acid-phosphatase and Nutrition-Disorders

Topics: Acid Phosphatase; Antibody Formation; Calcium; Child; Deficiency Diseases; Glucosephosphate Dehydrogenase; Humans; Immunity; Immunity, Cellular; Infections; Iron; Leukocytes; Lysosomes; NADH, NADPH Oxidoreductases; Nutrition Disorders; Peroxidases; Phagocytosis; Phosphogluconate Dehydrogenase; Protein-Energy Malnutrition

Oral administration of metanil yellow (MY) at 3.0% (w/w) dose level to adult male albino rats maintained on low protein (LP) diet for 30 days resulted in a greater decrease in absolute and relative weights of testes than in those rats maintained on a normal protein (NP) diet. A marked decrease in the activities of lactate dehydrogenase and hyaluronidase and content of lactic acid in LP + MY fed animals suggested that low protein diet enhanced the vulnerability of germ cells towards metanil yellow. The lack of significant changes in the cholesterol content of testis, the fructose content of the coagulating glands and the dorso-lateral prostate, the activities of alkaline phosphatase in the seminal vesicle, and acid phosphatase in ventral prostate of the MY treated animals suggested that their androgenic status were not affected.

Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Azo Compounds; Cholesterol; Food Coloring Agents; Fructose; Male; Nutrition Disorders; Protein Deficiency; Rats; Testis

Studies were made of the effects of pre- and post-weaning undernutrition and/or protein deficiency on intestinal phytase and phosphatase activities in albino rats and reversibility of the same by subsequent dietary rehabilitation. Neonatal undernutrition induced by rearing the pups in litters of 16 caused a marked decrease in alkaline phytase activity (as compared to those reared in litters of 8), while acid phytase activity decreased to a lesser extent and acid and alkaline phosphatase activities did not change. When neonatally undernourished rats were subsequently continued on a 4 or a 20% protein diet in restricted amounts (2.5 g/day) for 6 weeks the decreases in the alkaline phytase activity but not in that of acid phytase were further aggravated. Acid and alkaline phosphatases were not influenced by these treatments either. On dietary rehabilitation of these rats for subsequent 6 weeks on a 20% protein diet (ad libitum) acid and alkaline phytase activities of intestine recovered partially. These studies indicate the importance of alkaline phytase activity as a marker of intestinal maturation and is also suggestive of interrelationships between nutrition, intestinal development and its alkaline phytase activity.

Topics: 6-Phytase; Acid Phosphatase; Age Factors; Alkaline Phosphatase; Animals; Animals, Newborn; Female; Humans; Intestines; Nutrition Disorders; Pregnancy; Rats

Inadequate dietary intake during late pregnancy may have significant effects on the developing fetal lung which undergoes rapid cellular multiplication and differentiation shortly before birth. The morphology, glycogen distribution and acid phosphatase activity in normal and starved neonatal rats have been studied sequentially, by using histochemical and cytochemical methods. It has been shown that the normal pattern of lung growth and enzymatic development is retarded in neonates of malnourished mothers. A slowed rate of cellular division and differentiation in the critical prenatal period resulted in a more immature air-blood barrier at birth, with glycogen retention by some epithelial cells. Delayed Type 2 cell maturation with diminished acid phosphatase activity suggests a decrease in surfactant production in the malnourished newborn. In addition, fewer alveolar macrophages with reduced acid phosphatase activity were observed in the perinatal period of starved rats; this finding might have implications for the handling of inhaled bacteria shortly after birth. These results indicate that nutritional status of the mother has a marked effect on fetal lung growth and development by inhibiting cellular proliferation, differentiation and enzyme development by epithelial and macrophagic cells.

Topics: Acid Phosphatase; Animals; Female; Gestational Age; Glycogen; Lung; Macrophages; Nutrition Disorders; Pregnancy; Pregnancy Complications; Pulmonary Alveoli; Rats

Topics: Acid Phosphatase; Animals; Arylsulfatases; Atrophy; Body Weight; Endoplasmic Reticulum; Glucuronidase; Lipid Metabolism; Liver; Liver Glycogen; Lysosomes; Male; Microscopy, Electron; Mitochondria, Liver; Nutrition Disorders; Rats; Starvation; Time Factors

Topics: Acid Phosphatase; Cathepsins; Child; DNA; Female; Humans; Hydrogen-Ion Concentration; Kwashiorkor; Leukocyte Count; Leukocytes; Male; Muramidase; Nutrition Disorders; Oxidoreductases; Peroxidases; Phenols; Phosphoric Monoester Hydrolases; Tetrazolium Salts

1. Enzymes pertinent to bactericidal activities of leucocytes were assayed in children suffering from protein-calorie malnutrition. 2. Leucocytes obtained from malnourished and control children contained similar activities for glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. Granule-bound NADPH oxidase activity was low in leucocytes isolated from malnourished patients and failed to show the phagocytic stimulation which is normally seen in control leucocytes. Further, leucocytes obtained from malnourished patients did not release the acid phosphatase from lysosomes during phagocytosis, unlike those from controls. 3. Treatment of the malnourishment with a diet high in calories and protein resulted in significant increase in the activities of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and NADPH oxidase and in releasing the acid phosphatase from the lysosomes into the supernatant fraction during phagocytosis. 4. The significance of these enzyme changes are discussed in relation to the increased susceptibility of these patients to infection.

Topics: Acid Phosphatase; Blood Bactericidal Activity; Child; Glucosephosphate Dehydrogenase; Humans; Leukocytes; NADP; Nutrition Disorders; Oxidoreductases; Phagocytosis; Phosphogluconate Dehydrogenase; Protein-Energy Malnutrition

Topics: Acid Phosphatase; Alkaline Phosphatase; Anemia; Animals; Bone and Bones; Cartilage, Articular; Chickens; Male; Microscopy; Nutrition Disorders; Osteoblasts; Vitamin A

Topics: Acid Phosphatase; Ceroid; Liver; Liver Diseases; Mice; Necrosis; Nutrition Disorders; Pigments, Biological; Rats; Research