acid-phosphatase and Ureteral-Obstruction

Topics: Acid Phosphatase; Adenocarcinoma; Administration, Oral; Castration; Clinical Trials as Topic; Diethylstilbestrol; Evaluation Studies as Topic; Humans; Male; Neoplasm Metastasis; Pain; Placebos; Prostatic Neoplasms; Time Factors; Ureteral Obstruction

Topics: Acid Phosphatase; Animals; Epithelium; Male; Rats; Rats, Inbred Strains; Ureter; Ureteral Obstruction

Ureteral obstruction occurred in 10% of the patients treated for prostatic carcinoma and most often was associated with poorly differentiated tumors. The response of ureteral obstruction to different forms of therapy was evaluated. Obstruction diminished in 22 of 25 orchiectomized patients (88%) but in only 1 of 6 patients receiving estrogen or antiandrogen therapy alone (17%). Patients who responded favorably to therapy had a significantly better survival than did non-responders. Patients treated early in the course of ureteral obstruction responded better than those treated late, while neither tumor stage nor grade correlated with response to therapy. Radiation therapy for endocrine-resistant ureteral obstruction was effective in only 2 of 8 cases (25%). The literature on ureteral obstruction from prostatic carcinoma and its treatment is reviewed.

Topics: Acid Phosphatase; Androgen Antagonists; Castration; Cyproterone; Diethylstilbestrol; Estrogens; Humans; Male; Maryland; Prostatic Neoplasms; Remission, Spontaneous; Time Factors; Ureteral Obstruction

Topics: Acid Phosphatase; Alkaline Phosphatase; Clinical Enzyme Tests; Hydronephrosis; Kidney Tubules; Nephrectomy; Pathology; Rats; Research; Ureteral Obstruction

Topics: Acid Phosphatase; Alkaline Phosphatase; Electron Transport Complex II; Kidney; Ligation; Rats; Research; Succinate Dehydrogenase; Ureteral Obstruction