acid-phosphatase and Postoperative-Complications

Topics: Acid Phosphatase; Adult; Bone Diseases; Cerebrosides; Epilepsy, Temporal Lobe; Gaucher Disease; Graft Rejection; Graft vs Host Reaction; Humans; Intellectual Disability; Kyphosis; Lymphopenia; Male; Postoperative Complications; Radionuclide Imaging; Spleen; Technetium; Thrombocytopenia; Transplantation, Homologous

Although there have been some case reports suggesting that bone in patients with pseudohypoparathyroidism (PHP) might respond to parathyroid hormone (PTH), no information is available as to whether serum PTH concentration is related to bone metabolic markers or to bone mineral density (BMD) in PHP.. To address these relationships, by comparing intact serum PTH, bone metabolic markers and BMD in patients with PHP with those in patients with idiopathic hypoparathyroidism (IHP) and postoperative hypoparathyroidism (OHP).. Intact serum PTH, bone metabolic markers (osteocalcin, tartrate-resistant acid phosphatase, pyridinoline, deoxypyridinoline) and BMD by dual-energy X-ray absorptiometry or single-photon absorptiometry were measured in patients with PHP Ia (n=2) and PHP Ib (n=8). The results were compared with those in patients with IHP (n=5) and OHP (n=14).. All bone metabolic markers measured were present in significantly greater amounts in patients with PHP Ib than in those with IHP+OHP. The Z score (standard deviation of average BMD at each age) of the BMD of femoral neck was significantly lower in patients with PHP Ib than in those with IHP+OHP. The Z scores of BMD of lumbar spine and radius were also lower in patients with PHP Ib than in those with IHP+OHP, but the difference was not significant. Moreover, the intact serum PTH concentrations were significantly and positively related to bone metabolic marker levels in all patients, and the intact serum PTH concentrations were significantly and negatively related to BMD of lumbar spine in PHP patients.. These results suggest that PTH stimulates bone turnover in PHP Ib patients, resulting in a relatively lower BMD in PHP Ib patients than in IHP+OHP patients. The present study indicates that bones of most cases of PHP could respond to PTH.

Topics: Acid Phosphatase; Adult; Aged; Amino Acids; Biomarkers; Bone Density; Cholecalciferol; Creatinine; Cyclic AMP; Erythrocyte Membrane; Female; GTP-Binding Protein alpha Subunits, Gs; Humans; Hypoparathyroidism; Isoenzymes; Kidney; Male; Middle Aged; Osteocalcin; Parathyroid Hormone; Phosphates; Postoperative Complications; Pseudohypoparathyroidism; Tartrate-Resistant Acid Phosphatase

A retrospective analysis of the results of an aggressive multimodal approach combining radical prostatectomy with adjuvant radiation, chemotherapy, or androgen deprivation therapy for patients with pathologic Stage D1 prostate carcinoma was performed to assess the impact of these therapies on survival, recurrence, local control, and morbidity.. Case records of 76 patients with pathologic Stage D1 tumors were reviewed. All had radical retropubic prostatectomy and were recommended adjuvant therapy based on the pathologic extent of the primary tumor and the number of involved lymph nodes.. With a median follow-up of 7 years, overall survival was estimated to be 88% and 66% at 5 and 10 years, respectively, and equaled age- and race-matched controls. Prostate cancer-specific survival at 5 and 10 years was 88% and 74%, respectively. The probability of developing a clinically detectable recurrence (excluding prostate-specific antigen [PSA]) was 29% and 62% at 5 and 10 years, respectively. When PSA was added to the detection data, the probability of developing a recurrence increased to 58% and 78% at 5 and 10 years, respectively. Recurrence and cause-specific survival correlated with Gleason sum. Univariate analysis of the adjuvant therapies demonstrated no effect on survival, but adjuvant radiation alone and in combination with androgen deprivation increased the time to recurrence. Local control was excellent, surgical morbidity was equivalent to that of all patients undergoing prostatectomy during the same time period, and the morbidity of adjuvant therapy was minimal.. Survival equivalent to age- and race-matched controls, with excellent control of the extensive primary tumor, can be achieved in patients with Stage D1 prostate carcinoma by a combination of radical prostatectomy and radiation therapy without the need for routine androgen deprivation therapy.

