acid-phosphatase and Rodent-Diseases

The effect of milk on bone health is controversial. In this study, the effects of yak milk in mice with retinoic acid-induced osteoporosis (OP) were evaluated. Yak milk was provided to OP mice as a nutrition supplement for 6 wk. The results showed that yak milk significantly reduced bone turnover markers (tartrate acid phosphatase and alkaline phosphatase). The yak milk treatment was also associated with remarkably increased bone mineral density, bone volume, trabecular thickness, and trabecular number, as well as improved biomechanical properties (maximum load and stress) of the tibia. Furthermore, yak milk mitigated the deterioration of the network and thickness of trabecular bone in treated OP mice compared with the OP model group. The results indicated that yak milk could improve bone mass and microarchitecture through the inhibition of bone resorption in OP mice.

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Bone Density; Cattle; Cattle Diseases; Mice; Milk; Osteoporosis; Rodent Diseases; Tartrates; Tretinoin

The skin of a new hairless mutation in the rat termed "bald" was examined histologically and enzyme histochemically with animals from three weeks to 18 months of age. The loss of hair in homozygous (bald) rats proved to occur as follows: a club hair rising within the hair follicle in the first catagen phase was not anchored and fell out due to dilatation of the follicular lumen. In the skin of bald rats from two to three months of age on, two types of cyst developed, one from the infundibulum of the hair follicle and the other from a lower follicular portion left in the dermis. Each had histologic patterns different from each other. The wall of the former cyst contained various-sized keratohyaline granules in a large number, while the latter was keratinized without granules. In addition to cyst formation, foreign-body granulomas frequently appeared from three months of age on, originating from degenerated follicular portions in the dermis. In advanced cases after 12 months of age, the granulomatous lesions were sharply demarcated from the other tissue. Histochemically, acid phosphatase activity was observed in the skin of bald rats, in the wall of the dilated hair follicles and the cystic wall where progressive keratinization with age occurred. This enzymatic activity tended to heighten as keratinization proceeded.

Topics: Acid Phosphatase; Animals; Cysts; Female; Granuloma; Hair; Histocytochemistry; Male; Mice; Rats; Rats, Mutant Strains; Rodent Diseases; Skin; Skin Diseases

Adipose tissue in various stages of fish oil-induced yellow fat disease in the rat had the same acid phosphatase and 5-nucleotidase activity pattern as similar stages of the disorder in mink and pig. A weak acid phosphatase and 5-nucleotidase activity was seen in interstitial lipofuscin-laden macrophages in "stage M" yellow fat disease without fat cell degeneration. Activity of these macrophagic enzymes increased when there was fat cell degeneration ("stage S" and "stage E" yellow fat disease). This different phosphatase activity in the same cell type may result from phagocytosis of substrates with variable digestibility. Macrophages directly surrounding affected fat cells in steatitis areas ("stage S" and "stage E") had strong acid phosphatase and 5-nucleotidase activity. As in the pig, increased 5-nucleotidase activity was found in affected fat cells, which probably indicates plasma membrane damage. Increased nonspecific esterase activity occurred around affected fat cells. Only a small part of this esterase activity originated from inflammatory cells. This indicates that an increase of esterase activity in degenerating adipose tissue may be an endogeneous process in this tissue.

Topics: Acid Phosphatase; Adipose Tissue; Animals; Esterases; Fish Products; Macrophages; Nucleotidases; Oils; Rats; Rodent Diseases; Steatitis; Vitamin E Deficiency

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Calcitonin; Carcinoma; Cholinesterases; Fluorescent Antibody Technique; Glycerolphosphate Dehydrogenase; Histocytochemistry; L-Lactate Dehydrogenase; Microscopy, Electron; Monoamine Oxidase; NADH, NADPH Oxidoreductases; Rats; Rodent Diseases; Staining and Labeling; Thyroid Neoplasms

Topics: Abscess; Acid Phosphatase; Agar; Animals; Cell Division; Cell Membrane; Cell Nucleus; Cell Wall; Coagulase; Cytoplasm; Histocytochemistry; Kidney Diseases; Mice; Microscopy, Electron; Microscopy, Electron, Scanning; Oxidation-Reduction; Protoplasts; Rodent Diseases; Staphylococcus; Succinate Dehydrogenase; Tellurium

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Blood Pressure; Body Weight; Cholesterol; Diet; Esterases; Hypertension; Isoenzymes; Kidney; Liver; Organ Size; Pedigree; Rats; Rats, Inbred Strains; Rodent Diseases; Thyroid Gland

Topics: Acid Phosphatase; Animals; Blood Bactericidal Activity; Bone Marrow Cells; Cattle; Cattle Diseases; Chediak-Higashi Syndrome; Cytoplasmic Granules; Humans; Kidney; Lipidoses; Lysosomes; Mice; Microscopy, Electron; Mink; Neutrophils; Peroxidases; Phagocytosis; Rodent Diseases; Staphylococcus

Topics: Acid Phosphatase; Animals; Disease Models, Animal; Eye Diseases; Inclusion Bodies, Viral; Inflammation; Lacrimal Apparatus; Lysosomes; Microscopy, Electron; Parotid Gland; Rats; Rodent Diseases; Salivary Gland Diseases; Submandibular Gland; Virus Diseases

Topics: Acid Phosphatase; Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium; Electrolytes; Enzymes; Fructose-Bisphosphate Aldolase; Hydroxybutyrate Dehydrogenase; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Magnesium; Magnesium Deficiency; Potassium; Rats; Rodent Diseases

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Apicomplexa; Coccidiosis; Dihydrolipoamide Dehydrogenase; Enteritis; Female; Glucose-6-Phosphatase; Guinea Pigs; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Male; Monoamine Oxidase; Rodent Diseases; Succinate Dehydrogenase