acridines has been researched along with Neoplasms in 140 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 75 (53.57) | 18.7374 |
1990's | 11 (7.86) | 18.2507 |
2000's | 23 (16.43) | 29.6817 |
2010's | 22 (15.71) | 24.3611 |
2020's | 9 (6.43) | 2.80 |
Authors | Studies |
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Sachdeva, H; Saquib, M; Tanwar, K | 1 |
Kurjata, J; Piorecka, K; Stanczyk, WA | 1 |
Chen, R; Huo, L; Jaiswal, Y; Jia, Z; Liang, Y; Liu, X; Lu, R; Nong, Y; Williams, L; Xu, H | 1 |
Büscher, M; Chaabane, S; Cheng, OW; Christ, SB; Dobbelstein, M; Li, Y; Ling, Y; Loehr, MO; Luedtke, NW; Munker, M; Pientka, R; Stomakhine, D; Weber, J; Wu, C; Zhao, K | 1 |
Bierbach, U; Chen, J; Day, CS; Mancera-Ortiz, IY; Slade, TA; Yao, X; Zhang, S | 1 |
Dallavalle, S; Dobričić, V; Fruttero, R; Gazzano, E; Lazzarato, L; Machuqueiro, M; Pajeva, I; Tsakovska, I; Zidar, N | 1 |
An, LK; Gong, X; Hu, D; Huang, ZS; Kang, S; Kuang, G; Li, D; Li, X; Shu, B; Wei, Z; Zhang, M | 1 |
Imerhasan, M; Li, H; Mahmut, M; Song, B | 1 |
Han, MK; Kim, AR; Maroli, N; Park, BH; Ponpandian, S; Prabakaran, DS; Ramesh, T; Ravichandiran, P; Yoo, DJ | 1 |
Kukowska, M | 1 |
Al-Akra, L; Bae, DH; Huang, MLH; Jansson, PJ; Lane, DJR; Park, KC; Richardson, DR; Sahni, S | 1 |
Chen, Y; Ding, H; Han, J; Jiang, H; Liu, YC; Lu, W; Luo, C; Wang, C; Wang, J; Xiong, H; Zhang, C; Zhang, N; Zhou, B | 1 |
Ling, Y; Sun, B; Wu, H; You, C; Zhou, Q | 1 |
Chen, JK; Galea, AM; Murray, V | 1 |
Brabec, V; Fedorocko, P; Harvanova, D; Imrich, J; Janovec, L; Kasparkova, J; Koval, J; Kozurkova, M; Kristian, P; Mikes, J; Mikesová, L; Plsikova, J; Rosocha, J; Sabolova, D; Stramova, Z; Ungvarsky, J; Vojtickova, M | 1 |
Bączek, T; Daghir-Wojtkowiak, E; Koba, M; Kuchcicka, A; Kurek, S; Szatkowska-Wandas, P | 1 |
Lamprecht, A; Singh, MS | 1 |
Amritkar, AA; Bangalore, PK; Karpoormath, R; Mahajan, AA; Miniyar, PB; Naphade, SS; Rane, RA | 1 |
Alwan, WS; Amritkar, AA; Karpoormath, R; Mahajan, AA; Naphade, SS; Rane, RA; Yerigiri, MC | 1 |
Hu, Y; Hu, Z; Huang, W; Li, Y; Wu, J; Zhou, Z | 1 |
Chen, C; Gao, C; Jiang, Y; Li, B; Li, L; Li, X; Liu, H; Sun, Q; Tan, C; Zhang, B | 1 |
GOLAND, PP; LEWIS, MR | 1 |
Price, PM; Saleem, A | 1 |
Chou, TC; Lee, CH; Shao, LE; Su, TL; Yu, AL; Yu, J | 1 |
Chen, YT; Chou, TC; Dong, H; Kapuriya, K; Kapuriya, N; Lee, TC; Lee, WC; Naliapara, Y; Su, TL; Tsai, TH; Zhang, X | 1 |
Ferguson, DM; Flatten, KS; Gálvez-Peralta, M; Hackbarth, JS; Hiasa, H; Kaufmann, SH; Xing, C | 1 |
Ho, HY; Su, TL; Wu, YC; Yen, WY; Yih, LH | 1 |
Neidle, S | 1 |
BUU-HOI, NP | 1 |
BUU-HOI, NP; LACASSAGNE, A | 1 |
Cholewiński, G; Dzierzbicka, K; Kołodziejczyk, AM | 1 |
Dopierała, A; Mazerski, J; Wrosz, P | 1 |
Byrne, HM; Johnson, LA; Laughton, CA; Willis, AE | 1 |
Dalla Costa, T; do Carmo Alves de Lima, M; Galdino, SL; Haas, S; Peporine Lopes, N; Pigatto, MC; Rocha Pitta, Id; Torres, B; Uchôa, Fde T | 1 |
Blache, Y; Bouyer, F; Chauffert, B; Desbois, N; Lacaille-Dubois, MA; Moretto, J; Pertuit, D; Szollosi, A | 1 |
Galdino, LS; Galdino-Pitta, MR; Lima, MC; Pitta, MG; Pitta, RI | 1 |
Bierbach, U; Ding, S; Kucera, GL; Qiao, X | 1 |
Chen, AP; Grem, JL; Hamilton, JM; Harold, N; Jasser, GB; Kao, V; Keith, B; Monahan, BP; Pace, M; Pang, J; Quinn, MG; Takimoto, CH | 1 |
Adjei, AA; Alberts, SR; Ames, MM; Atherton, P; Boemer, SA; Erlichman, C; Goldberg, RM; Hanson, LJ; Kaufmann, SH; Pitot, HC; Reid, JM; Ruben, S; Sloan, JA | 1 |
Aboagye, EO; de Bono, J; Ellard, S; Flanagan, E; Ganesan, TS; Harris, AL; Paul, J; Price, P; Propper, DJ; Saleem, A; Talbot, DC; Twelves, C | 1 |
Ellis, MJ; Laughton, CA; Missailidis, S; Modi, C; Robins, RA; Stanslas, J; Stevens, MF | 1 |
Adjei, AA; Dees, EC; Donehower, RC; Elza-Brown, K; Noe, DA; O'Reilly, S; Rowinsky, EK | 1 |
PONTARELLI, DJ | 1 |
BRILMAYER, C; KOHLER, A; MACK, A | 1 |
LETTRE, H; SEIDLER, E; WRBA, H | 1 |
MASIN, F; MASIN, M; VON BERTALANFFY, L | 1 |
GATI, E; SUGAR, J | 1 |
WITTEKIND, D | 2 |
DE BRUYN, PP; SMITH, NH | 1 |
TURNER, TR | 1 |
ALTERA, KP; BIJLENGA, G; COHEN, D; FERRIGAN, L | 1 |
DUBRAUSZKY, V | 1 |
AVERY, P; GOLDIE, H; HOUSTON, S; McIVER, W; WALKER, M | 1 |
SHURE, AQ; VENETTA, BD | 1 |
WELLMANN, KF | 1 |
BALIS, ME; PECORA, P; SALSER, JS | 1 |
MALTONI, C; ZAJDELA, F | 1 |
SHERIF, M | 2 |
KORGAONKAR, KS; SUKHATANKAR, JV | 1 |
ACKERMAN, NB | 1 |
KHODAS, MI | 1 |
ALPER, T | 1 |
KAWASAKI, DM; WILSON, JH | 1 |
ACKERMAN, NB; SHEMESH, A | 1 |
ASZODI, Z; PAPP, L; WITTMAN, I | 1 |
IRIS, L; LIOTET, S | 1 |
STAHLE, J; WIMAN, LG | 1 |
LEDOCHOWSKI, A; LEDOCHOWSKI, Z; RADZIKOWSKI, C | 1 |
MATSUOKA, Y; OKADA, Y; YAGURA, T; YAMAMURA, Y | 1 |
GERBER, P | 1 |
SUNG, SS | 1 |
BATT, RE | 1 |
HANSCHKE, HJ; HITSCHOLD, D | 1 |
BREUNINGER, ER; CREECH, HJ; MILLER, AJ; PECK, RM | 1 |