Topics: Acid Phosphatase; Adenocarcinoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Diethylstilbestrol; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Neoplasm Recurrence, Local; Neoplasm Staging; Orchiectomy; Postoperative Complications; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms; Radiotherapy, Adjuvant; Retrospective Studies; Survival Rate

Topics: Acid Phosphatase; Adult; Aged; Anesthesia; Biopsy; Esterases; Female; Histocytochemistry; Humans; Liver; Liver Diseases; Liver Glycogen; Middle Aged; Phospholipids; Postoperative Complications; RNA

A research has been conducted studying the enzyme system of the liver using biopsy material of the organ taken during the operation from patients with echinococcosis and an experiment with infantile white mice. It is proved reduction of the activity of the alkaline and acid phosphatase as well as of the glycogen along with their progressive reduction during the disease progression. Compared with the other researches--histological and by electronic microscope, etc.--there are proved great hepatic damages due to the echinococcosis that have caused change of the treatment tactics: large preoperative period, including reconstructions of the glycogenic depot in the organ, gentle to the liver anesthesia, exact postoperative reanimation. Very good results have been obtained concerning the postoperative complications and operative mortality: observing the developed acute liver insufficiency--in the past the mortality has been 27.60% throughout 2.49% of the operated patients; after those measures the acute liver insufficiency after this kind of operation is seen just once (0.40% of the patients) and the mortality is 0.

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Echinococcosis, Hepatic; Echinococcus; Glycogen; Hepatic Insufficiency; Humans; Liver; Mice; Postoperative Complications

Laparoscopic pelvic lymphadenectomy (LPLND) can be performed safely and with minimal morbidity in the staging of prostate cancer. Its utility in evaluating patients at high risk for metastatic disease before primarily nonsurgical treatment modalities was evaluated.. Twenty-four consecutive patients who underwent LPLND between June 1993 and July 1996 were studied. These patients were considered poor surgical candidates based on several risk factors, as follows: elevation of serum PSA >20 in 19 patients (79%); elevation of serum acid phosphatase in 4 patients (17%); digital rectal examination findings indicative of extraprostatic extension or seminal vesical involvement in 14 patients (58%); and poorly differentiated tumors on prostate biopsy in 19 patients (79%). Nineteen patients (79%) had two or more of these risk factors. Median PSA for the entire series of patients was 35.2 ng/mL (range 7.9 to 133 ng/mL), and median Gleason score was 7 (range 5 to 9). Preoperative CT or MRI was negative for pelvic lymph node metastases in 17 of 23 patients (79%), and bone scan was negative in all 24 patients.. Unilateral (n = 2) or bilateral (n = 22) LPLND was performed in all patients. Six patients (25%) had lymph node metastases detected laparoscopically. Five of the six patients had palpable extraprostatic extension (T3a/b) or invasion of a seminal vesical (T3c), and in four of these patients the site of the metastatic lymph nodes was ipsilateral to the palpable prostate abnormality. None of the risk factors was independently predictive of lymph node metastases within this series of patients. An average of 10.8 +/- 6.5 lymph nodes was removed at a mean operative time of 174 +/- 10 minutes for patients undergoing bilateral LPLND. Estimated blood loss was minimal for 20 of 22 patients (92%) undergoing LPLND alone, and there were no complications requiring open exploration. Mean postoperative hospital stay was 1.2 +/- 0.5 days for patients undergoing LPLND alone.. LPLND can be used efficiently to identify patients with nodal metastases from select high-risk patients. This, in turn, can exclude such patients from noncurative local and regional therapy.

