aconitine and Drug-Overdose

Patients who overdose on aconite can present with life-threatening ventricular arrhythmia. Aconite must be prepared and used with caution to avoid cardiotoxic effects that can be fatal. We herein describe a case of a patient who had an accidental aconite overdose but survived with no lasting effects. The patient had prepared Chinese herbal medication to treat his pain, which resulted in an accidental overdose of aconite with cardiotoxic and neurotoxic effects. The patient had ventricular tachycardia, bidirectional ventricular tachycardia and ventricular fibrillation. Following treatment with anti-arrhythmic medications, defibrillation and cardiopulmonary resuscitation, he made an uneventful recovery, with no further cardiac arrhythmias reported.

Topics: Aconitine; Adult; Anti-Arrhythmia Agents; Cardiopulmonary Resuscitation; Cardiotoxicity; Drug Overdose; Drugs, Chinese Herbal; Electric Countershock; Electrocardiography; Humans; Male; Tachycardia; Tachycardia, Ventricular; Treatment Outcome; Ventricular Fibrillation

Topics: Aconitine; Aconitum; Adult; Combined Modality Therapy; Drug Overdose; Female; Humans; Male; Medicine, Korean Traditional; Middle Aged; Plant Extracts; Plant Leaves; Plant Roots; Treatment Outcome

Topics: Aconitine; Arrhythmias, Cardiac; Drug Overdose; Drugs, Chinese Herbal; Female; Humans; Middle Aged; Quadriplegia; Sodium Channels