmann, AM | 1 |
| O'Toole, S | 1 |
| Chin, V | 2 |
| Taniguchi, S | 1 |
| Matsui, T | 1 |
| Kimura, K | 1 |
| Funaki, S | 1 |
| Miyamoto, Y | 1 |
| Uchida, Y | 1 |
| Sudo, T | 1 |
| Kikuta, J | 1 |
| Hara, T | 1 |
| Motooka, D | 1 |
| Liu, YC | 1 |
| Okuzaki, D | 1 |
| Morii, E | 1 |
| Emoto, N | 1 |
| Shintani, Y | 1 |
| Ishii, M | 1 |
| Paajanen, J | 1 |
| Ilonen, I | 1 |
| Lauri, H | 1 |
| Järvinen, T | 1 |
| Sutinen, E | 2 |
| Ollila, H | 1 |
| Rouvinen, E | 1 |
| Lemström, K | 1 |
| Räsänen, J | 1 |
| Ritvos, O | 2 |
| Koli, K | 2 |
| Myllärniemi, M | 2 |
| Marini, KD | 1 |
| Croucher, DR | 1 |
| McCloy, RA | 1 |
| Vaghjiani, V | 1 |
| Gonzalez-Rajal, A | 1 |
| Hastings, JF | 1 |
| Szczepny, A | 1 |
| Kostyrko, K | 1 |
| Marquez, C | 1 |
| Jayasekara, WSN | 1 |
| Alamgeer, M | 1 |
| Boolell, V | 1 |
| Han, JZR | 1 |
| Waugh, T | 1 |
| Lee, HC | 1 |
| Oakes, SR | 1 |
| Kumar, B | 1 |
| Harrison, CA | 1 |
| Hedger, MP | 1 |
| Lorensuhewa, N | 1 |
| Kita, B | 1 |
| Barrow, R | 1 |
| Robinson, BW | 1 |
| de Kretser, DM | 1 |
| Wu, J | 1 |
| Ganju, V | 1 |
| Sweet-Cordero, EA | 1 |
| Burgess, A | 1 |
| Martelotto, LG | 1 |
| Rossello, FJ | 1 |
| Cain, JE | 1 |
| Watkins, DN | 1 |
| Kim, SH | 1 |
| Kim, JW | 1 |
| Hwang, IG | 1 |
| Jang, JS | 1 |
| Hong, S | 1 |
| Kim, TY | 1 |
| Baek, JY | 1 |
| Shin, SH | 1 |
| Sun, S | 1 |
| Hong, DS | 1 |
| Kim, HJ | 1 |
| Hong, YS | 1 |
| Woo, IS | 1 |
| Lee, JH | 1 |
| Kim, JH | 1 |
| Wamsley, JJ | 1 |
| Kumar, M | 1 |
| Allison, DF | 1 |
| Clift, SH | 1 |
| Holzknecht, CM | 1 |
| Szymura, SJ | 1 |
| Hoang, SA | 1 |
| Xu, X | 1 |
| Moskaluk, CA | 1 |
| Jones, DR | 1 |
| Bekiranov, S | 1 |
| Mayo, MW | 1 |
| Tamminen, JA | 1 |
| Yin, M | 1 |
| Rönty, M | 1 |
| Pasternack, A | 1 |
| Loumaye, A | 1 |
| de Barsy, M | 1 |
| Nachit, M | 1 |
| Lause, P | 1 |
| Frateur, L | 1 |
| van Maanen, A | 1 |
| Trefois, P | 1 |
| Gruson, D | 1 |
| Thissen, JP | 1 |
| Shan, Y | 1 |
| Li, S | 1 |
| Lang, E | 1 |
| Klikovits, T | 2 |
| Lohinai, Z | 1 |
| Torok, S | 1 |
| Berta, J | 1 |
| Bendek, M | 2 |
| Berger, W | 2 |
| Klepetko, W | 2 |
| Dong, Y | 1 |
| Ghanim, B | 1 |
| Stockhammer, P | 1 |
| Ozsvar, J | 1 |
| Jakopovic, M | 1 |
| Samarzija, M | 1 |
| Brcic, L | 1 |
| Szirtes, I | 1 |
| Reid, G | 1 |
| Kirschner, MB | 1 |
| Kao, SC | 1 |
| Opitz, I | 1 |
| Weder, W | 1 |
| Frauenfelder, T | 1 |
| Nguyen-Kim, TD | 1 |
| Aigner, C | 1 |
| van Zandwijk, N | 1 |
| Wang, B | 1 |
| Feng, Y | 1 |
| Song, X | 1 |
| Liu, Q | 1 |
| Ning, Y | 1 |
| Ou, X | 1 |
| Yang, J | 1 |
| Zhang, X | 1 |
| Wen, F | 1 |
| Afrakhte, M | 1 |
| Morén, A | 1 |
| Jossan, S | 1 |
| Itoh, S | 1 |
| Sampath, K | 1 |
| Westermark, B | 1 |
| Heldin, CH | 1 |
| Heldin, NE | 1 |
| ten Dijke, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Activin A (ActA) in the Human Cancer Cachexia[NCT01604642] | 150 participants (Actual) | Interventional | 2012-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 other studies available for activins and Cancer of Lung
| Article | Year |
|---|---|
