actein and Triple-Negative-Breast-Neoplasms

actein has been researched along with Triple-Negative-Breast-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for actein and Triple-Negative-Breast-Neoplasms

Article	Year
Development of actein derivatives as potent anti-triple negative breast cancer agents. Bioorganic & medicinal chemistry letters, 2023, 06-01, Volume: 89 Actein is a natural triterpenoid glycoside, isolated from the rhizomes of Cimicifuga foetida, which have been demonstrated to be potential in the treatment of breast cancer previously. Herein, we described the design and synthesis of a series of actein derivatives as anti-triple negative breast cancer (TNBC) inhibitors. Of which, the most promising derivative 27 exhibited significant inhibitory activity against human TNBC cell lines HCC1806 and MDA-MB-231, with IC Topics: Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; Saponins; Triple Negative Breast Neoplasms; Triterpenes	2023

Article

Year

Development of actein derivatives as potent anti-triple negative breast cancer agents.

Bioorganic & medicinal chemistry letters, 2023, 06-01, Volume: 89

Actein is a natural triterpenoid glycoside, isolated from the rhizomes of Cimicifuga foetida, which have been demonstrated to be potential in the treatment of breast cancer previously. Herein, we described the design and synthesis of a series of actein derivatives as anti-triple negative breast cancer (TNBC) inhibitors. Of which, the most promising derivative 27 exhibited significant inhibitory activity against human TNBC cell lines HCC1806 and MDA-MB-231, with IC

Topics: Apoptosis; Cell Line; Cell Line, Tumor; Cell Proliferation; Humans; Saponins; Triple Negative Breast Neoplasms; Triterpenes

2023