acid-phosphatase and Serum-Sickness

Topics: Acid Phosphatase; Adult; Animals; Antibody Specificity; Antigen-Antibody Complex; Arthus Reaction; Autoantibodies; Autoimmune Diseases; Basement Membrane; Binding Sites; Chemotaxis; Complement System Proteins; Elastic Tissue; Electrophoresis, Disc; Epithelium; Female; Fluorescent Antibody Technique; Glomerulonephritis; Haplorhini; Humans; Immune System Diseases; Immunization, Passive; Immunoglobulin G; Leukocytes; Lysosomes; Male; Microbial Collagenase; Pancreatic Elastase; Protein Binding; Serum Sickness; Skin Diseases

Adult white mice were continually treated by intraperitoneal injections of normal serum of various species (neat, horse, man, rabbit, mouse) for 3 hours up to 16 days. Control animals received injections of physiological saline under the same conditions. In the mouse pancreas, the repeated intraperitoneal injections of foreign serum conformably resulted in an interstitial edema, a first granulocytic and histiocytic, later on markedly lymphoplasmactyic interstitial inflammation with single dystrophic acinar cells as well as in a mild intersitial fibrosis after 8 or 16, resp., days of serum application. Histochemically, the exocrine pancreas cells showed a moderate increase in activity of adenosintriphosphatase, nonspecif esterase as well as acid and acaline phosphatase. All the changes described were most considerably pronounced after treatment with bovine serum. The interstitial pancreatitis after continual foreign serum applications regarded as the morphologie expression of a pathogenic immune phenomenon of the serum sickness type in case of a serum sickness reaction taking place preferably in the peritoneal cavity.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Blood; Cattle; Edema; Esterases; Histiocytes; Horses; Humans; Immunization; Leukocytes; Lymphocytes; Male; Mice; Pancreas; Pancreatitis; Peritoneal Cavity; Rabbits; Serum Sickness; Time Factors