BREUNINGER, ER; CREECH, HJ; MILLER, AJ; PECK, RM; PRESTON, RK | 1 |
ACKERMAN, NB; HALDORSEN, DK; MADSEN, AJ; MCFEE, AS; WALLACE, DL | 1 |
HAMPTON, EG | 1 |
KERN, G | 1 |
CHRISTOFFERSEN, P | 1 |
CHRISTOFFERSEN, P; WANTZIN, C | 1 |
BURK, D; HUNTER, JC; WOODS, MW | 1 |
SEYDEL, HG | 1 |
de KASTNER, M; de MELLO, R; dos SANTOS, L; NEVES, EM | 1 |
CARAMAZZA, G; CITTI, U; SANI, G | 1 |
SCHICKER, H | 1 |
Baguley, BC; Jacintho, JD; Kovacic, P; Wakelin, LP | 1 |
Aiba, K; Eguchi, K; Hida, T; Horikoshi, N; Kuwabara, T; Ogawa, M; Saeki, T; Sugiura, T; Takashima, S | 1 |
de Boer-Dennert, M; de Leeuw, K; Jewell, RC; Luyten, GP; Paul, EM; Planting, AS; Purvis, NB; Sonneveld, P; Sparreboom, A; van der Burg, ME; van der Gaast, A; Verweij, J; Wissel, PS | 1 |
Alexander, RW; Bierbach, U; Budiman, ME | 1 |
Laughton, CA; Missailidis, S; Modi, C; Stevens, MF; Trapani, V | 1 |
Dicker, DT; El-Deiry, WS; Ho, WC; MacKinnon, C; Marmorstein, R; Wang, W; Winkler, JD | 1 |
Gedda, L; Ghirmai, S; Kullberg, EB; Lundqvist, H; Malmström, PU; Orlova, A; Stenerlöw, B; Tolmachev, V | 1 |
Aitken, RJ; Baker, MA | 1 |
Bierbach, U; Guddneppanavar, R | 1 |
Hardwick, LJ; van Veen, HW; Velamakanni, S | 1 |
Beijnen, JH; Jewell, RC; Kuppens, IE; Mangum, SG; Paul, EM; Radema, SA; Schellens, JH; Voest, EE; Witteveen, EO | 1 |
Faller, DV; Rankin, AM; Spanjaard, RA | 1 |
Canellakis, ES; Pawlak, K; Vitkauskas, G | 1 |
Cowan, DS; Hicks, KO; Wilson, WR | 1 |
Baguley, BC; Brady, F; Brown, G; Denny, WA; Harte, RJ; Jones, T; Luthra, SK; Osman, S; Price, PM | 1 |
Baguley, BC; Brady, F; Brown, G; Denny, WA; Harte, RJ; Hume, SP; Jones, T; Luthra, SK; Matthews, JC; Osman, S; Price, PM | 1 |
Adamson, PC; Arndt, C; Balis, FM; Berg, SL; Blaney, SM; Blatt, J; O'Brien, M; Poplack, DG | 1 |
Ashizawa, T; Gomi, K; Okabe, M; Shimizu, M | 1 |
Baker, L; Flaherty, L; Foster, BJ; Heilbrun, LK; Kraut, M; LoRusso, P; McCormick, J; Poplin, E; Valdivieso, M | 1 |
Baguley, BC; Evans, BD; Harvey, VJ; McCrystal, MR; Porter, DJ; Thompson, PI | 1 |
Baguley, BC; Dunlop, IC; Evans, BD; Gamage, RS; Kestell, P; McCrystal, MR; Paxton, JW | 1 |
Baguley, BC; Evans, BD; Kestell, P; McCrystal, MR; Paxton, JW; Robertson, IG; Schofield, PC | 1 |
Beale, P; Bleehen, NM; de Bono, J; Dennis, I; Flavin, A; Gardner, C; Hutchison, C; Judson, I; Macham, MA; Rodriguez, A; Sludden, J; Twelves, CJ; Vasey, P | 1 |
Ballinger, JR; Moore, MJ; Muzzammil, T | 1 |
Aboagye, EO; Bleehen, N; Brady, F; Brown, GD; Connors, T; Harte, RJ; Jones, T; Luthra, SK; Matthews, JC; Osman, S; Price, PM; Saleem, A | 1 |
Alvarez, MR | 1 |
Brodzka, W | 1 |
Darzynkiewicz, Z; Melamed, MR; Sharpless, T; Traganos, F | 1 |
Benjamin, RS; Bodey, GP; Burgess, MA; Gutterman, JU; Hall, SW; Legha, SS; Valdivieso, M | 1 |
Bender, RA; Glaubiger, D; Gormley, P; Howser, K; Levine, AS; Von Hoff, DD; Young, RC | 1 |
Chiuten, DF; Gormley, PE; Lichtenfeld, JL; Scoltock, M; Van Echo, DA; Wiernik, PH | 1 |
Arnaboldi, A; Bianchi, A; Daffara, P; Santamaria, L | 1 |
Jackson, RC; Leopold, WR; Sebolt, JS; Shillis, JL | 1 |
Hamelehle, KL; Jackson, RC; Pinter, CD; Scavone, SV; Sebolt, JS; Von Hoff, DD | 1 |
Nilsson, S; Trulson, A; Venge, P | 1 |
West, SS | 1 |
Cone, CD; May, JF; Rounds, DE | 1 |
Adams, LR; Kamentsky, LA; Melamed, MR; Traganos, F; Zimring, A | 1 |
Roth, D | 1 |
Goujon, F; Rondia, D | 1 |
Choné, B | 1 |
Gröger, D; Johne, S | 1 |
Roth, JR | 1 |
Grinenko, GI; Smolianskaia, AZ | 1 |
Swiecki, J | 1 |
Hultin, T | 1 |
Horvat, Z; Ivanov, D | 1 |
Knorre, D | 1 |
Panecka, A | 2 |
Thom, R | 1 |
Hett, JH; Quint, RH; Wallace, FJ | 1 |
17 review(s) available for acridines and Neoplasms
Article | Year |
---|---|
Design and Development of Triazole Derivatives as Prospective Anticancer Agents: A Review.
Topics: Acridines; Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Prospective Studies; Pyrimidines; Structure-Activity Relationship; Triazoles | 2022 |
Acriflavine, an Acridine Derivative for Biomedical Application: Current State of the Art.
Topics: Acridines; Acriflavine; Anti-Bacterial Agents; COVID-19 Drug Treatment; Humans; Intercalating Agents; Neoplasms; SARS-CoV-2 | 2022 |
Improvement of conventional anti-cancer drugs as new tools against multidrug resistant tumors.
Topics: Acridines; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Drug Design; Drug Resistance, Neoplasm; Glycoconjugates; Humans; Nanoparticles; Neoplasms; Nitric Oxide; Plant Preparations; Polymers; Technology, Pharmaceutical | 2020 |
Amino acid or peptide conjugates of acridine/acridone and quinoline/quinolone-containing drugs. A critical examination of their clinical effectiveness within a twenty-year timeframe in antitumor chemotherapy and treatment of infectious diseases.
