acid-phosphatase and Rheumatic-Heart-Disease

A study of myocardium of patients with mitral stenosis was performed using ultrahistochemical methods at different stages of disease and in the course of valve replacement operation. A quantitative analysis of degenerative changes was introduced, the results of which correlated with the severity of heart failure. A pronounced heterogeneity in mitochondrial enzyme activity has been detected cytochemically. In some apparently "unaffected" cardiomyocytes an active alterative process was expressed in an increase of sarcolemma permeability for electron-microscopic tracers. An elevated fenestration of membrane barriers was noted at the stages of anoxic heart arrest. Using tannic acid it was possible to demonstrate a penetration of plasma protein-polysaccharide complexes into cell sarcoplasma. There were observed topographic variations in the distribution of acid phosphatase activity.

Topics: Acid Phosphatase; Cell Membrane Permeability; Electron Transport Complex IV; Heart Valve Diseases; Histocytochemistry; Humans; Microscopy, Electron; Mitral Valve; Myocardium; Rheumatic Heart Disease; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adult; Clinical Enzyme Tests; Enzyme Activation; Female; Humans; Leukocytes; Male; Mitral Valve Insufficiency; Periodicity; Peroxidases; Rheumatic Heart Disease; Seasons

Topics: Acid Phosphatase; Adolescent; Adult; Alpha-Globulins; Cathepsins; DNA; Female; Glycoproteins; Hexosamines; Humans; Male; Middle Aged; Rheumatic Heart Disease; RNA; Uronic Acids

Topics: Acid Phosphatase; Adult; Aspirin; Female; Humans; Indomethacin; Male; Prednisolone; Rheumatic Heart Disease

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adolescent; Adult; Humans; Lysosomes; Membranes; Myocardium; Rheumatic Heart Disease; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Female; Humans; Lysosomes; Male; Middle Aged; Permeability; Rheumatic Diseases; Rheumatic Heart Disease