aconitine and Skin-Neoplasms

aconitine has been researched along with Skin-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for aconitine and Skin-Neoplasms

Article	Year
In vitro and in vivo anticancer activity of aconitine on melanoma cell line B16. Molecules (Basel, Switzerland), 2013, Jan-08, Volume: 18, Issue:1 The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future. Topics: Aconitine; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Inhibitory Concentration 50; Melanoma, Experimental; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays	2013

Article

Year

In vitro and in vivo anticancer activity of aconitine on melanoma cell line B16.

Molecules (Basel, Switzerland), 2013, Jan-08, Volume: 18, Issue:1

The anti-tumor effect of aconitine in melanoma cell line B16 has been studied in this paper. We found that B16 cells showed significantly reduced growth rates and increased apoptotic effects in the presence of aconitine. Furthermore, aconitine inhibited the PI3K/AKT and MAPK/ERK1/2 signaling pathways, thus regulating the levels of protein and mRNA of PCNA and apoptotic related signaling molecules. Above all, we found that aconitine showed an anti-melanoma effect in suppressing tumor growth in vivo. In conclusion, we show that aconitine may be a useful anticancer drug in the future.

Topics: Aconitine; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Humans; Inhibitory Concentration 50; Melanoma, Experimental; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Tumor Burden; Xenograft Model Antitumor Assays

2013