Topics: Acid Phosphatase; Biomarkers, Tumor; Biopsy; Blood Loss, Surgical; Bone and Bones; Evaluation Studies as Topic; Follow-Up Studies; Forecasting; Hospitalization; Humans; Intraoperative Complications; Laparoscopy; Length of Stay; Lymph Node Excision; Lymphatic Metastasis; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Pelvis; Physical Examination; Postoperative Complications; Prostate-Specific Antigen; Prostatic Neoplasms; Radionuclide Imaging; Risk Factors; Safety; Seminal Vesicles; Time Factors; Tomography, X-Ray Computed

The value of serum acid phosphatase (S-ACP) as a marker of transurethral resection (TUR) syndrome was studied in 105 patients undergoing TURP. In ten patients who developed TUR syndrome the elevation of S-ACP was statistically significantly higher than in the rest of the patients. In seven patients prostatic cancer was diagnosed in the resection chips, but there were no differences in the S-ACP levels during TURP between these patients and the rest of the group. According to the present study, S-ACP seems to be a reliable and cheap marker of TUR syndrome, but the method is slow as compared to ethanol, which restricts its use.

Topics: Acid Phosphatase; Aged; Clinical Enzyme Tests; Humans; Incidence; Male; Postoperative Complications; Prostatectomy; Prostatic Hyperplasia; Syndrome; Therapeutic Irrigation; Water-Electrolyte Imbalance

In 36 male Wistar rats extrahepatic cholestasis was induced by ligation and transsection of the common bile duct. After 1, 2 and 3 weeks of cholestasis the bile flow was restored by means of a Roux-en-Y choledochojejunostomy. Plasma levels of bilirubin, alkaline phosphatase, GOT and clotting factor X were measured weekly. Liver biopsies were taken at the time of restored bile flow as well as 3 and 8 weeks thereafter. Histochemical reaction for lactate dehydrogenase activity and Sirius Red F3BA staining were used as measure for functional liver parenchyma and collagen, respectively. Acid phosphatase, alkaline phosphatase and 5'-nucleotidase activities as well as the glycogen content were demonstrated in cryostat sections of the same biopsies. After 1, 2 and 3 weeks of common bile duct obstruction, levels of bilirubin, alkaline phosphatase and GOT significantly increased, whereas levels of clotting factor X decreased. RBF resulted in normalization of all these levels to control range. The volume density of functional parenchyma was found to be reduced to 90%, 73% and 64% of the control values following 1, 2 and 3 weeks of common bile duct obstruction respectively, returning to 96%, 94% and 88% at 8 weeks, respectively, after restored bile flow. The collagen content increased significantly during cholestasis up to 5-fold after 3 weeks of common bile duct obstruction. After restored bile flow, a slight decrease of collagen was measured in some animals but in none of the three groups a return to normal values appeared. Cholestasis induced an alteration in localization and/or activity of the three enzymes analyzed as well as a depletion of glycogen stores. All changes in activity and distribution pattern of the three enzymes, as well as the glycogen depletion during common bile duct obstruction normalised after restored bile flow was performed. However, the longer common bile duct obstruction had existed, the longer period was needed for full recovery. In conclusion, even after 3 weeks of common bile duct obstruction the parenchyma/stroma relationship grossly normalized after restored bile flow with an almost complete restoration of the parenchyma and a concomitant recovery of liver function. However, collagen once formed, did not disappear but remained as more condensed septa, which apparently did not interfere with normal function.

