acid-phosphatase and Mycosis-Fungoides

Topics: Acid Phosphatase; Dermatitis, Exfoliative; Esterases; Glucuronidase; Glycogen; Humans; Lymphocytes; Microscopy, Electron; Mycosis Fungoides; Reticulocytes; Sezary Syndrome; Skin Neoplasms

Topics: Acid Phosphatase; Adenosine Triphosphatases; Glucuronidase; Humans; Immunoenzyme Techniques; Lymphocytes; Mycosis Fungoides; Skin Neoplasms; T-Lymphocytes, Helper-Inducer

In 4 patients with mycosis fungoides in the praemycotic, infiltrative and tumour stage of the disease, a differentiation and functional characterization of the infiltrate cells, obtained from cell suspensions and cutaneous smears, was carried out by means of enzyme cytochemical and immunological methods. The lymphocyte-associated acid esterase is considered to be a marker for mature T-cell populations. Apart from monocytes and histiocytes, acid esterase-positive small lymphocytoid cells with T-cell properties are found in the praenycotic stage. In the tumour stage, large lymphocytoid cells become increasingly prevalent, they show no acid esterase activity, but an intracytoplasmatic-localized reaction in the acid phosphatase activity. On the basis of the cytochemical pattern, it is assumed that these cells represent proliferating lymphoblasts.

Topics: Acid Phosphatase; Esterases; Histocytochemistry; Humans; Immunoenzyme Techniques; Lymphocyte Activation; Mycosis Fungoides; Receptors, Antigen, B-Cell; Skin; Skin Neoplasms; T-Lymphocytes

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adult; Aged; Alkaline Phosphatase; Esterases; Female; Glucuronidase; Humans; Immunoenzyme Techniques; Leukemia, Hairy Cell; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Male; Middle Aged; Mycosis Fungoides; Nucleotidases; Rosette Formation

Topics: Acid Phosphatase; B-Lymphocytes; Esterases; Humans; Lymphatic Diseases; Lymphoma; Mycosis Fungoides; Skin Neoplasms; Syndrome; T-Lymphocytes

Topics: Acid Phosphatase; Humans; Male; Middle Aged; Mycosis Fungoides; T-Lymphocytes

Topics: Acid Phosphatase; Alkaline Phosphatase; Connective Tissue; Connective Tissue Cells; DNA; Enzymes; Esterases; Fibroma; Fibrosarcoma; Granulation Tissue; Histiocytoma, Benign Fibrous; Histocytochemistry; Humans; Leprosy; Leucyl Aminopeptidase; Lymphoma, Large B-Cell, Diffuse; Mycosis Fungoides; Skin; Skin Diseases; Skin Neoplasms; Tuberculosis, Cutaneous

A 76 year old man with mycosis fungoides developed an immunoblastic sarcoma and a leukemic blood picture in the final tumor stage after 6 years, in which the disease had clinically progressed in a typical manner. The results of histological and cytochemical studies of autopsy material are presented. Based on these findings and evidence of the T cell nature of mycosis fungoides, the immunoblastic sarcoma observed in the terminal stage of this case of mycosis fungoides might be of the rare T cell type.

Topics: Acid Phosphatase; Aged; Esterases; Humans; Leukemia; Leukocyte Count; Lymphoma, Non-Hodgkin; Male; Mycosis Fungoides; Skin Neoplasms; Syndrome; T-Lymphocytes

Topics: Acid Phosphatase; Anemia; Anemia, Aplastic; Azo Compounds; Blood Cells; Bone Marrow Cells; Histocytochemistry; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Mycosis Fungoides; Neoplasms; Polycythemia Vera; Sarcoma