acid-phosphatase and Progeria

The authors study the cellular activity of RES against the microbes intracellular and extracellular parasites in rats with pronounced Progeria-like syndrome of Selye. RES of the experimentally aged animals copes, through with a certain delay, with the invading extracellular bacterium Diplococcus pneumoniae, but is utterly helpless against the intracellular microbe Br. abortus 19. These relations are completly inverted in the rats that have not been experimentally aged.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aging; Animals; Blood; Blood Bactericidal Activity; Brucella abortus; Immunization; Liver; Lung; Phagocytes; Phagocytosis; Progeria; Rats; Spleen; Streptococcus pneumoniae

The authors study the morphology of the cells in the peritoneal exsudate and the phosphatase activity of the peritoneal macrophages, obtained from rats with Selye's Progeria-like syndrome. Judging by their morphologic characteristics the macrophages of the experimentally aged rats, before and after contact with Brucella abortus 19 do not differ from those obtained from the unsubjected to experimental ageing rats. The acid phosphatase activity and the adenosinetriphosphatase activity of the macrophages prior to contact with Brucella abortus 19 are nearly identical for both groups of animals. Following contact the activity of the enzymes increases but this increase is slower by aged rats and reaches its maximum 1--2 days later.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aging; Animals; Antigens, Bacterial; Ascitic Fluid; Brucella abortus; Immunization; Macrophages; Progeria; Rats