acid-phosphatase and Meningioma

Topics: Acid Phosphatase; Animals; Brain Neoplasms; Glioma; Glucuronidase; Humans; Lysosomes; Meningioma; Neoplasms, Experimental; Neuroma; Rats

Somatic cells do not have telomerase activity but immortalized cell lines and more than 85 % of the cancer cells show telomerase activation to prevent the telomere from progressive shortening. The activation of this enzyme has been found in a variety of human tumors and tumor-derived cell lines, but only few studies on telomerase activity in human brain tumors have been reported. Here, we evaluated telomerase activity in different grades of human astrocytoma and meningioma brain tumors. In this study, assay for telomerase activity performed on 50 eligible cases consisted of 26 meningioma, 24 astrocytoma according to the standard protocols. In the brain tissues, telomerase activity was positive in 39 (65 %) of 50 patients. One sample t test showed that the telomerase activity in meningioma and astrocytoma tumors was significantly positive entirely (P < 0.001). Also, grade I of meningioma and low grades of astrocytoma (grades I and II) significantly showed telomerase activity. According to our results, we suggest that activation of telomerase is an event that starts mostly at low grades of brain including meningioma and astrocytoma tumors.

Topics: Acid Phosphatase; Adult; Aged; Astrocytoma; Brain Neoplasms; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Male; Meningioma; Middle Aged; Neoplasm Grading; Tartrate-Resistant Acid Phosphatase; Telomerase

In meningiomas extending into pericranial structures, phenomena of invasive growth are observed that have been little known up to now in this onkotype but are of differential diagnostic importance in these locations. 6 out of 10 meningiomas invading the ethmoidal sinus and/or skeletal muscles showed intravasal extension of tumour cells in small vessels of the neighbouring tissue. In 5 out of 7 cases with muscle invasion next to interstitial growth, the spreading of meningioma cells within isolated myofibers could be observed. As shown by enzyme- and immunohistochemical methods, the latter survived for a longer time in spite of active mitotic proliferation and axial spreading of the tumour cells within the sarcoplasm tube. A relation to peculiarities of histology, growth activity and clinical course does not seem to exist.

Topics: Acid Phosphatase; Adenosine Triphosphatases; Adult; Aged; Biomarkers; Biopsy; Dihydrolipoamide Dehydrogenase; Female; Head and Neck Neoplasms; Humans; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Neck Muscles; Neoplasm Invasiveness; Retrospective Studies

Estimation of activity of five hydrolytic enzymes was made in foru histologically different types of human meningiomas derived from surgery. The hydrolytic enzymes examined in 13 tumors included four lysosomal enzymes: beta-glucuronidase, N-acetyl-beta-D-glucosaminidase (hexosaminidase), beta-galactosidase, and acid phosphatase. The fifth enzyme studied was alkaline phosphatase. The one papillary-type meningioma examined appeared to contain generally greater activities of the lysosomal enzymes than the other tumor types. Alkaline phosphatase was decidedly greater in transitional type meningiomas. The correlation of histological types with alkaline phosphatase activity is discussed with regard to previous observations.

Topics: Acid Phosphatase; Alkaline Phosphatase; Galactosidases; Glucuronidase; Hexosaminidases; Humans; Meningeal Neoplasms; Meningioma

Topics: Acetylglucosaminidase; Acid Phosphatase; Adult; Arylsulfatases; Child; Female; Glucuronidase; Humans; Lysosomes; Male; Meningeal Neoplasms; Meningioma

Topics: Acid Phosphatase; Adenoma, Chromophobe; Astrocytoma; Biopsy; Brain Neoplasms; Choroid Plexus; Ependymoma; Glioblastoma; Hemangiosarcoma; Histocytochemistry; Humans; Medulloblastoma; Meningioma; Neurilemmoma; Oligodendroglioma; Papilloma; Pituitary Neoplasms; Rosaniline Dyes; Sarcoma; Staining and Labeling

Topics: Acid Phosphatase; Adenoma, Chromophobe; Ameloblastoma; Astrocytoma; Biopsy; Brain; Brain Neoplasms; Cell Differentiation; Cerebellar Neoplasms; Cerebellum; Choroid Neoplasms; Choroid Plexus; Ependyma; Ependymoma; Esterases; Ganglia; Ganglioneuroma; Hemangiosarcoma; Histocytochemistry; Humans; Medulla Oblongata; Medulloblastoma; Meninges; Meningioma; Neuroectodermal Tumors, Primitive, Peripheral; Neuroma; Neurons; Oligodendroglioma; Pituitary Gland; Pituitary Neoplasms; Sarcoma

Topics: Acid Phosphatase; Adult; Aged; Alkaline Phosphatase; Brain Neoplasms; Female; Histocytochemistry; Humans; Male; Meningioma; Middle Aged

Topics: Acid Phosphatase; Adenoma, Chromophobe; Adenosine Triphosphatases; Alkaline Phosphatase; Brain Neoplasms; Glioblastoma; Histocytochemistry; Humans; Meningioma; Neurilemmoma; Peripheral Nervous System Neoplasms; Pituitary Neoplasms; Succinate Dehydrogenase; Vestibulocochlear Nerve

Topics: Acid Phosphatase; Alkaline Phosphatase; Cell Nucleus; Cytoplasm; Esterases; Humans; Meningioma; Microscopy, Electron; NAD; Oxidoreductases

Topics: Acid Phosphatase; Alkaline Phosphatase; Esterases; Histocytochemistry; Humans; Lysosomes; Meningioma; Necrosis

Topics: Acid Phosphatase; Alkaline Phosphatase; Brain Neoplasms; Cytoplasm; Cytoplasmic Granules; Electron Transport Complex IV; Esterases; Humans; L-Lactate Dehydrogenase; Leucyl Aminopeptidase; Meningioma; NAD; Spinal Cord Neoplasms; Succinate Dehydrogenase

Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Astrocytoma; Brain Neoplasms; Carcinoma; Ependymoma; Esterases; Glioma; Glucosyltransferases; Histocytochemistry; Humans; Meningioma; Neurilemmoma; Oligodendroglioma; Sarcoma

Topics: Acid Phosphatase; Adenoma; Brain Abscess; Brain Neoplasms; Cerebral Cortex; Ependymoma; Glioma; Histocytochemistry; Humans; Lymphoma, Large B-Cell, Diffuse; Medulloblastoma; Meningioma; Microscopy, Fluorescence; Pituitary Neoplasms; Staining and Labeling

Topics: Acid Phosphatase; Alkaline Phosphatase; Cerebrospinal Fluid; Clinical Enzyme Tests; Esterases; Humans; Meningeal Neoplasms; Meningioma; Neoplasms

Topics: Acid Phosphatase; Alkaline Phosphatase; Aminopeptidases; Brain; Cerebellar Neoplasms; Esterases; Glioma; Medulloblastoma; Meningeal Neoplasms; Meningioma; Neoplasms, Nerve Tissue; Neurochemistry; Neurofibroma

Topics: Acid Phosphatase; Incidence; Meningeal Neoplasms; Meningioma; Phosphoric Monoester Hydrolases