Topics: Acridines; Acridones; Amino Acids; Animals; Anti-Infective Agents; Antineoplastic Agents; Communicable Diseases; Humans; Neoplasms; Peptides; Quinolines; Quinolones; Treatment Outcome | 2017 |
The potential of acridine carboxamide Pt complexes as anti-cancer agents : a review.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Chromatin; Coordination Complexes; CpG Islands; DNA; DNA Topoisomerases; Drug Resistance, Neoplasm; Humans; Neoplasms; Nucleosomes | 2014 |
Acridone-based antitumor agents: a mini-review.
Topics: Acridines; Acridones; Animals; Antineoplastic Agents; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Neoplasms | 2015 |
Human telomeric G-quadruplex: the current status of telomeric G-quadruplexes as therapeutic targets in human cancer.
Topics: Acridines; Antineoplastic Agents; Drug Delivery Systems; G-Quadruplexes; Humans; Neoplasms; Nucleic Acid Conformation; Telomere | 2010 |
Natural and synthetic acridines/acridones as antitumor agents: their biological activities and methods of synthesis.
Topics: Acridines; Acridones; Animals; Antineoplastic Agents; Biological Products; Drug Screening Assays, Antitumor; Humans; Neoplasms | 2011 |
Niche for acridine derivatives in anticancer therapy.
Topics: Acridines; Antineoplastic Agents; Humans; Neoplasms | 2013 |
Mechanisms of action of DNA intercalating acridine-based drugs: how important are contributions from electron transfer and oxidative stress?
Topics: Acridines; Amsacrine; Antineoplastic Agents; DNA; Electron Transport; Humans; Intercalating Agents; Neoplasms; Oxidative Stress | 2003 |
Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility.
Topics: Acridines; Child; Cytoplasm; Electron Transport; Genetic Diseases, Inborn; Germ-Line Mutation; Humans; Infertility, Male; Luminescence; Male; NAD; NADP; NADPH Oxidases; Neoplasms; Nitric Oxide; Oxidative Stress; Paternal Age; Reactive Oxygen Species; Spermatozoa | 2005 |
Adenine-N3 in the DNA minor groove - an emerging target for platinum containing anticancer pharmacophores.
Topics: Acridines; Adenine; Animals; Antineoplastic Agents; DNA Adducts; Humans; Models, Molecular; Molecular Structure; Neoplasms; Organoplatinum Compounds; Platinum Compounds | 2007 |
The emerging pharmacotherapeutic significance of the breast cancer resistance protein (ABCG2).
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Technology, Pharmaceutical; Tetrahydroisoquinolines; Topotecan | 2007 |
Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular mechanisms of cytotoxicity.
Topics: Acridines; Aminobenzoates; Animals; Antineoplastic Agents; Enzyme Inhibitors; Humans; Naphthalenes; Neoplasms; Oligonucleotides; Oligonucleotides, Antisense; Telomerase; Telomere; Tumor Cells, Cultured | 2008 |
The pyrazoloacridines: approaches to the development of a carcinoma-selective cytotoxic agent.
Topics: Acridines; Animals; Antineoplastic Agents; Drug Design; Humans; Neoplasms; Pyrazoles | 1990 |
[Natural acridine derivatives].
Topics: Acridines; Antineoplastic Agents; Chemical Phenomena; Chemistry; Chemistry, Organic; Neoplasms; Organic Chemistry Phenomena; Plants, Medicinal; Structure-Activity Relationship | 1972 |
Frameshift mutations.
Topics: Acridines; Alkylating Agents; Base Sequence; Coliphages; DNA Replication; DNA Viruses; DNA, Viral; Escherichia coli; Genetic Code; Hemoglobins, Abnormal; Heterocyclic Compounds; Humans; Models, Chemical; Muramidase; Mutagens; Mutation; Neoplasms; Saccharomyces; Salmonella typhimurium; Transcription, Genetic | 1974 |
17 trial(s) available for acridines and Neoplasms
Article | Year |
---|---|
A phase I pharmacologic and pharmacodynamic study of pyrazoloacridine given as a weekly 24-hour continuous intravenous infusion in adult cancer patients.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Agranulocytosis; Antineoplastic Agents; Apoptosis; Drug Administration Schedule; Female; Gastrointestinal Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Pyrazoles | 2002 |
A phase I and pharmacologic study of pyrazoloacridine (NSC 366140) and carboplatin in patients with advanced cancer.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; DNA Adducts; Drug Interactions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Platinum; Pyrazoles | 2002 |
Use of positron emission tomography in pharmacokinetic studies to investigate therapeutic advantage in a phase I study of 120-hour intravenous infusion XR5000.
Topics: Acridines; Adult; Aged; Area Under Curve; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Tissue Distribution; Tomography, Emission-Computed | 2003 |
A phase I and pharmacologic study of pyrazoloacridine and cisplatin in patients with advanced cancer.
Topics: Acridines; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Pyrazoles; Recombinant Proteins; Time Factors; Treatment Outcome | 2003 |
Phase I and pharmacokinetic study of KW-2170, a novel pyrazoloacridone compound, in patients with malignant tumors.
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Neoplasms; Pyrazoles | 2004 |
A phase I and pharmacologic study of the MDR converter GF120918 in combination with doxorubicin in patients with advanced solid tumors.
Topics: Acridines; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Drug Interactions; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Tetrahydroisoquinolines | 2005 |
A phase I, randomized, open-label, parallel-cohort, dose-finding study of elacridar (GF120918) and oral topotecan in cancer patients.
Topics: Acridines; Administration, Oral; Adult; Aged; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cohort Studies; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Proteins; Neoplasms; Research Design; Tetrahydroisoquinolines; Topotecan | 2007 |
Carbon-11 labelling of the antitumour agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA) and determination of plasma metabolites in man.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carbon Radioisotopes; Dose-Response Relationship, Drug; Female; Humans; Isotope Labeling; Male; Middle Aged; Neoplasms; Tomography, Emission-Computed | 1997 |
Studies on the metabolism of the novel antitumor agent [N-methyl-11C]N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in rats and humans prior to phase I clinical trials.
Topics: Acridines; Adult; Aged; Animals; Antineoplastic Agents; Brain; Chromatography, High Pressure Liquid; Female; Humans; Kidney; Liver; Lung; Male; Middle Aged; Myocardium; Neoplasms; Plasma; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed | 1997 |
Phase I trial and pharmacokinetic study of pyrazoloacridine in children and young adults with refractory cancers.
Topics: Acridines; Adolescent; Adult; Antineoplastic Agents; Child; Child, Preschool; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Neoplasms; Neutropenia; Pyrazoles; Thrombocytopenia | 1998 |
Phase I clinical trial of pyrazoloacridine NSC366140 (PD115934).
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Nausea; Neoplasms; Pyrazoles; Vomiting | 1995 |
Phase I study of the cytotoxic agent N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Facial Pain; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1999 |
Plasma pharmacokinetics of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in a phase I trial.
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1999 |
Metabolism of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in cancer patients undergoing a phase I clinical trial.
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Biotransformation; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1999 |
Phase I and pharmacokinetic study of DACA (XR5000): a novel inhibitor of topoisomerase I and II. CRC Phase I/II Committee.
Topics: Acridines; Adult; Aged; Antineoplastic Agents; Area Under Curve; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Pain; Patient Selection; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1999 |
Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Carbon Radioisotopes; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms; Tissue Distribution; Tomography, Emission-Computed | 2001 |
Phase I study of methanesulfonamide, N-[4-(9-acridinylamino)-3-methoxyphenyl]-(m-AMSA) using a single-dose schedule.