Topics: 5'-Nucleotidase; Acid Phosphatase; Alkaline Phosphatase; Anastomosis, Roux-en-Y; Animals; Bile Ducts; Choledochostomy; Cholestasis, Extrahepatic; Collagen; Fibrosis; Hematologic Tests; Homeostasis; Liver Glycogen; Male; Postoperative Complications; Rats; Rats, Wistar

To examine the role of nerve-sparing radical prostatectomy in patients with clinical stage B2 prostate cancer we reviewed the first 77 such patients in our series since we adopted the nerve-sparing technique. A total of 47 patients (61%) underwent bilateral and 26 (34%) underwent unilateral nerve-sparing prostatectomy, while in 4 (5%) both neurovascular bundles were resected. Among the patients followed for 12 months 27 of 41 (66%) treated with bilateral and 7 of 19 (37%) treated with unilateral nerve-sparing prostatectomy had potency preserved. With the strict clinicopathological criteria of organ-confined tumor, that is intracapsular tumor with negative surgical margins and undetectable postoperative prostate specific antigen levels, complete tumor excision was achieved in 17 patients (36%) treated with bilateral and 7 of 26 (27%) treated with unilateral nerve-sparing prostatectomy. All patients in whom both neurovascular bundles were resected had pathological stage C or D1 disease. Of the 24 patients who had complete tumor excision by the strict criteria only 15 (19.5% of the 77 preoperatively potent patients) had potency preserved. Of these patients 19 had microscopically positive margins without seminal vesicle invasion (pathological stage C1) with undetectable postoperative prostate specific antigen levels. In addition, 4 patients had seminal vesicle involvement with negative surgical margins and undetectable postoperative prostate specific antigen levels. If these patients also are considered as having complete tumor excision, there was an over-all complete tumor excision rate of 61% (47 of 77), of whom 25 (32% of the 77 patients) had preservation of potency. Ten patients with clinical stage B2 tumor whose potency was preserved had histological and serological evidence of incomplete tumor excision. Of 53 patients with pathological stage C1 disease 9 (17%) had margins positive only in the regions of the neurovascular bundles. Preoperative prostate specific antigen and acid phosphatase levels, and findings on transrectal ultrasonography failed to predict accurately which patients had extracapsular tumor extension. Patients with poorly differentiated tumors and/or bulky disease on rectal examination had a higher incidence of extracapsular extension and positive margins. We conclude that in the majority of potent patients with clinical stage B2 prostate cancer not all of the goals of nerve-sparing radical prostatectomy are realized.(ABSTRACT TRUNCATED

Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Biomarkers, Tumor; Erectile Dysfunction; Humans; Male; Postoperative Complications; Prostate; Prostate-Specific Antigen; Prostatectomy; Prostatic Neoplasms

Topics: Acid Phosphatase; Animals; Ischemia; Ligation; Liver; Lysosomes; Male; Portal Vein; Postoperative Complications; Rabbits

Symptoms following transurethral prostatic resection for benign prostatic hypertrophy were evaluated in 100 patients. The occurrence of post-transurethral resection symptoms was monitored postoperatively and was found to be associated with an increase in serum acid phosphatase. The transient elevation of serum acid phosphatase after transurethral prostatic resection indicates that intraoperative absorption of prostatic tissue substances occurs. The intraoperative absorption of prostatic tissue substances may have a significant role in producing symptoms of post-transurethral resection syndromes.

Topics: Acid Phosphatase; Humans; Male; Nausea; Postoperative Complications; Prostatectomy; Prostatic Hyperplasia; Sodium; Urethra

Topics: Acid Phosphatase; Humans; Male; Postoperative Complications; Prostate; Syndrome

In 6 patients undergoing transurethral resection of the prostate for benign prostatic hyperplasia symptoms of post-transurethral prostate resection syndrome developed. Serum acid phosphatase determinations in the recovery room showed that all patients had high acid phosphatase levels although each had normal levels preoperatively. All patients showed a normal acid phosphatase level on the first postoperative day. The acid phosphatase elevations indicate significant intraoperative absorption of prostate tissue substances. The association of clinical symptoms with enzyme elevation suggests that the etiology of the confusing clinical syndromes following transurethral prostate surgery may be due to the intravenous absorption of not only irrigant solution but also tissue substances from the prostate gland.

