aconitine and Tachycardia--Supraventricular

Cross-over trial studied comparative effectiveness and tolerance of allapinine, rhythmonorm and isoptine in patients with paroxysmal supraventricular tachycardia (PSVT). Treatment effects did not differ much. Analysis of the preventive efficiency of the above drugs with reference to PSVT form has demonstrated that in paroxysmal atrioventricular reciprocal tachycardia the highest activity was shown by isoptine and rhythmonorm, in paroxysmal orthodromic reciprocal tachycardia--by rhythmonorm and allapinin. In long-term therapy, a preventive effects of allapinin, rhythmonorm and isoptine achieved at short-term course therapy persisted in 90.9, 95.6 and 81.5% patients, respectively. All the above drugs cause moderate inhibition of atrioventricular and intraventricular conduction. Isoptin had the best tolerance.

Topics: Aconitine; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cross-Over Studies; Female; Humans; Male; Middle Aged; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil

Platelet aggregability was studied in 81 patients with prior myocardial infarction with various cardiac arrhythmias and its effects of some antiarrhythmic agents (allapinine, ethacizine, obsidan and cordarone). It was 32-39% higher in patients with frequent ventricular extrasystole (VE) and VE of high grades (4a and 4b by the classification of Lown and Wolt) than in control patients (without arrhythmias) and patients with supraventricular and rare VE. Ethacizine and cordarone produced a significant inhibitory effects on platelet functional activity, but the effects of allapinine and obsidan on this parameter were insignificant. There was no correlation between the magnitude of antiarrhythmic effects of the drugs and their antiaggregatory properties. It was shown that the results of examining the effects of antiarrhythmic agents on platelet aggregability in vitro were not in agreement with those obtained in vivo.

Topics: Aconitine; Adult; Amiodarone; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Heart Rate; Humans; Male; Middle Aged; Phenothiazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Propranolol; Tachycardia, Supraventricular

A double blind randomized cross-over study was conducted to analyze antiarrhythmic activity of the new Soviet drugs allapinin , ethacizine in comparison with mexitil. Altogether 33 patients with ventricular disorders of cardiac rhythm of high gradations after Lown B. were investigated including patients with paroxysmal ventricular tachycardia. The authors managed to establish and compare the group antiarrhythmic efficacy and safety of each drug, and to assess a degree of selective efficacy of each of them.

Topics: Aconitine; Aconitum; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Mexiletine; Middle Aged; Phenothiazines; Random Allocation; Tachycardia, Ectopic Junctional; Tachycardia, Paroxysmal; Tachycardia, Supraventricular

Doppler echocardiography is an excellent tool to study the hemodynamic effects of cardiac drugs. Resting and exercise effects produced by metoprolol and allapinin on Doppler-derived measures of left ventricular (LV) performance were examined in patients with paroxysmal supraventricular tachycardias. Seventeen patients underwent continuous wave Doppler examination from the suprasternal notch at rest and during each stage of a standard exercise protocol. The study was repeated following 3-4 days of treatment with metoprolol given in a daily dose of 200 mg. The hemodynamic effects of allapinin, 100 mg daily, were evaluated in the same manner in 8 patients. With metoprolol, all resting Doppler measurements were altered insignificantly and all Doppler--derived parameters of aortic flow (peak, velocity, mean acceleration, cardiac index and LV ejection force) were much lower at the maximum exercise. Allapinin failed to alter any Doppler measurements of aortic blood flow at rest or during the peak exercise.

Topics: Aconitine; Adolescent; Adult; Echocardiography, Doppler; Exercise Test; Hemodynamics; Humans; Metoprolol; Middle Aged; Rest; Tachycardia, Paroxysmal; Tachycardia, Supraventricular

Pharmacokinetics of allapinin tablets, used as a single dose, alone or in combination with other antiarrhythmic drugs (cordarone, mexitil, ritmilen) were assessed in 11 patients with frequent extrasystoles. Allapinin pharmacokinetic pattern was basically similar in patients in whom it was very effective and those in whom it had no effect. Combined use of the above-mentioned antiarrhythmic drugs and allapinin did not affect the latter's pharmacokinetic parameters. Allapinin pharmacokinetics can be described using a one-part model.

Topics: Aconitine; Aconitum; Cardiac Complexes, Premature; Dose-Response Relationship, Drug; Humans; Tablets; Tachycardia, Supraventricular; Time Factors