Topics: Acridines; Adolescent; Adult; Antineoplastic Agents; Bone Marrow Diseases; Child; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle Aged; Neoplasms; Phenylenediamines | 1978 |
106 other study(ies) available for acridines and Neoplasms
Article | Year |
---|---|
Design and Synthesis of Acridine-Triazole and Acridine-Thiadiazole Derivatives and Their Inhibitory Effect against Cancer Cells.
Topics: Acridines; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dermatologic Agents; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Thiadiazoles; Triazoles; Zebrafish | 2022 |
DNA templated Click Chemistry via 5-vinyl-2'-deoxyuridine and an acridine-tetrazine conjugate induces DNA damage and apoptosis in cancer cells.
Topics: Acridines; Apoptosis; Click Chemistry; DNA; DNA Damage; Humans; Neoplasms | 2023 |
Development of Prodrug-Payloads for Targeted Therapeutic Applications of Platinum-Acridine Anticancer Agents.
Topics: Acridines; Antineoplastic Agents; Humans; Neoplasms; Platinum; Prodrugs | 2023 |
Syntheses and Evaluation of New Bisacridine Derivatives for Dual Binding of G-Quadruplex and i-Motif in Regulating Oncogene
Topics: Acridines; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Screening Assays, Antitumor; G-Quadruplexes; Humans; Mice; Mice, Nude; Molecular Docking Simulation; Neoplasms; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myc; Structure-Activity Relationship; Transplantation, Heterologous | 2020 |
One-Pot Green Synthesis of Acridine Alkaloid Derivatives and Screening of in vitro Anti-cancer Activity Against Cdc25b and SHP1.
Topics: Acridines; Australia; cdc25 Phosphatases; Humans; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Structure-Activity Relationship | 2021 |
Mitochondria-targeted acridine-based dual-channel fluorescence chemosensor for detection of Sn
Topics: Acridines; Fluorescent Dyes; Humans; Ions; Mitochondria; Neoplasms; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Water | 2021 |
Tumor stressors induce two mechanisms of intracellular P-glycoprotein-mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones.
Topics: Acridines; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Hypoxia-Inducible Factor 1, alpha Subunit; Lysosomes; Models, Biological; Neoplasm Proteins; Neoplasms; Organelle Biogenesis; Protein Transport; RNA Interference; Tetrahydroisoquinolines; Thiosemicarbazones; Tumor Microenvironment | 2018 |
Discovery of 1,8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening.
Topics: Acridines; Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Histone Acetyltransferases; Humans; Molecular Docking Simulation; Neoplasms; p300-CBP Transcription Factors; Saccharomyces cerevisiae Proteins; Small Molecule Libraries | 2018 |
pH and thermo dual stimulus-responsive liposome nanoparticles for targeted delivery of platinum-acridine hybrid agent.
Topics: Acridines; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Delayed-Action Preparations; Drug Delivery Systems; Humans; Hydrogen-Ion Concentration; Liposomes; Nanoparticles; Neoplasms; Organoplatinum Compounds; Temperature | 2019 |
Novel trisubstituted acridines as human telomeric quadruplex binding ligands.
Topics: Acridines; Animals; Antineoplastic Agents; Cattle; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; DNA; G-Quadruplexes; Humans; Ligands; Molecular Docking Simulation; Neoplasms | 2014 |
The application of connected QSRR and QSAR strategies to predict the physicochemical interaction of acridinone derivatives with DNA.
Topics: Acridines; Antineoplastic Agents; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Computer Simulation; DNA; Drug Discovery; Humans; Models, Biological; Neoplasms; Nucleic Acid Conformation; Quantitative Structure-Activity Relationship | 2014 |
Cargoing P-gp inhibitors via nanoparticle sensitizes tumor cells against doxorubicin.
Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Carriers; Drug Resistance, Neoplasm; Humans; Nanoparticles; Neoplasms; Polyvinyl Alcohol; Sodium Dodecyl Sulfate; Surface-Active Agents; Tetrahydroisoquinolines; Verapamil | 2015 |
Synthesis of novel amides based on acridone scaffold with interesting antineoplastic activity.
Topics: Acridines; Acridones; Amides; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2015 |
HZ08 reverse P-glycoprotein mediated multidrug resistance in vitro and in vivo.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Dogs; Drug Resistance, Multiple; Humans; Isoquinolines; KB Cells; Madin Darby Canine Kidney Cells; Mice; Neoplasms; Tetrahydroisoquinolines; Transplantation, Heterologous; Verapamil | 2015 |
Synthesis and biological evaluation of benzimidazole acridine derivatives as potential DNA-binding and apoptosis-inducing agents.
Topics: Acridines; Antineoplastic Agents; Apoptosis; Benzimidazoles; Cell Line, Tumor; DNA; Humans; Intercalating Agents; Neoplasms | 2015 |
In vivo staining and retardation of tumors in mice by acridine compounds.
Topics: Acridines; Animals; Coloring Agents; Mice; Neoplasms; Staining and Labeling | 1948 |
Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure.
Topics: Acridines; Antineoplastic Agents; Area Under Curve; Fluorouracil; Humans; Neoplasms; Solubility | 2008 |
BO-0742, a derivative of AHMA and N-mustard, has selective toxicity to drug sensitive and drug resistant leukemia cells and solid tumors.
Topics: Acridines; Aniline Compounds; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Hematopoietic Stem Cells; Humans; Leukemia; Male; Mice; Multidrug Resistance-Associated Proteins; Neoplasms; Nitrogen Mustard Compounds; Xenograft Model Antitumor Assays | 2009 |
Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker.
Topics: Acridines; Animals; Antineoplastic Agents, Alkylating; Carbamates; Carbonates; Cell Line, Tumor; DNA; Dose-Response Relationship, Drug; Drug Design; Half-Life; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Neoplasms; Rats; Xenograft Model Antitumor Assays | 2009 |
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Topics: Acridines; Aminacrine; Antineoplastic Agents; Cell Line; Chemistry, Pharmaceutical; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Doxorubicin; Drug Design; Drug Screening Assays, Antitumor; Etoposide; Humans; Models, Chemical; Neoplasms; RNA, Small Interfering | 2009 |
Glyfoline induces mitotic catastrophe and apoptosis in cancer cells.
Topics: Acridines; Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Female; HeLa Cells; Humans; Lung Neoplasms; Male; Mice; Microtubules; Mitosis; Neoplasms; Prostatic Neoplasms; Tubulin | 2010 |
The chemistry of carcinogenic nitrogen compounds; new derivatives of the angular benzacridines and of some related nuclei.
Topics: Acridines; Carcinogens; Humans; Neoplasms; Nitrogen; Nitrogen Compounds; Organic Chemicals | 1946 |
Carcinogenic activity on the skin of mice of substances from the group of angular benzacridines.
Topics: Acridines; Neoplasms | 1946 |
[Acridines as antitumor drugs].
Topics: Acridines; Antineoplastic Agents; Humans; Neoplasms | 2011 |
An integrative biological approach to the analysis of tissue culture data: application to the antitumour agent RHPS4.
Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cellular Senescence; Chromatin; Doxorubicin; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Kinetics; Models, Theoretical; Neoplasms; Time Factors; Tissue Culture Techniques | 2011 |
Polycyclic aromatic hydrocarbons: 15 Listings - benz[a]anthracene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenz[a,h]acridine, dibenz[a,j]acridine, dibenz[a,h]anthracene, 7H-dibenzo[c,g]carbazole, dibenzo[a,e]pyr
Topics: Acridines; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Benzopyrenes; Carbazoles; Carcinogens, Environmental; Chrysenes; Environmental Pollutants; Fluorenes; Humans; Neoplasms; Polycyclic Aromatic Hydrocarbons; Pyrenes | 2011 |
Pre-clinical pharmacokinetics of the acridine antitumour candidate AC04 and its 1-oxo-metabolite plasma profile.
Topics: Acridines; Animals; Antineoplastic Agents; Area Under Curve; Chromatography, High Pressure Liquid; Chromatography, Liquid; Male; Neoplasms; Rats; Thiazolidinediones; Tissue Distribution | 2012 |
Synthesis, cytotoxicity and structure-activity relationships between ester and amide functionalities in novel acridine-based platinum(II) complexes.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cytotoxins; Humans; Neoplasms; Platinum | 2012 |
Using a build-and-click approach for producing structural and functional diversity in DNA-targeted hybrid anticancer agents.
Topics: Acridines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; DNA; Drug Design; Drug Screening Assays, Antitumor; Humans; Neoplasms; Platinum; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship | 2012 |
Antitumor polycyclic acridines. Part 12. Physical and biological properties of 8,13-diethyl-6-methylquino[4,3,2-kl]acridinium iodide: a lead compound in anticancer drug design.
Topics: Acridines; Antineoplastic Agents; Biochemistry; Cell Cycle; Cell Nucleus; Circular Dichroism; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cytoplasm; DNA; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Neoplasms; Nucleic Acid Heteroduplexes; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Simple method for control of vaginal discharge related to carcinoma of the cervix.
Topics: Acridines; Cervix Uteri; Coloring Agents; Female; Humans; Neoplasms; Sulfanilamide; Sulfanilamides; Vagina; Vaginal Discharge | 1954 |
[Determination of trypaflavine in the urine in diagnosis of tumors in relation to the atebrin and eosin test].
Topics: Acridines; Body Fluids; Coloring Agents; Eosine Yellowish-(YS); Humans; Neoplasms; Quinacrine; Urine | 1954 |
[Study with radiophosphorus on the effect of inhibiting substance on duplication rate and phosphate uptake by tumors].
Topics: Acridines; Antineoplastic Agents; Colchicine; Coloring Agents; Neoplasms; Phosphates; Phosphorus; Phosphorus Radioisotopes; Phosphorus, Dietary | 1954 |
Use of acridine-orange fluorescence technique in exfoliative cytology.
Topics: Acridine Orange; Acridines; Coloring Agents; Fluorescence; Humans; Neoplasms; Staining and Labeling | 1956 |
[Change of acridine orange uptake by cells of Ehrlich ascites tumors under the effect of different chemotherapeutic agents].
Topics: Acridine Orange; Acridines; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Connective Tissue; Humans; Neoplasms | 1958 |
[Observations on an unusual type of acridine orange accumulation in vital exudate cells].
Topics: Acridine Orange; Acridines; Diploidy; Encephalomyelitis; Exudates and Transudates; Humans; Neoplasms | 1958 |
[Vital staining of mouse ascites carcinoma with acridine orange].
Topics: Acridine Orange; Acridines; Ascites; Coloring Agents; Encephalomyelitis; Humans; Neoplasms; Staining and Labeling | 1958 |
Comparison between the in vivo and in vitro interaction of aminoacridines with nucleic acids and other compounds.
Topics: Acridines; Aminoacridines; In Vitro Techniques; Neoplasms; Nucleic Acids | 1959 |
Fluorescence photomicrography of acridine orange-stained exfoliative cytologica preparations.
Topics: Acridine Orange; Acridines; Fluorescence; Humans; Neoplasms; Photomicrography | 1960 |
The use of acridine orange fluorescent staining of peripheral blood cells as a rapid method for the detection of abnormal proliferation of haematopoietic tissues.
Topics: Acridine Orange; Acridines; Blood Cells; Fluorescent Dyes; Hematopoietic System; Humans; Leukemia; Neoplasms; Staining and Labeling | 1962 |
[Acridine orange - chromium fluoride in the cancer identification test].
Topics: Acridine Orange; Acridines; Chromium; Coloring Agents; Female; Fluorides; Humans; Neoplasms; Phosphates; Staining and Labeling; Uterine Cervical Neoplasms | 1961 |
Free tumor cell growth in the serous fluid of an experimental subcutaneous cavity in the mouse.
Topics: Acridines; Animals; Cell Cycle; Cell Proliferation; Mice; Neoplasms; Neoplasms, Experimental; Oils | 1961 |
Adsorption isotherm studies of unfixed S-37-A and Ehrlich ascites tumor cells using acridine orange.
Topics: Acridine Orange; Acridines; Adsorption; Animals; Carcinoma, Ehrlich Tumor; Humans; Neoplasms; Research | 1961 |
[Critical remarks on acridine orange-fluorochrome in cytological cancer diagnosis].
Topics: Acridine Orange; Acridines; Cytodiagnosis; Fluorescence; Fluorescent Dyes; Humans; Merbromin; Microscopy; Microscopy, Fluorescence; Neoplasms | 1962 |
STUDIES OF COMPOUNDS THAT INHIBIT CELL GROWTH.
Topics: Acridines; Adenine; Animals; Carcinoma; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Guanine; Liver; Mercaptopurine; Mice; Neoplasms; Nucleotides; Pharmacology; Proteins; Research | 1963 |
CHANGES OF THE SUB-EPITHELIAL CONNECTIVE TISSUES IN THE EARLY STAGES OF SKIN CARCINOGENESIS INDUCED BY CHEMICAL AGENTS.
Topics: Acridines; Animals; Benz(a)Anthracenes; Benzopyrenes; Carcinogenesis; Carcinogens; Connective Tissue; Croton Oil; Guinea Pigs; Methylcholanthrene; Mice; Neoplasms; Neoplasms, Experimental; Pathology; Rabbits; Rats; Research; Skin Neoplasms; Toxicology | 1963 |
EXPERIMENTAL AND CLINICAL STUDIES ON THE FLUOROBIOLOGY OF THE CERVIX. II. NUCLEIC ACIDS' VARIATION IN EARLY STAGES OF INDUCED CARCINOGENESIS.
Topics: Acridines; Animals; Carcinogenesis; Coloring Agents; DNA; DNA, Neoplasm; Female; Fluorescence; Fluorescent Dyes; Humans; Mice; Microscopy; Microscopy, Fluorescence; Neoplasms; Neoplasms, Experimental; Nucleic Acids; Research; RNA; RNA, Neoplasm; Staining and Labeling; Uterine Cervical Neoplasms; Vaginal Smears | 1963 |
ANTI-TUMOUR ACTIVITY OF THE FLUORESCENT DYE, ACRIDINE ORANGE, ON YOSHIDA SARCOMA (ASCITES).
Topics: Acridine Orange; Acridines; Animals; Antineoplastic Agents; Ascites; Fluorescent Dyes; Neoplasms; Rats; Research; Sarcoma; Sarcoma, Yoshida | 1963 |
INCREASED CONCENTRATION OF AMINOACRIDINE COMPOUNDS BY TUMORS IN RATS.
Topics: Acridines; Aminacrine; Aminoacridines; Autoradiography; Metabolism; Neoplasms; Neoplasms, Experimental; Rats; Research | 1963 |
[EFFECTS OF VARIOUS PHYSICAL AGENTS ON THE LUMINESCENT PROPERTIES OF DESOXYRIBONUCLEIC ACID IN VITRO].
