acid-phosphatase and Parotid-Neoplasms

Prostate-specific antigen (PSA) is secreted by both normal and neoplastic acinar cells of the prostate gland, and the immunohistochemical detection of PSA is widely accepted as an excellent method for confirming the prostatic origin of metastatic tumor implants in men with prostate cancer. Less recognized is the observation that certain nonprostatic tissues and their neoplastic counterparts also secrete PSA. As one example, salivary gland ducts and certain salivary gland neoplasms have been reported to be immunoreactive for PSA. Potentially, this nonspecificity could be a diagnostic pitfall when using immunoperoxidase on fine-needle aspiration (FNA) biopsy specimens to differentiate metastatic prostate cancer from primary salivary gland tumors. We report on a case where strong PSA immunoreactivity of a parotid oncocytoma led to its confusion with metastatic prostate cancer.

Topics: Acid Phosphatase; Adenocarcinoma; Adenoma, Oxyphilic; Aged; Diagnostic Errors; Humans; Immunoenzyme Techniques; Male; Parotid Neoplasms; Prostate-Specific Antigen; Prostatic Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma; Goserelin; Humans; Male; Parotid Neoplasms; Prostate; Prostate-Specific Antigen; Remission Induction

A case of prostate cancer in which the parotid gland was the sole site of metastatic disease is presented. Special immunohistochemical stains of the excisional biopsy allowed for rapid, accurate diagnosis and appropriately directed successful therapy.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Antigens, Neoplasm; Biomarkers, Tumor; Humans; Immunohistochemistry; Male; Parotid Neoplasms; Prostate-Specific Antigen; Prostatic Neoplasms

The monomorphic basal cell adenoma of parotid gland is a rare tumor of salivary glands. Its diagnosis is difficult with adenoid cystic carcinoma. In the case reported here, a peculiar type named membranous adenoma, the thickness of basement membranes, their penetration inside the epithelial lobules, form true cylinders as in adenoid cystic carcinoma. The histoenzymology and the electron microscopy provide important diagnostic arguments: activity of alkaline phosphatases lower than in cystic adenoid carcinoma; cells of adenoma more differentiated (epidermoid or secretory cells) than those of cystic adenoid carcinoma. The prognosis of the tumor is good, though recurrences may occur.

Topics: Acid Phosphatase; Adenoma; Adult; Alkaline Phosphatase; Epithelium; Female; Histocytochemistry; Humans; Microscopy, Electron; Oxidoreductases; Parotid Neoplasms

Parotid adenolymphoma is composed of two histologic components, epithelial and lymphoid. Although some theories regarding the histogenesis of this tumor have long been disputed, there have been no definite conclusions. The purpose of this study was to clarify the origin of the epithelial components of this tumor using histochemical and immunopathological techniques, electron microscopy and a survey of HE-stained tumor sections. The results obtained indicated that the functions of the epithelial components were similar to those of the striated duct of the normal parotid gland, and morphological studies showed that the origin of the epithelial components may arise from parotid ductal inclusion in the lymphnodes in or around the parotid gland.

Topics: 5'-Nucleotidase; Acid Phosphatase; Adenolymphoma; Adenosine Triphosphatases; Adult; Aged; Epithelium; Glucuronidase; Humans; Immunoglobulin A; Microscopy, Electron; Middle Aged; Naphthol AS D Esterase; Nucleotidases; Parotid Neoplasms; Staining and Labeling

In a primary material of 314 epithelial parotid tumours treated at the University Hospital in Umeå since 1958, fiften (11 female and 4 male patients) were classified as acinic cell carcinomas. Four of the female patients were in the age range 16--19 years. At the ultrastructural level, granulated cells were the predominant cell type in four tumours studied. Agranulated cells highly reminiscent of intercalated duct cells were also encountered, however. Various cytochemical techniques were employed to demonstrate periodate reactive carbohydrates and acid phosphatase activity. Tumour specimens were also collected and analysed for their content of amylase and cyclic AMP. The cyto- and biochemical findings are discussed and correlated to those observed in normal salivary gland tissue.

Topics: Acid Phosphatase; Adolescent; Adult; Aged; Amylases; Biopsy, Needle; Carcinoma; Cyclic AMP; Female; Histocytochemistry; Humans; Male; Middle Aged; Organoids; Parotid Neoplasms; Staining and Labeling

Topics: Acid Phosphatase; Adult; Amylases; Diagnosis, Differential; Humans; Parotid Gland; Parotid Neoplasms; Phosphates; Potassium; Proteins; Saliva; Salivary Gland Diseases; Secretory Rate; Sodium

Topics: Acid Phosphatase; Adenolymphoma; Aged; Epithelium; Histocytochemistry; Humans; Lysosomes; Male; Microscopy; Microscopy, Electron; Parotid Neoplasms

Topics: Acid Phosphatase; Adenocarcinoma, Mucinous; Adenoma; Adenoma, Pleomorphic; Adenosine Triphosphatases; Adult; Aged; Alkaline Phosphatase; Carcinoma, Adenoid Cystic; Cystadenoma; Dihydrolipoamide Dehydrogenase; Female; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Leucyl Aminopeptidase; Male; Middle Aged; Monoamine Oxidase; Parotid Neoplasms; Salivary Gland Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Animals; Anthracenes; Esterases; Fructose-Bisphosphate Aldolase; Glucose-6-Phosphatase; Glucuronidase; Glutamate Dehydrogenase; Glycerolphosphate Dehydrogenase; Hydroxybutyrate Dehydrogenase; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Malate Dehydrogenase; Mice; Monoamine Oxidase; Neoplasms, Experimental; Oxidoreductases; Parotid Gland; Parotid Neoplasms; Succinate Dehydrogenase