acth-(4-7)--pro-gly-pro- has been researched along with Stomach-Ulcer* in 2 studies
2 other study(ies) available for acth-(4-7)--pro-gly-pro- and Stomach-Ulcer
| Article | Year |
|---|---|
Possible mechanism underlying the effect of Semax on the formation of indomethacin-induced ulcers in rats.
Intraperitoneal injection of Semax (synthetic analogue of ACTH4-7, MEHFPGP) in a dose of 50 mg/kg produced a protective effect on rats with experimental indomethacin-induced ulcers. Experiments on narcotized rats showed that Semax in the studied dose had no effect on basal blood flow in the stomach, but prevented reduction of blood flow induced by indomethacin. The antiulcer effect of Semax is probably related to improvement of blood flow in the gastric wall disturbed by indomethacin. Topics: Adrenocorticotropic Hormone; Animals; Anti-Ulcer Agents; Indomethacin; Male; Peptide Fragments; Rats; Regional Blood Flow; Stomach; Stomach Ulcer | 2002 |
Effect of Semax on homeostasis of gastric mucosa in albino rats.
The ACTH(4-7)analogue Semax administered intraperitoneally in a dose of 50 microg/kg 1 h before exposure to ulcerogenic factors (ethanol, water immersion immobilization stress) protected gastric mucosa from damage. Postoperative treatment with Semax for 5 days after application of glacial acetic acid on the mucosa prevented acetic acid-induced ulcers and promoted their healing. The antiulcer effects of Semax in the studied dose were comparable with those of tripeptide Pro-Gly-Pro in a dose of 1 mg/kg. Topics: Adrenocorticotropic Hormone; Animals; Gastric Mucosa; Homeostasis; Neuroprotective Agents; Peptide Fragments; Rats; Stomach Ulcer | 2000 |