Topics: Acridines; DNA; DNA, Neoplasm; Hot Temperature; In Vitro Techniques; Luminescence; Neoplasms; Research; Sarcoma; Sarcoma, Experimental; Thymus Gland | 1963 |
LETHAL MUTATIONS AND CELL DEATH.
Topics: Acridines; Bacteria; Cell Death; Escherichia coli; Mutation; Neoplasms; Neoplasms, Experimental; Paramecium; Pharmacology; Radiation Genetics; Salmonella typhimurium; Shigella; Tissue Culture Techniques; Ultraviolet Rays; Viruses | 1963 |
OFFICE APPLICATION OF RAPID ACRIDINE ORANGE TECHNIC USING FLUORESCENCE MICROSCOPY.
Topics: Acridine Orange; Acridines; Coloring Agents; Female; Fluorescence; Gynecology; Humans; Microscopy; Microscopy, Fluorescence; Neoplasms; Staining and Labeling; Vaginal Smears | 1963 |
LOCALIZATION OF AMINOACRIDINE FLUORESCENCE IN LUNG TUMORS OF RATS.
Topics: Acridines; Aminacrine; Aminoacridines; Animals; Carcinoma; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Fluorescence; Iodine Isotopes; Liver Neoplasms; Lung Neoplasms; Metabolism; Neoplasms; Quinacrine; Rats; Research | 1964 |
[RECENT USE OF DYE SOLUTIONS IN DIAGNOSIS. I. CHROMOLAPAROSCOPY. (PRELIMINARY REPORT)].
Topics: Acridines; Chlortetracycline; Clinical Laboratory Techniques; Congo Red; Dogs; Endoscopy; Fluoresceins; Fluorescent Dyes; Methylene Blue; Neoplasms; Research | 1964 |
[TRIAL APPLICATION TO OCULAR HISTOLOGY OF ACRIDINE ORANGE STAINING IN FLUORESCENCE MICROSCOPY].
Topics: Acridine Orange; Acridines; Choroid Neoplasms; Coloring Agents; Eye; Fluorescence; Histological Techniques; Microscopy; Microscopy, Fluorescence; Neoplasms; RNA; Sarcoma; Staining and Labeling | 1964 |
EXFOLIATIVE CYTOLOGY IN OTOLARYNGOLOGY USING SULFHYDRYL ACTIVITY, ACRIDINE ORANGE AND MORPHOLOGIC STAINING PROCEDURES.
Topics: Acridine Orange; Acridines; Coloring Agents; Cytodiagnosis; Ear; Esophageal Neoplasms; Fluorescence; Humans; Laryngeal Neoplasms; Microscopy; Microscopy, Fluorescence; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasms; Nose Neoplasms; Otolaryngology; Paranasal Sinus Neoplasms; Pharyngeal Neoplasms; Staining and Labeling; Sulfhydryl Compounds | 1964 |
RESEARCH OF ANTITUMOUR COMPOUNDS. REMARKS ABOUT THE RELATIONSHIP BETWEEN THE CHEMICAL STRUCTURE AND TUMOUR-INHIBITING ACTIVITY OF SOME ACRIDINE DERIVATIVES.
Topics: Acridines; Animals; Antineoplastic Agents; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Research; Sarcoma 180 | 1964 |
IMMUNOLOGIC UNRESPONSIVENESS INDUCED BY ANTICARCINOGENIC AGENTS AND STEROID HORMONE.
Topics: Acridines; Animals, Newborn; Anticarcinogenic Agents; Antineoplastic Agents; Cortisone; Cyclophosphamide; Immunity; Mercaptopurine; Neoplasms; Pharmacology; Quinolines; Rabbits; Research | 1964 |
VIROGENIC HAMSTER TUMOR CELLS: INDUCTION OF VIRUS SYNTHESIS.
Topics: Acridines; Adenoviridae; Adenoviridae Infections; Complement Fixation Tests; Cricetinae; Ependymoma; Hydrogen Peroxide; Kidney; Mitomycin; Neoplasms; Oncogenic Viruses; Pharmacology; Polyomavirus; Research; Sarcoma; Sarcoma, Experimental; Simian virus 40; Tissue Culture Techniques; Virus Cultivation | 1964 |
[CARCINOGENIC POWER AND ELECTRON TRANSITION ENERGIES. NEW THEORETICAL AND EXPERIMENTAL DATA].
Topics: Acridines; Aniline Compounds; Benz(a)Anthracenes; Carcinogens; Chemical Phenomena; Chemistry; Electrons; Hydrocarbons; Neoplasms; Neoplasms, Experimental; Pharmacology; Rabbits; Rats; Research; Statistics as Topic; Toxicology | 1964 |
FLUORESCENCE MICROSCOPY IN EXFOLIATIVE CYTOLOGY: CYTOLOGIC CANCER SCREENING WITH ACRIDINE ORANGE IN THE OFFICE.
Topics: Acridine Orange; Acridines; Coloring Agents; Cytodiagnosis; Early Detection of Cancer; Female; Fluorescence; Humans; Mass Screening; Microscopy; Microscopy, Fluorescence; Neoplasms; Staining and Labeling; Vaginal Smears | 1964 |
[UROLOGIC DIAGNOSTIC CYTOLOGY EMPLOYING FLUORESCENCE-MICROSCOPY].
Topics: Acridines; Adenocarcinoma; Carcinoma; Carcinoma, Papillary; Cytodiagnosis; DNA; DNA, Neoplasm; Fluorescence; Humans; Microscopy; Microscopy, Fluorescence; Neoplasms; Pathology; RNA; RNA, Neoplasm; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urine | 1964 |
EXPERIMENTAL AND CLINICAL STUDIES ON THE FLUOROBIOLOGY OF THE CERVIX. 3. ON A NEW CANCER TEST: BASIC CONSIDERATIONS.
Topics: Acridines; Animals; Biomedical Research; Cervix Uteri; DNA; Estradiol; Female; Fluorescence; Humans; Methylcholanthrene; Mice; Microscopy; Microscopy, Fluorescence; Neoplasms; Pharmacology; Research; RNA; Toxicology; Uterine Cervical Neoplasms | 1964 |
ACRIDINE AND QUINOLINE ANALOGS OF NITROGEN MUSTARD WITH AMIDE SIDE CHAINS.
Topics: Acridines; Amides; Animals; Chemistry, Pharmaceutical; Mechlorethamine; Mice; Neoplasms; Neoplasms, Experimental; Nitrogen Mustard Compounds; Pharmacology; Quinolines; Research | 1964 |
FURTHER INVESTIGATIONS OF HETEROCYCLIC ALKYLATING AGENTS.
Topics: Acridines; Alkylating Agents; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Heterocyclic Compounds; Mice; Neoplasms; Neoplasms, Experimental; Pharmacology; Quinolines; Research | 1964 |
AMINOACRIDINE UPTAKE BY EXPERIMENTAL TUMORS.
Topics: Acridines; Aminacrine; Animals; Autoradiography; Carcinoma 256, Walker; Carcinoma, Hepatocellular; Fluorescence; Iodine Isotopes; Liver Neoplasms; Lung Neoplasms; Metabolism; Microscopy; Microscopy, Fluorescence; Neoplasms; Neoplasms, Experimental; Quinacrine; Rats; Research; Stomach Neoplasms | 1965 |
VIRAL ANTIGEN IN RAT EMBRYO IN CULTURE INFECTED WITH THE H-1 VIRUS ISOLATED FROM TRANSPLANTABLE HUMAN TUMORS: CYTOCHEMICAL STUDIES.
