acriflavine and Arthritis--Rheumatoid

acriflavine has been researched along with Arthritis--Rheumatoid* in 1 studies

Other Studies

1 other study(ies) available for acriflavine and Arthritis--Rheumatoid

Article	Year
HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis. Nature communications, 2019, 10-08, Volume: 10, Issue:1 Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone erosion. Leflunomide is originally developed to suppress inflammation via its metabolite A77 1726 to attenuate bone erosion. However, distinctive responsiveness to Leflunomide is observed among RA individuals. Here we show that Leflunomide exerts immunosuppression but limited efficacy in RA individuals distinguished by higher serum C-reactive protein (CRP Topics: Acriflavine; Adult; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Aryl Hydrocarbon Receptor Nuclear Translocator; Bone Resorption; C-Reactive Protein; Cells, Cultured; Collagen; Female; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunosuppressive Agents; Leflunomide; Liver; Male; Mice; Mice, Knockout; Middle Aged; Primary Cell Culture; Rats; Receptors, Aryl Hydrocarbon; RNA, Small Interfering; Signal Transduction; Treatment Outcome	2019

Article

Year

HIF1α inhibition facilitates Leflunomide-AHR-CRP signaling to attenuate bone erosion in CRP-aberrant rheumatoid arthritis.

Nature communications, 2019, 10-08, Volume: 10, Issue:1

Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by progressive bone erosion. Leflunomide is originally developed to suppress inflammation via its metabolite A77 1726 to attenuate bone erosion. However, distinctive responsiveness to Leflunomide is observed among RA individuals. Here we show that Leflunomide exerts immunosuppression but limited efficacy in RA individuals distinguished by higher serum C-reactive protein (CRP

Topics: Acriflavine; Adult; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Aryl Hydrocarbon Receptor Nuclear Translocator; Bone Resorption; C-Reactive Protein; Cells, Cultured; Collagen; Female; Hepatocytes; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunosuppressive Agents; Leflunomide; Liver; Male; Mice; Mice, Knockout; Middle Aged; Primary Cell Culture; Rats; Receptors, Aryl Hydrocarbon; RNA, Small Interfering; Signal Transduction; Treatment Outcome

2019