Topics: Acid Phosphatase; Aged; Humans; Male; Middle Aged; Postoperative Complications; Prostatectomy; Prostatic Hyperplasia

Twenty-one total hip arthroplasties were revised because of aseptic loosening. The bone and soft tissue membrane bordering the cement in a total of 37 biopsies from the acetabulum and femur were studied histologically and by enzyme histochemistry. The soft tissue membrane was infiltrated with macrophages and had high acid phosphatase activity. Other inflammatory cells were rare or absent. Concomitant bone formation and bone resorption were usually present at the bone-soft tissue border. The bone generally consisted of viable, remodeled lamellar bone. The host bone seemed to have been resorbed by a soft tissue front moving outward from the cement. Reactive new bone formation began at the bone-soft tissue border and appeared to constrain the resorptive process. Articular wear seemed to play no part in initiating the loosening process. The role of bone cement in this respect is obscure, because there were no obvious local signs of cytotoxicity. These observations support the theory of mechanical instability as the primary cause of the tissue reaction.

Topics: Acetabulum; Acid Phosphatase; Adult; Aged; Biopsy; Bone Cements; Bone Resorption; Connective Tissue; Female; Femur; Foreign-Body Reaction; Hip Prosthesis; Humans; Macrophages; Male; Membranes; Middle Aged; NADPH Dehydrogenase; Postoperative Complications; Stress, Mechanical

The average diameter of the different enzymatic types of extra- and intrafusal muscle fibres is determined by means of a one millimeter scale ocular micrometer in the gastrocnemius muscle of twenty four female rats during three months, at regular intervals following tenotomy. There is a predominant atrophy of the type II extrafusal as well as intrafusal fibres in the period of immobilization. However, when the muscle becomes functional again, by healing and elongation of the tendon, the intrafusal type II fibres remain atrophic in contrast to the extrafusal ones, which regain their normal size.

Topics: Achilles Tendon; Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Cholinesterases; Esterases; Female; Hindlimb; L-Lactate Dehydrogenase; Muscle Spindles; Muscles; Muscular Atrophy; Nucleotidases; Postoperative Complications; Rats; Succinate Dehydrogenase; Wound Healing

Six patients who received renal transplants were closely monitored to compare the sensitivity of urine levels of beta-galactosidase and N-acetyl-beta-glucosaminidase with conventional clinical and laboratory parameters in the detection of impending rejection. A rapid (60 minute), simple, accurate fluorometric assay was used to measure activities of both enzymes. Eighty per cent of ten rejection episodes were accompanied by a two- to sixfold increase in enzyme release. Parallel changes in serum creatinine levels and urinary volume occurred in six rejection episodes, but in two episodes, elevated urinary enzyme levels were observed two and four days prior to clinical evidence of rejection. It is concluded that urinary lysosomal enzyme measurements by fluorometric assay are valuable indicators of acute renal rejection, particularly when the diagnosis is not clearly established by conventional criteria that show only minimal changes. Continuing studies in a large group of renal transplant recipients are under way to evaluate the validity of this conclusion and to determine whether enzyme measurements, will, indeed, be indicative of early rejection.

Topics: Acetylglucosaminidase; Acid Phosphatase; Animals; Cadaver; Creatinine; Dogs; Fluorometry; Galactosidases; Graft Rejection; Hexosaminidases; Humans; Immunosuppressive Agents; Kidney Transplantation; Lysosomes; Methylprednisolone; Postoperative Complications; Transplantation, Homologous; Urination

The bones of adult rats became progressively osteopenic 1 to 5 weeks following jejunoileal bypass or resection. These changes were accompanied by increased levels of metaphyseal enzyme activities as well as by loss of histochemically identifiable osteoid. Osteoid tissue and the ability to mineralize skeletal collagen were recovered more rapidly and fully in the resection group than in the bypass group. Metaphyseal alkaline phosphatase concentrations increased in both groups coincident with the elevated lysosomal enzymes levels, and the skeletons showed a calcium deficit (low Ca/HOPr ratio) within the first 3 weeks. In resected rats the osteopenia and bone blood chemistry were consistent with hyperparathyroidism secondary to impared Ca absorption. In bypassed rats the results suggest that the osteopenia might be related to the release of a "resorptive factor" from the excluded intestinal segment.

