acid-phosphatase and Spinal-Cord-Diseases

Alterations in the dorsal root potential (DRP) which was evoked by stimulation of the common peroneal nerve of the rat, have been studied in the course of transganglionic degenerative atrophy (TDA) of primary sensory terminals in the upper dorsal horn. TDA was induced by perineural application of Vinca alkaloids around the sciatic nerve. In 9 to 30 days after this treatment, latency of DRP increased, whereas its amplitude and duration decreased. In this period, no C fibre response could be elicited. As a possible mechanism underlying the alterations of DRP, the functional consequences of atrophic changes of primary central afferent terminals are being discussed in terms of the close correlation between structure and function and the possible inferences of the electrophysiological reaction to the therapeutic application of Vinca alkaloids in the iontophoretic treatment of chronic intractable pain.

Topics: Acid Phosphatase; Animals; Atrophy; Electrophysiology; Histocytochemistry; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Diseases; Spinal Nerve Roots

Topics: Acid Phosphatase; Alkaline Phosphatase; Humans; Intervertebral Disc Displacement; Spinal Cord Diseases; Spinal Cord Neoplasms

Topics: Acetylcholinesterase; Acid Phosphatase; Animals; Axons; Cats; Cell Nucleus; Choline; Cytoplasmic Granules; Dihydrolipoamide Dehydrogenase; Endoplasmic Reticulum; Female; Galactosamine; Galactose; Glucosamine; Golgi Apparatus; Inclusion Bodies; Injections, Spinal; Lysosomes; Male; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Neuroglia; Neurons; Phagocytes; Spinal Cord; Spinal Cord Diseases; Sulfhydryl Compounds; Synapses

Topics: Acetylcholinesterase; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Amino Acids; Animals; Esterases; Ganglia, Spinal; Glucosephosphate Dehydrogenase; Male; Niacinamide; Oxidoreductases; Rats; Spinal Cord; Spinal Cord Diseases; Succinate Dehydrogenase; Time Factors