acid-phosphatase and Paranasal-Sinus-Neoplasms

Prostatic cancer is commonly manifested by obstructive uropathy, regional lymphatic metastases, and hematogenous metastases to the axial skeleton. It is relatively rare that initial signs begin with the involvement of other sites. Intracranial metastases especially are seldom found and may be unfamiliar to not only pathologists but also to physicians. In this article, we present a case where the metastasis was first manifest as a sphenoid sinus tumor prior to the demonstration of the primary site and the prostate was confirmed to be primary by biopsy specimen with immunoperoxidase method. In addition to discussing the route of the tumor spread, we deal with a prostatic specific antigen efficient for identifying the primary site.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Bone Neoplasms; Humans; Male; Paranasal Sinus Neoplasms; Prostatic Neoplasms; Sphenoid Sinus; Tomography, X-Ray Computed

Metastatic carcinoma to the sphenoid sinus is a rare event. A case of metastatic adenocarcinoma from the prostate gland to the sphenoid sinus and diagnosed with the aid of immunoperoxidase staining is presented. A concurrent review of the literature uncovered only 17 previously reported cases of carcinoma metastatic to the sphenoid sinus. Among these cases, adenocarcinoma from the large bowel and prostate gland predominated.

Topics: Acid Phosphatase; Adenocarcinoma; Adult; Aged; Humans; Immunoenzyme Techniques; Male; Middle Aged; Paranasal Sinus Neoplasms; Prostate; Prostatic Neoplasms; Sphenoid Sinus

The clinical application of an immunohistochemical technique for prostatic acid phosphatase allowed the accurate diagnosis of metastatic prostatic carcinoma in 17 patients whose condition was not recognized by either clinical or histologic observations. The cardinal manifestations in these 17 patients included supraclavicular lymphadenopathy in 7, hilar lymphadenopathy in 1, pulmonary infiltration in 2, simulating carcinoma of the rectum in 4, fracture of femur in 1, orbital tumor in 1, and brain tumor in 1. A retrospective analysis of the radiologic features of these patients showed that the unusual manifestations were due to the route of metastasis, that is, direct invasion, lymphatic, and hematogenous. Radiologic studies, even in these unusual cases, are both useful in establishing the diagnosis and helpful in delineating the mode of metastasis of prostatic carcinoma.

Topics: Acid Phosphatase; Adenocarcinoma; Aged; Bone Neoplasms; Brain Neoplasms; Histocytochemistry; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Paranasal Sinus Neoplasms; Prostatic Neoplasms; Rectal Neoplasms; Retroperitoneal Neoplasms; Tomography, X-Ray Computed

Topics: Acid Phosphatase; Alanine Transaminase; Alkaline Phosphatase; Arylsulfatases; Aspartate Aminotransferases; beta-Glucosidase; Creatine Kinase; Humans; L-Lactate Dehydrogenase; Nasal Mucosa; Nose Diseases; Nose Neoplasms; Paranasal Sinus Neoplasms; Phosphoric Diester Hydrolases; Rhinitis, Atrophic; Sinusitis