acteoside has been researched along with Sepsis* in 1 studies
1 other study(ies) available for acteoside and Sepsis
Article | Year |
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Acteoside improves survival in cecal ligation and puncture-induced septic mice via blocking of high mobility group box 1 release.
Acteoside, an active phenylethanoid glycoside, has been used traditionally as an anti-inflammatory agent. The molecular mechanism by which acteoside reduces inflammation was investigated in lipopolysaccharide (LPS)-induced Raw264.7 cells and in a mouse model of cecal ligation and puncture (CLP)-induced sepsis. In vitro, acteoside inhibits high mobility group box 1 (HMGB1) release and iNOS/NO production and induces heme oxygenase-1 (HO-1) expression in a concentration-dependent manner, while HO-1 siRNA antagonizes the inhibition of HMGB1 and NO. The effect of acteoside is inhibited by the p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 and Nfr2 siRNA, indicating that acteoside induces HO-1 via p38 MAPK and NF-E2-related factor 2 (Nrf2). In vivo, acteoside increases survival and decreases serum and lung HMGB1 levels in CLP-induced sepsis. Overall, these results that acteoside reduces HMGB1 release and may be beneficial for the treatment of sepsis. Topics: Animals; Cecum; Glucosides; Heme Oxygenase-1; HMGB1 Protein; Ligation; Male; Mice; Mice, Inbred BALB C; Phenols; Sepsis | 2013 |