acridines has been researched along with Acute Confusional Senile Dementia in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 2 (7.14) | 18.2507 |
| 2000's | 3 (10.71) | 29.6817 |
| 2010's | 13 (46.43) | 24.3611 |
| 2020's | 9 (32.14) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, CY; Chen, LC; Chen, YY; Chu, JC; Hsu, KC; Huang, WJ; Lin, MH; Lin, TE; Pan, SL; Shiao, YJ; Su, CJ; Tseng, HJ; Wang, CY; Yang, YC | 1 |
| Huang, G; Zhou, S | 1 |
| Czarnecka, K; Kręcisz, P; Maciejewska, K; Niedziałek, D; Skibiński, R; Szymański, P; Wieczorek, G | 1 |
| Hroch, M; Karasova-Zdarova, J; Korabecny, J; Mezeiova, E; Mzik, M; Pejchal, J; Sestak, V | 1 |
| Piplani, P; Sharma, A | 1 |
| Chen, L; Chen, Y; Duan, Y; Feng, F; Huang, J; Jiang, X; Liu, C; Liu, W; Qu, W; Sun, H; Wang, Y; Zhou, J | 1 |
| Askari, N; Fathi Hafshejani, S; Hatami, M; Kermani, ET; Lotfi, S; Mortazavi, M; Pouramiri, B; Pourjamali, N; Rahmani, T; Rezvannejad, E; Zahedifar, M | 1 |
| Cao, Y; Dai, Y; Liu, W; Liu, Z; Ping, Y; Qu, S; Tao, Z; Wang, D; Wang, X; Yu, P; Zhang, L | 1 |
| Abdallah, IM; Al-Shami, KM; Kaddoumi, A; Yang, E | 1 |
| Bajda, M; Czarnecka, K; Girek, M; Jończyk, J; Kabziński, J; Majsterek, I; Malawska, B; Mikiciuk-Olasik, E; Skibiński, R; Szymański, P | 1 |
| Bachurin, SO; Boltneva, NP; Charushin, VN; Chupakhin, ON; Lushchekina, SV; Makhaeva, GF; Richardson, RJ; Rudakova, EV; Serebryakova, OG; Shchepochkin, AV; Ustyugov, AA | 1 |
| Bajda, M; Chufarova, N; Czarnecka, K; Girek, M; Halczuk, K; Jończyk, J; Kabziński, J; Maciejewska, K; Majsterek, I; Skibiński, R; Szymański, P | 1 |
| Chufarova, N; Cuchra, M; Czarnecka, K; Majsterek, I; Skibiński, R; Szymański, P | 1 |
| Bajda, M; Czarnecka, K; Girek, M; Gumieniczek, A; Jończyk, J; Malawska, B; Mikiciuk-Olasik, E; Olszewska, P; Sikora, J; Skibiński, R; Szymański, P | 1 |
| Akbarzadeh, T; Edraki, N; Foroumadi, A; Karimpor-Razkenari, E; Khanavi, M; Mahdavi, M; Moghadam, FH; Najafi, Z; Sabourian, R; Saeedi, M; Shafiee, A; Sharifzadeh, M; Tehrani, MB | 1 |
| Barthel, A; Böhm, G; Csuk, R; Kluge, R; Raschke, C; Ströhl, D; Trieschmann, L | 1 |
| Bauer, U; Elsinghorst, PW; Grosche, J; Gütschow, M; Härtig, W; Hoffmann, A; Kacza, J; Paulke, BR | 1 |
| Dohnal, V; Fisar, Z; Holas, O; Hroudova, J; Jun, D; Korabecny, J; Kuca, K; Musilek, K; Nachon, F; Nepovimova, E; Opletalova, V; Patocka, J; Zemek, F | 1 |
| Antosova, A; Biscarini, F; Bystrenova, E; Chelli, B; Gazova, Z; Imrich, J; Kristian, P; Siposova, K; Valle, F; Vilkova, M | 1 |
| Andrieux, K; Brambilla, D; Couvreur, P; Hashemi, SH; Le Droumaguet, B; Moghimi, SM; Nicolas, J; Wu, LP | 1 |
| Karpiński, A; Mikiciuk-Olasik, E; Szymanski, P | 1 |
| Markowicz, M; Mikiciuk-Olasik, E; Szymański, P | 1 |
| Cui, Y; Gu, J; Liang, Y; Wang, D; Xu, J; Zhang, D; Zhao, X | 1 |
| Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T | 1 |
| Candelora, K; Marsh, GM; Summers, WK; Viesselman, JO | 1 |
| Cavalli, A; Hansch, C; Recanatini, M | 1 |
| Findeis, MA | 1 |
| Butterfield, DA; Rangachari, A | 1 |
4 review(s) available for acridines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
The biological activities of butyrylcholinesterase inhibitors.
