acid-phosphatase and Nephrotic-Syndrome

Topics: Acid Phosphatase; Adult; Alkaline Phosphatase; Female; Hemorrhagic Fever with Renal Syndrome; Humans; Male; Nephrotic Syndrome

Topics: Acid Phosphatase; Adolescent; Adult; Azathioprine; Glycerophosphates; Humans; Lymphocytes; Middle Aged; Nephrotic Syndrome; Orotic Acid; Succinate Dehydrogenase

Diacetylbenzidine was used to induce a nephrotic syndrome in female rats. Enzymes involved in glycoprotein metabolism were evaluated during an early stage of induced renal disease before extensive histologic changes occurred. The results show that lysosomal acid hydrolases are not activated or released to any measurable degree during the early stages of the disease. Minimal differences in the composition of glomerular basement membrane of nephrotic rats were found despite heavy proteinuria. Glomerular specific activities of certain glycoprotein:glycosyl transferases were depressed in nephrotic animals. A new viewpoint to explain the pathology of glomerular proteinuria is presented based on the phenomenon of sublethal autolysis affecting cell surface structure and function, of which activity levels of glycoprotein:glycosyl transferases are an example. Increased activities of glycosyl transferases and Na-D ATPase were noted in the cortex from nephrotic animals. These studies involving cortex indicate that the pathologic process is not confined to the glomerulus and may contribute information concerning Na+ transport in the nephrotic rat.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Aminobiphenyl Compounds; Animals; Autolysis; Benzidines; Diuresis; Female; Glucosyltransferases; Glycoproteins; Glycoside Hydrolases; Hydrolases; Hyperlipidemias; Kidney Cortex; Kidney Glomerulus; N-Acylneuraminate Cytidylyltransferase; Nephrotic Syndrome; Peptide Hydrolases; Protein Denaturation; Proteinuria; Rats; Transferases

Topics: Acid Phosphatase; Amyloidosis; Glomerulonephritis; Glycerolphosphate Dehydrogenase; Humans; Lupus Erythematosus, Systemic; Lymphocytes; Nephrotic Syndrome; Succinate Dehydrogenase

Topics: Acid Phosphatase; Alkaline Phosphatase; Amyloidosis; Glomerulonephritis; Glycerolphosphate Dehydrogenase; Humans; Leukocytes; Lupus Erythematosus, Systemic; Nephrotic Syndrome; Neutrophils; Peroxidases; Purpura; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adolescent; Adult; Biopsy; Child; Glomerulonephritis; Glucosephosphate Dehydrogenase; Histocytochemistry; Humans; Isocitrate Dehydrogenase; Kidney; Kidney Glomerulus; Kidney Tubules; L-Lactate Dehydrogenase; Nephrosis; Nephrotic Syndrome

Topics: Acid Phosphatase; Acute Kidney Injury; Alkaline Phosphatase; Animals; Chromates; Chromatography, Gel; Erythrocytes; Glomerulonephritis; Humans; Kidney; Kidney Failure, Chronic; Liver Cirrhosis; Nephrectomy; Nephrotic Syndrome; Rabbits; Renal Dialysis

Topics: Acid Phosphatase; Alkaline Phosphatase; Child; Child, Preschool; Enzymes; Female; Fructose-Bisphosphate Aldolase; Humans; L-Lactate Dehydrogenase; Male; Nephrotic Syndrome

Topics: Acid Phosphatase; Electrons; Epithelium; Histocytochemistry; Hyalin; Immune Sera; Kidney Glomerulus; Kidney Tubules; Lysosomes; Microscopy; Microscopy, Electron; Mitochondria; Nephrotic Syndrome; Nucleosides; Proteinuria; Rats; Research