acid-phosphatase and Paraplegia

Purine metabolism is depending on a large amount of enzymes to ensure cellular homeostasis. Among these enzymes, we have been interested in the 5'-nucleotidase cN-II and its role in cancer biology and in response of cancer cells to treatments. This protein has been cited and studied in a large number of papers published during the last decade for its involvement in non-cancerous pathologies such as hereditary spastic paraplegia, schizophrenia, and blood pressure regulation. Here, we review these articles in order to give an overview of the recently discovered clinical relevance of cN-II.

Topics: 5'-Nucleotidase; Acid Phosphatase; Animals; Blood Pressure; GPI-Linked Proteins; Homeostasis; Humans; Paraplegia

The spinal cords of adult cats were injured at about L1 level by using Allen's method and the animals were divided randomly into 2 groups: a) electro-acupuncture treatment group and b) control group. The acid phosphatase (ACP) was detected at 3 and 7 days after spinal cord injury. The more ACP positive labelings were found in the treatment group than in the control group at both 3 (P < 0.05) and 7 days (P < 0.01) after injury. The results suggested that electro-acupuncture could increase the concentration of ACP of the injured spinal cord and the increased ACP concentration could make worse to the injured spinal cord at early time and improve regeneration during recovery period.

Topics: Acid Phosphatase; Animals; Cats; Electroacupuncture; Female; Male; Paraplegia; Random Allocation; Spinal Cord Injuries

Topics: Acid Phosphatase; Adenocarcinoma; Age Factors; Aged; Biopsy; Bone Neoplasms; Bone Resorption; Calcium; Humans; Male; Middle Aged; Neoplasm Metastasis; Pain; Paraplegia; Phosphorus; Prostatic Neoplasms; Urography

Topics: Acid Phosphatase; Alkaline Phosphatase; Blood Pressure; Calcium; Cardiac Output; Heart Rate; Humans; Male; Middle Aged; Osteitis Deformans; Paraplegia; Phosphates; Spinal Diseases