Topics: Acridines; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Methoxsalen; Structure-Activity Relationship | 2022 |
Acridine: A Scaffold for the Development of Drugs for Alzheimer's Disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Neurodegenerative Diseases | 2023 |
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biocompatible Materials; Biomarkers; Brain; Chromones; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetite Nanoparticles; Nanoparticles; Thiazoles | 2011 |
Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Congo Red; Doxorubicin; Drug Design; Humans; Molecular Structure; Neurofibrillary Tangles; Peptide Fragments; Polymers; Protein Binding; Rifampin | 2000 |
1 trial(s) available for acridines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
A single-center, randomized, open-label, dose-escalation study to evaluate the pharmacokinetics of tacrine analogue octahydrogenacridine succinate tablets in healthy Chinese subjects.
Topics: Acridines; Adult; Aged; Alzheimer Disease; China; Dose-Response Relationship, Drug; Female; Humans; Intestinal Absorption; Male; Reference Values; Succinates; Tablets; Tacrine | 2012 |
23 other study(ies) available for acridines and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Synthesis and biological evaluation of acridine-based histone deacetylase inhibitors as multitarget agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Mice; Molecular Structure; Peptide Fragments; Protein Aggregates; Structure-Activity Relationship; Tumor Cells, Cultured | 2020 |
Novel Cyclopentaquinoline and Acridine Analogs as Multifunctional, Potent Drug Candidates in Alzheimer's Disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2022 |
UHPLC-HRMS study of pharmacokinetics of a novel hybrid cholinesterase inhibitor K1234: A comparison between in silico, in vitro and in vivo data.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Mice | 2022 |
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glycogen Synthase Kinase 3; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Morris Water Maze Test; Phosphorylation; Protein Conformation; tau Proteins; Thiazoles | 2020 |
Design, synthesis and biological assessment of acridine derivatives containing 1,3,4-thiadiazole moiety as novel selective acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Cholinesterase Inhibitors; Drug Design; Enzyme Activation; Hep G2 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Protein Binding; Tacrine; Thiadiazoles | 2020 |
Determination of plasma β-amyloids by rolling circle amplification chemiluminescent immunoassay for noninvasive diagnosis of Alzheimer's disease.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Immobilized; Biomarkers; DNA Probes; DNA, Single-Stranded; Humans; Immunoassay; Limit of Detection; Luminescent Agents; Luminescent Measurements; Nucleic Acid Amplification Techniques; Reproducibility of Results | 2021 |
Blood-Brain Barrier Disruption Increases Amyloid-Related Pathology in TgSwDI Mice.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; Blood-Brain Barrier; Brain; Cell Line; Disease Models, Animal; Immunoglobulin G; Immunohistochemistry; Male; Matrix Metalloproteinase 9; Mice; Mice, Transgenic; NF-kappa B; Signal Transduction; Synapses; Tetrahydroisoquinolines; Tight Junctions | 2021 |
Tetrahydroacridine derivatives with fluorobenzoic acid moiety as multifunctional agents for Alzheimer's disease treatment.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzoates; Cholinesterase Inhibitors; Cholinesterases; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2017 |
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Horses; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2017 |
Tetrahydroacridine derivatives with dichloronicotinic acid moiety as attractive, multipotent agents for Alzheimer's disease treatment.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Models, Molecular; Molecular Structure; Nicotinic Acids; Structure-Activity Relationship; Tumor Cells, Cultured | 2018 |
New tacrine-acridine hybrids as promising multifunctional drugs for potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Computer Simulation; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Inhibitory Concentration 50; Molecular Docking Simulation; Structure-Activity Relationship; Tacrine | 2018 |
Synthesis, biological evaluation and molecular modeling of new tetrahydroacridine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acridines; Alzheimer Disease; Cholinesterase Inhibitors; Drug Design; Humans; Models, Molecular; Structure-Activity Relationship | 2015 |
Design and synthesis of novel anti-Alzheimer's agents: Acridine-chromenone and quinoline-chromenone hybrids.
