acid-phosphatase and Testicular-Diseases

Topics: Acid Phosphatase; alpha-Glucosidases; Anticoagulants; Biomarkers; Carnitine; Citrates; Citric Acid; Diagnosis, Differential; Epididymitis; Fructose; Humans; Male; Oligospermia; Pancreatic Elastase; Spermatozoa; Testicular Diseases; Zinc

Topics: Acid Phosphatase; Animals; Body Fluids; Bulbourethral Glands; Cattle; Citrates; Dihydrotestosterone; Dogs; Fructose; Humans; Inositol; Male; Potassium; Prostaglandins; Prostate; Prostatic Neoplasms; Proteins; Putrescine; Rats; Secretory Rate; Semen; Seminal Vesicles; Species Specificity; Spermatozoa; Spermine; Swine; Testicular Diseases; Testosterone

Lead poisoning is a worldwide health problem, and its treatment is under investigation. The aim of this study was to access the efficacy of Coriandrum sativum (coriander) in reducing lead-induced changes in mice testis. Animal exposed to lead nitrate showed significant decrease in testicular SOD, CAT, GSH, total protein, and tissue lead level. This was accompanied by simultaneous increase in the activities of LPO, AST, ALT, ACP, ALP, and cholesterol level. Serum testosterone level and sperm density were suppressed in lead-treated group compared with the control. These influences of lead were prevented by concurrent daily administration of C. sativum extracts to some extent. Treating albino mice with lead-induced various histological changes in the testis and treatment with coriander led to an improvement in the histological testis picture. The results thus led us to conclude that administration of C. sativum significantly protects against lead-induced oxidative stress. Further work need to be done to isolate and purify the active principle involved in the antioxidant activity of this plant.

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Catalase; Cholesterol; Coriandrum; Dose-Response Relationship, Drug; Glutathione; Lead; Lipid Peroxidation; Male; Mice; Nitrates; Oxidative Stress; Phytotherapy; Plant Extracts; Seeds; Sperm Count; Superoxide Dismutase; Testicular Diseases; Testis; Testosterone; Treatment Outcome

In the last few years, a marked decrease in male fertility has been reported. Environmental factors were recently suspected for this effect. Among those factors is the misuse of drugs and in particular antibiotics. Quinolones are a group of antibacterial agents with broad-spectrum activity. Testicular impairment of some quinolone members is controversial; a matter which stimulated our attention to investigate the adverse testicular effects of the most familiar quinolone members, namely: ofloxacin, ciprofloxacin and pefloxacin. They were given to rats in doses of 72, 135 and 72 mg kg(-1) day(-1) p.o., respectively, for 15 consecutive days. Ofloxacin was also used to establish a dose-response relationship in doses of 36, 72 and 360 mg kg(-1) day(-1) p.o. for 15 consecutive days. Results revealed that ofloxacin, ciprofloxacin and pefloxacin reduced testicular LDH-X activity by 39.8%, 62.7% and 60.7%, respectively. Moreover, sperm count, motility and daily sperm production were markedly decreased. Ofloxacin induced a dose-dependent decrease in testicular LDH-X activity, sperm count and motility. Furthermore, daily sperm production showed a marked reduction which amounted to 26.1% and 40. 0% following administration of ofloxacin (72, 360 mg kg(-1) day(-1) x 15 days), respectively. Moreover, administration of ofloxacin resulted in marked testicular histopathological changes. It is concluded that, ofloxacin, ciprofloxacin and pefloxacin significantly impaired both testicular function and structure in rats.

Topics: Acid Phosphatase; Animals; Anti-Infective Agents; Ciprofloxacin; Fertility; L-Lactate Dehydrogenase; Male; Ofloxacin; Organ Size; Pefloxacin; Prostate; Rats; Sperm Count; Sperm Motility; Testicular Diseases; Testis

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Cholesterol; Epididymis; Glycogen; Male; Mice; Phosphamidon; Sperm Motility; Spermatozoa; Testicular Diseases

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Diethylhexyl Phthalate; Dihydrolipoamide Dehydrogenase; Glucosephosphate Dehydrogenase; Male; Phthalic Acids; Rats; Rats, Inbred Strains; Succinate Dehydrogenase; Testicular Diseases; Testis

With the aim of gaining knowledge about the lysosomal apparatus of the rat epididymis, four acid hydrolases were analysed in homogenates of the whole organ and, in other experiments, in separated segments: proximal and distal caput, corpus and cauda. The activities were similar to those in the liver, and they were 50% recovered in a cytosol of 43 000 g x 60 min. Ten days after castration all segments showed similar changes, the activities of beta-glucuronidase and cathepsin D increased above normal levels while those of DNAase and acid phosphatase were found slightly decreased. After vasectomy region I (caput and corpus) showed decreased beta-glucuronidase activity and increased acid phosphatase activity. The activity of cathepsin D increased in both regions. In cryptorchid rats (90 days) the epididymis greatly decreased in weight, the activities of acid phosphatase and DNAase slightly decreased in region II (cauda) and in region I, respectively. In the abdominal epididymis (90 days) only region II decreased in weight. DNAase activity decreased in region I while cathepsin D did so in both regions. The results showed that a) the enzymes behave quite independently from each other, suggesting the existence of a specific regulation for each of them b) there were characteristic changes in enzymatic activity for each experimental condition.

Topics: Acid Phosphatase; Animals; Castration; Cathepsin D; Cathepsins; Cryptorchidism; Deoxyribonucleases; Epididymis; Glucuronidase; Male; Organ Size; Rats; Subcellular Fractions; Testicular Diseases; Vasectomy

Topics: 17-Ketosteroids; Acid Phosphatase; Adult; Alcoholic Intoxication; Alkaline Phosphatase; Humans; Male; Middle Aged; Sperm Count; Testicular Diseases

Topics: Acid Phosphatase; Adrenal Glands; Animal Nutritional Physiological Phenomena; Animals; Ascorbic Acid; Atrophy; Body Weight; Deoxyribonucleases; Fatty Acids, Unsaturated; Hyaluronoglucosaminidase; Hydrogen-Ion Concentration; Hydrolases; Liver; Male; Organ Size; Rats; Testicular Diseases; Testis; Vitamin A; Vitamin A Deficiency

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Glucosyltransferases; Humans; Infertility, Male; Leucyl Aminopeptidase; Male; NAD; Nucleosides; Nucleotidyltransferases; Oxidoreductases; Phosphoric Monoester Hydrolases; Spermatozoa; Succinate Dehydrogenase; Testicular Diseases; Transferases

Topics: Acid Phosphatase; Animals; Diet; Female; Galactosidases; Glucuronidase; Hydrolases; Liver Diseases; Lysosomes; Male; Necrosis; Rats; Testicular Diseases; Testis; Vitamin E Deficiency

Topics: Acid Phosphatase; Adult; Atrophy; Fructose; Glucuronidase; Humans; Male; Semen; Spermatozoa; Testicular Diseases