Activin-A impedes the establishment of CD4
Topics: Activins; Adoptive Transfer; Animals; Biomarkers; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphoc | 2021 |
Clinical relevance of circulating activin A and follistatin in small cell lung cancer.
Topics: Activins; Follistatin; Humans; Lung Neoplasms; Small Cell Lung Carcinoma | 2021 |
Activin-A, Growth Differentiation Factor-11 and Transforming Growth Factor-β as predictive biomarkers for platinum chemotherapy in advanced non-small cell lung cancer.
Topics: Activins; Adult; Biomarkers; Bone Morphogenetic Proteins; Carcinoma, Non-Small-Cell Lung; Growth Dif | 2022 |
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma.
Topics: Activins; Animals; Carcinoma; Follistatin; Humans; Lung; Lung Neoplasms; Macrophages, Alveolar; Mice | 2023 |
Elevated Circulating Activin A Levels in Patients With Malignant Pleural Mesothelioma Are Related to Cancer Cachexia and Reduced Response to Platinum-based Chemotherapy.
Topics: Activins; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biomarkers | 2020 |
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy.
Topics: A549 Cells; Activins; Adenocarcinoma of Lung; Animals; Carboplatin; Cell Line, Tumor; Cell Survival; | 2018 |
Serum biomarkers for predicting overall survival and early mortality in older patients with metastatic solid tumors.
Topics: Activins; Aged; Aged, 80 and over; Antineoplastic Agents; Biliary Tract Neoplasms; Biomarkers; C-Rea | 2019 |
Activin upregulation by NF-κB is required to maintain mesenchymal features of cancer stem-like cells in non-small cell lung cancer.
Topics: Activins; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Human | 2015 |
Overexpression of activin-A and -B in malignant mesothelioma - attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth.
Topics: Activin Receptors, Type I; Activin Receptors, Type II; Activins; Aged; Cell Movement; Enzyme Activat | 2015 |
Role of Activin A and myostatin in human cancer cachexia.
Topics: Activins; Adult; Aged; Aged, 80 and over; Body Composition; Cachexia; Colorectal Neoplasms; Cross-Se | 2015 |
Expression of Cripto-1 gene protein and Activin-A in human lung adenocarcinoma tissue.
Topics: Activins; Adenocarcinoma; Adenocarcinoma of Lung; Biomarkers, Tumor; Female; GPI-Linked Proteins; Hu | 2015 |
High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.
Topics: Activins; Adenocarcinoma; Adenocarcinoma of Lung; Biomarkers, Tumor; Case-Control Studies; Cell Prol | 2016 |
Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.
Topics: Activins; Aged; Biomarkers, Tumor; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Humans; Lu | 2016 |
Involvement of ERK, Bcl-2 family and caspase 3 in recombinant human activin A-induced apoptosis in A549.
Topics: Activins; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Caspase 3; Cell Line, Tumor; | 2009 |
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members.
Topics: Activins; Animals; Bone Morphogenetic Proteins; Cell Line; DNA-Binding Proteins; Drug Synergism; Epi | 1998 |