Topics: Acridines; Antigens; Antigens, Viral; Cell Nucleus; Cytopathogenic Effect, Viral; Cytoplasm; Deoxyribonucleases; DNA; Embryo, Mammalian; Embryo, Nonmammalian; Fluorescent Antibody Technique; Hemagglutination Inhibition Tests; Humans; Microscopy; Microscopy, Phase-Contrast; Neoplasms; Oncogenic Viruses; Rats; Tissue Culture Techniques | 1964 |
[DEMONSTRATION OF RIBONUCLEIC ACID WITH ACRIDINE ORANGE IN CYTOLOGICAL SMEARS].
Topics: Acridine Orange; Acridines; Coloring Agents; Cytodiagnosis; Humans; Neoplasms; RNA; RNA, Neoplasm; Staining and Labeling | 1964 |
[EVALUATION OF ACRIDINE ORANGE METHODS IN THE CYTODIAGNOSIS OF CANCER].
Topics: Acridine Orange; Acridines; Cytodiagnosis; Female; Humans; Neoplasms; Uterine Cervical Neoplasms | 1965 |
[SUITABILITY OF THE ACRIDINE ORANGE METHOD FOR DETECTING CIRCULATING TUMOR CELLS].
Topics: Acridine Orange; Acridines; Neoplasms; Neoplastic Cells, Circulating; Staining and Labeling | 1965 |
INHIBITION OF ANAEROBIC GLYCOLYSIS OF ASCITES CANCER CELLS BY ACRIDINE DYES AND LIGHT.
Topics: Acridines; Animals; Ascites; Carbohydrate Metabolism; Clinical Enzyme Tests; Coenzymes; Coloring Agents; Glycolysis; Light; Metabolism; Mice; NAD; Neoplasms; Neoplasms, Experimental; Oxidation-Reduction; Research; Thiazines | 1965 |
RADIATION-INDUCED CHANGES IN THE CYTOPLASMIC ACRIDINE ORANGE STAINING OF EXFOLIATED CELLS.
Topics: Acridine Orange; Acridines; Cytodiagnosis; Cytoplasm; Female; Fluorescent Dyes; Humans; Mouth Neoplasms; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Prognosis; Radiotherapy Dosage; RNA; RNA, Neoplasm; Staining and Labeling; Uterine Neoplasms; Vaginal Smears | 1965 |
Comparative results of Papanicolaou method and acridine-orange fluorescence technic in the exfoliative cytology.
Topics: Acridine Orange; Acridines; Cytodiagnosis; Fluorescence; Fluorescent Dyes; Humans; Microscopy; Neoplasms | 1962 |
[Fluorochromicization of vaginal smears with acridine orange in the early diagnosis of cancer of the uterus].
Topics: Acridine Orange; Acridines; Chromium; Coloring Agents; Early Detection of Cancer; Female; Humans; Neoplasms; Staining and Labeling; Uterine Neoplasms; Vaginal Smears | 1962 |
[Research on the behavior of injected acridine orange solution in albino experimental animals with spontaneous and inoculated tumors].
Topics: Acridine Orange; Acridines; Animals; Animals, Laboratory; Neoplasms; Neoplasms, Experimental; Research | 1962 |
DNA minor groove adducts formed by a platinum-acridine conjugate inhibit association of tata-binding protein with its cognate sequence.
Topics: Acridines; Adenine; Animals; Antineoplastic Agents; Binding Sites; DNA Adducts; Humans; Neoplasms; Nitrogen; Organoplatinum Compounds; TATA-Box Binding Protein; Transcription, Genetic | 2005 |
Antitumor polycyclic acridines. Part 16. Triplex DNA as a target for DNA-binding polycyclic acridine derivatives.
Topics: Acridines; Amino Acid Motifs; Apoptosis; Buffers; Circular Dichroism; DNA; Hot Temperature; Humans; Hydrogen-Ion Concentration; Kinetics; Ligands; Macromolecular Substances; Mesylates; Models, Chemical; Neoplasms; Nucleic Acid Conformation; Nucleic Acids; Oligonucleotides; Protein Binding; Purines; Pyrimidines; Spectrometry, Fluorescence; Spectrophotometry; Temperature; Ultraviolet Rays | 2005 |
Acridine derivatives activate p53 and induce tumor cell death through Bax.
Topics: Acridines; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Drug Design; Humans; Intercalating Agents; Mice; Mice, Nude; Neoplasms; Pyrimidines; Quinacrine; Transcription, Genetic; Tumor Suppressor Protein p53; Ubiquitin; Xenograft Model Antitumor Assays | 2005 |
An aminoacridine derivative for radionuclide therapy: DNA binding properties studied in a novel cell-free in vitro assay.
Topics: Acridines; Benzamides; Biological Assay; Cell-Free System; Chloramines; DNA Adducts; DNA Damage; Humans; Indicators and Reagents; Iodine Radioisotopes; Neoplasms; Sepharose; Tosyl Compounds | 2005 |
A new in vitro assay for anticancer compounds and a biochemical assay for their effect on metabolic cooperation.
Topics: Acridines; Animals; Antineoplastic Agents; Cell Aggregation; Cell Membrane Permeability; DNA Replication; Drug Evaluation, Preclinical; Humans; Hypoxanthine Phosphoribosyltransferase; Intercalating Agents; Neoplasms; Protein Biosynthesis; Structure-Activity Relationship; Transcription, Genetic | 1982 |
Multicellular membranes as an in vitro model for extravascular diffusion in tumours.
Topics: Acridines; Animals; Cell Hypoxia; Cell Membrane; Cricetinae; Cricetulus; Diffusion; In Vitro Techniques; Misonidazole; Neoplasms; Nitroimidazoles; Phenanthridines | 1996 |
Antitumor activity of KW-2170, a novel pyrazoloacridone derivative.
Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Doxorubicin; Drug Resistance, Multiple; Female; Fibrosarcoma; Gastrointestinal Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Molecular Structure; Neoplasms; Prostatic Neoplasms; Pyrazoles; Sarcoma 180; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
In vitro comparison of sestamibi, tetrofosmin, and furifosmin as agents for functional imaging of multidrug resistance in tumors.
Topics: Acridines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug Resistance, Neoplasm; Furans; Humans; Isoquinolines; Neoplasms; Organophosphorus Compounds; Organotechnetium Compounds; Technetium Tc 99m Sestamibi; Tetrahydroisoquinolines; Tomography, Emission-Computed, Single-Photon; Tumor Cells, Cultured | 2000 |
Microfluorometric comparisons of heat-induced nuclear acridine orange metachromasia between normal cells and neoplastic cells from primary tumors of diverse origin.
Topics: Acridines; Adenocarcinoma; Animals; Carcinogens; Cell Nucleus; Chromatin; Dog Diseases; Dogs; Female; Fluorometry; Histocytochemistry; Hot Temperature; Leukemia, Experimental; Lymphocytes; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neoplasms; Nitrosourea Compounds; Nucleic Acid Denaturation; Staining and Labeling; Vagina; Vaginal Neoplasms | 1975 |
[Application of cytoenzymatic tests and acridine orange staining in evaluation of the character of fluids from somatic cavities (author's transl)].
Topics: Acid Phosphatase; Acridines; Exudates and Transudates; Histocytochemistry; Humans; Naphthol AS D Esterase; Neoplasms; Staining and Labeling | 1977 |
Cytology automation by flow cytometry.
