acivicin and Neoplasms

acivicin has been researched along with Neoplasms in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19906 (50.00)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Brumby, AM; Humbert, PO; Manning, SA; Parisot, JP; Richardson, HE; Schlosser, T; Street, IP; Willoughby, LF1
Weber, G1
Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ1
Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S1
Bruno, S; McGovren, JP; Neil, GL; Penta, J; Poster, DS1
Kufe, DW; McGovren, JP; Schade, D; Weiss, GR1
Souba, WW1
Baruchel, S; Bell, B; Bernstein, M; Devine, S; Dubowy, R; Grier, H; Kretschmar, C; Langevin, AM; Vietti, T; Whitehead, VM1
Brown, T; Hidalgo, M; Kuhn, JG; MacGovren, JP; Rodriguez, G; Rowinsky, EK; Von Hoff, DD; Weiss, G1
Doi, H; Komatsu, H; Nishihira, T; Satomi, S1
Alberti, D; Bruggink, J; Earhart, RH; Fischer, PH; Hamilton, RD; Koeller, JM; Simon, K; Tormey, DC; Tutsch, K; Willson, JK1

Reviews

5 review(s) available for acivicin and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.
    Cancer research, 1983, Volume: 43, Issue:8

    Topics: Adenosine Monophosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Deoxyribonucleotides; Gene Expression Regulation; Gluconeogenesis; Guanosine Monophosphate; Humans; Inosine Monophosphate; Isoxazoles; Kidney Neoplasms; Liver Neoplasms; Liver Regeneration; Models, Biological; Neoplasms; Purines; Pyrimidines; Ribonucleotides

1983
Acivicin. An antitumor antibiotic.
    Cancer clinical trials, 1981,Fall, Volume: 4, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Glycine; Humans; Isoxazoles; Neoplasms; Neoplasms, Experimental; Oxazoles

1981
Glutamine and cancer.
    Annals of surgery, 1993, Volume: 218, Issue:6

    Topics: Antimetabolites, Antineoplastic; Cell Division; Diazooxonorleucine; Glutamine; Humans; Intestinal Mucosa; Intestines; Isoxazoles; Lymphocytes; Muscles; Neoplasms; Parenteral Nutrition, Total; Randomized Controlled Trials as Topic

1993
[Anti-cancer therapy with amino acid imbalance].
    Nihon rinsho. Japanese journal of clinical medicine, 2001, Volume: 59 Suppl 5

    Topics: Amino Acids; Antimetabolites, Antineoplastic; Arginine; Asparagine; Glutamine; Humans; Isoxazoles; Methionine; Neoplasms; Valine

2001

Trials

2 trial(s) available for acivicin and Neoplasms

ArticleYear
A phase I study of acivicin in refractory pediatric solid tumors. A Pediatric Oncology Group study.
    Investigational new drugs, 1995, Volume: 13, Issue:3

    Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Enzyme Inhibitors; gamma-Glutamyltransferase; Humans; Injections, Intravenous; Isoxazoles; Neoplasms; Tumor Cells, Cultured

1995
A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:11

    Topics: Adult; Aged; Amino Acids; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Electrolytes; Female; Glucose; Glutamine; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Parenteral Nutrition Solutions; Solutions; Thrombocytopenia; Treatment Outcome

1998

Other Studies

5 other study(ies) available for acivicin and Neoplasms

ArticleYear
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.
    Disease models & mechanisms, 2013, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Benzamides; Biological Availability; Cell Proliferation; Cytidine Triphosphate; Diphenylamine; Drosophila melanogaster; Drug Screening Assays, Antitumor; Glutamine; Isoxazoles; Neoplasms; Pharmacogenetics; Pilot Projects

2013
Acivicin: a new glutamine antagonist in clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental

1984
Phase I evaluation of AT-125 single dose every three weeks.
    Investigational new drugs, 1984, Volume: 2, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles

1984
Phase I and pharmacological study of acivicin by 24-hour continuous infusion.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Antimetabolites; Digestive System; Drug Evaluation; Humans; Infusions, Parenteral; Isoxazoles; Kinetics; Neoplasms; Nervous System; Oxazoles

1982
Phase I clinical trial of a combination of dipyridamole and acivicin based upon inhibition of nucleoside salvage.
    Cancer research, 1988, Oct-01, Volume: 48, Issue:19

    Topics: Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Dipyridamole; Drug Evaluation; Humans; Isoxazoles; Leukocyte Count; Metabolic Clearance Rate; Neoplasms; Nucleosides

1988