actinonin and Respiratory-Tract-Infections

Low-molecular-weight beta-sulfonyl- and beta-sulfinylhydroxamic acid derivatives have been synthesized and found to be potent inhibitors of Escherichia coli peptide deformylase (PDF). Most of the compounds synthesized and tested displayed antibacterial activities that cover several pathogens found in respiratory tract infections, including Chlamydia pneumoniae, Mycoplasma pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. The potential of these compounds as antibacterial agents is discussed with respect to selectivity, intracellular concentrations in bacteria, and potential for resistance development.

Topics: Amidohydrolases; Aminopeptidases; Anti-Bacterial Agents; Chlamydophila pneumoniae; Crystallography, X-Ray; Drug Resistance, Microbial; Enzyme Inhibitors; Escherichia coli; Haemophilus influenzae; Hydroxamic Acids; Models, Molecular; Moraxella catarrhalis; Mycoplasma pneumoniae; Protease Inhibitors; Respiratory Tract Infections; Stereoisomerism; Structure-Activity Relationship