Topics: Acid Phosphatase; Animals; Bone and Bones; Bone Diseases; Calcium; Female; Glucuronidase; Glycosaminoglycans; Hydroxyproline; Intestine, Small; L-Lactate Dehydrogenase; Magnesium; Malate Dehydrogenase; Methods; Phosphorus; Postoperative Complications; Rats; Sulfatases

Topics: Acid Phosphatase; Acute Kidney Injury; Aged; Carcinoma; Cryosurgery; Humans; Male; Middle Aged; Postoperative Complications; Prostatic Neoplasms; Rectal Fistula; Urinary Fistula; Urinary Incontinence, Stress; Urination Disorders

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Animals; Blood Vessels; Cicatrix; Dogs; Fibroblasts; Histocytochemistry; Inflammation; Peritoneum; Polyglycolic Acid; Postoperative Complications; Staining and Labeling; Sutures; Time Factors; Tissue Adhesions; Vascular Surgical Procedures; Vena Cava, Inferior

Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Blood Urea Nitrogen; Bone Neoplasms; Cryosurgery; Follow-Up Studies; Humans; Hydronephrosis; Immunoglobulins; Male; Middle Aged; Neoplasm Metastasis; Pain Management; Palliative Care; Postoperative Complications; Prostate; Prostatic Neoplasms; Time Factors; Urinary Tract Infections; Urination Disorders

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Bronchi; Bronchial Fistula; Histocytochemistry; Humans; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Postoperative Complications; Proteins; RNA; Succinate Dehydrogenase; Sulfhydryl Compounds; Tuberculosis, Pulmonary

Topics: Acid Phosphatase; Adaptation, Physiological; Alkaline Phosphatase; Amino Acids; Animals; Biopsy; Blood Glucose; Cell Membrane Permeability; Dogs; Duodenum; Epithelial Cells; Epithelium; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Microscopy, Electron; Postoperative Complications; Staining and Labeling; Time Factors

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Humans; Leukocytes; Middle Aged; Neoplasms; Postoperative Complications; Time Factors

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Biopsy; Carcinoma; Diethylstilbestrol; Duodenal Ulcer; Erectile Dysfunction; Humans; Male; Methods; Middle Aged; Neoplasm Metastasis; Palpation; Postoperative Complications; Prognosis; Prostatectomy; Prostatic Neoplasms; Spinal Neoplasms; Urinary Tract Infections; Urine

Topics: Abdomen; Acid Phosphatase; Animals; Female; Glucuronidase; Liver; Male; Mice; Peritoneum; Porphyrins; Postoperative Complications; Rats; Tissue Adhesions

Topics: Acid Phosphatase; Acute Kidney Injury; Adult; Alkaline Phosphatase; Anuria; Clinical Enzyme Tests; Glucuronidase; Humans; Kidney Transplantation; Male; Methods; Postoperative Complications; Spectrophotometry; Transplantation, Homologous

Topics: Acid Phosphatase; Alkaline Phosphatase; Anuria; Fractures, Spontaneous; Humans; Hyperparathyroidism; Osteitis Fibrosa Cystica; Parathyroid Neoplasms; Pathology; Postoperative Care; Postoperative Complications; Radiography; Surgical Procedures, Operative

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Animals; Antineoplastic Agents; Aspartate Aminotransferases; Azathioprine; Bilirubin; Blood Protein Electrophoresis; Cholangiography; Dogs; Immunosuppressive Agents; Liver; Liver Transplantation; Pharmacology; Postoperative Complications; Prednisolone; Research; Transplantation Immunology; Transplantation, Homologous