actinonin and Inflammation

actinonin has been researched along with Inflammation* in 1 studies

Other Studies

1 other study(ies) available for actinonin and Inflammation

Article	Year
Formyl peptide receptor-mediated proinflammatory consequences of peptide deformylase inhibition in Staphylococcus aureus. Microbes and infection, 2010, Volume: 12, Issue:5 The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the deformylation-blocking antibiotic actinonin. We show that human polymorphonuclear leukocytes respond via the formyl peptide receptor (FPR) with increased calcium ion fluxes, chemotactic migration, IL-8 release, and CD11b upregulation to the human pathogen Staphylococcus aureus upon actinonin treatment. These data underscore the crucial role of bacterial FPs in innate immunity and indicate that deformylase inhibition may have considerable proinflammatory consequences. Topics: Amidohydrolases; Bacterial Proteins; Calcium; CD11b Antigen; Chemotaxis; Enzyme Inhibitors; Humans; Hydroxamic Acids; Inflammation; Interleukin-8; Neutrophils; Receptors, Formyl Peptide; Staphylococcus aureus	2010

Article

Year

Formyl peptide receptor-mediated proinflammatory consequences of peptide deformylase inhibition in Staphylococcus aureus.

Microbes and infection, 2010, Volume: 12, Issue:5

The biosynthesis of proteins with N-terminal formylated methionine residues and subsequent protein deformylation are unique and invariant bacterial processes. They are exploited by the capacity of the human innate immune system to sense formylated peptides (FPs) and targeted by the deformylation-blocking antibiotic actinonin. We show that human polymorphonuclear leukocytes respond via the formyl peptide receptor (FPR) with increased calcium ion fluxes, chemotactic migration, IL-8 release, and CD11b upregulation to the human pathogen Staphylococcus aureus upon actinonin treatment. These data underscore the crucial role of bacterial FPs in innate immunity and indicate that deformylase inhibition may have considerable proinflammatory consequences.

Topics: Amidohydrolases; Bacterial Proteins; Calcium; CD11b Antigen; Chemotaxis; Enzyme Inhibitors; Humans; Hydroxamic Acids; Inflammation; Interleukin-8; Neutrophils; Receptors, Formyl Peptide; Staphylococcus aureus

2010