acid-phosphatase and Stomach-Ulcer

Topics: Acid Phosphatase; Acute Disease; Adult; Aged; Alkaline Phosphatase; Cathepsin B; Cathepsin C; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Duodenal Ulcer; Humans; Leukocytes; Lysosomes; Middle Aged; Peptic Ulcer Hemorrhage; Stomach Ulcer

Autotransfusion of hemosorbent-treated blood was used as a method of stimulation of reparative regeneration processes in 52 patients with continuously non-healing gastric ulcers. In 35 patients (67%) the ulcers cicatrized during the first 2 weeks of the posttransfusion period. The investigation of the enzymatic status of neutrophils showed that autotransfusion of sorbent blood raised the functional activity of neutrophils and the cation protein level in them which could promote the cleansing of the ulcer surface from necrotic masses and intensify processes of cicatrization.

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Blood Transfusion, Autologous; Carboxylic Ester Hydrolases; Female; Hemoperfusion; Humans; Male; Middle Aged; Neutrophils; Peroxidases; Stomach Ulcer; Wound Healing

In examination of 51 patient with acute gastrointestinal bleeding of ulcer etiology, the activity of lysosomal enzymes, peroxide oxidation of lipids were increased, the activity of antioxidant system was decreased. This can lead to inhibition of proliferative processes, stipulating the severity of blood loss, course of the postoperative period, the incidence of postoperative complications, and lethality.

Topics: Acid Phosphatase; Acute Disease; Adult; Aged; Cathepsin D; Deoxyribonucleases; Duodenal Ulcer; Enzyme Activation; Humans; Lipid Peroxidation; Lysosomes; Middle Aged; Peptic Ulcer Hemorrhage; Ribonucleases; Stomach Ulcer

Lysosomes are known to be implicated in many disease states in both humans and animals. In order to assess the possible role of lysosomes in the aetiology of human gastric ulceration, lysosomal enzyme levels and some of their properties were determined in human gastric antrum and in three discrete porcine gastric regions. Of the four regions investigated, the strongest similarity emerged between the enzymes of the porcine pyloric gland area and those of the human antrum. These data suggest that the pyloric gland is an appropriate model tissue for a comparative in vitro study of lysosomal involvement in human gastric ulceration.

Topics: Acid Phosphatase; Animals; beta-Galactosidase; beta-N-Acetyl-Galactosaminidase; Galactosidases; Hexosaminidases; Humans; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Pyloric Antrum; Species Specificity; Stomach; Stomach Ulcer; Swine

Experiments were performed on white rats with experimental acetate ulcer of the stomach and intestine. At the height of destruction of gastric mucosa tissue (60 minutes from the onset of ulcer formation) a consistent increase in acid phosphatase secretion was recorded. This process was accompanied, as a rule, by significant elevation of proteolytic activity (pH 6.5-7.0) in tissue extract obtained from the affected area. It is suggested that the increased proteolytic activity observed at pH 6.5-7.0 in the tissue extract from the ulcerous area is most likely related to the release of lysosomal proteases at the height of tissue destruction. It thus appears that ulcer of the gastric mucosa induced by acetic acid application is determined by interstitial proteolytic activity of cathepsins that are released during the destruction of lysosomal membranes.

Topics: Acid Phosphatase; Animals; Duodenal Ulcer; Female; Gastric Mucosa; Hydrogen-Ion Concentration; Male; Peptide Hydrolases; Rats; Stomach Ulcer

Topics: Acid Phosphatase; Adenocarcinoma; Alkaline Phosphatase; Aminopeptidases; Epithelium; Esterases; Gastric Mucins; Gastric Mucosa; Glucuronidase; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Oxidoreductases; Phosphoric Monoester Hydrolases; Stomach Neoplasms; Stomach Ulcer; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Autopsy; Burns; Cholinesterases; Colonic Diseases; Duodenal Ulcer; Esophagitis, Peptic; Gallbladder Diseases; Gastric Mucosa; Glycosaminoglycans; Histocytochemistry; Humans; Mucins; Nucleoproteins; Pharyngeal Diseases; Stomach Ulcer; Ulcer

Topics: Acid Phosphatase; Adrenal Cortex Hormones; Adrenal Glands; Animals; Dihydrolipoamide Dehydrogenase; Electron Transport Complex IV; Female; Gastric Mucosa; Histocytochemistry; L-Lactate Dehydrogenase; Male; NAD; Rabbits; Stomach Ulcer; Succinate Dehydrogenase; Transplantation, Autologous

Topics: Acetylcholinesterase; Acid Phosphatase; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Amylases; Aspartate Aminotransferases; Cholinesterases; Diagnosis, Differential; Duodenal Ulcer; Humans; Hydrolases; Middle Aged; Stomach Neoplasms; Stomach Ulcer; Transaminases

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Animals; Antibody Formation; Antigens; Cholelithiasis; Female; Glucuronidase; Hexosaminidases; Histocytochemistry; Humans; Lupus Erythematosus, Systemic; Lymph Nodes; Lymphocytes; Male; Peroxidases; Plasma Cells; Rabbits; Rats; Sarcoidosis; Stomach Neoplasms; Stomach Ulcer; Tuberculosis

Topics: Acid Phosphatase; Animals; Dogs; Enteritis; Gastric Juice; Gastric Mucosa; Hemodynamics; Ileum; Intestinal Mucosa; Mesenteric Vascular Occlusion; RNA Nucleotidyltransferases; Shock, Hemorrhagic; Stomach Ulcer; Stress, Physiological; Trypsin

Topics: Acid Phosphatase; Animals; Dogs; Glucuronidase; Hydrogen-Ion Concentration; Intestinal Secretions; Models, Biological; Protease Inhibitors; Shock, Hemorrhagic; Stomach Ulcer; Trypsin

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Calcium; Chlorine; Dogs; Gastric Mucosa; Injections, Intramuscular; Intestine, Small; Parathyroid Hormone; Peptic Ulcer; Phosphorus; Potassium; Quinolines; Stomach Ulcer

Topics: Acid Phosphatase; Adrenocorticotropic Hormone; Aging; Alkaline Phosphatase; Animals; Anura; Appendicitis; Autonomic Nervous System; Cell Differentiation; Cortisone; Digestive System; Dogs; Electron Transport Complex IV; Esterases; Estrone; Fishes; Guinea Pigs; Histocytochemistry; Humans; Methods; Methyltestosterone; Myenteric Plexus; Neurons; Nucleic Acids; Polysaccharides; Protein Biosynthesis; Pyloric Stenosis; Radiation Injuries, Experimental; Rats; Sex Factors; Stomach Ulcer; Succinate Dehydrogenase