Topics: Acridines; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Chromones; Dose-Response Relationship, Drug; Drug Design; Humans; Models, Molecular; Molecular Structure; Neuroprotective Agents; PC12 Cells; Quinolines; Rats; Structure-Activity Relationship | 2016 |
Synthesis of monomeric and dimeric acridine compounds as potential therapeutics in Alzheimer and prion diseases.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Dimerization; Drug Evaluation, Preclinical; Humans; In Vitro Techniques; Molecular Structure; Prion Diseases; Prions | 2009 |
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Topics: Acridines; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Cholinesterase Inhibitors; Chromones; Disease Models, Animal; Drug Delivery Systems; Enbucrilate; Fluorescent Dyes; Hippocampus; Humans; Mice; Mice, Transgenic; Nanoparticles; Plaque, Amyloid; Polymethacrylic Acids; Polystyrenes; Presenilin-1; tau Proteins | 2010 |
Synthesis and in vitro evaluation of N-(Bromobut-3-en-2-yl)-7-methoxy-1,2,3,4-tetrahydroacridin-9-amine as a cholinesterase inhibitor with regard to Alzheimer's disease treatment.
Topics: Acridines; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Drug Evaluation, Preclinical; Heterocyclic Compounds, 3-Ring; Humans; Tacrine | 2010 |
Structure-activity relationship of acridine derivatives to amyloid aggregation of lysozyme.
Topics: Acridines; Alzheimer Disease; Amyloid; Animals; Cell Line; Cell Survival; Chickens; DNA; Humans; Inhibitory Concentration 50; Muramidase; Structure-Activity Relationship | 2011 |
Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Benzoates; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Drug Stability; Enzyme Activation; Humans; Hydrolysis; Kinetics; Limit of Detection; Oxidation-Reduction; Sensitivity and Specificity; Spectroscopy, Fourier Transform Infrared; Structure-Activity Relationship; Tacrine | 2011 |
Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Cholinesterase Inhibitors; Enzyme Activation; Humans; Kinetics; Niacin; Tacrine | 2011 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Use of THA in treatment of Alzheimer-like dementia: pilot study in twelve patients.
Topics: Acridines; Adult; Aged; Alzheimer Disease; Dementia; Drug Evaluation; Female; Humans; Male; Memory; Middle Aged; Pilot Projects; Receptors, Cholinergic; Tacrine | 1981 |
A comparative QSAR analysis of acetylcholinesterase inhibitors currently studied for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Benzylamines; Brain; Cholinesterase Inhibitors; Drug Design; Electrophorus; Erythrocytes; Humans; Mathematics; Mice; Molecular Structure; Physostigmine; Rats; Structure-Activity Relationship | 1997 |
Membrane-altering effects of velnacrine and N-methylacridinium: relevance to tacrine and Alzheimer's disease.
Topics: Acridines; Alzheimer Disease; Cytoskeletal Proteins; Cytoskeleton; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Humans; In Vitro Techniques; Protein Binding; Structure-Activity Relationship; Tacrine | 1992 |