acridone has been researched along with Leukemia in 3 studies
acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Comparing 8a-treated CCRF-CEM leukemia cells with vehicle control (DMSO), 23 distinct metabolites involved in five metabolic pathways were identified." | 5.39 | Acridone derivative 8a induces oxidative stress-mediated apoptosis in CCRF-CEM leukemia cells: application of metabolomics in mechanistic studies of antitumor agents. ( Cao, D; Chen, Z; Gao, C; Gao, D; Jiang, Y; Li, S; Liu, F; Liu, H; Wang, Y, 2013) |
| " The biologic activity of the acridone compounds against leukemia CCRF-CEM cells demonstrated that some of the compounds displayed good antiproliferative activity, among which compound 6a containing dimethylamine substituents at the terminal C2 and C7 positions exhibited the highest cytotoxicity with IC50 at 0." | 3.81 | Synthesis and antiproliferative activity of 2,7-diamino l0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomeric G-quadruplex DNA ligands. ( Gao, C; He, S; Jiang, Y; Li, S; Liu, F; Zhang, W, 2015) |
| "Comparing 8a-treated CCRF-CEM leukemia cells with vehicle control (DMSO), 23 distinct metabolites involved in five metabolic pathways were identified." | 1.39 | Acridone derivative 8a induces oxidative stress-mediated apoptosis in CCRF-CEM leukemia cells: application of metabolomics in mechanistic studies of antitumor agents. ( Cao, D; Chen, Z; Gao, C; Gao, D; Jiang, Y; Li, S; Liu, F; Liu, H; Wang, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Murata, T | 1 |
| Kohno, S | 1 |
| Ogawa, K | 1 |
| Ito, C | 1 |
| Itoigawa, M | 1 |
| Ito, M | 1 |
| Hikita, K | 1 |
| Kaneda, N | 1 |
| Wang, Y | 1 |
| Gao, D | 1 |
| Chen, Z | 1 |
| Li, S | 2 |
| Gao, C | 2 |
| Cao, D | 1 |
| Liu, F | 2 |
| Liu, H | 1 |
| Jiang, Y | 2 |
| Zhang, W | 1 |
| He, S | 1 |
3 other studies available for acridone and Leukemia
| Article | Year |
|---|---|
Cytotoxic activity of dimeric acridone alkaloids derived from Citrus plants towards human leukaemia HL-60 cells.
Topics: Acridones; Alkaloids; Antineoplastic Agents, Phytogenic; Cell Survival; Citrus paradisi; Cytotoxins; | 2020 |
Acridone derivative 8a induces oxidative stress-mediated apoptosis in CCRF-CEM leukemia cells: application of metabolomics in mechanistic studies of antitumor agents.
Topics: Acridines; Acridones; Antineoplastic Agents; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Prolifera | 2013 |
Synthesis and antiproliferative activity of 2,7-diamino l0-(3,5-dimethoxy)benzyl-9(10H)-acridone derivatives as potent telomeric G-quadruplex DNA ligands.
Topics: Acridines; Acridones; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Diamin | 2015 |