Topics: Acridines; Cell Division; Cell Nucleus; Chromatin; Cytodiagnosis; DNA, Neoplasm; Edetic Acid; Humans; Mitosis; Neoplasms; Nucleic Acid Denaturation; Rheology; RNA, Neoplasm | 1977 |
Phase 1 clinical investigation of 4'-(9-acridinylamino)methanesulfon-m-anisidide (NSC 249992), a new acridine derivative.
Topics: Acridines; Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Bone Marrow; Drug Administration Schedule; Drug Evaluation; Female; Humans; Injections, Intravenous; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Melanoma; Middle Aged; Neoplasms; Phenylenediamines; Remission, Spontaneous | 1978 |
Phase I clinical and pharmacological study of 4'-(9-acridinylamino)-methanesulfon-m-anisidide using an intermittent biweekly schedule.
Topics: Acridines; Aged; Antineoplastic Agents; Bone Marrow; Drug Evaluation; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms; Phenylenediamines; Remission, Spontaneous | 1979 |
Photocarcinogenesis by methoxypsoralen, neutral red and proflavine.
Topics: Acridines; Animals; Breast Neoplasms; Female; Methoxsalen; Mice; Neoplasms; Neutral Red; Phenazines; Proflavine; Sebaceous Gland Neoplasms; Skin; Thyroid Neoplasms; Ultraviolet Rays | 1979 |
Pyrazoloacridines, a new class of anticancer agents with selectivity against solid tumors in vitro.
Topics: Acridines; Antineoplastic Agents; Cell Cycle; Cell Line; DNA; Humans; Neoplasms; Oxygen; Pyrazoles; RNA; Structure-Activity Relationship; Tumor Stem Cell Assay | 1987 |
Lucigenin-enhanced chemiluminescence in blood is increased in cancer.
Topics: Acridines; Adult; Aged; Aged, 80 and over; Cell Separation; Female; Humans; Kidney Neoplasms; Leukocyte Count; Luminescent Measurements; Luminol; Male; Middle Aged; Monocytes; Neoplasms; Neutrophils; Prostatic Neoplasms | 1989 |
The microscope, spectra, and automated analysis.
Topics: Acridines; Amino Acids; Animals; Autoanalysis; Binding Sites; Coloring Agents; Histocytochemistry; Leukocytes; Lymphocytes; Mice; Microscopy; Microscopy, Fluorescence; Neoplasms; Optical Rotatory Dispersion; Spectrum Analysis; Staining and Labeling | 1970 |
Intercellular transfer of toxic components after laser irradiation.
Topics: Acid Phosphatase; Acridines; Adenocarcinoma; Argon; Cell Line; Cell Nucleus; Colonic Neoplasms; Culture Techniques; Cytoplasm; Female; Fibroma; Histocytochemistry; Hot Temperature; Lasers; Lysosomes; Microscopy, Phase-Contrast; Neoplasms; Photosensitivity Disorders; Radiation Effects; Staining and Labeling; Uterine Neoplasms | 1971 |
Acridine orange metachromasia for characterization of leukocytes in leukemia, lymphoma, and other neoplasms.
Topics: Acridines; Breast Neoplasms; Cell Nucleus; Cytoplasm; Fluorescent Dyes; Fluorometry; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Mycosis Fungoides; Neoplasms; Photometry; Polycythemia Vera; Staining and Labeling | 1972 |
Automating cancer cytodiagnosis by determining unbound acridine dye.
Topics: Acridines; Cytodiagnosis; Humans; Leukoplakia; Mouth Neoplasms; Neoplasms; Nucleic Acids; Staining and Labeling | 1966 |
[New research on the induction of liver hydroxylases: action of nitrogen polycyclic hydrocarbons].
Topics: Acridines; Air Pollution; Animals; Benzopyrenes; Enzyme Induction; Heterocyclic Compounds; Liver; Male; Mixed Function Oxygenases; Neoplasms; Nitrogen; Rats | 1968 |
[Results of tumor-cell kinetic studies within the scope of puncture cytology].
Topics: Acridines; Antineoplastic Agents; Ascitic Fluid; Autoradiography; Biopsy; Cell Movement; Female; Gold Isotopes; Histocytochemistry; Humans; Mitosis; Neoplasm Metastasis; Neoplasms; Neoplastic Cells, Circulating; Pleural Effusion; Thymidine; Tritium | 1972 |
[Dissemination of bacteria with multiple drug resistance in patients in the Oncological Clinic].
Topics: Acridines; Anti-Bacterial Agents; Bacteria; Bacteriophage Typing; Chloramphenicol; Chlortetracycline; Coloring Agents; Erythromycin; Erythromycin Ethylsuccinate; Escherichia coli; Humans; Neomycin; Neoplasms; Oxacillin; Oxytetracycline; Penicillin Resistance; Pseudomonas aeruginosa; Staphylococcus; Streptococcus; Streptomycin; Sulfathiazoles | 1967 |
[Preliminary evaluation of the toxicity of C-283 compound used intravenously].
Topics: Acridines; Aged; Antineoplastic Agents; Humans; Injections, Intravenous; Kidney; Liver; Middle Aged; Neoplasms; Nitro Compounds; Phlebitis; Propylamines | 1971 |
The early interference of liver carcinogens with protein synthesis and its possible bearing on the problem of tumor induction.
Topics: Acridines; Animals; Carbon Isotopes; Carbon Tetrachloride; Carcinogens; Centrifugation, Density Gradient; Chromatography, Gel; Electrophoresis, Disc; In Vitro Techniques; Liver; Macromolecular Substances; Mice; Microsomes, Liver; Neoplasms; Orotic Acid; Peptide Chain Initiation, Translational; Phenylalanine; Potassium Chloride; Protein Biosynthesis; Rats; Ribosomes; RNA; RNA, Messenger | 1971 |
[Acridine fluorescence in exfoliative cytodiagnosis].
Topics: Acridines; Cytodiagnosis; Humans; Methods; Microscopy, Fluorescence; Neoplasms | 1969 |
[Acridine orange fluorochromation of neoplasms in histological slides in relation to cytodiagnosis].
Topics: Acridines; Aged; Cytodiagnosis; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Neoplasms | 1966 |
[The significance of cytological examinations under fluorescence microscope for diagnosis and surgical treatment of maignant tumours. I].
Topics: Acridines; Breast Neoplasms; Colonic Neoplasms; Cytodiagnosis; Esophageal Neoplasms; Humans; Lung Neoplasms; Microscopy, Fluorescence; Neoplasms; Stomach Neoplasms | 1970 |
[The significance of cytological examinations under fluorescence microscope for diagnosis and surgical treatment of malignant tumours. II].
Topics: Acridines; Adolescent; Adult; Aged; Cytodiagnosis; Esophageal Neoplasms; Female; Humans; Intestinal Neoplasms; Lung Neoplasms; Male; Microscopy, Fluorescence; Middle Aged; Neoplasm Metastasis; Neoplasms; Neoplastic Cells, Circulating; Stomach Neoplasms | 1970 |
Fluorescence microscope and electron-microscope studies on the effect of trenimon on human tumour cells.
Topics: Acridines; Cell Nucleolus; Endoplasmic Reticulum; Exudates and Transudates; Golgi Apparatus; Humans; Inhalation; Lysosomes; Microscopy, Electron; Microscopy, Fluorescence; Mitochondria; Neoplasms; Ribosomes; RNA, Neoplasm; Triaziquone | 1968 |
Fluorescence cystoscopy.
Topics: Acridines; Cystoscopy; Fluorescence; Humans; Neoplasms; Tetracycline; Ultraviolet Rays | 1966 |