acid-phosphatase has been researched along with Parakeratosis* in 2 studies
2 other study(ies) available for acid-phosphatase and Parakeratosis
| Article | Year |
|---|---|
Histochemistry in psoriasis. 5'-Nucleotidase in psoriatic parakeratotic horny layer.
The 5'-nucleotidase activity in psoriatic and normal human epidermis was studied in comparison to acid phosphatase activity. The optimum pH in normal human epidermis was about 5.0 at room temperature. The activity of both enzymes was found to be high in the transitional zone. Acid phosphatase (non-specific) activity was strongly positive in the psoriatic parakeratotic horny layers whereas 5'-nucleotidase activity in that area was completely absent. The results suggest that the enzyme which degrades nucleoside-5'-phosphate to nucleoside and inorganic phosphate is not acid phosphatase but 5'-nucleotidase. Nuclear preservation in psoriatic hyperkeratosis was attributed to absence or inactivation of specific enzymes of nuclear degradation, such as 5'-nucleotidase, rather than acid phosphatase. Topics: Acid Phosphatase; Adult; Epidermis; Humans; Hydrogen-Ion Concentration; Keratosis; Nucleotidases; Parakeratosis; Psoriasis; Skin | 1979 |
Evaluation of coal tar fractions for use in psoriasiform diseases using the mouse tail test. III. High boiling tar oil acids.
Twelve phenolic fractions of creosote and anthracene oils derived from a high temperature tar were applied in an ointment base to mouse tail skin. After treatment with the higher boiling acids, formerly parakeratotic scale areas underwent granular layer induction and 'basket-weave' keratin was produced. Changes in distribution of acid phosphatase and in horny layer fluorescence were consistent with the conversion to an orthokeratotic state. It is suggested that some of these phenols may be of value in the treatment of chronic psoriasis. Topics: Acid Phosphatase; Animals; Anthracenes; Coal Tar; Creosote; Keratins; Mice; Parakeratosis; Phenols; Psoriasis; Skin | 1975 |