acid-phosphatase and Spinal-Neoplasms

This study evaluated the ability of bisphosphonate to prevent bone resorption induced by metastatic tumor cells.. Autopsy specimens of a bone metastasis from a woman with a primary squamous cell carcinoma of the tongue who developed multiple osteolytic lesions and hypercalcemia and was treated with pamidronate were studied histologically, histochemically, and ultrastructurally. In an animal experiment, cultured tumor cells (1 x 10(5)) obtained from a metastatic submandibular lymph node in the same patient were injected in the left ventricle of nude mice, and a resulting metastatic bone lesion was studied histologically and histochemically.. In the autopsy specimens, despite the presence of many resorption lacunae on bone surface, only a few small tartrate-resistant acid phosphatase (TRAPase)-positive cells were observed, and most of them were stained weakly and detached from the bone surface. In the animal experiment, 1 of 10 animals (10%) formed osteolytic bone metastasis, and many TRAPase-positive cells were observed histochemically.. Biphosphonate inhibits bone resorption induced by tumor, possibly by decreasing the number of osteoclasts and inhibiting their function.

Topics: Acid Phosphatase; Aged; Animals; Bone Neoplasms; Bone Resorption; Carcinoma, Squamous Cell; Diphosphonates; Female; Humans; Hypercalcemia; Isoenzymes; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Osteoclasts; Pamidronate; Spinal Neoplasms; Tartrate-Resistant Acid Phosphatase; Thoracic Vertebrae; Tongue Neoplasms; Tumor Cells, Cultured

The authors report a patient who was admitted to the hospital with neurologic symptoms and signs that were thought to be caused by a primary intracranial tumor.. Craniotomy resulted in successful resection of an occipital lobe tumor reported histologically as a papillary adenocarcinoma, probably metastatic from the kidney. However, a complete diagnostic study failed to demonstrate the primary focus.. Thirteen months later, the patient was readmitted to the hospital and found to have metastatic prostatic carcinoma. Immunoperoxidase staining for prostatic acid phosphatase of the prostatic tissue and of the previously resected brain tumor tissue indicated that the brain lesion was metastatic from the prostate.

Topics: Acid Phosphatase; Adenocarcinoma, Papillary; Aged; Brain Neoplasms; Carcinoembryonic Antigen; Humans; Lumbar Vertebrae; Male; Prostatic Neoplasms; Spinal Neoplasms; Tomography, X-Ray Computed

Topics: Acid Phosphatase; Autopsy; Carcinoma; Chromaffin System; Diagnosis, Differential; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Pheochromocytoma; Prostatic Neoplasms; Spinal Neoplasms; Urinary Bladder Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Extremities; Female; Histocytochemistry; Male; Mandibular Neoplasms; Mice; Neoplasms, Radiation-Induced; Osteoblasts; Osteoclasts; Osteosarcoma; Pelvis; Radium; Ribs; Sacrum; Sarcoma, Experimental; Skull Neoplasms; Spinal Neoplasms; Tail

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Bone Neoplasms; Breast Neoplasms; False Positive Reactions; Female; Humans; Iron Isotopes; Lung Neoplasms; Male; Mandibular Neoplasms; Mouth Neoplasms; Neoplasm Metastasis; Osteosarcoma; Pelvic Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Radionuclide Imaging; Spinal Neoplasms; Strontium Isotopes

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Biopsy; Carcinoma; Diethylstilbestrol; Duodenal Ulcer; Erectile Dysfunction; Humans; Male; Methods; Middle Aged; Neoplasm Metastasis; Palpation; Postoperative Complications; Prognosis; Prostatectomy; Prostatic Neoplasms; Spinal Neoplasms; Urinary Tract Infections; Urine